JP2023508947A - 循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム - Google Patents

循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム Download PDF

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JP2023508947A
JP2023508947A JP2022538934A JP2022538934A JP2023508947A JP 2023508947 A JP2023508947 A JP 2023508947A JP 2022538934 A JP2022538934 A JP 2022538934A JP 2022538934 A JP2022538934 A JP 2022538934A JP 2023508947 A JP2023508947 A JP 2023508947A
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cancer
methylation
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JP2023508947A5 (cg-RX-API-DMAC7.html
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アレックス ロバートソン，
ニール ピーターマン，
ニコル ランバート，
ハルク テツカン，
ロヒト スリヴァス，
ピーター ジョージ，
ジェイソン クロース，
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レクセント バイオ， インコーポレイテッド
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
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    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B20/00—ICT specially adapted for functional genomics or proteomics, e.g. genotype-phenotype associations
    • G16B20/10—Ploidy or copy number detection
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/118—Prognosis of disease development
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    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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JP2022538934A 2019-12-24 2020-12-23 循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム Pending JP2023508947A (ja)

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JP2025188196A JP2026049725A (ja) 2019-12-24 2025-11-07 循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム

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US201962953368P 2019-12-24 2019-12-24
US62/953,368 2019-12-24
US202062993564P 2020-03-23 2020-03-23
US62/993,564 2020-03-23
PCT/US2020/066976 WO2021133993A2 (en) 2019-12-24 2020-12-23 Methods and systems for molecular disease assessment via analysis of circulating tumor dna

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JP2025188196A Division JP2026049725A (ja) 2019-12-24 2025-11-07 循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム

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JP2023508947A5 JP2023508947A5 (cg-RX-API-DMAC7.html) 2023-12-25

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JP2025188196A Pending JP2026049725A (ja) 2019-12-24 2025-11-07 循環腫瘍ｄｎａの分析を介した分子疾患評価のための方法およびシステム

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US (1) US20230135171A1 (cg-RX-API-DMAC7.html)
EP (1) EP4081665A4 (cg-RX-API-DMAC7.html)
JP (2) JP2023508947A (cg-RX-API-DMAC7.html)
CN (1) CN115087749A (cg-RX-API-DMAC7.html)
AU (1) AU2020414737A1 (cg-RX-API-DMAC7.html)
CA (1) CA3165763A1 (cg-RX-API-DMAC7.html)
TW (1) TWI893039B (cg-RX-API-DMAC7.html)
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Publication number Priority date Publication date Assignee Title
US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
CA3226747A1 (en) * 2021-07-27 2023-02-02 Chunxiao Song Compositions and methods related to tet-assisted pyridine borane sequencing for cell-free dna
EP4405507A4 (en) * 2021-09-20 2025-11-05 Droplet Biosciences Inc METHODS FOR DISEASE ASSESSMENT USING A DRAINAGE FLUID
EP4433607A4 (en) * 2021-11-19 2025-10-15 Found Medicine Inc FRAGMENT CONSENSUS METHODS FOR ULTRASENSITIVE DETECTION OF ABERRANT METHYLATION
CN114703284A (zh) * 2022-04-15 2022-07-05 北京莱盟君泰国际医疗技术开发有限公司 一种血液游离dna甲基化定量检测方法及其应用
KR102789317B1 (ko) * 2023-10-06 2025-04-02 (주)지놈포미 고심도 세포 유리 핵산 시퀀싱 기반의 질병 조기 검출 장치 및 방법
WO2025075256A1 (ko) * 2023-10-06 2025-04-10 (주)지놈포미 고심도 세포 유리 핵산 시퀀싱 기반의 질병 조기 검출 장치 및 방법
CN117987556A (zh) * 2024-02-23 2024-05-07 上海微荷医学检验实验室有限公司 用于确定肿瘤组织的目标CpG位点的甲基化水平的方法
CN118448038A (zh) * 2024-04-26 2024-08-06 天津大学 一种基于多组学动态ctDNA监测食管鳞状细胞癌疗效的方法

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160017419A1 (en) * 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a dna mixture
WO2018161031A1 (en) * 2017-03-02 2018-09-07 Youhealth Biotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110168099B (zh) * 2016-06-07 2024-06-07 加利福尼亚大学董事会 用于疾病和病症分析的无细胞dna甲基化模式
CA3049457C (en) * 2017-01-20 2023-05-16 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
CA3096678A1 (en) * 2018-04-13 2019-10-17 Grail, Inc. Multi-assay prediction model for cancer detection
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装
CN112384982A (zh) * 2018-06-06 2021-02-19 莱森特生物公司 用于指纹识别生物样本的方法

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20160017419A1 (en) * 2014-07-18 2016-01-21 The Chinese University Of Hong Kong Methylation pattern analysis of tissues in a dna mixture
WO2018161031A1 (en) * 2017-03-02 2018-09-07 Youhealth Biotech, Limited Methylation markers for diagnosing hepatocellular carcinoma and lung cancer

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Publication number Publication date
TWI893039B (zh) 2025-08-11
US20230135171A1 (en) 2023-05-04
WO2021133993A3 (en) 2021-09-30
EP4081665A2 (en) 2022-11-02
AU2020414737A1 (en) 2022-07-14
CA3165763A1 (en) 2021-07-01
JP2026049725A (ja) 2026-03-18
EP4081665A4 (en) 2024-01-10
CN115087749A (zh) 2022-09-20
WO2021133993A2 (en) 2021-07-01
TW202138566A (zh) 2021-10-16

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