JP2023507033A - ポリペプチド、タンパク質複合体及びそれを作製する方法 - Google Patents

ポリペプチド、タンパク質複合体及びそれを作製する方法 Download PDF

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JP2023507033A
JP2023507033A JP2022538373A JP2022538373A JP2023507033A JP 2023507033 A JP2023507033 A JP 2023507033A JP 2022538373 A JP2022538373 A JP 2022538373A JP 2022538373 A JP2022538373 A JP 2022538373A JP 2023507033 A JP2023507033 A JP 2023507033A
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antigen
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リチャード・ワーガチャック
アシュワニ・グプタ
ルイス・ダ・クルス
デイヴィッド・エス・ヤング
ニコラス・モリン
シュガン・ヤオ
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キソジ・バイオテクノロジー・インコーポレイテッド
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
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    • C07K16/2896—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
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    • C12P21/02—Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
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JP2022538373A 2019-12-20 2020-12-18 ポリペプチド、タンパク質複合体及びそれを作製する方法 Pending JP2023507033A (ja)

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US201962951701P 2019-12-20 2019-12-20
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PCT/CA2020/051753 WO2021119832A1 (en) 2019-12-20 2020-12-18 Polypeptides, protein complexes and method for making same

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CA3231417A1 (en) * 2021-09-10 2023-03-16 Jian Shi Anti-ang2 antibody, preparation method therefor, and application thereof
EP4408893A4 (en) 2021-09-29 2026-02-18 Kisoji Biotechnology Inc Binding agents targeting tumor cells expressing too much 2
TWI876227B (zh) * 2021-11-17 2025-03-11 大陸商南京再明醫藥有限公司 多特異性抗體及其藥物用途
EP4599066A1 (en) * 2022-10-03 2025-08-13 Kisoji Biotechnology Inc. Multispecific binding agents targeting dopamine receptor d2 and methods of use thereof
EP4608867A1 (en) * 2022-10-25 2025-09-03 Kisoji Biotechnology Inc. Binding agents targeting cd36-expressing tumor cells
PE20252392A1 (es) 2022-12-12 2025-10-10 Lanova Medicines Ltd Anticuerpos biespecificos que se dirigen a pd1 y vegf
CN121419995A (zh) * 2023-04-04 2026-01-27 加拿大商木曾路生物科技公司 靶向表达trop2的肿瘤细胞的结合剂
EP4520768A1 (en) 2023-09-06 2025-03-12 BioNTech SE Vhh-ch3 fusion proteins

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JP2017508726A (ja) * 2014-01-15 2017-03-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改善されたプロテインＡ結合を有するＦｃ領域バリアント
JP2017518965A (ja) * 2014-05-02 2017-07-13 モメンタ ファーマシューティカルズ インコーポレイテッ エンジニアリングされたＦｃ構築物に関連する組成物および方法
WO2018075692A2 (en) * 2016-10-19 2018-04-26 Invenra Inc. Antibody constructs
JP2019504062A (ja) * 2016-01-11 2019-02-14 インヒブルクス インコーポレイテッド 多価多重特異性ｏｘ４０結合融合タンパク質
JP2019504831A (ja) * 2016-01-11 2019-02-21 インヒブルクス インコーポレイテッド 多価かつ多重特異性の４１ｂｂ結合融合タンパク質
WO2019068756A1 (en) * 2017-10-03 2019-04-11 Merck Patent Gmbh MODIFIED CYSTEINE MOLECULES BINDING TO ANTIGEN
WO2019134710A1 (en) * 2018-01-08 2019-07-11 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2019191120A1 (en) * 2018-03-27 2019-10-03 Systimmune, Inc. Guidance and navigation control proteins and method of making and using thereof

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RS60499B1 (sr) * 2011-12-20 2020-08-31 Medimmune Llc Modifikovani polipeptidi za bispecifične skelete antitela
ES2846881T3 (es) * 2015-05-01 2021-07-30 Inhibrx Inc Moléculas que se dirigen al sistema de secreción de tipo III
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US20160257748A1 (en) * 2013-09-25 2016-09-08 Amgen Inc. V-c-fc-v-c antibody
JP2017508726A (ja) * 2014-01-15 2017-03-30 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ 改善されたプロテインＡ結合を有するＦｃ領域バリアント
JP2017518965A (ja) * 2014-05-02 2017-07-13 モメンタ ファーマシューティカルズ インコーポレイテッ エンジニアリングされたＦｃ構築物に関連する組成物および方法
JP2019504062A (ja) * 2016-01-11 2019-02-14 インヒブルクス インコーポレイテッド 多価多重特異性ｏｘ４０結合融合タンパク質
JP2019504831A (ja) * 2016-01-11 2019-02-21 インヒブルクス インコーポレイテッド 多価かつ多重特異性の４１ｂｂ結合融合タンパク質
WO2018075692A2 (en) * 2016-10-19 2018-04-26 Invenra Inc. Antibody constructs
WO2019068756A1 (en) * 2017-10-03 2019-04-11 Merck Patent Gmbh MODIFIED CYSTEINE MOLECULES BINDING TO ANTIGEN
WO2019134710A1 (en) * 2018-01-08 2019-07-11 Nanjing Legend Biotech Co., Ltd. Multispecific antigen binding proteins and methods of use thereof
WO2019191120A1 (en) * 2018-03-27 2019-10-03 Systimmune, Inc. Guidance and navigation control proteins and method of making and using thereof

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EP4077374A4 (en) 2023-12-27
TW202136294A (zh) 2021-10-01
TWI907375B (zh) 2025-12-11
CA3171363A1 (en) 2021-06-24
EP4077374A1 (en) 2022-10-26
CN115003693A (zh) 2022-09-02
AR120870A1 (es) 2022-03-23
US20230242676A1 (en) 2023-08-03

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