JP2023534720A - Ｓｃｎ２ａ中の機能喪失変異に関連する障害を処置するための組成物及び方法 - Google Patents

Ｓｃｎ２ａ中の機能喪失変異に関連する障害を処置するための組成物及び方法 Download PDF

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JP2023534720A
JP2023534720A JP2023504330A JP2023504330A JP2023534720A JP 2023534720 A JP2023534720 A JP 2023534720A JP 2023504330 A JP2023504330 A JP 2023504330A JP 2023504330 A JP2023504330 A JP 2023504330A JP 2023534720 A JP2023534720 A JP 2023534720A
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intron
antisense oligonucleotide
scn2a
mrna
sequence
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JP2023534720A5 (enExample
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ペトロー スティーブン
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ザ フローリー インスティテュート オブ ニューロサイエンス アンド メンタル ヘルス
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JP2023504330A 2020-07-22 2021-07-22 Ｓｃｎ２ａ中の機能喪失変異に関連する障害を処置するための組成物及び方法 Pending JP2023534720A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AU2020902550A AU2020902550A0 (en) 2020-07-22 Compositions and methods for treating disorders associated with loss-of-function mutations in SCN2A
AU2020902550 2020-07-22
PCT/AU2021/050788 WO2022016222A1 (en) 2020-07-22 2021-07-22 Compositions and methods for treating disorders associated with loss-of-function mutations in scn2a

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JP2023534720A true JP2023534720A (ja) 2023-08-10
JP2023534720A5 JP2023534720A5 (enExample) 2024-07-18

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US (1) US20230272387A1 (enExample)
EP (1) EP4185697A4 (enExample)
JP (1) JP2023534720A (enExample)
KR (1) KR20230095056A (enExample)
CN (1) CN116368227A (enExample)
AU (1) AU2021311137A1 (enExample)
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CO (1) CO2023001922A2 (enExample)
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MX (1) MX2023000907A (enExample)
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EP4473113A4 (en) * 2022-02-04 2026-03-25 Praxis Prec Medicines Inc TREATMENT METHODS FOR DISORDERS RELATED TO SCN2A
KR20250180156A (ko) 2024-06-21 2025-12-31 중앙대학교 산학협력단 뇌전증의 예방 또는 치료용 조성물, 및 뇌전증 치료제 스크리닝 방법과 이의 조성물

Citations (1)

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WO2019143831A1 (en) * 2018-01-17 2019-07-25 Rogcon U.R., Inc. Compositions and methods for increasing expression of scn2a

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DE1252330T1 (de) * 1999-11-26 2003-11-27 Mcgill University, Montreal Loci der idiopathischen epilepsie, mutationen derselben und verfahren zu deren verwendung zur feststellung, prognose und behandlung von epilepsie
EP1268856A2 (de) * 2000-04-07 2003-01-02 Epigenomics AG Detektion von snp's und cytosin-methylierungen
AU2001276919A1 (en) * 2000-07-13 2002-01-30 Genaissance Pharmaceuticals, Inc. Haplotypes of the mmp13 gene
CA2541836A1 (en) * 2003-10-13 2005-04-21 Bionomics Limited A diagnostic method for neonatal or infantile epilepsy syndromes
CN101148665A (zh) * 2005-12-05 2008-03-26 广州医学院第二附属医院 钠离子通道scn1a基因突变及基因突变检测方法和用途
WO2010151671A2 (en) * 2009-06-24 2010-12-29 Curna, Inc. Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
EP2490699A1 (en) * 2009-10-20 2012-08-29 Santaris Pharma A/S Oral delivery of therapeutically effective lna oligonucleotides
US20150141320A1 (en) * 2012-05-16 2015-05-21 Rana Therapeutics, Inc. Compositions and methods for modulating gene expression
CN109843914B (zh) * 2016-07-06 2024-03-15 沃泰克斯药物股份有限公司 用于治疗疼痛相关病症的材料和方法
KR20190030833A (ko) * 2017-09-15 2019-03-25 가톨릭대학교 산학협력단 신장암 환자의 예후 진단 및 치료 전략 결정용 연령 특이적 마커
HUE070436T2 (hu) * 2017-10-23 2025-06-28 Stoke Therapeutics Inc Antiszensz oligomerek nonszensz-mediált RNS-lebomláson alapuló állapotok és betegségek kezelésére
BR112021003224A2 (pt) * 2018-08-20 2021-07-20 Rogcon, Inc. oligonucleotídeos antissentido direcionados a scn2a para o tratamento de encefalopatias por scn1a
US20220090087A1 (en) * 2019-01-23 2022-03-24 The Florey Institute Of Neuroscience And Mental Health Antisense oligonucleotides targeting scn2a retained introns

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Publication number Priority date Publication date Assignee Title
WO2019143831A1 (en) * 2018-01-17 2019-07-25 Rogcon U.R., Inc. Compositions and methods for increasing expression of scn2a

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CA3186629A1 (en) 2022-01-27
BR112023000988A2 (pt) 2023-03-28
EP4185697A1 (en) 2023-05-31
ECSP23012641A (es) 2023-03-31
CO2023001922A2 (es) 2023-06-09
CN116368227A (zh) 2023-06-30
WO2022016222A1 (en) 2022-01-27
EP4185697A4 (en) 2025-01-01
PE20230982A1 (es) 2023-06-21
MX2023000907A (es) 2023-04-27
IL299999A (en) 2023-03-01
KR20230095056A (ko) 2023-06-28
CL2023000208A1 (es) 2023-07-21
US20230272387A1 (en) 2023-08-31
AU2021311137A1 (en) 2023-03-23

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