JP2023504795A5 - - Google Patents
Info
- Publication number
- JP2023504795A5 JP2023504795A5 JP2022531434A JP2022531434A JP2023504795A5 JP 2023504795 A5 JP2023504795 A5 JP 2023504795A5 JP 2022531434 A JP2022531434 A JP 2022531434A JP 2022531434 A JP2022531434 A JP 2022531434A JP 2023504795 A5 JP2023504795 A5 JP 2023504795A5
- Authority
- JP
- Japan
- Prior art keywords
- pyrazole
- quinoline
- acetamide
- pyridine
- diseases
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2025116497A JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP19383057.7 | 2019-11-28 | ||
| EP19383057 | 2019-11-28 | ||
| PCT/EP2020/083566 WO2021105317A1 (en) | 2019-11-28 | 2020-11-27 | Benzylamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025116497A Division JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2023504795A JP2023504795A (ja) | 2023-02-07 |
| JP2023504795A5 true JP2023504795A5 (https=) | 2023-12-06 |
| JP7808032B2 JP7808032B2 (ja) | 2026-01-28 |
Family
ID=68808255
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022531434A Active JP7808032B2 (ja) | 2019-11-28 | 2020-11-27 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
| JP2025116497A Pending JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2025116497A Pending JP2025163046A (ja) | 2019-11-28 | 2025-07-10 | トランスフォーミング増殖因子－β受容体Ｉ／ＡＬＫ５の阻害剤としてのベンジルアミド誘導体 |
Country Status (16)
| Country | Link |
|---|---|
| US (2) | US12297186B2 (https=) |
| EP (1) | EP4065572A1 (https=) |
| JP (2) | JP7808032B2 (https=) |
| KR (1) | KR20220107180A (https=) |
| CN (1) | CN114787145B (https=) |
| AR (1) | AR120578A1 (https=) |
| AU (1) | AU2020394531A1 (https=) |
| BR (1) | BR112022010251A2 (https=) |
| CA (1) | CA3160963A1 (https=) |
| ES (1) | ES3029608T1 (https=) |
| IL (1) | IL293388B2 (https=) |
| MX (1) | MX2022005843A (https=) |
| PH (1) | PH12022551177A1 (https=) |
| SA (1) | SA522432749B1 (https=) |
| WO (1) | WO2021105317A1 (https=) |
| ZA (1) | ZA202205149B (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3978487A1 (en) | 2020-09-30 | 2022-04-06 | Origo Biopharma, S.L. | 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
| TW202543626A (zh) | 2024-02-22 | 2025-11-16 | 西班牙商亞哥邁伯西班牙有限公司 | 新穎結晶相形式 |
| WO2026082960A1 (en) | 2024-10-18 | 2026-04-23 | Agomab Therapeutics Nv | 1,5-naphtyridine and quinoline based inhibitors of alk5 |
| WO2026082968A1 (en) | 2024-10-18 | 2026-04-23 | Agomab Therapeutics Nv | Novel compounds |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3621540A1 (de) | 1986-06-27 | 1988-01-07 | Basf Ag | Chinolinderivate, verfahren zu ihrer herstellung, diese enthaltende mikrobizide und ihre verwendung zur bekaempfung von bakterien und pilzen |
| ATE291020T1 (de) | 2001-02-02 | 2005-04-15 | Smithkline Beecham Corp | Pyrazolderivate gegen tgf überexprimierung |
| CA2496295C (en) | 2002-09-18 | 2010-11-23 | Michael John Munchhof | Novels pyrazole compounds as transforming growth factor (tgf) inhibitors |
| WO2004026302A1 (en) | 2002-09-19 | 2004-04-01 | Eli Lilly And Company | Methods of inhibiting tgf beta with substituted pyrazoles |
| CL2004000234A1 (es) | 2003-02-12 | 2005-04-15 | Biogen Idec Inc | Compuestos derivados 3-(piridin-2-il)-4-heteroaril-pirazol sustituidos, antagonistas de aik5 y/o aik4; composicion farmaceutica y uso del compuesto en el tratamiento de desordenes fibroticos como esclerodermia, lupus nefritico, cicatrizacion de herid |
| CA2720343A1 (en) | 2008-04-04 | 2009-10-08 | Takeda Pharmaceutical Company Limited | Heterocyclic derivative and use thereof |
| US8937150B2 (en) | 2009-06-11 | 2015-01-20 | Abbvie Inc. | Anti-viral compounds |
| CN102762551A (zh) | 2009-12-21 | 2012-10-31 | 拜尔农作物科学股份公司 | 噻吩基吡(嘧)啶基吡唑及其用于防治植物致病菌的用途 |
| AU2012281281B2 (en) * | 2011-07-13 | 2017-06-01 | Tiumbio Co., Ltd | 2-pyridyl substituted imidazoles as ALK5 and/or ALK4 inhibitors |
| EP3283479B1 (en) * | 2015-04-01 | 2022-12-14 | Rigel Pharmaceuticals, Inc. | Tgf-beta inhibitors |
| WO2016172631A2 (en) | 2015-04-24 | 2016-10-27 | President And Fellows Of Harvard College | Substrate selective inhibitors of insulin-degrading enzyme (ide) and uses thereof |
| KR102434226B1 (ko) * | 2016-06-30 | 2022-08-19 | 한미약품 주식회사 | Alk5 억제제로서의 신규 피라졸 유도체 및 이의 용도 |
| US20210002265A1 (en) | 2018-03-02 | 2021-01-07 | Université de Lausanne | Pyrazole derivatives as inhibitors of the wnt signalling pathway |
| US11945803B2 (en) | 2018-08-07 | 2024-04-02 | Tosk, Inc. | Modulators of RAS GTPase |
| CN110433164A (zh) | 2019-08-15 | 2019-11-12 | 南开大学 | TGF-beta受体分子抑制剂在治疗小鼠动物模型中急性髓系白血病的应用 |
| EP3978487A1 (en) | 2020-09-30 | 2022-04-06 | Origo Biopharma, S.L. | 2-(3-pyridin-2-yl-4-quinolin-4-yl-pyrazol-1-yl)-acetamide derivatives as inhibitors of transforming growth factor-beta receptor i/alk5 |
-
2020
- 2020-11-27 WO PCT/EP2020/083566 patent/WO2021105317A1/en not_active Ceased
- 2020-11-27 MX MX2022005843A patent/MX2022005843A/es unknown
- 2020-11-27 CA CA3160963A patent/CA3160963A1/en active Pending
- 2020-11-27 ES ES20811359T patent/ES3029608T1/es active Pending
- 2020-11-27 JP JP2022531434A patent/JP7808032B2/ja active Active
- 2020-11-27 BR BR112022010251A patent/BR112022010251A2/pt unknown
- 2020-11-27 PH PH1/2022/551177A patent/PH12022551177A1/en unknown
- 2020-11-27 IL IL293388A patent/IL293388B2/en unknown
- 2020-11-27 AR ARP200103298A patent/AR120578A1/es unknown
- 2020-11-27 KR KR1020227017493A patent/KR20220107180A/ko active Pending
- 2020-11-27 CN CN202080080848.3A patent/CN114787145B/zh active Active
- 2020-11-27 US US17/780,099 patent/US12297186B2/en active Active
- 2020-11-27 EP EP20811359.7A patent/EP4065572A1/en active Pending
- 2020-11-27 AU AU2020394531A patent/AU2020394531A1/en active Pending
-
2022
- 2022-05-10 ZA ZA2022/05149A patent/ZA202205149B/en unknown
- 2022-05-26 SA SA522432749A patent/SA522432749B1/ar unknown
-
2025
- 2025-05-06 US US19/200,279 patent/US20250333395A1/en active Pending
- 2025-07-10 JP JP2025116497A patent/JP2025163046A/ja active Pending
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