JP2023521772A - 操作されたトランスアミナーゼポリペプチド - Google Patents

操作されたトランスアミナーゼポリペプチド Download PDF

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Publication number
JP2023521772A
JP2023521772A JP2022561487A JP2022561487A JP2023521772A JP 2023521772 A JP2023521772 A JP 2023521772A JP 2022561487 A JP2022561487 A JP 2022561487A JP 2022561487 A JP2022561487 A JP 2022561487A JP 2023521772 A JP2023521772 A JP 2023521772A
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JP
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seq
sequence
transaminase
engineered transaminase
polypeptide
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JP2023521772A5 (https=
Inventor
スコット ジェイ． ノヴィック，
ニッキ デラス，
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コデクシス， インコーポレイテッド
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Publication of JP2023521772A publication Critical patent/JP2023521772A/ja
Publication of JP2023521772A5 publication Critical patent/JP2023521772A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1096—Transferases (2.) transferring nitrogenous groups (2.6)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C12P17/18—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms containing at least two hetero rings condensed among themselves or condensed with a common carbocyclic ring system, e.g. rifamycin
    • C12P17/182—Heterocyclic compounds containing nitrogen atoms as the only ring heteroatoms in the condensed system

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2022561487A 2020-04-10 2021-04-06 操作されたトランスアミナーゼポリペプチド Pending JP2023521772A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063008047P 2020-04-10 2020-04-10
US63/008,047 2020-04-10
PCT/US2021/025967 WO2021207200A2 (en) 2020-04-10 2021-04-06 Engineered transaminase polypeptides

Publications (2)

Publication Number Publication Date
JP2023521772A true JP2023521772A (ja) 2023-05-25
JP2023521772A5 JP2023521772A5 (https=) 2024-03-13

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JP2022561487A Pending JP2023521772A (ja) 2020-04-10 2021-04-06 操作されたトランスアミナーゼポリペプチド

Country Status (7)

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US (3) US11788071B2 (https=)
EP (1) EP4133064A4 (https=)
JP (1) JP2023521772A (https=)
CN (1) CN115427557A (https=)
CA (1) CA3179751A1 (https=)
IL (1) IL296841A (https=)
WO (1) WO2021207200A2 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN115851649B (zh) * 2022-04-21 2024-12-03 凯莱英医药集团（天津）股份有限公司 转氨酶突变体及其应用
CN118909842B (zh) * 2024-07-23 2025-07-22 苏州诺恩斯生物科技有限公司 一种制备西他列汀化合物的微生物菌株及应用
CN119193731A (zh) * 2024-09-23 2024-12-27 苏州弗莱明生物技术有限公司 一种维纳卡兰的制备方法
CN121699899A (zh) * 2026-02-12 2026-03-20 天津科技大学 一种转氨酶突变体、方法及其在制备罗替戈汀关键手性中间体中的应用

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JP2016501544A (ja) * 2012-12-21 2016-01-21 コデクシス， インコーポレイテッド キラルアミンを合成するための操作された生体触媒および方法
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Also Published As

Publication number Publication date
EP4133064A4 (en) 2024-07-24
US12331325B2 (en) 2025-06-17
CA3179751A1 (en) 2021-10-14
IL296841A (en) 2022-11-01
WO2021207200A2 (en) 2021-10-14
US20210317421A1 (en) 2021-10-14
US20250320472A1 (en) 2025-10-16
EP4133064A2 (en) 2023-02-15
US11788071B2 (en) 2023-10-17
WO2021207200A3 (en) 2021-12-16
US20240002816A1 (en) 2024-01-04
CN115427557A (zh) 2022-12-02

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