JP2023527309A5 - - Google Patents
Info
- Publication number
- JP2023527309A5 JP2023527309A5 JP2022571116A JP2022571116A JP2023527309A5 JP 2023527309 A5 JP2023527309 A5 JP 2023527309A5 JP 2022571116 A JP2022571116 A JP 2022571116A JP 2022571116 A JP2022571116 A JP 2022571116A JP 2023527309 A5 JP2023527309 A5 JP 2023527309A5
- Authority
- JP
- Japan
- Prior art keywords
- poly
- virus
- human
- methyl
- rna polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202063027292P | 2020-05-19 | 2020-05-19 | |
| US63/027,292 | 2020-05-19 | ||
| USPCT/US2021/031629 | 2021-05-10 | ||
| PCT/US2021/031629 WO2021226597A2 (en) | 2020-05-08 | 2021-05-10 | Circular rna compositions and methods |
| PCT/US2021/033276 WO2021236855A1 (en) | 2020-05-19 | 2021-05-19 | Circular rna compositions and methods |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023527309A JP2023527309A (ja) | 2023-06-28 |
| JP2023527309A5 true JP2023527309A5 (enExample) | 2024-04-23 |
Family
ID=76744897
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022571116A Pending JP2023527309A (ja) | 2020-05-19 | 2021-05-19 | 環状ｒｎａ組成物及び方法 |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US20240042015A1 (enExample) |
| JP (1) | JP2023527309A (enExample) |
| CN (1) | CN116322788A (enExample) |
| AU (1) | AU2021276410A1 (enExample) |
| BR (1) | BR112022023554A2 (enExample) |
| CA (1) | CA3179423A1 (enExample) |
| MX (1) | MX2022014660A (enExample) |
| WO (1) | WO2021236855A1 (enExample) |
Families Citing this family (57)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN112399860B (zh) | 2018-06-06 | 2024-08-16 | 麻省理工学院 | 用于在真核细胞中翻译的环状rna |
| HRP20240586T1 (hr) | 2018-10-09 | 2024-07-19 | The University Of British Columbia | Sastavi i sustavi koji sadrže transfekcijske sposobne vezikle bez organskih otapala i deterdženta i s njim povezanim postupcima |
| AU2022234607B2 (en) | 2021-03-10 | 2025-01-23 | Rznomics Inc. | Self-circularized RNA structure |
| MX2024003262A (es) | 2021-09-17 | 2024-06-19 | Flagship Pioneering Innovations Vi Llc | Composiciones y metodos para producir poliribonucleotidos circulares. |
| WO2023100159A2 (en) * | 2021-12-03 | 2023-06-08 | Kashiv Biosciences, Llc | Multicistron expression vector for covid-19 vaccine |
| KR20240118881A (ko) * | 2021-12-23 | 2024-08-05 | 플래그쉽 파이어니어링 이노베이션스 브이아이, 엘엘씨 | 항푸소제닉 폴리펩티드를 인코딩하는 원형 폴리리보뉴클레오티드 |
| CN114249662B (zh) * | 2021-12-27 | 2024-06-21 | 硅羿科技（上海）有限公司 | 一种药用脂质体辅料alc-0315的制备方法 |
| WO2023126053A1 (en) * | 2021-12-28 | 2023-07-06 | BioNTech SE | Lipid-based formulations for administration of rna |
| CN119110847A (zh) * | 2022-01-11 | 2024-12-10 | 北京大学 | 针对sars-cov-2变体的环状rna疫苗及其使用方法 |
| WO2023133684A1 (en) * | 2022-01-11 | 2023-07-20 | Peking University | Circular rna vaccines against sars-cov-2 variants and methods of use thereof |
| CN118574646A (zh) * | 2022-01-19 | 2024-08-30 | 上海优替济生生物医药有限公司 | 环状rna及其用途 |
| EP4466029A1 (en) * | 2022-01-21 | 2024-11-27 | Orna Therapeutics, Inc. | Systemic administration of circular rna polynucleotides encoding muscle proteins or protein complexes |
| EP4482477A1 (en) * | 2022-02-23 | 2025-01-01 | ACM Biolabs Pte Ltd | Polymer-lipid hybrid nanoparticles comprising a lipid and a block copolymer as well as methods of making and uses thereof |
| WO2023182948A1 (en) * | 2022-03-21 | 2023-09-28 | Bio Adventure Co., Ltd. | Internal ribosome entry site (ires), plasmid vector and circular mrna for enhancing protein expression |
| CN115850104B (zh) * | 2022-04-29 | 2023-07-18 | 北京剂泰医药科技有限公司 | 可电离脂质化合物 |
| TW202408542A (zh) * | 2022-05-20 | 2024-03-01 | 大陸商浙江健新原力製藥有限公司 | 製備環狀ｒｎａ的方法 |
| CN115074364A (zh) * | 2022-06-25 | 2022-09-20 | 中国农业大学 | 环状RNA分子circRNA928及其编码基因与应用 |
| CN119768517A (zh) * | 2022-07-08 | 2025-04-04 | 上海环码生物医药有限公司 | 用于纯化环状核酸的方法和系统 |
| WO2024102677A1 (en) | 2022-11-08 | 2024-05-16 | Orna Therapeutics, Inc. | Circular rna compositions |
| AU2023398825A1 (en) | 2022-12-15 | 2025-06-26 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| KR20250122519A (ko) | 2022-12-22 | 2025-08-13 | 젠스크립트 유에스에이 인크. | 자가환형화 rna의 제조 방법 |
| CN116411023B (zh) * | 2023-02-24 | 2025-08-12 | 北京大学人民医院 | 一种新型环状rna成环序列构建car-t细胞及在治疗小细胞肺癌中的应用 |
| CN121358494A (zh) * | 2023-03-15 | 2026-01-16 | 旗舰创业创新第六有限责任公司 | 免疫原性组合物及其用途 |
| WO2024220625A1 (en) | 2023-04-19 | 2024-10-24 | Sail Biomedicines, Inc. | Delivery of polynucleotides from lipid nanoparticles comprising rna and ionizable lipids |
| WO2024226621A1 (en) * | 2023-04-25 | 2024-10-31 | Ginkgo Bioworks, Inc. | Novel internal ribosome entry site (ires) and intron sequences |
| EP4705481A2 (en) | 2023-05-05 | 2026-03-11 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| AU2024279278A1 (en) | 2023-05-31 | 2025-12-18 | Capstan Therapeutics, Inc. | Lipid nanoparticle formulations and compositions |
| CN119015401B (zh) * | 2023-06-21 | 2025-07-08 | 浙江大学 | 一种基于rna的肿瘤疫苗、制备方法、免疫佐剂及应用 |
| WO2025007148A1 (en) | 2023-06-30 | 2025-01-02 | Orna Therapeutics, Inc. | Polymer lipid nanoparticle compositions for delivering circular polynucleotides |
| CN119265241A (zh) | 2023-06-30 | 2025-01-07 | 深圳菁童生命科学有限公司 | 一种无相分离转录因子介导启始阶段重编程使细胞年轻化的方法 |
| WO2025011529A2 (en) * | 2023-07-07 | 2025-01-16 | Shanghai Circode Biomed Co., Ltd. | Circular rna vaccines for seasonal flu and methods of uses |
| WO2025011502A1 (zh) * | 2023-07-07 | 2025-01-16 | 仁景(苏州)生物科技有限公司 | 制备环状rna方法及用于所述方法的核酸序列 |
| CN121909034A (zh) * | 2023-07-24 | 2026-04-21 | 斯特兰德生物科技公司 | 用于产生用于体外细胞疗法的工程化免疫细胞的基于rna的合成回路 |
| CN116732039B (zh) * | 2023-08-03 | 2023-11-14 | 呈诺再生医学科技(北京)有限公司 | 一种促进rna序列在细胞内直接环化翻译的序列组合及其应用 |
| WO2025036467A1 (en) * | 2023-08-17 | 2025-02-20 | Wuhan University | Circular rna with increased stability and expression |
| WO2025049690A1 (en) | 2023-08-29 | 2025-03-06 | Orna Therapeutics, Inc. | Circular polyethylene glycol lipids |
| AU2024335327A1 (en) | 2023-09-01 | 2026-03-26 | Renagade Therapeutics Management Inc. | Gene editing systems, compositions, and methods for treatment of vexas syndrome |
| WO2025101501A1 (en) | 2023-11-07 | 2025-05-15 | Orna Therapeutics, Inc. | Circular rna compositions |
| CN117771264B (zh) * | 2023-11-27 | 2024-06-25 | 山东省农业科学院畜牧兽医研究所 | circHIF1α在制备抵御细菌感染的新型疫苗中的应用 |
| WO2025117969A1 (en) | 2023-12-01 | 2025-06-05 | Orna Therapeutics, Inc. | Process for manufacturing lipid nanoparticles |
| WO2025128871A2 (en) | 2023-12-13 | 2025-06-19 | Renagade Therapeutics Management Inc. | Lipid nanoparticles comprising coding rna molecules for use in gene editing and as vaccines and therapeutic agents |
| WO2025140249A1 (en) * | 2023-12-26 | 2025-07-03 | Suzhou Abogen Biosciences Co., Ltd. | A circular rna and relevant constructs and a method using the same |
| CN117866948B (zh) * | 2024-01-10 | 2024-12-13 | 上海环码生物医药有限公司 | 用于纯化环状核酸的阴选方法和系统 |
| WO2025155753A2 (en) | 2024-01-17 | 2025-07-24 | Renagade Therapeutics Management Inc. | Improved gene editing system, guides, and methods |
| WO2025179198A1 (en) * | 2024-02-23 | 2025-08-28 | Sail Biomedicines, Inc. | Circular polyribonucleotides and unmodified linear rnas with reduced immunogenicity |
| CN118291452B (zh) * | 2024-02-28 | 2025-03-14 | 山西高等创新研究院 | 一种基于i型内含子核酶体外制备环状rna的系统及其应用 |
| WO2025190113A1 (zh) * | 2024-03-14 | 2025-09-18 | 广州国家实验室 | 一种用于制备环状rna的载体及其应用 |
| WO2025222086A1 (en) * | 2024-04-19 | 2025-10-23 | Ginkgo Bioworks, Inc. | Novel intron sequences for circularizing rna molecules |
| CN118127022B (zh) * | 2024-04-30 | 2024-07-12 | 四川大学 | 变异链球菌环状RNA circcsbD及应用、其过表达菌株及构建方法和应用 |
| WO2025250751A1 (en) | 2024-05-31 | 2025-12-04 | Orna Therapeutics, Inc. | Circular rna compositions and methods |
| CN118813602B (zh) * | 2024-06-21 | 2025-07-08 | 毕昇(北京)生物科技有限公司 | 基于尖孢镰刀菌CoB基因的I型内含子的构建体及其构建方法、RNA环化方法、环状RNA和应用 |
| WO2026006644A1 (en) * | 2024-06-26 | 2026-01-02 | Emervax, Inc. | Circular mrna yellow fever vaccine |
| WO2026003582A2 (en) | 2024-06-27 | 2026-01-02 | Axelyf ehf. | Lipids and lipid nanoparticles |
| WO2026006593A1 (en) | 2024-06-28 | 2026-01-02 | Orna Therapeutics, Inc. | Synthetic internal ribosome entry sites |
| WO2026072709A1 (en) | 2024-09-25 | 2026-04-02 | Orna Therapeutics, Inc. | Chimeric antigen receptors targeting bcma |
| CN119326915A (zh) * | 2024-10-18 | 2025-01-21 | 联健生物(苏州)有限公司 | 一种促进组织修复的纳米制剂及其应用 |
| CN118995640A (zh) * | 2024-10-21 | 2024-11-22 | 云南省肿瘤医院(昆明医科大学第三附属医院) | 一种具有溶瘤作用的柯萨奇病毒b组5型毒株及其应用 |
Family Cites Families (43)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3854480A (en) | 1969-04-01 | 1974-12-17 | Alza Corp | Drug-delivery system |
| US3832253A (en) | 1973-03-21 | 1974-08-27 | Baxter Laboratories Inc | Method of making an inflatable balloon catheter |
| US4450150A (en) | 1973-05-17 | 1984-05-22 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery depots, and method for preparing and using the same |
| US4235871A (en) | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4667014A (en) | 1983-03-07 | 1987-05-19 | Syntex (U.S.A.) Inc. | Nonapeptide and decapeptide analogs of LHRH, useful as LHRH antagonists |
| US4452775A (en) | 1982-12-03 | 1984-06-05 | Syntex (U.S.A.) Inc. | Cholesterol matrix delivery system for sustained release of macromolecules |
| US4501728A (en) | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| CA1200416A (en) | 1983-05-13 | 1986-02-11 | Societe Des Produits Nestle S.A. | Food process |
| US5019369A (en) | 1984-10-22 | 1991-05-28 | Vestar, Inc. | Method of targeting tumors in humans |
| US4897355A (en) | 1985-01-07 | 1990-01-30 | Syntex (U.S.A.) Inc. | N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US4737323A (en) | 1986-02-13 | 1988-04-12 | Liposome Technology, Inc. | Liposome extrusion method |
| IN165717B (enExample) | 1986-08-07 | 1989-12-23 | Battelle Memorial Institute | |
| US5075109A (en) | 1986-10-24 | 1991-12-24 | Southern Research Institute | Method of potentiating an immune response |
| US4837028A (en) | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| FR2645866B1 (fr) | 1989-04-17 | 1991-07-05 | Centre Nat Rech Scient | Nouvelles lipopolyamines, leur preparation et leur emploi |
| JPH04167172A (ja) | 1990-10-31 | 1992-06-15 | Nec Corp | ベクトルプロセッサ |
| US5334761A (en) | 1992-08-28 | 1994-08-02 | Life Technologies, Inc. | Cationic lipids |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5744335A (en) | 1995-09-19 | 1998-04-28 | Mirus Corporation | Process of transfecting a cell with a polynucleotide mixed with an amphipathic compound and a DNA-binding protein |
| IL135578A0 (en) | 1997-10-29 | 2001-05-20 | Genzyme Corp | Compositions and methods for treating lysosomal storage disease |
| US5948902A (en) | 1997-11-20 | 1999-09-07 | South Alabama Medical Science Foundation | Antisense oligonucleotides to human serine/threonine protein phosphatase genes |
| WO2001060414A2 (en) | 2000-02-17 | 2001-08-23 | Genzyme Corporation | Genetic modification of the lung as a portal for gene delivery |
| MXPA05000511A (es) | 2001-07-12 | 2005-09-30 | Jefferson Foote | Anticuepros super humanizados. |
| US20040014194A1 (en) | 2002-03-27 | 2004-01-22 | Schering Corporation | Beta-secretase crystals and methods for preparing and using the same |
| CA2569664C (en) | 2004-06-07 | 2013-07-16 | Protiva Biotherapeutics, Inc. | Lipid encapsulated interfering rna |
| CA2689042A1 (en) | 2007-02-16 | 2008-08-28 | Merck & Co., Inc. | Compositions and methods for potentiated activity of biologicaly active molecules |
| CA2740000C (en) | 2008-10-09 | 2017-12-12 | Tekmira Pharmaceuticals Corporation | Improved amino lipids and methods for the delivery of nucleic acids |
| EP3269395A1 (en) | 2008-11-07 | 2018-01-17 | Massachusetts Institute Of Technology | Aminoalcohol lipidoids and uses thereof |
| US20130037977A1 (en) | 2010-04-08 | 2013-02-14 | Paul A. Burke | Preparation of Lipid Nanoparticles |
| CA2824526C (en) | 2011-01-11 | 2020-07-07 | Alnylam Pharmaceuticals, Inc. | Pegylated lipids and their use for drug delivery |
| RU2013154295A (ru) | 2011-06-08 | 2015-07-20 | Шир Хьюман Дженетик Терапис, Инк. | КОМПОЗИЦИИ ЛИПИДНЫХ НАНОЧАСТИЦ И СПОСОБЫ ДЛЯ ДОСТАВКИ мРНК |
| ES2795110T3 (es) | 2011-06-08 | 2020-11-20 | Translate Bio Inc | Lípidos escindibles |
| WO2013012476A2 (en) | 2011-07-21 | 2013-01-24 | Arizona Chemical Company, Llc | Branched polyether-polyamide block copolymers and methods of making and using the same |
| PL4023249T3 (pl) * | 2014-04-23 | 2025-03-10 | Modernatx, Inc. | Szczepionki z kwasem nukleinowym |
| US10407683B2 (en) * | 2014-07-16 | 2019-09-10 | Modernatx, Inc. | Circular polynucleotides |
| JP6948313B6 (ja) | 2015-09-17 | 2022-01-14 | モデルナティエックス インコーポレイテッド | 治療剤の細胞内送達のための化合物および組成物 |
| HRP20230209T1 (hr) | 2015-10-28 | 2023-04-14 | Acuitas Therapeutics Inc. | Novi lipidi i lipidne formulacije nanočestica za isporuku nukleinskih kiselina |
| WO2017222911A1 (en) * | 2016-06-20 | 2017-12-28 | The Board Of Trustees Of The Leland Stanford Junior University | Circular rnas and their use in immunomodulation |
| JP6792847B2 (ja) * | 2016-12-27 | 2020-12-02 | 国立大学法人 東京大学 | ｍＲＮＡの機能化方法 |
| CN111819185A (zh) * | 2017-12-15 | 2020-10-23 | 旗舰创业创新第六有限责任公司 | 包含环状多核糖核苷酸的组合物及其用途 |
| CN112055695A (zh) * | 2018-05-01 | 2020-12-08 | 弗莱德哈钦森癌症研究中心 | 用于基因表达的纳米粒子和其用途 |
| AU2019310448A1 (en) * | 2018-07-24 | 2021-03-11 | Mayo Foundation For Medical Education And Research | Circularized engineered rna and methods |
| JP2022552371A (ja) | 2019-10-15 | 2022-12-15 | モデルナティエックス インコーポレイテッド | 免疫調節ポリペプチドをコードするｍＲＮＡ及びその使用 |
-
2021
- 2021-05-19 WO PCT/US2021/033276 patent/WO2021236855A1/en not_active Ceased
- 2021-05-19 MX MX2022014660A patent/MX2022014660A/es unknown
- 2021-05-19 BR BR112022023554A patent/BR112022023554A2/pt unknown
- 2021-05-19 JP JP2022571116A patent/JP2023527309A/ja active Pending
- 2021-05-19 CA CA3179423A patent/CA3179423A1/en active Pending
- 2021-05-19 CN CN202180047874.0A patent/CN116322788A/zh active Pending
- 2021-05-19 US US17/999,378 patent/US20240042015A1/en active Pending
- 2021-05-19 AU AU2021276410A patent/AU2021276410A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2023527309A5 (enExample) | ||
| US12318444B2 (en) | Rotavirus vaccines | |
| JP7803621B2 (ja) | ヒトサイトメガロウイルスワクチン | |
| AU2024200425B2 (en) | Cancer vaccines | |
| US12201682B2 (en) | Henipavirus vaccine | |
| US12551734B2 (en) | Betacoronavirus mRNA vaccines | |
| JP2025041835A (ja) | 呼吸器合胞体ウイルスワクチン | |
| CA3041307A1 (en) | Human cytomegalovirus vaccine | |
| US20250099572A1 (en) | Vaccine compositions | |
| CN120379690A (zh) | 基于核酸的通用疫苗和其使用方法 | |
| JP2025520111A (ja) | Ｒｎａアジュバント、その方法及び使用 | |
| CN121604975A (zh) | Rna疫苗 | |
| HK40109231A (zh) | Rna分子 | |
| WO2026080559A1 (en) | Microneedle arrays and methods of use | |
| CN121909041A (zh) | 用于动物健康的rna疫苗 | |
| HK40125987A (zh) | 诱导针对水痘带状疱疹病毒的免疫反应的免疫原性组合物和方法 |