JP2023530785A - ｛２－［３－シクロヘキシル－３－（ｔｒａｎｓ－４－プロポキシ－シクロヘキシル）－ウレイド］－チアゾール－５－イルスルファニル｝－酢酸の結晶形およびその使用 - Google Patents

｛２－［３－シクロヘキシル－３－（ｔｒａｎｓ－４－プロポキシ－シクロヘキシル）－ウレイド］－チアゾール－５－イルスルファニル｝－酢酸の結晶形およびその使用 Download PDF

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JP2023530785A
JP2023530785A JP2023519156A JP2023519156A JP2023530785A JP 2023530785 A JP2023530785 A JP 2023530785A JP 2023519156 A JP2023519156 A JP 2023519156A JP 2023519156 A JP2023519156 A JP 2023519156A JP 2023530785 A JP2023530785 A JP 2023530785A
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crystalline form
peaks
xrpd pattern
theta
degrees
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JP2023530785A5 (https=
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テン，ジン
ツァオ，イージョン
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ブイティーブイ・セラピューティクス・エルエルシー
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Publication of JP2023530785A5 publication Critical patent/JP2023530785A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/54—Nitrogen and either oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/426—1,3-Thiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Diabetes (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
JP2023519156A 2020-06-08 2021-06-07 ｛２－［３－シクロヘキシル－３－（ｔｒａｎｓ－４－プロポキシ－シクロヘキシル）－ウレイド］－チアゾール－５－イルスルファニル｝－酢酸の結晶形およびその使用 Pending JP2023530785A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063035994P 2020-06-08 2020-06-08
US63/035,994 2020-06-08
PCT/US2021/036082 WO2021252309A1 (en) 2020-06-08 2021-06-07 Crystalline forms of {2-[3-cyclohexyl-3-(trans-4-propoxy- cyclohexyl)-ureido]-thiazol-5-ylsulfanyl} -acetic acid and and uses thereof

Publications (2)

Publication Number Publication Date
JP2023530785A true JP2023530785A (ja) 2023-07-19
JP2023530785A5 JP2023530785A5 (https=) 2024-06-13

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JP2023519156A Pending JP2023530785A (ja) 2020-06-08 2021-06-07 ｛２－［３－シクロヘキシル－３－（ｔｒａｎｓ－４－プロポキシ－シクロヘキシル）－ウレイド］－チアゾール－５－イルスルファニル｝－酢酸の結晶形およびその使用

Country Status (9)

Country Link
US (1) US20230219910A1 (https=)
EP (1) EP4161639A4 (https=)
JP (1) JP2023530785A (https=)
KR (1) KR20230048501A (https=)
CN (2) CN121202809A (https=)
AU (1) AU2021289591A1 (https=)
CA (1) CA3181665A1 (https=)
MX (2) MX2022015524A (https=)
WO (1) WO2021252309A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HK1213197A1 (zh) * 2013-03-04 2016-06-30 Vtv治疗有限责任公司 包括葡糖激酶活化劑的固體組合物及其製備和使用方法
CN112040945A (zh) 2018-06-12 2020-12-04 Vtv治疗有限责任公司 葡萄糖激酶激活剂与胰岛素或胰岛素类似物组合的治疗用途
US12391658B2 (en) 2020-02-18 2025-08-19 Vtv Therapeutics Llc Sulfoxide and sulfone glucokinase activators and methods of use thereof
CA3181722A1 (en) 2020-06-08 2021-12-16 Jing TENG Salts or co-crystals of {2-[3-cyclohexyl-3-(trans-4-propoxy-cyclohexyl)-ureido]-thiazol-5-ylsulfanyl}-acetic acid and uses thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510741A (ja) * 2013-03-04 2016-04-11 ブイティーブイ・セラピューティクス・エルエルシー グルコキナーゼ活性化剤を含む固体組成物ならびにその同じものを作製および使用する方法
JP2016513625A (ja) * 2013-03-04 2016-05-16 ブイティーブイ・セラピューティクス・エルエルシー 安定なグルコキナーゼ活性化剤組成物

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0506662B8 (pt) * 2004-01-06 2021-05-25 Novo Nordisk As compostos ativadores de glucoquinase
NZ603614A (en) * 2010-05-26 2014-10-31 Transtech Pharma Llc Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
BR112014028622A2 (pt) * 2012-05-17 2017-06-27 Transtech Pharma Llc composições de ativador de glucoquinase para o tratamento de diabetes
EP3556354B1 (en) * 2016-12-15 2025-05-21 Hua Medicine (Shanghai) Ltd. Oral preparation of glucokinase activator and preparation method therefor

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016510741A (ja) * 2013-03-04 2016-04-11 ブイティーブイ・セラピューティクス・エルエルシー グルコキナーゼ活性化剤を含む固体組成物ならびにその同じものを作製および使用する方法
JP2016513625A (ja) * 2013-03-04 2016-05-16 ブイティーブイ・セラピューティクス・エルエルシー 安定なグルコキナーゼ活性化剤組成物

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
BASTIN,R.J. ET AL: "Salt selection and optimization procedures for pharmaceutical new chemical entities", ORGANIC PROCESS RESEARCH & DEVELOPMENT, vol. 4, JPN6009059058, 2000, pages 427 - 435, ISSN: 0005722934 *
寺田勝英: "熱分析の医薬品開発への応用", NETSU SOKUTEI, vol. 38, no. 2, JPN6023001927, 2011, pages 46 - 53, ISSN: 0005722932 *
山野光久: "医薬品のプロセス研究における結晶多形現象への取り組み", 有機合成化学協会, vol. 65, no. 9, JPN6023001929, 2007, pages 907 - 913, ISSN: 0005722933 *

Also Published As

Publication number Publication date
MX2022015524A (es) 2023-03-22
US20230219910A1 (en) 2023-07-13
CN121202809A (zh) 2025-12-26
KR20230048501A (ko) 2023-04-11
CA3181665A1 (en) 2021-12-16
EP4161639A4 (en) 2024-01-17
AU2021289591A1 (en) 2023-01-19
EP4161639A1 (en) 2023-04-12
WO2021252309A1 (en) 2021-12-16
MX2026000786A (es) 2026-03-02
CN116056760A (zh) 2023-05-02

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