JP2023511439A5 - - Google Patents
Info
- Publication number
- JP2023511439A5 JP2023511439A5 JP2022544745A JP2022544745A JP2023511439A5 JP 2023511439 A5 JP2023511439 A5 JP 2023511439A5 JP 2022544745 A JP2022544745 A JP 2022544745A JP 2022544745 A JP2022544745 A JP 2022544745A JP 2023511439 A5 JP2023511439 A5 JP 2023511439A5
- Authority
- JP
- Japan
- Prior art keywords
- use according
- protein
- domain
- cancer
- amino acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025247000A JP2026062701A (ja) | 2020-01-28 | 2025-12-12 | がんの治療のためのｉｌ１５／ｉｌ１５ｒアルファヘテロ二量体ｆｃ融合タンパク質 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202062966976P | 2020-01-28 | 2020-01-28 | |
| US62/966,976 | 2020-01-28 | ||
| PCT/US2021/015552 WO2021155042A1 (en) | 2020-01-28 | 2021-01-28 | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025247000A Division JP2026062701A (ja) | 2020-01-28 | 2025-12-12 | がんの治療のためのｉｌ１５／ｉｌ１５ｒアルファヘテロ二量体ｆｃ融合タンパク質 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2023511439A JP2023511439A (ja) | 2023-03-17 |
| JP2023511439A5 true JP2023511439A5 (cg-RX-API-DMAC7.html) | 2024-02-05 |
Family
ID=74672461
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022544745A Withdrawn JP2023511439A (ja) | 2020-01-28 | 2021-01-28 | がんの治療のためのｉｌ１５／ｉｌ１５ｒアルファヘテロ二量体ｆｃ融合タンパク質 |
| JP2025247000A Pending JP2026062701A (ja) | 2020-01-28 | 2025-12-12 | がんの治療のためのｉｌ１５／ｉｌ１５ｒアルファヘテロ二量体ｆｃ融合タンパク質 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025247000A Pending JP2026062701A (ja) | 2020-01-28 | 2025-12-12 | がんの治療のためのｉｌ１５／ｉｌ１５ｒアルファヘテロ二量体ｆｃ融合タンパク質 |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US20230149509A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP4096698A1 (cg-RX-API-DMAC7.html) |
| JP (2) | JP2023511439A (cg-RX-API-DMAC7.html) |
| KR (1) | KR20220132598A (cg-RX-API-DMAC7.html) |
| CN (1) | CN115397456A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2021213767A1 (cg-RX-API-DMAC7.html) |
| BR (1) | BR112022014849A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA3165460A1 (cg-RX-API-DMAC7.html) |
| IL (1) | IL294944A (cg-RX-API-DMAC7.html) |
| MX (1) | MX2022009100A (cg-RX-API-DMAC7.html) |
| TW (1) | TW202136318A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2021155042A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MX2019004327A (es) * | 2016-10-14 | 2019-10-14 | Xencor Inc | Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1. |
| AU2018291497A1 (en) | 2017-06-30 | 2020-01-16 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15Ra and antigen binding domains |
| WO2019204646A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Lag-3 targeted heterodimeric fusion proteins containing il-15/il-15ra fc-fusion proteins and lag-3 antigen binding domains |
| CA3097625A1 (en) | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof |
| US11618776B2 (en) | 2018-12-20 | 2023-04-04 | Xencor, Inc. | Targeted heterodimeric Fc fusion proteins containing IL-15/IL-15RA and NKG2D antigen binding domains |
| TW202128757A (zh) | 2019-10-11 | 2021-08-01 | 美商建南德克公司 | 具有改善之特性的 PD-1 標靶 IL-15/IL-15Rα FC 融合蛋白 |
| AU2020379735A1 (en) | 2019-11-05 | 2022-05-26 | Regeneron Pharmaceuticals, Inc. | N-terminal SCFV multispecific binding molecules |
| EP4376869A1 (en) * | 2021-07-28 | 2024-06-05 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the treatment of blood cancers |
| WO2023015198A1 (en) * | 2021-08-04 | 2023-02-09 | Genentech, Inc. | Il15/il15r alpha heterodimeric fc-fusion proteins for the expansion of nk cells in the treatment of solid tumours |
| CN119923274A (zh) | 2022-07-07 | 2025-05-02 | 基因泰克公司 | IL15/IL15Rα异二聚体Fc融合蛋白与FcRH5xCD3双特异性抗体的组合用于治疗血癌 |
| WO2024039973A2 (en) * | 2022-08-05 | 2024-02-22 | Staidson Biopharma Inc. | Masking polypeptide, activatable novel prodrugs and methods of use thereof |
| TW202532440A (zh) | 2023-10-19 | 2025-08-16 | 美商建南德克公司 | 用於治療ＨＥＲ２陽性癌症的ＩＬ１５／ＩＬ１５Ｒα異二聚體ＦＣ融合蛋白及ＨＥＲ２ｘＣＤ３雙特異性抗體之組合 |
| WO2025233861A1 (en) * | 2024-05-08 | 2025-11-13 | Suzhou Forlong Biotechnology Co., Ltd. | Long-acting il-15 agonist for treating tumor |
| WO2025252840A1 (en) | 2024-06-04 | 2025-12-11 | Technische Universitaet Muenchen, In Vertretung Des Freistaates Bayern | Half-life modulation by a tag comprising at least one constant domain of an immunoglobulin light chain |
Family Cites Families (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6551576B1 (en) | 1989-12-22 | 2003-04-22 | Bristol-Myers Squibb Medical Imaging, Inc. | Container with multi-phase composition for use in diagnostic and therapeutic applications |
| ES2027518A6 (es) | 1990-12-18 | 1992-06-01 | Andromaco Lab | Procedimiento para la preparacion de nuevas asociaciones no covalentes polisacarido-proteina con actividad farmacologica. |
| US7083572B2 (en) | 1993-11-30 | 2006-08-01 | Bristol-Myers Squibb Medical Imaging, Inc. | Therapeutic delivery systems |
| US6071535A (en) | 1996-01-31 | 2000-06-06 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| US5874105A (en) | 1996-01-31 | 1999-02-23 | Collaborative Laboratories, Inc. | Lipid vesicles formed with alkylammonium fatty acid salts |
| US6120751A (en) | 1997-03-21 | 2000-09-19 | Imarx Pharmaceutical Corp. | Charged lipids and uses for the same |
| EP0915987A2 (en) | 1997-04-21 | 1999-05-19 | Donlar Corporation | POLY-($g(a)-L-ASPARTIC ACID), POLY-($g(a)-L-GLUTAMIC ACID) AND COPOLYMERS OF L-ASP AND L-GLU, METHOD FOR THEIR PRODUCTION AND THEIR USE |
| US7195780B2 (en) | 2002-10-21 | 2007-03-27 | University Of Florida | Nanoparticle delivery system |
| US7449443B2 (en) | 2000-03-23 | 2008-11-11 | California Institute Of Technology | Method for stabilization of proteins using non-natural amino acids |
| US6586207B2 (en) | 2000-05-26 | 2003-07-01 | California Institute Of Technology | Overexpression of aminoacyl-tRNA synthetases for efficient production of engineered proteins containing amino acid analogues |
| US6824790B2 (en) | 2002-01-09 | 2004-11-30 | Enzrel Inc. | Liposome drug delivery of polycyclic, aromatic, antioxidant or anti-inflammatory compounds |
| WO2003066859A2 (en) | 2002-02-07 | 2003-08-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Amino acid sequences capable of facilitating penetration across a biological barrier |
| EP1490677A4 (en) | 2002-02-27 | 2006-01-18 | California Inst Of Techn | COMPUTER METHOD FOR DESIGNING ENZYMES FOR THE INCORPORATION OF AMINO ACID ANALOGUES INTO PROTEINS |
| US7090868B2 (en) | 2002-09-13 | 2006-08-15 | University Of Florida | Materials and methods for drug delivery and uptake |
| ES2367430T3 (es) | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
| US8088734B2 (en) | 2003-01-21 | 2012-01-03 | Unigene Laboratories Inc. | Oral delivery of peptides |
| AU2004317954A1 (en) | 2003-09-17 | 2005-10-13 | Chiasma, Inc. | Compositions capable of facilitating penetration across a biological barrier |
| EP1675620B1 (en) | 2003-10-09 | 2019-05-08 | Ambrx, Inc. | Polymer derivatives |
| BRPI0507169A (pt) | 2004-02-02 | 2007-06-26 | Ambrx Inc | polipeptìdeos do hormÈnio de crescimento humano modificados e seu usos |
| CA2563533C (en) | 2004-04-15 | 2013-10-01 | Shmuel A. Ben-Sasson | Compositions capable of facilitating penetration across a biological barrier |
| WO2006062506A1 (en) | 2004-12-03 | 2006-06-15 | Enzrel, Inc. | Chitosan-coated liposome drug delivery of antioxidant or anti-inflammatory compounds |
| EP3530736A3 (en) | 2005-05-09 | 2019-11-06 | ONO Pharmaceutical Co., Ltd. | Human monoclonal antibodies to programmed death 1 (pd-1) and methods for treating cancer using anti-pd-1 antibodies alone or in combination with other immunotherapeutics |
| KR101704734B1 (ko) | 2005-07-01 | 2017-02-09 | 이. 알. 스퀴부 앤드 선즈, 엘.엘.씨. | 예정 사멸 리간드 1 (피디-엘1)에 대한 인간 모노클로날 항체 |
| US20070184076A1 (en) | 2006-02-07 | 2007-08-09 | Unger Evan C | Liquid-filled nanodroplets for anti-cancer therapy |
| IL188647A0 (en) | 2008-01-08 | 2008-11-03 | Orina Gribova | Adaptable structured drug and supplements administration system (for oral and/or transdermal applications) |
| PT2242773T (pt) | 2008-02-11 | 2017-09-15 | Cure Tech Ltd | Anticorpos monoclonais para o tratamento de tumores |
| US8168757B2 (en) | 2008-03-12 | 2012-05-01 | Merck Sharp & Dohme Corp. | PD-1 binding proteins |
| KR101001360B1 (ko) | 2008-06-16 | 2010-12-14 | (주)기가레인 | 전자 기기의 접지에 전기적으로 연결되는 인쇄회로기판 |
| EA201500417A1 (ru) | 2008-08-25 | 2015-11-30 | Эмплиммьюн, Инк. | Композиции антагонистов pd-1 и способы применения |
| WO2010098788A2 (en) | 2008-08-25 | 2010-09-02 | Amplimmune, Inc. | Pd-i antagonists and methods for treating infectious disease |
| WO2010089411A2 (en) | 2009-02-09 | 2010-08-12 | Universite De La Mediterranee | Pd-1 antibodies and pd-l1 antibodies and uses thereof |
| EP2504028A4 (en) | 2009-11-24 | 2014-04-09 | Amplimmune Inc | SIMULTANEOUS INHIBITION OF PD-L1 / PD-L2 |
| CA2833636A1 (en) | 2011-04-20 | 2012-10-26 | Amplimmune, Inc. | Antibodies and other molecules that bind b7-h1 and pd-1 |
| US8686119B2 (en) | 2011-07-24 | 2014-04-01 | Curetech Ltd. | Variants of humanized immunomodulatory monoclonal antibodies |
| US9457086B2 (en) | 2013-03-05 | 2016-10-04 | Enteris Biopharma, Inc. | Pharmaceuticals for oral delivery |
| US10259887B2 (en) | 2014-11-26 | 2019-04-16 | Xencor, Inc. | Heterodimeric antibodies that bind CD3 and tumor antigens |
| CA2973099C (en) | 2015-01-12 | 2021-09-14 | Enteris Biopharma, Inc. | Solid oral dosage forms |
| MX2019004327A (es) | 2016-10-14 | 2019-10-14 | Xencor Inc | Proteinas de fusion heterodimericas biespecificas que contienen proteinas de fusion fc il-15/il-15ra y fragmentos de anticuerpo pd-1. |
| CA3097625A1 (en) * | 2018-04-18 | 2019-10-24 | Xencor, Inc. | Il-15/il-15ra heterodimeric fc fusion proteins and uses thereof |
-
2021
- 2021-01-28 AU AU2021213767A patent/AU2021213767A1/en active Pending
- 2021-01-28 WO PCT/US2021/015552 patent/WO2021155042A1/en not_active Ceased
- 2021-01-28 BR BR112022014849A patent/BR112022014849A2/pt unknown
- 2021-01-28 IL IL294944A patent/IL294944A/en unknown
- 2021-01-28 CA CA3165460A patent/CA3165460A1/en active Pending
- 2021-01-28 JP JP2022544745A patent/JP2023511439A/ja not_active Withdrawn
- 2021-01-28 KR KR1020227029305A patent/KR20220132598A/ko active Pending
- 2021-01-28 EP EP21707111.7A patent/EP4096698A1/en active Pending
- 2021-01-28 CN CN202180010911.0A patent/CN115397456A/zh active Pending
- 2021-01-28 TW TW110103329A patent/TW202136318A/zh unknown
- 2021-01-28 MX MX2022009100A patent/MX2022009100A/es unknown
-
2022
- 2022-07-22 US US17/814,456 patent/US20230149509A1/en active Pending
-
2025
- 2025-12-12 JP JP2025247000A patent/JP2026062701A/ja active Pending
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