JP2023510352A - Ｐｃｓｋ９の標的化のための組成物および方法 - Google Patents

Ｐｃｓｋ９の標的化のための組成物および方法 Download PDF

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JP2023510352A
JP2023510352A JP2022542340A JP2022542340A JP2023510352A JP 2023510352 A JP2023510352 A JP 2023510352A JP 2022542340 A JP2022542340 A JP 2022542340A JP 2022542340 A JP2022542340 A JP 2022542340A JP 2023510352 A JP2023510352 A JP 2023510352A
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gna
sequence
seq
protein
casx
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JPWO2021142342A5 (https=
JP2023510352A5 (https=
Inventor
オークス，ベンジャミン
ヒギンズ，ショーン
スピナー，ハンナ
デニー，サラ
ティ スタール，ブレット
テイラー，キアン
バニー，キャサリン
コリン，イザベル
アディル，マルーフ
アーンズ，コール
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Scribe Therapeutics Inc
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Scribe Therapeutics Inc
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    • C12N9/6424—Serine endopeptidases (3.4.21)
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JP2022542340A 2020-01-10 2021-01-08 Ｐｃｓｋ９の標的化のための組成物および方法 Pending JP2023510352A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202062959685P 2020-01-10 2020-01-10
US62/959,685 2020-01-10
PCT/US2021/012804 WO2021142342A1 (en) 2020-01-10 2021-01-08 Compositions and methods for the targeting of pcsk9

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JP2023510352A true JP2023510352A (ja) 2023-03-13
JPWO2021142342A5 JPWO2021142342A5 (https=) 2024-01-16
JP2023510352A5 JP2023510352A5 (https=) 2024-01-16

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US (1) US20230167424A1 (https=)
EP (1) EP4087930A1 (https=)
JP (1) JP2023510352A (https=)
KR (1) KR20220125332A (https=)
CN (1) CN115427570A (https=)
AU (1) AU2021206270A1 (https=)
CA (1) CA3163714A1 (https=)
IL (1) IL294620A (https=)
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AU2021392719B2 (en) 2020-12-03 2025-08-14 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
WO2022261150A2 (en) 2021-06-09 2022-12-15 Scribe Therapeutics Inc. Particle delivery systems
US20250388885A1 (en) * 2022-03-11 2025-12-25 Epicrispr Biotechnologies, Inc. Compositions, systems, and methods for treating familial hypercholesterolemia by targeting pcsk9
WO2023235818A2 (en) * 2022-06-02 2023-12-07 Scribe Therapeutics Inc. Engineered class 2 type v crispr systems
WO2023235888A2 (en) 2022-06-03 2023-12-07 Scribe Therapeutics Inc. COMPOSITIONS AND METHODS FOR CpG DEPLETION
WO2023240027A1 (en) 2022-06-07 2023-12-14 Scribe Therapeutics Inc. Particle delivery systems
WO2023240076A1 (en) 2022-06-07 2023-12-14 Scribe Therapeutics Inc. Compositions and methods for the targeting of pcsk9
WO2023240074A1 (en) 2022-06-07 2023-12-14 Scribe Therapeutics Inc. Compositions and methods for the targeting of pcsk9
US20250361525A1 (en) 2022-06-08 2025-11-27 Scribe Therapeutics Inc. Aav vectors for gene editing
IL317874A (en) 2022-06-24 2025-02-01 Tune Therapeutics Inc Compounds, systems and methods for reducing low density lipoproteins through targeted gene suppression
JP2025532127A (ja) 2022-09-23 2025-09-29 アイオーニス ファーマシューティカルズ， インコーポレーテッド Ｍｅｃｐ２発現を低減する化合物及び方法
TW202444906A (zh) 2023-03-29 2024-11-16 美商斯奎柏治療公司 用於靶向pcsk9之組合物及方法
WO2024238723A1 (en) * 2023-05-16 2024-11-21 Omega Therapeutics, Inc. Methods and compositions for modulating pcsk9 expression
CN118086311B (zh) * 2023-05-25 2024-08-09 苏州时安生物技术有限公司 抑制PCSK9基因表达的siRNA、其缀合物和药物组合物及用途
WO2025006782A2 (en) * 2023-06-30 2025-01-02 Chroma Medicine, Inc. Guide rna compositions
CN116978457B (zh) * 2023-09-22 2023-12-22 成都斯马特科技有限公司 避免rna检测过程中假基因干扰的引物和探针组合及其设计方法
CN119506351B (zh) * 2024-11-20 2025-08-19 中国人民解放军陆军军医大学第二附属医院 一体化pcsk9腺嘌呤碱基编辑系统及应用

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US20230167424A1 (en) 2023-06-01
IL294620A (en) 2022-09-01

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