JP2023512997A - ドーズダイヤル使用中に即時的なフィードバックを可能にする薬物投入調節装置 - Google Patents
ドーズダイヤル使用中に即時的なフィードバックを可能にする薬物投入調節装置 Download PDFInfo
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- 239000003814 drug Substances 0.000 title claims abstract description 53
- 229940079593 drug Drugs 0.000 title claims abstract description 52
- 238000002347 injection Methods 0.000 claims abstract description 52
- 239000007924 injection Substances 0.000 claims abstract description 52
- 238000005192 partition Methods 0.000 claims abstract description 8
- 238000012377 drug delivery Methods 0.000 claims description 13
- 230000008878 coupling Effects 0.000 claims description 9
- 238000010168 coupling process Methods 0.000 claims description 9
- 238000005859 coupling reaction Methods 0.000 claims description 9
- 230000009471 action Effects 0.000 claims description 2
- 229940090047 auto-injector Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 230000002093 peripheral effect Effects 0.000 description 2
- 230000008569 process Effects 0.000 description 2
- 230000008859 change Effects 0.000 description 1
- 238000011982 device technology Methods 0.000 description 1
- 238000007599 discharging Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 230000000717 retained effect Effects 0.000 description 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/20—Automatic syringes, e.g. with automatically actuated piston rod, with automatic needle injection, filling automatically
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- A—HUMAN NECESSITIES
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- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31526—Dosing by means of stepwise axial movements, e.g. ratchet mechanisms or detents
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31525—Dosing
- A61M5/31528—Dosing by means of rotational movements, e.g. screw-thread mechanisms
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31535—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose
- A61M5/31543—Means improving security or handling thereof, e.g. blocking means, means preventing insufficient dosing, means allowing correction of overset dose piston rod reset means, i.e. means for causing or facilitating retraction of piston rod to its starting position during cartridge change
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3155—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe
- A61M5/31551—Mechanically operated dose setting member by rotational movement of dose setting member, e.g. during setting or filling of a syringe including axial movement of dose setting member
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/31556—Accuracy improving means
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- A—HUMAN NECESSITIES
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- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31533—Dosing mechanisms, i.e. setting a dose
- A61M5/31545—Setting modes for dosing
- A61M5/31548—Mechanically operated dose setting member
- A61M5/3156—Mechanically operated dose setting member using volume steps only adjustable in discrete intervals, i.e. individually distinct intervals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31578—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod
- A61M5/3158—Constructional features or modes of drive mechanisms for piston rods based on axial translation, i.e. components directly operatively associated and axially moved with plunger rod performed by axially moving actuator operated by user, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/31576—Constructional features or modes of drive mechanisms for piston rods
- A61M5/31583—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod
- A61M5/31585—Constructional features or modes of drive mechanisms for piston rods based on rotational translation, i.e. movement of piston rod is caused by relative rotation between the user activated actuator and the piston rod performed by axially moving actuator, e.g. an injection button
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
- A61M5/178—Syringes
- A61M5/31—Details
- A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
- A61M5/31565—Administration mechanisms, i.e. constructional features, modes of administering a dose
- A61M5/3159—Dose expelling manners
- A61M5/31593—Multi-dose, i.e. individually set dose repeatedly administered from the same medicament reservoir
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/58—Means for facilitating use, e.g. by people with impaired vision
- A61M2205/581—Means for facilitating use, e.g. by people with impaired vision by audible feedback
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2205/00—General characteristics of the apparatus
- A61M2205/82—Internal energy supply devices
- A61M2205/8275—Mechanical
- A61M2205/8281—Mechanical spring operated
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- Health & Medical Sciences (AREA)
- Vascular Medicine (AREA)
- Engineering & Computer Science (AREA)
- Anesthesiology (AREA)
- Biomedical Technology (AREA)
- Heart & Thoracic Surgery (AREA)
- Hematology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
Abstract
Description
Claims (5)
- 中空のハウジング(10)、前記ハウジング(10)の一側上に回転自在に結合されたドーズダイヤル(20)、前記ハウジング(10)の他側上に固着された状態で薬物が内蔵されたカートリッジが収容されると共に、薬物が吐き出される注入ニードルが一側上に結合されるカートリッジホルダー(30)、前記ドーズダイヤル(20)内に配される注入ボタン40)、及び前記ハウジング(10)に回転不能に結合されるバネベース(150)を含む薬物投入調節装置において、
前記ハウジング(10)内に配されたトーションバネ(140)にねじりモーメントを保存して注入しようとする薬物の量を設定させる注入量設定モジュール(100)と、
前記トーションバネ(140)に加えられたねじりモーメントの解除を通じて運動することにより、前記カートリッジホルダー(30)に内蔵されたカートリッジから外部に吐き出させる薬物吐出モジュール(200)と、を含み、
前記バネベース(150)は、前記ドーズダイヤル(20)の回動時に、前記ドーズダイヤル(20)に形成されたラッチ突起(22)に対応するように形成されたラッチ(152)を含み、前記ドーズダイヤル(20)の内部隔壁の一面上に半径方向に沿って放射状に形成された多数のラッチ突起(22)と前記ラッチ(152)とが順に接して音を発生させる過程を通じて薬物注入設定量に対するフィードバックを提供することを特徴とする、薬物投入調節装置。 - 前記注入量設定モジュール(100)は、前記注入ボタン(40)の動作によって、前記ドーズダイヤル(20)にスイッチング可能に結合されるリセットチューブ(110)、前記リセットチューブ(110)の外側上に結合されて同時に回動するラチェットチューブ(120)、前記ラチェットチューブ(120)の外面上に軸方向に沿って摺動自在に回動するスケールドラム(130)、及び前記ハウジング(10)と前記ラチェットチューブ(120)上に両先端が結合されたトーションバネ(140)を含み、
前記リセットチューブ(110)に結合されたロッドガイド(210)が、前記ピストンロッド(220)の内部上にスクリュー回転結合で結束されることにより、前記ロッドガイド(210)の回転を通じて前記ピストンロッド(220)の下部直線運動を可能にすることにより、ピストンロッド(220)とロッドガイド(210)とのスクリュー方式結合を通じたカートリッジ薬物放出構造を有する、請求項1に記載の薬物投入調節装置。 - 前記トーションバネ(140)は、両端がそれぞれバネベース(150)及びラチェットチューブ(120)上に結合され、
前記ドーズダイヤル(20)を通じた回転時には、
前記ラチェットチューブ(120)に固定された前記トーションバネ(140)の一側は、回動する一方、前記バネベース(150)に固定された前記トーションバネ(140)の他側は、固定された状態を保持することにより、バネのねじれ状態を作る、請求項1に記載の薬物投入調節装置。 - 前記ボタンプレート(160)は、前記ドーズダイヤル(20)内に隔壁を通じて形成された第1ダイヤルチャンバ上で前記ドーズダイヤル(20)の内面に円周方向に沿って形成されたプレート固定段差(24)に固定される、請求項1に記載の薬物投入調節装置。
- 前記注入量設定モジュール(100)は、前記ドーズダイヤル(20)内に固設されるが、ボタンバネ(50)を支持する機能を行うボタンプレート(160)を含み、
前記注入ボタン(40)は、前記ボタンプレート(160)に摺動自在に貫通した状態に結合し、
前記薬物吐出モジュール(200)は、
前記注入ボタン(40)の動作によって、前記注入量設定モジュール(100)上にスイッチング可能に結合されるロッドガイド(210)、
前記ロッドガイド(210)の外側上にスクリュー結合された状態で前記ロッドガイド(210)の回動によって直線運動を実施することにより、カートリッジホルダー(30)に内蔵されたカートリッジの薬物を外部に吐き出させるピストンロッド(220)を含み、
前記注入ボタン(40)は、前記ドーズダイヤル(20)の回転によって同時に回動する一方、前記ボタンプレート(160)を通じて安定したプッシング動作を可能にする、請求項1に記載の薬物投入調節装置。
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KR10-2020-0145238 | 2020-11-03 | ||
KR1020200145238A KR102256035B1 (ko) | 2020-11-03 | 2020-11-03 | 도즈 다이얼 사용 중 즉시적인 피드백을 가능하게 하는 약물 투입 조절 장치 |
PCT/KR2021/015682 WO2022098047A1 (ko) | 2020-11-03 | 2021-11-02 | 도즈 다이얼 사용 중 즉시적인 피드백을 가능하게 하는 약물 투입 조절 장치 |
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CN116726316B (zh) * | 2023-05-31 | 2024-05-17 | 上海新耀湃科医疗科技股份有限公司 | 定量注射笔,及其使用方法 |
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JP2016514554A (ja) * | 2013-04-05 | 2016-05-23 | ノボ・ノルデイスク・エー/エス | 薬剤送達装置の投与記録装置 |
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PT1003581E (pt) * | 1998-01-30 | 2001-04-30 | Novo Nordisk As | Seringa de injeccao |
EP1645301A1 (en) * | 2004-10-11 | 2006-04-12 | Novo Nordisk A/S | Injection device |
PT2274030E (pt) * | 2008-05-02 | 2012-12-07 | Sanofi Aventis Deutschland | Dispositivo de administração de medicamento |
TW201138882A (en) * | 2010-01-25 | 2011-11-16 | Sanofi Aventis Deutschland | Drive assembly for a drug delivery device and drug delivery device |
KR101521742B1 (ko) * | 2011-02-03 | 2015-05-19 | 에스에이치엘 그룹 에이비 | 약물 주입 장치 |
CA2831031C (en) * | 2011-03-24 | 2016-05-03 | Shl Group Ab | Medicament delivery device |
TW201603847A (zh) * | 2014-07-01 | 2016-02-01 | 賽諾菲公司 | 注射裝置及組裝方法 |
KR102256035B1 (ko) * | 2020-11-03 | 2021-05-26 | (주)풍림파마텍 | 도즈 다이얼 사용 중 즉시적인 피드백을 가능하게 하는 약물 투입 조절 장치 |
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JP2013539697A (ja) * | 2010-10-13 | 2013-10-28 | サノフィ−アベンティス・ドイチュラント・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツング | 用量設定機構及びそれを使用する方法 |
JP2016514554A (ja) * | 2013-04-05 | 2016-05-23 | ノボ・ノルデイスク・エー/エス | 薬剤送達装置の投与記録装置 |
JP2016530012A (ja) * | 2013-09-03 | 2016-09-29 | サノフイ | 用量設定およびリセット機構を有するペン型薬物注射デバイス |
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US20230072979A1 (en) | 2023-03-09 |
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