JP2023533616A5 - - Google Patents
Info
- Publication number
- JP2023533616A5 JP2023533616A5 JP2023524490A JP2023524490A JP2023533616A5 JP 2023533616 A5 JP2023533616 A5 JP 2023533616A5 JP 2023524490 A JP2023524490 A JP 2023524490A JP 2023524490 A JP2023524490 A JP 2023524490A JP 2023533616 A5 JP2023533616 A5 JP 2023533616A5
- Authority
- JP
- Japan
- Prior art keywords
- compound according
- cycloalkyl
- compound
- alkyl
- bonded
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063046325P | 2020-06-30 | 2020-06-30 | |
| US63/046,325 | 2020-06-30 | ||
| PCT/US2021/039982 WO2022006331A2 (en) | 2020-06-30 | 2021-06-30 | Pyridine-1,5-diones exhibitng mnk inhibition and their method of use |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023533616A JP2023533616A (ja) | 2023-08-03 |
| JP2023533616A5 true JP2023533616A5 (https=) | 2024-06-26 |
Family
ID=79315594
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023524490A Pending JP2023533616A (ja) | 2020-06-30 | 2021-06-30 | Ｍｎｋ阻害を示すピリジン－１，５－ジオン及びそれらの使用方法 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US20230286983A1 (https=) |
| EP (1) | EP4171565A4 (https=) |
| JP (1) | JP2023533616A (https=) |
| KR (1) | KR20230041715A (https=) |
| CN (1) | CN116194112A (https=) |
| AU (1) | AU2021300363A1 (https=) |
| BR (1) | BR112022026275A2 (https=) |
| CA (1) | CA3183551A1 (https=) |
| IL (1) | IL299512A (https=) |
| MX (1) | MX2022016516A (https=) |
| WO (1) | WO2022006331A2 (https=) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA3225747A1 (en) * | 2021-06-30 | 2023-01-05 | 4E Therapeutics, Inc. | Spirocyclic pyridine-1,5-diones exhibiting mnk inhibition and their method of use |
| EP4646266A1 (en) * | 2023-01-04 | 2025-11-12 | 4E Therapeutics, Inc. | Solid state forms of mnk inhibitors |
| WO2026006417A1 (en) * | 2024-06-26 | 2026-01-02 | 4E Therapeutics, Inc. | Formulations of mnk inhibitors |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5575274B2 (ja) * | 2010-02-26 | 2014-08-20 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | 医薬組成物のためのｍｎｋｌ／ｍｎｋ２阻害活性を有する４−［シクロアルキルオキシ（ヘテロ）アリールアミノ］チエノ「２，３−ｄ］ピリミジン |
| CN103874496A (zh) * | 2011-08-22 | 2014-06-18 | 默沙东公司 | 作为bace抑制剂的2-螺-取代的亚氨基噻嗪类及其单和二氧化物、组合物及其用途 |
| GB201205669D0 (en) * | 2012-03-30 | 2012-05-16 | Agency Science Tech & Res | Bicyclic heterocyclic derivatives as mnk2 and mnk2 modulators and uses thereof |
| TWI713455B (zh) * | 2014-06-25 | 2020-12-21 | 美商伊凡克特治療公司 | ＭｎＫ抑制劑及其相關方法 |
| WO2017068064A1 (en) * | 2015-10-22 | 2017-04-27 | Selvita S.A. | Pyridone derivatives and their use as kinase inhibitors |
| BR112018008711A2 (pt) * | 2015-10-29 | 2018-10-30 | Effector Therapeutics Inc | compostos de pirrolo-, pirazolo-, imidazo-pirimidina e piridina que inibem mnk1 e mnk2 |
| GB201520500D0 (en) * | 2015-11-20 | 2016-01-06 | Medical Res Council Technology | Compounds |
| WO2017165908A1 (en) * | 2016-03-31 | 2017-10-05 | South Australian Health And Medical Research Institute Limited | Method of inhibiting high fat diet-related conditions |
| CA3064000A1 (en) * | 2017-05-24 | 2018-11-29 | Effector Therapeutics, Inc. | Methods and compositions for cellular immunotherapy |
| CN113286592A (zh) * | 2018-10-24 | 2021-08-20 | 效应治疗股份有限公司 | Mnk抑制剂的结晶形式 |
| CN111484494B (zh) * | 2019-01-29 | 2022-09-13 | 诺沃斯达药业(上海)有限公司 | 抑制mnk1和mnk2的多环化合物 |
| EP3972593B1 (en) * | 2019-05-23 | 2025-07-02 | Board of Regents, The University of Texas System | Inhibitor of mnk for the treatment of neuropathic pain |
| CN110256432A (zh) * | 2019-06-27 | 2019-09-20 | 诺沃斯达药业有限公司 | 抑制mnk1和mnk2的多环化合物 |
-
2021
- 2021-06-30 JP JP2023524490A patent/JP2023533616A/ja active Pending
- 2021-06-30 WO PCT/US2021/039982 patent/WO2022006331A2/en not_active Ceased
- 2021-06-30 BR BR112022026275A patent/BR112022026275A2/pt unknown
- 2021-06-30 MX MX2022016516A patent/MX2022016516A/es unknown
- 2021-06-30 CA CA3183551A patent/CA3183551A1/en active Pending
- 2021-06-30 IL IL299512A patent/IL299512A/en unknown
- 2021-06-30 US US18/003,829 patent/US20230286983A1/en active Pending
- 2021-06-30 CN CN202180056845.0A patent/CN116194112A/zh active Pending
- 2021-06-30 KR KR1020237003174A patent/KR20230041715A/ko active Pending
- 2021-06-30 AU AU2021300363A patent/AU2021300363A1/en active Pending
- 2021-06-30 EP EP21831750.1A patent/EP4171565A4/en active Pending
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