JP2023538881A - タンパク質の製造方法 - Google Patents

タンパク質の製造方法 Download PDF

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Publication number
JP2023538881A
JP2023538881A JP2023510442A JP2023510442A JP2023538881A JP 2023538881 A JP2023538881 A JP 2023538881A JP 2023510442 A JP2023510442 A JP 2023510442A JP 2023510442 A JP2023510442 A JP 2023510442A JP 2023538881 A JP2023538881 A JP 2023538881A
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JP
Japan
Prior art keywords
hours
protein
cells
cell
temperature setpoint
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Pending
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JP2023510442A
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English (en)
Japanese (ja)
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JP2023538881A5 (https=
Inventor
モーガン ルイス，アマンダ
ジーン－ウェイ リー，アリソン
アン ラモン，ナンシー
ウェイン キャロン，テランス
チャールズ ベイツ，ロナルド
トーマス ルドウィッグ，リチャード
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Bristol Myers Squibb Co
Original Assignee
Bristol Myers Squibb Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Bristol Myers Squibb Co filed Critical Bristol Myers Squibb Co
Publication of JP2023538881A publication Critical patent/JP2023538881A/ja
Publication of JP2023538881A5 publication Critical patent/JP2023538881A5/ja
Pending legal-status Critical Current

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/005—Glycopeptides, glycoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00—Preparation of peptides or proteins
    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • G01N2400/38—Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence, e.g. gluco- or galactomannans, Konjac gum, Locust bean gum or Guar gum

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Genetics & Genomics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Cell Biology (AREA)
  • Biomedical Technology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
JP2023510442A 2020-08-14 2021-08-13 タンパク質の製造方法 Pending JP2023538881A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US202063066127P 2020-08-14 2020-08-14
US63/066,127 2020-08-14
US202163199547P 2021-01-07 2021-01-07
US63/199,547 2021-01-07
PCT/US2021/045959 WO2022036232A2 (en) 2020-08-14 2021-08-13 Method of making protein

Publications (2)

Publication Number Publication Date
JP2023538881A true JP2023538881A (ja) 2023-09-12
JP2023538881A5 JP2023538881A5 (https=) 2024-08-22

Family

ID=77864623

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2023510442A Pending JP2023538881A (ja) 2020-08-14 2021-08-13 タンパク質の製造方法

Country Status (5)

Country Link
US (1) US20230323422A1 (https=)
EP (1) EP4196598A2 (https=)
JP (1) JP2023538881A (https=)
KR (1) KR20230045615A (https=)
WO (1) WO2022036232A2 (https=)

Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532642A (ja) * 2001-06-13 2004-10-28 ジェネンテック・インコーポレーテッド 動物細胞の培養方法と動物細胞でのポリペプチド産生
JP2006511224A (ja) * 2002-12-23 2006-04-06 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質製造のための哺乳類細胞培養方法を用いる生成物品質の増大
JP2006520186A (ja) * 2002-12-23 2006-09-07 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質を製造するための哺乳類細胞培養法
JP2009520503A (ja) * 2005-12-20 2009-05-28 ブリストル−マイヤーズ スクイブ カンパニー 組成物および組成物の製造方法
JP2009543550A (ja) * 2006-07-13 2009-12-10 ワイス 糖タンパク質の生産
WO2012149197A2 (en) * 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
JP2013507979A (ja) * 2009-10-26 2013-03-07 エフ．ホフマン−ラ ロシュ アーゲー グリコシル化された免疫グロブリンの調製方法
JP2018521676A (ja) * 2015-08-04 2018-08-09 リヒター ゲデオン エヌワイアールティー． 組換えタンパク質のガラクトース含有量を増加させる方法
JP2018523481A (ja) * 2015-08-17 2018-08-23 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼの製造
JP2023537760A (ja) * 2020-08-14 2023-09-05 ブリストル－マイヤーズ スクイブ カンパニー タンパク質の製造工程

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD266710A3 (de) 1983-06-06 1989-04-12 Ve Forschungszentrum Biotechnologie Verfahren zur biotechnischen Herstellung van alkalischer Phosphatase
CA2384880C (en) * 1999-09-27 2010-09-21 Genentech, Inc. Methods for making recombinant proteins using apoptosis inhibitors
HK1211981A1 (en) * 2012-09-02 2016-06-03 Abbvie Inc. Methods to control protein heterogeneity
CN108463243B (zh) * 2015-11-19 2022-06-14 夏尔人类遗传性治疗公司 重组人c1酯酶抑制剂及其用途
IL263342B2 (en) * 2016-06-10 2023-11-01 Lonza Ag Method for stabilizing proteins

Patent Citations (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2004532642A (ja) * 2001-06-13 2004-10-28 ジェネンテック・インコーポレーテッド 動物細胞の培養方法と動物細胞でのポリペプチド産生
JP2006511224A (ja) * 2002-12-23 2006-04-06 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質製造のための哺乳類細胞培養方法を用いる生成物品質の増大
JP2006520186A (ja) * 2002-12-23 2006-09-07 ブリストル−マイヤーズ　スクイブ　カンパニー タンパク質を製造するための哺乳類細胞培養法
JP2009520503A (ja) * 2005-12-20 2009-05-28 ブリストル−マイヤーズ スクイブ カンパニー 組成物および組成物の製造方法
JP2009543550A (ja) * 2006-07-13 2009-12-10 ワイス 糖タンパク質の生産
JP2013507979A (ja) * 2009-10-26 2013-03-07 エフ．ホフマン−ラ ロシュ アーゲー グリコシル化された免疫グロブリンの調製方法
WO2012149197A2 (en) * 2011-04-27 2012-11-01 Abbott Laboratories Methods for controlling the galactosylation profile of recombinantly-expressed proteins
JP2018521676A (ja) * 2015-08-04 2018-08-09 リヒター ゲデオン エヌワイアールティー． 組換えタンパク質のガラクトース含有量を増加させる方法
JP2018523481A (ja) * 2015-08-17 2018-08-23 アレクシオン ファーマシューティカルズ， インコーポレイテッド アルカリホスファターゼの製造
JP2023537760A (ja) * 2020-08-14 2023-09-05 ブリストル－マイヤーズ スクイブ カンパニー タンパク質の製造工程

Also Published As

Publication number Publication date
EP4196598A2 (en) 2023-06-21
WO2022036232A2 (en) 2022-02-17
US20230323422A1 (en) 2023-10-12
WO2022036232A9 (en) 2022-08-25
WO2022036232A3 (en) 2022-06-09
KR20230045615A (ko) 2023-04-04

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