CA3162800A1 - Stapled triazole co-agonists of the glucagon and glp-1 receptors - Google Patents

Stapled triazole co-agonists of the glucagon and glp-1 receptors Download PDF

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Publication number
CA3162800A1
CA3162800A1 CA3162800A CA3162800A CA3162800A1 CA 3162800 A1 CA3162800 A1 CA 3162800A1 CA 3162800 A CA3162800 A CA 3162800A CA 3162800 A CA3162800 A CA 3162800A CA 3162800 A1 CA3162800 A1 CA 3162800A1
Authority
CA
Canada
Prior art keywords
acid
pra
peptide
another class
lysine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3162800A
Other languages
English (en)
French (fr)
Inventor
Elisabetta Bianchi
Qiaolin Deng
Songnian Lin
Federica Orvieto
Anandan Palani
Antonello Pessi
Tomi K. Sawyer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck Sharp and Dohme LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck Sharp and Dohme LLC filed Critical Merck Sharp and Dohme LLC
Publication of CA3162800A1 publication Critical patent/CA3162800A1/en
Pending legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/28—Insulins
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/26—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Endocrinology (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Toxicology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Emergency Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3162800A 2019-12-23 2020-12-18 Stapled triazole co-agonists of the glucagon and glp-1 receptors Pending CA3162800A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP19425098.1A EP3842061A1 (en) 2019-12-23 2019-12-23 Stapled triazole co-agonists of the glucagon and glp-1 receptors
EP19425098.1 2019-12-23
PCT/US2020/065796 WO2021133644A1 (en) 2019-12-23 2020-12-18 Stapled triazole co-agonists of the glucagon and glp-1 receptors

Publications (1)

Publication Number Publication Date
CA3162800A1 true CA3162800A1 (en) 2021-07-01

Family

ID=69326342

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3162800A Pending CA3162800A1 (en) 2019-12-23 2020-12-18 Stapled triazole co-agonists of the glucagon and glp-1 receptors

Country Status (10)

Country Link
US (1) US20230063794A1 (https=)
EP (2) EP3842061A1 (https=)
JP (1) JP2023508349A (https=)
KR (1) KR20220119475A (https=)
CN (1) CN115226391A (https=)
AU (1) AU2020412677A1 (https=)
BR (1) BR112022012499A2 (https=)
CA (1) CA3162800A1 (https=)
MX (1) MX2022007929A (https=)
WO (1) WO2021133644A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2024532362A (ja) * 2021-08-27 2024-09-05 イエール ユニバーシティ 細胞外タンパク質の分子分解誘導剤
WO2023028590A1 (en) 2021-08-27 2023-03-02 Yale University Molecular degraders of extracellular proteins

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Also Published As

Publication number Publication date
CN115226391A (zh) 2022-10-21
BR112022012499A2 (pt) 2022-09-06
US20230063794A1 (en) 2023-03-02
JP2023508349A (ja) 2023-03-02
EP4081243A4 (en) 2024-01-10
KR20220119475A (ko) 2022-08-29
EP3842061A1 (en) 2021-06-30
EP4081243A1 (en) 2022-11-02
WO2021133644A1 (en) 2021-07-01
AU2020412677A1 (en) 2022-07-14
MX2022007929A (es) 2022-09-29

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Legal Events

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Free format text: ST27 STATUS EVENT CODE: A-1-1-W10-W00-W100 (AS PROVIDED BY THE NATIONAL OFFICE); EVENT TEXT: LETTER SENT

Effective date: 20260129