JP2023526495A - ＳＡＲＳ－ＣｏＶ－２ワクチン - Google Patents

ＳＡＲＳ－ＣｏＶ－２ワクチン Download PDF

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JP2023526495A
JP2023526495A JP2022571114A JP2022571114A JP2023526495A JP 2023526495 A JP2023526495 A JP 2023526495A JP 2022571114 A JP2022571114 A JP 2022571114A JP 2022571114 A JP2022571114 A JP 2022571114A JP 2023526495 A JP2023526495 A JP 2023526495A
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sars
cov
sequence
seq
epitope
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JPWO2021236854A5 (https=
JP2023526495A5 (https=
Inventor
ロマン イェレンスキー
ミン ドゥク カオ
マイク ゾン
ジャスティン ヘルベルト
カリン ヨース
シアラン ダニエル スカラン
レオニド ギトリン
エイミー レイチェル ラパポート
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グリットストーン バイオ インコーポレイテッド
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Publication of JPWO2021236854A5 publication Critical patent/JPWO2021236854A5/ja
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A61K39/215—Coronaviridae, e.g. avian infectious bronchitis virus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K2039/53—DNA (RNA) vaccination
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
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    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55511—Organic adjuvants
    • A61K2039/55555—Liposomes; Vesicles, e.g. nanoparticles; Spheres, e.g. nanospheres; Polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55561—CpG containing adjuvants; Oligonucleotide containing adjuvants
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/605—MHC molecules or ligands thereof
    • A—HUMAN NECESSITIES
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/36011—Togaviridae
    • C12N2770/36111—Alphavirus, e.g. Sindbis virus, VEE, EEE, WEE, Semliki
    • C12N2770/36141—Use of virus, viral particle or viral elements as a vector
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    • C12N2840/00—Vectors comprising a special translation-regulating system
    • C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
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  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Pulmonology (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2022571114A 2020-05-19 2021-05-19 ＳＡＲＳ－ＣｏＶ－２ワクチン Pending JP2023526495A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US202063027283P 2020-05-19 2020-05-19
US63/027,283 2020-05-19
US202063047789P 2020-07-02 2020-07-02
US63/047,789 2020-07-02
US202163139292P 2021-01-19 2021-01-19
US63/139,292 2021-01-19
PCT/US2021/033275 WO2021236854A1 (en) 2020-05-19 2021-05-19 Sars-cov-2 vaccines

Publications (3)

Publication Number Publication Date
JP2023526495A true JP2023526495A (ja) 2023-06-21
JPWO2021236854A5 JPWO2021236854A5 (https=) 2024-05-27
JP2023526495A5 JP2023526495A5 (https=) 2024-05-27

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JP2022571114A Pending JP2023526495A (ja) 2020-05-19 2021-05-19 ＳＡＲＳ－ＣｏＶ－２ワクチン

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Country Link
US (1) US20230330215A1 (https=)
EP (1) EP4153730A4 (https=)
JP (1) JP2023526495A (https=)
KR (1) KR20230025670A (https=)
CN (1) CN116437951A (https=)
AU (1) AU2021273827A1 (https=)
CA (1) CA3178115A1 (https=)
IL (1) IL297795A (https=)
WO (1) WO2021236854A1 (https=)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12194089B2 (en) 2020-02-04 2025-01-14 CureVac SE Coronavirus vaccine
AU2021323389B1 (en) * 2020-11-12 2022-03-24 Ahs Hospital Corp. SARS-CoV-2 immunodominant peptide constructs and uses thereof
US20240156946A1 (en) 2020-12-22 2024-05-16 CureVac SE Rna vaccine against sars-cov-2 variants
US20240409587A1 (en) * 2021-04-12 2024-12-12 La Jolla Institute For Immunology Coronavirus T Cell Epitopes and Uses Thereof
WO2022268916A2 (en) * 2021-06-23 2022-12-29 Ose Immunotherapeutics Pan-coronavirus peptide vaccine
WO2023081936A2 (en) * 2021-11-08 2023-05-11 Gritstone Bio, Inc. Sars-cov-2 vaccines
CN116212012A (zh) * 2021-12-02 2023-06-06 上海泽润生物科技有限公司 复合佐剂以及包含它的疫苗制剂
WO2023100159A2 (en) * 2021-12-03 2023-06-08 Kashiv Biosciences, Llc Multicistron expression vector for covid-19 vaccine
TWI845133B (zh) * 2022-01-27 2024-06-11 中央研究院 胜肽介導的活性劑遞送
CN114832099B (zh) * 2022-04-08 2023-11-28 国科宁波生命与健康产业研究院 一种用于治疗SARS-CoV-2变异毒株感染的多肽制剂
CN114907453B (zh) * 2022-04-08 2023-07-25 国科宁波生命与健康产业研究院 一种用于治疗SARS-CoV-2病毒感染的S蛋白多肽
US12084703B2 (en) 2022-05-12 2024-09-10 SunVax mRNA Therapeutics Inc. Synthetic self-amplifying mRNA molecules with secretion antigen and immunomodulator
CN119677546A (zh) * 2022-07-12 2025-03-21 吉利德科学公司 Hiv免疫原性多肽和疫苗及其用途
WO2024026553A1 (en) * 2022-08-03 2024-02-08 Centre Hospitalier De L'université De Montréal Novel antigenic epitope against sars-cov-2 and uses thereof
CN119907804A (zh) * 2022-09-19 2025-04-29 百奥泰生物制药股份有限公司 一种冠状病毒多价疫苗及其应用
WO2024089638A1 (en) 2022-10-28 2024-05-02 Glaxosmithkline Biologicals Sa Nucleic acid based vaccine

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2729116C2 (ru) * 2015-12-16 2020-08-04 Гритстоун Онколоджи, Инк. Идентификация, производство и применение неоантигенов

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BIORXIV PREPRINT, JPN6025027375, 25 April 2020 (2020-04-25), pages 1 - 14, ISSN: 0005635285 *

Also Published As

Publication number Publication date
IL297795A (en) 2022-12-01
US20230330215A1 (en) 2023-10-19
EP4153730A1 (en) 2023-03-29
CA3178115A1 (en) 2021-11-25
KR20230025670A (ko) 2023-02-22
EP4153730A4 (en) 2024-12-25
AU2021273827A1 (en) 2023-01-19
CN116437951A (zh) 2023-07-14
WO2021236854A1 (en) 2021-11-25

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