JP2023508349A - グルカゴン受容体およびｇｌｐ－１受容体のステープルトリアゾールコアゴニスト - Google Patents

グルカゴン受容体およびｇｌｐ－１受容体のステープルトリアゾールコアゴニスト Download PDF

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Publication number
JP2023508349A
JP2023508349A JP2022538471A JP2022538471A JP2023508349A JP 2023508349 A JP2023508349 A JP 2023508349A JP 2022538471 A JP2022538471 A JP 2022538471A JP 2022538471 A JP2022538471 A JP 2022538471A JP 2023508349 A JP2023508349 A JP 2023508349A
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pra
acid
peptide
another class
nle
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JP2022538471A
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Japanese (ja)
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JP2023508349A5 (https=
Inventor
ビアンキ，エリザベッタ
デン，チャオリン
リン，ソンニアン
オルヴィエート，フェデリカ
パラニ，アナンダン
ペッシ，アントネッロ
ソーヤー，トミ・ケー
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メルク・シャープ・アンド・ドーム・エルエルシー
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Publication of JP2023508349A publication Critical patent/JP2023508349A/ja
Publication of JP2023508349A5 publication Critical patent/JP2023508349A5/ja
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2022538471A 2019-12-23 2020-12-18 グルカゴン受容体およびｇｌｐ－１受容体のステープルトリアゾールコアゴニスト Pending JP2023508349A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19425098.1A EP3842061A1 (en) 2019-12-23 2019-12-23 Stapled triazole co-agonists of the glucagon and glp-1 receptors
EP19425098.1 2019-12-23
PCT/US2020/065796 WO2021133644A1 (en) 2019-12-23 2020-12-18 Stapled triazole co-agonists of the glucagon and glp-1 receptors

Publications (2)

Publication Number Publication Date
JP2023508349A true JP2023508349A (ja) 2023-03-02
JP2023508349A5 JP2023508349A5 (https=) 2023-12-18

Family

ID=69326342

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022538471A Pending JP2023508349A (ja) 2019-12-23 2020-12-18 グルカゴン受容体およびｇｌｐ－１受容体のステープルトリアゾールコアゴニスト

Country Status (10)

Country Link
US (1) US20230063794A1 (https=)
EP (2) EP3842061A1 (https=)
JP (1) JP2023508349A (https=)
KR (1) KR20220119475A (https=)
CN (1) CN115226391A (https=)
AU (1) AU2020412677A1 (https=)
BR (1) BR112022012499A2 (https=)
CA (1) CA3162800A1 (https=)
MX (1) MX2022007929A (https=)
WO (1) WO2021133644A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024532362A (ja) * 2021-08-27 2024-09-05 イエール ユニバーシティ 細胞外タンパク質の分子分解誘導剤
WO2023028590A1 (en) 2021-08-27 2023-03-02 Yale University Molecular degraders of extracellular proteins

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JP2014525901A (ja) * 2011-06-22 2014-10-02 インディアナ ユニヴァーシティ リサーチ アンド テクノロジー コーポレイション グルカゴン／ｇｌｐ−１レセプタコ−アゴニスト

Also Published As

Publication number Publication date
CN115226391A (zh) 2022-10-21
BR112022012499A2 (pt) 2022-09-06
US20230063794A1 (en) 2023-03-02
EP4081243A4 (en) 2024-01-10
KR20220119475A (ko) 2022-08-29
EP3842061A1 (en) 2021-06-30
EP4081243A1 (en) 2022-11-02
WO2021133644A1 (en) 2021-07-01
CA3162800A1 (en) 2021-07-01
AU2020412677A1 (en) 2022-07-14
MX2022007929A (es) 2022-09-29

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