TWI907375B - 多肽、蛋白質複合物及其製造方法 - Google Patents

多肽、蛋白質複合物及其製造方法

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Publication number
TWI907375B
TWI907375B TW109145364A TW109145364A TWI907375B TW I907375 B TWI907375 B TW I907375B TW 109145364 A TW109145364 A TW 109145364A TW 109145364 A TW109145364 A TW 109145364A TW I907375 B TWI907375 B TW I907375B
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Taiwan
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domain
dimer
antigen
protein complex
seq
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TW109145364A
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English (en)
Chinese (zh)
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TW202136294A (zh
Inventor
理查 瓦甘恰克
亞許瓦尼 甘普塔
路易斯 達克魯斯
士範 楊
姚書剛
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加拿大商木曾路生物科技公司
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/62—DNA sequences coding for fusion proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A—HUMAN NECESSITIES
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    • C07K16/24—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
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    • C07K16/2809—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
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    • C07K16/2803—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
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    • C07K16/286—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
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    • A—HUMAN NECESSITIES
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    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/569—Single domain, e.g. dAb, sdAb, VHH, VNAR or nanobody®
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    • C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
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TW109145364A 2019-12-20 2020-12-21 多肽、蛋白質複合物及其製造方法 TWI907375B (zh)

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US201962951701P 2019-12-20 2019-12-20
US62/951,701 2019-12-20

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TW202136294A TW202136294A (zh) 2021-10-01
TWI907375B true TWI907375B (zh) 2025-12-11

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EP (1) EP4077374A4 (enExample)
JP (1) JP2023507033A (enExample)
CN (1) CN115003693A (enExample)
AR (1) AR120870A1 (enExample)
CA (1) CA3171363A1 (enExample)
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CA3231417A1 (en) * 2021-09-10 2023-03-16 Jian Shi Anti-ang2 antibody, preparation method therefor, and application thereof
EP4408893A4 (en) 2021-09-29 2026-02-18 Kisoji Biotechnology Inc Binding agents targeting tumor cells expressing too much 2
TWI876227B (zh) * 2021-11-17 2025-03-11 大陸商南京再明醫藥有限公司 多特異性抗體及其藥物用途
EP4599066A1 (en) * 2022-10-03 2025-08-13 Kisoji Biotechnology Inc. Multispecific binding agents targeting dopamine receptor d2 and methods of use thereof
EP4608867A1 (en) * 2022-10-25 2025-09-03 Kisoji Biotechnology Inc. Binding agents targeting cd36-expressing tumor cells
PE20252392A1 (es) 2022-12-12 2025-10-10 Lanova Medicines Ltd Anticuerpos biespecificos que se dirigen a pd1 y vegf
CN121419995A (zh) * 2023-04-04 2026-01-27 加拿大商木曾路生物科技公司 靶向表达trop2的肿瘤细胞的结合剂
EP4520768A1 (en) 2023-09-06 2025-03-12 BioNTech SE Vhh-ch3 fusion proteins

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CN104011221A (zh) * 2011-12-20 2014-08-27 米迪缪尼有限公司 用于双特异性抗体支架的经修饰的多肽
CN108883153A (zh) * 2016-01-11 2018-11-23 印希比股份有限公司 多价和多特异性ox40结合融合蛋白

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WO2013012733A1 (en) * 2011-07-15 2013-01-24 Biogen Idec Ma Inc. Heterodimeric fc regions, binding molecules comprising same, and methods relating thereto
US20160257748A1 (en) * 2013-09-25 2016-09-08 Amgen Inc. V-c-fc-v-c antibody
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ES2846881T3 (es) * 2015-05-01 2021-07-30 Inhibrx Inc Moléculas que se dirigen al sistema de secreción de tipo III
WO2016192613A1 (zh) * 2015-06-01 2016-12-08 中山大学 具有融合至常规Fab片段的单域抗原结合片段的二价抗体
KR20180096789A (ko) * 2016-01-11 2018-08-29 인히브릭스, 인크. 다가 및 다중특이적 41bb-결합 융합 단백질
CN110177805B (zh) * 2016-10-19 2024-04-02 英温拉公司 抗体构建体
JP7543134B2 (ja) * 2017-10-03 2024-09-02 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツング システイン操作された抗原結合分子
KR20200118423A (ko) * 2018-01-08 2020-10-15 난징 레전드 바이오테크 씨오., 엘티디. 다중특이성 항원 결합 단백질 및 이의 사용 방법
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CN104011221A (zh) * 2011-12-20 2014-08-27 米迪缪尼有限公司 用于双特异性抗体支架的经修饰的多肽
CN108883153A (zh) * 2016-01-11 2018-11-23 印希比股份有限公司 多价和多特异性ox40结合融合蛋白

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WO2021119832A1 (en) 2021-06-24
EP4077374A4 (en) 2023-12-27
JP2023507033A (ja) 2023-02-20
TW202136294A (zh) 2021-10-01
CA3171363A1 (en) 2021-06-24
EP4077374A1 (en) 2022-10-26
CN115003693A (zh) 2022-09-02
AR120870A1 (es) 2022-03-23
US20230242676A1 (en) 2023-08-03

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