CN115087749A - 用于通过分析循环肿瘤dna进行分子疾病评定的方法和系统 - Google Patents

用于通过分析循环肿瘤dna进行分子疾病评定的方法和系统 Download PDF

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CN115087749A
CN115087749A CN202080094820.5A CN202080094820A CN115087749A CN 115087749 A CN115087749 A CN 115087749A CN 202080094820 A CN202080094820 A CN 202080094820A CN 115087749 A CN115087749 A CN 115087749A
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tumor
sequencing
methylation
cancer
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亚历克斯·罗伯逊
尼尔·彼得曼
尼克·兰伯特
哈洛克·泰兹坎
罗希思·斯里瓦斯
彼得·乔治
杰森·克洛斯
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Nexant Biological Co
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Nexant Biological Co
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    • G16B20/10—Ploidy or copy number detection
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • G—PHYSICS
    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
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    • G16—INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16B—BIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B30/00—ICT specially adapted for sequence analysis involving nucleotides or amino acids
    • G16B30/10—Sequence alignment; Homology search
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers

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CN202080094820.5A 2019-12-24 2020-12-23 用于通过分析循环肿瘤dna进行分子疾病评定的方法和系统 Pending CN115087749A (zh)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962953368P 2019-12-24 2019-12-24
US62/953,368 2019-12-24
US202062993564P 2020-03-23 2020-03-23
US62/993,564 2020-03-23
PCT/US2020/066976 WO2021133993A2 (en) 2019-12-24 2020-12-23 Methods and systems for molecular disease assessment via analysis of circulating tumor dna

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CN115087749A true CN115087749A (zh) 2022-09-20

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US (1) US20230135171A1 (cg-RX-API-DMAC7.html)
EP (1) EP4081665A4 (cg-RX-API-DMAC7.html)
JP (2) JP2023508947A (cg-RX-API-DMAC7.html)
CN (1) CN115087749A (cg-RX-API-DMAC7.html)
AU (1) AU2020414737A1 (cg-RX-API-DMAC7.html)
CA (1) CA3165763A1 (cg-RX-API-DMAC7.html)
TW (1) TWI893039B (cg-RX-API-DMAC7.html)
WO (1) WO2021133993A2 (cg-RX-API-DMAC7.html)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118448038A (zh) * 2024-04-26 2024-08-06 天津大学 一种基于多组学动态ctDNA监测食管鳞状细胞癌疗效的方法

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* Cited by examiner, † Cited by third party
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US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
CA3226747A1 (en) * 2021-07-27 2023-02-02 Chunxiao Song Compositions and methods related to tet-assisted pyridine borane sequencing for cell-free dna
EP4405507A4 (en) * 2021-09-20 2025-11-05 Droplet Biosciences Inc METHODS FOR DISEASE ASSESSMENT USING A DRAINAGE FLUID
EP4433607A4 (en) * 2021-11-19 2025-10-15 Found Medicine Inc FRAGMENT CONSENSUS METHODS FOR ULTRASENSITIVE DETECTION OF ABERRANT METHYLATION
CN114703284A (zh) * 2022-04-15 2022-07-05 北京莱盟君泰国际医疗技术开发有限公司 一种血液游离dna甲基化定量检测方法及其应用
KR102789317B1 (ko) * 2023-10-06 2025-04-02 (주)지놈포미 고심도 세포 유리 핵산 시퀀싱 기반의 질병 조기 검출 장치 및 방법
WO2025075256A1 (ko) * 2023-10-06 2025-04-10 (주)지놈포미 고심도 세포 유리 핵산 시퀀싱 기반의 질병 조기 검출 장치 및 방법
CN117987556A (zh) * 2024-02-23 2024-05-07 上海微荷医学检验实验室有限公司 用于确定肿瘤组织的目标CpG位点的甲基化水平的方法

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CN106795562A (zh) * 2014-07-18 2017-05-31 香港中文大学 Dna混合物中的组织甲基化模式分析
CN110168099A (zh) * 2016-06-07 2019-08-23 加利福尼亚大学董事会 用于疾病和病症分析的无细胞dna甲基化模式
US20190316209A1 (en) * 2018-04-13 2019-10-17 Grail, Inc. Multi-Assay Prediction Model for Cancer Detection
US20190371428A1 (en) * 2017-01-20 2019-12-05 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
WO2019236906A1 (en) * 2018-06-06 2019-12-12 Lexent Bio, Inc. Methods for fingerprinting of biological samples

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BR112019018272A2 (pt) * 2017-03-02 2020-07-28 Youhealth Oncotech, Limited marcadores metilação para diagnosticar hepatocelular carcinoma e câncer
JP7455757B2 (ja) * 2018-04-13 2024-03-26 フリーノーム・ホールディングス・インコーポレイテッド 生体試料の多検体アッセイのための機械学習実装

Patent Citations (5)

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CN106795562A (zh) * 2014-07-18 2017-05-31 香港中文大学 Dna混合物中的组织甲基化模式分析
CN110168099A (zh) * 2016-06-07 2019-08-23 加利福尼亚大学董事会 用于疾病和病症分析的无细胞dna甲基化模式
US20190371428A1 (en) * 2017-01-20 2019-12-05 Sequenom, Inc. Methods for non-invasive assessment of copy number alterations
US20190316209A1 (en) * 2018-04-13 2019-10-17 Grail, Inc. Multi-Assay Prediction Model for Cancer Detection
WO2019236906A1 (en) * 2018-06-06 2019-12-12 Lexent Bio, Inc. Methods for fingerprinting of biological samples

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ANDREW A. DAVIS等: "Early assessment of molecular progression and response by whole-genome circulating tumor DNA in advanced solid tumors", MEDRXIV, 25 November 2019 (2019-11-25), pages 1 - 22 *
XU ZHAI等: "Methylation of RASSF1A and CDH13 Genes in Individualized Chemotherapy for Patients with Non-small Cell Lung Cancer", ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, vol. 15, no. 12, 31 December 2014 (2014-12-31), pages 4925 - 4928 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN118448038A (zh) * 2024-04-26 2024-08-06 天津大学 一种基于多组学动态ctDNA监测食管鳞状细胞癌疗效的方法

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TWI893039B (zh) 2025-08-11
US20230135171A1 (en) 2023-05-04
WO2021133993A3 (en) 2021-09-30
EP4081665A2 (en) 2022-11-02
JP2023508947A (ja) 2023-03-06
AU2020414737A1 (en) 2022-07-14
CA3165763A1 (en) 2021-07-01
JP2026049725A (ja) 2026-03-18
EP4081665A4 (en) 2024-01-10
WO2021133993A2 (en) 2021-07-01
TW202138566A (zh) 2021-10-16

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