JP2023512452A - Ｂｃｍａ指向性細胞免疫療法組成物および方法 - Google Patents

Ｂｃｍａ指向性細胞免疫療法組成物および方法 Download PDF

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JP2023512452A
JP2023512452A JP2022542664A JP2022542664A JP2023512452A JP 2023512452 A JP2023512452 A JP 2023512452A JP 2022542664 A JP2022542664 A JP 2022542664A JP 2022542664 A JP2022542664 A JP 2022542664A JP 2023512452 A JP2023512452 A JP 2023512452A
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bcma
chimeric antigen
antigen receptor
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JP2023512452A5 (enExample
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ラクシュミ ラジャンガム，カンヤ
バーナビー トレイガー，ジェイムズ
グオ ブーレン，ルシュアン
グオ，チャオ
ライダ リアナ ラゼティック，アレクサンドラ
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Nkarta Inc
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Nkarta Inc
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JP2022542664A 2020-01-13 2021-01-11 Ｂｃｍａ指向性細胞免疫療法組成物および方法 Pending JP2023512452A (ja)

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US202062960285P 2020-01-13 2020-01-13
US62/960,285 2020-01-13
PCT/US2021/012977 WO2021146147A1 (en) 2020-01-13 2021-01-11 Bcma-directed cellular immunotherapy compositions and methods

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KR (1) KR20220128650A (enExample)
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Families Citing this family (10)

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Publication number Priority date Publication date Assignee Title
EP3805371A1 (en) 2014-05-15 2021-04-14 National University of Singapore Modified natural killer cells and uses thereof
CN117363636A (zh) 2017-03-27 2024-01-09 新加坡国立大学 一种编码嵌合受体的多核苷酸
JP7360174B2 (ja) 2018-02-09 2023-10-12 ナショナル ユニヴァーシティー オブ シンガポール ナチュラルキラー細胞免疫療法における活性化キメラ受容体及びその使用
US12441787B2 (en) 2018-04-02 2025-10-14 National University Of Singapore Neutralization of human cytokines with membrane-bound anti-cytokine non-signaling binders expressed in immune cells
WO2020044239A1 (en) 2018-08-29 2020-03-05 National University Of Singapore A method to specifically stimulate survival and expansion of genetically-modified immune cells
KR20210137085A (ko) 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
CA3241912A1 (en) * 2021-12-07 2023-06-15 Huafeng Wei Antibody binding to bcma and use thereof
WO2025171388A1 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens with modified domains and related methods and uses
WO2025171383A2 (en) 2024-02-09 2025-08-14 Dispatch Biotherapeutics, Inc. Engineered cancer antigens and related methods and uses
WO2026006767A1 (en) 2024-06-28 2026-01-02 Dispatch Biotherapeutics, Inc. Tethered il-9/il-9r and related engineered cells and methods

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014565A2 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
WO2018183385A1 (en) * 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20060057680A1 (en) * 2004-08-11 2006-03-16 Zheng Xin X Mutant interleukin-15 polypeptides
AU2013246443B2 (en) * 2012-04-11 2017-04-27 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Chimeric antigen receptors targeting B-cell maturation antigen
IL305629A (en) * 2013-02-15 2023-11-01 Univ California Chimeric antigen receptor and methods of using it
GB201503742D0 (en) * 2015-03-05 2015-04-22 Ucl Business Plc Chimeric antigen receptor
TWI833684B (zh) * 2015-06-25 2024-03-01 美商生物細胞基因治療有限公司 嵌合抗原受體（ｃａｒ）、組合物及其使用方法
ES3052818T3 (en) * 2018-02-09 2026-01-14 Us Health Tethered interleukin-15 and interleukin-21
IL279367B2 (en) * 2018-06-13 2026-05-01 Novartis Ag BCMA chimeric antigen receptors and their uses
CN109320615B (zh) * 2018-09-25 2023-09-22 上海恒润达生生物科技股份有限公司 靶向新型bcma的嵌合抗原受体及其用途
KR20210137085A (ko) * 2019-03-05 2021-11-17 엔카르타, 인크. Cd19 유도된 키메라 항원 수용체 및 면역 요법에서 이의 용도
CN114174325A (zh) * 2019-06-04 2022-03-11 恩卡尔塔公司 用于免疫疗法的工程化自然杀伤细胞和工程化t细胞的组合

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016014565A2 (en) * 2014-07-21 2016-01-28 Novartis Ag Treatment of cancer using humanized anti-bcma chimeric antigen receptor
WO2018183385A1 (en) * 2017-03-27 2018-10-04 National University Of Singapore Truncated nkg2d chimeric receptors and uses thereof in natural killer cell immunotherapy

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AU2021207795A1 (en) 2022-07-28
MX2022008638A (es) 2022-08-08
EP4090337A1 (en) 2022-11-23
KR20220128650A (ko) 2022-09-21
CN115279381A (zh) 2022-11-01
WO2021146147A1 (en) 2021-07-22
US20230028399A1 (en) 2023-01-26
EP4090337A4 (en) 2024-04-24
IL294518A (en) 2022-09-01

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