JP2023509388A - 治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス - Google Patents

治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス Download PDF

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JP2023509388A
JP2023509388A JP2022538307A JP2022538307A JP2023509388A JP 2023509388 A JP2023509388 A JP 2023509388A JP 2022538307 A JP2022538307 A JP 2022538307A JP 2022538307 A JP2022538307 A JP 2022538307A JP 2023509388 A JP2023509388 A JP 2023509388A
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cells
group
til
population
cancer
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コーデス ウルレク
フリーセ クリスティーナ
キアゲテアプ－ムラ ニゴライ
ヒーゲ クリスティーナ
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セービーオ アクティーゼルスカブ
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • C12N5/0638—Cytotoxic T lymphocytes [CTL] or lymphokine activated killer cells [LAK]
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    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
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    • C12N2502/30—Coculture with; Conditioned medium produced by tumour cells

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JP2022538307A 2019-12-18 2020-12-18 治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス Pending JP2023509388A (ja)

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JP2024168495A JP2024175144A (ja) 2019-12-18 2024-09-27 治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス

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EP19217356 2019-12-18
EP19217356.5 2019-12-18
PCT/EP2020/087151 WO2021123255A1 (en) 2019-12-18 2020-12-18 Improved process for culturing tumor-infiltrating lymphocytes for therapeutic use

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JP2024168495A Division JP2024175144A (ja) 2019-12-18 2024-09-27 治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス

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JP2023509388A true JP2023509388A (ja) 2023-03-08
JP2023509388A5 JP2023509388A5 (https=) 2023-12-26

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JP2024168495A Pending JP2024175144A (ja) 2019-12-18 2024-09-27 治療用途の腫瘍浸潤性リンパ球を培養するための改善プロセス

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US (1) US20230018646A1 (https=)
EP (1) EP4077640B1 (https=)
JP (2) JP2023509388A (https=)
KR (1) KR20220119080A (https=)
CN (1) CN114929861A (https=)
AU (1) AU2020408201A1 (https=)
BR (1) BR112022011702A2 (https=)
CA (1) CA3161510A1 (https=)
DK (1) DK4077640T3 (https=)
ES (1) ES2984777T3 (https=)
IL (1) IL293874B2 (https=)
MX (1) MX2022007416A (https=)
PH (1) PH12022551495A1 (https=)
WO (1) WO2021123255A1 (https=)

Families Citing this family (3)

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Publication number Priority date Publication date Assignee Title
CA3158133A1 (en) 2020-04-28 2021-11-04 Lyell Immunopharma, Inc. Methods for culturing cells
CN116421720A (zh) * 2023-04-26 2023-07-14 乔国梁 抗肿瘤联用细胞产品和抗肿瘤细胞产品
CN118853565A (zh) * 2024-09-14 2024-10-29 青岛华赛伯曼医学细胞生物有限公司 一种肿瘤浸润淋巴细胞的培养工艺

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157636A1 (en) * 2014-04-10 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
WO2019086711A1 (en) * 2017-11-06 2019-05-09 Ludwig Institute For Cancer Research Ltd Method for expansion of lymphocytes

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103374548A (zh) * 2012-04-27 2013-10-30 上海诺昊亚医学诊断技术有限公司 一种肿瘤浸润淋巴细胞的高效扩增培养液
CN110520530A (zh) * 2016-10-18 2019-11-29 明尼苏达大学董事会 肿瘤浸润性淋巴细胞和治疗方法
KR102618948B1 (ko) * 2016-11-17 2023-12-27 이오반스 바이오테라퓨틱스, 인크. 잔유 종양 침윤 림프구 및 그의 제조 및 사용 방법

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015157636A1 (en) * 2014-04-10 2015-10-15 H. Lee Moffitt Cancer Center And Research Institute, Inc. Enhanced expansion of tumor-infiltrating lymphocytes for adoptive cell therapy
WO2019086711A1 (en) * 2017-11-06 2019-05-09 Ludwig Institute For Cancer Research Ltd Method for expansion of lymphocytes

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHRISTINA FRIESE; ET AL: "CTLA-4 blockade boosts the expansion of tumor-reactive CD8+ tumor-infiltrating lymphocytes in ovaria", SCIENTIFIC REPORTS, vol. VOL:10, NR:1, JPN5023003943, 3 March 2020 (2020-03-03), pages 3914 - 1, ISSN: 0005333684 *

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CN114929861A (zh) 2022-08-19
WO2021123255A1 (en) 2021-06-24
ES2984777T3 (es) 2024-10-31
BR112022011702A2 (pt) 2022-09-06
IL293874B2 (en) 2024-03-01
JP2024175144A (ja) 2024-12-17
CA3161510A1 (en) 2021-06-24
IL293874A (en) 2022-08-01
MX2022007416A (es) 2022-09-19
KR20220119080A (ko) 2022-08-26
PH12022551495A1 (en) 2023-11-13
US20230018646A1 (en) 2023-01-19
AU2020408201A1 (en) 2022-07-14
EP4077640B1 (en) 2024-05-08
DK4077640T3 (da) 2024-07-29
IL293874B1 (en) 2023-11-01
EP4077640A1 (en) 2022-10-26

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