JP2023165893A - Phytotoxicity reducing agent containing bactericidal compound as active ingredient, and herbicidal composition with reduced phytotoxicity containing the phytotoxicity reducing agent and a herbicidal compound - Google Patents

Abstract

To provide a phytotoxicity reducing agent that is expected to have a disease control effect derived from bactericidal activity, and can be generally used to various cultivation crops and can exhibit a good phytotoxicity reducing effect.SOLUTION: A phytotoxicity reducing agent has, as an active ingredient, at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate-methyl, isoprothiolane and amisulbrom or a salt thereof.SELECTED DRAWING: None

Description

TECHNICAL FIELD The present invention relates to a drug harm reducer. More specifically, the present invention relates to a herbicidal harm reducing agent containing a fungicidal compound as an active ingredient, and a herbicidal composition with reduced herbicidal damage containing the herbicidal harm reducing agent and a herbicidal compound.

BACKGROUND ART The use of herbicides is indispensable in crop cultivation in order to ensure appropriate yields of the crops and realize efficient cultivation of the crops. The herbicides currently in use are selective to the crops concerned, and in principle do not cause damage to the crops other than the plants to be controlled.

However, the crop selectivity of the herbicide is not necessarily sufficient, and depending on the conditions in which the herbicide is used, the herbicide may cause growth disturbances, growth inhibition, growth inhibition, appearance of brown spots, and tillering inhibition of the crop. Known or unknown undesirable phytotoxicity may occur, such as yellowing, leaf blight, withering, wilting, whitening, twisting, browning, root growth inhibition, etc.

To date, in order to avoid such phytotoxicity, attempts have been made to use herbicides with different effects in combination, or to use a compound with a phytotoxicity-reducing effect (Safener) in combination with herbicides (Patent Documents 1- 4, Non-Patent Document 1).

The compounds selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane and amisulbrome are known fungicidal compounds, and each compound is listed in Table 1 below. As shown in the relevant patent documents.

In the past, it has been reported that the fungicidal compound 3-hydroxy-5-isoxazole (hereinafter referred to as "hydroxyisoxazole") has the effect of reducing herbicide damage in rice (Non-Patent Document 2).

Furthermore, it is known that isothiazole carboxamides, which are resistance inducers, have the effect of reducing herbicide damage by treating seeds and applying them to seedling boxes (Patent Documents 16 to 18).

Furthermore, isoprothiolane, which has bactericidal and insecticidal activities, is known to have a phytotoxicity-reducing effect on the herbicide tefuryltrione (Patent Document 19).

Japanese Patent Application Publication No. 2016-40235 WO2010/070822 WO2011/145318 WO2011/145329 Special Publication No. 42-25660 WO2003/016303 Japanese Patent Application Publication No. 1-131163 Special Publication No. 42-6818 US Patent 3290353 US Patent 3,631,176 US Patent 4020095 Special Publication No. 47-34126 Patent No. 4438919 Japanese Patent Application Publication No. 2001-187786 Japanese Patent Application Publication No. 2005-112738 Special Publication No. 2001-522840 Japanese Patent Application Publication No. 2004-346030 Japanese Patent Application Publication No. 2007-137833 Japanese Patent Application Publication No. 2008-69091

Pesticide Outlook December 2001, pages 10-15 Research on the growth regulating effect of 3-hydroxy-5-isoxazole on crops. Third report: Effects of flood damage on rice seedlings and herbicide mitigation effects. Masami Ogawa, Yasuo Ota. Journal of the Crop Science Society of Japan, Vol. 43, pp. 531-537. (1974)

However, these conventional drug damage reducers contain as active ingredients compounds that have herbicidal activity or compounds that do not have biological activity (herbicidal activity, bactericidal activity, insecticidal activity, etc.) when used alone, and target specific targets. By limiting the use to cultivated plants, the phytotoxicity of a specific herbicide can be reduced. Therefore, existing phytotoxicity reducers cannot be universally used for various cultivated crops (Patent Documents 1 to 4, Non-Patent Document 1).

Specifically, for the fungicidal compound hydroxyisoxazole, herbicides whose phytotoxicity reducing effects have been confirmed include simetrine and DCPA (propanil; Dimethyl 2,3,5,6-tetrachlorobenzene-1,4- dicarboxylate), MCC (swep) and MCP (ethyl 2-methyl-4-chlorophenoxyacetate), which are mainly photosynthesis-inhibiting herbicides. Therefore, no knowledge has been obtained regarding the effects of herbicides developed in recent years on reducing phytotoxicity.

Furthermore, although isoprothiolane is known to reduce herbicide damage to tefuryltrione, no knowledge has been obtained regarding its effect in reducing herbicide damage to other herbicides.

Furthermore, the herbicide damage reducing effect of fungicidal compounds having fungicidal activity such as picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane, and amisulbrome has not been clarified at present.

The object of the present invention is to exhibit a phytotoxicity reducing effect on various herbicides that have biological activities other than herbicidal effects and exhibit different actions, and to have a superior phytotoxicity reducing effect on cultivated plants than existing phytotoxicity reducing agents. Another objective is to find a new phytotoxicity reducing agent that can be used in a wide range of fields without being limited to cultivated plants.

The present inventors conducted various studies in order to solve the above problems, and as a result, they discovered that certain fungicidal compounds exhibit the effect of reducing herbicide damage. That is, it was discovered that a herbicidal harm reducing agent containing a predetermined fungicidal compound as an active ingredient, and a herbicidal composition containing the herbicidal harm reducing agent and a herbicidal compound have a good herbicidal harm reducing effect, and the present invention was completed.

That is, the present invention is as follows [1] to [19].
[1] A product for crops containing as an active ingredient at least one compound or a salt thereof selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane, and amisulbrome. Drug damage reducer.
[2] The drug harm reducer according to [1], wherein the active ingredient is hydroxyisoxazole, picarbutrazox, amisulbrome, or a salt thereof.
[3] The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, broad bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Mizuna, turnip, Nabana, Chinese cabbage, broccoli, cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris , chrysanthemum, fig, citrus, lumber (sapling), Western grass (bentgrass, ryegrass, bluegrass), or Japanese grass, [1] or [2].
[4] The phytotoxicity reducing agent according to any one of [1] to [3], wherein the crop is rice.
[5] A herbicidal composition containing at least one type of herbicidal compound or a salt thereof and the phytotoxicity reducing agent for crops according to any one of [1] to [4].
[6] The herbicidal compound is at least one type of herbicidal compound or a salt thereof selected from the group consisting of the following (A1) to (A6),
(A1) ACCase inhibitory herbicidal compound,
(A2) acetolactate synthase inhibiting herbicidal compound,
(A3) bleaching herbicidal compound,
(A4) VLCFA inhibitory herbicidal compound,
(A5) protoporphyrinogen IX oxidase inhibitory herbicidal compound,
(A6) synthetic auxin herbicidal compound,
The herbicidal composition according to [5], wherein the active ingredient contained in the drug harm reducer is at least one compound or a salt thereof selected from the group consisting of hydroxyisoxazole, picarbutrazox, and amisulbrome. thing.
[7] The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, broad bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Japanese radish, Japanese radish, Japanese radish, Japanese radish , Chinese cabbage, broccoli, cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honey beet, ginger, rakkyo, tobacco, carnation, The herbicidal composition according to [5] or [6], which is an iris, chrysanthemum, fig, citrus, lumber (sapling), Western grass (bentgrass, ryegrass, bluegrass), or Japanese grass.
[8] The herbicidal composition according to any one of [5] to [7], wherein the crop is rice.
[9] Any one of [5] to [8], wherein the herbicidal compound is at least one herbicidal compound or a salt thereof selected from the group consisting of (A2) and (A3) below. herbicidal composition.
(A2) acetolactate synthase inhibiting herbicidal compound,
(A3) Whitening type herbicidal compound.
[10] The herbicidal composition according to [9], wherein the herbicidal compound is at least one herbicidal compound or a salt thereof selected from the group consisting of (A2-1) and (A3-1) below. .
(A2-1) a sulfonylurea herbicidal compound, a pyrimidinylbenzoic acid herbicidal compound, or a triazolopyrimidine herbicidal compound,
(A3-1) Pyrazole herbicidal compound or triketone herbicidal compound.
[11] A method of reducing phytotoxic damage to crops by an application method selected from the group consisting of (B1) to (B4) below.
(B1) A method of mixing and applying the phytotoxicity reducing agent a according to any one of [1] to [4] and the herbicidal composition b that does not contain the phytotoxicity reducing agent,
(B2) A method of independently applying the phytotoxicity reducing agent a according to any one of [1] to [4] and the herbicidal composition b not containing the phytotoxicity reducing agent to the same crop,
(B3) Applying the phytotoxicity reducer a according to any one of [1] to [4] and the herbicidal composition c according to any one of [5] to [10] independently to the same crop. how to,
(B4) A method of applying the herbicidal composition c according to any one of [5] to [10].
[12] Plants and/or seeds are treated with phytotoxicity reducer a, herbicidal composition b, or herbicidal composition c, or applied to soil and/or roots or rhizomes of plants are treated. , the method for reducing drug damage according to [11].
[13] The method for reducing phytotoxicity according to [12], wherein the treatment of seeds is spraying, smearing, dipping, dusting, or scattering on the seeds.
[14] The method for reducing phytotoxicity according to [12], wherein the application to soil is treatment to paddy soil, treatment to soil surface, irrigation to soil, or mixing to soil.
[15] The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Mizuna, turnip, Nabana, Chinese cabbage, yellowtail, cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris , chrysanthemum, fig, citrus, lumber (sapling), western grass (bentgrass, ryegrass, bluegrass), or Japanese grass. [11].
[16] The method for reducing phytotoxicity according to [11] or [15], wherein the crop is rice.
[17] Apply the application method selected from the group consisting of (B1) to (B4) once or twice to the plant before transplanting, or once to the soil and/or the roots or rhizomes of the plant. Or the method for reducing drug damage according to [11], which is performed twice.
[18] The application method of (B2) above includes applying phytotoxicity reducer a once or twice to the plant before transplanting, and applying herbicidal composition b that does not contain the phytotoxicity reducer to the soil and/or after transplantation. Or, the method for reducing phytotoxicity according to [11] or [17], wherein the crop is applied to a plant body, and the crop is rice.
[19] The herbicidal composition b is selected from the group consisting of (A2-1) and (A3-1) above, where the drug harm reducer a is hydroxyisoxazole, picarbutrazox, or amisulbrome or a salt thereof. , at least one herbicidal compound or a salt thereof, the method for reducing drug damage according to [11], [17] or [18].

The present invention is based on the discovery that fungicidal compounds exhibit the effect of reducing herbicide damage. That is, according to the present invention, by applying a phytotoxicity reducer having fungicidal activity before or during herbicide treatment, a disease control effect derived from fungicidal activity can be expected, and it is universally applicable to various cultivated crops. It can be used in a variety of ways, and a good effect on reducing drug damage can be obtained.

Next, various terms used in this specification will be explained.

"Pharmaceutical damage reducer" means that when agricultural materials are used on cultivated crops to control weeds and pests, they may cause growth disorders, growth suppression, growth suppression, appearance of brown spots, and tillering suppression of the crops. In cases where known or unknown undesirable chemical damage such as yellowing, leaf blight, withering, wilting, whitening, twisting, browning, inhibition of root growth, etc. is expected, use together with agricultural materials or use of agricultural materials. This is a composition that reduces drug damage when used alone before or after.

The salt of "a compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane, and amisulbrome" refers to metal salts, acid addition salts, etc. of the compound. , e.g. salts of alkali metals such as lithium, sodium, potassium, salts of alkaline earth metals such as calcium, barium, magnesium, e.g. salts of aluminum or salts of transition metals such as manganese, copper, zinc, iron, e.g. Salts of hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid, hydriodic acid, etc., salts of inorganic acids such as nitric acid, sulfuric acid, phosphoric acid, chloric acid, perchloric acid, etc., such as methanesulfone acids, salts of sulfonic acids such as ethanesulfonic acid, trifluoromethanesulfonic acid, benzenesulfonic acid, p-toluenesulfonic acid, such as formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, Examples include salts of carboxylic acids such as malic acid, succinic acid, benzoic acid, mandelic acid, ascorbic acid, lactic acid, gluconic acid, and citric acid, and salts of amino acids such as glutamic acid and aspartic acid.

"ACCase-inhibiting herbicidal compounds" refer to, for example, allyloxypropionic acid compounds, cyclohexadione oxime compounds, etc., such as propaquizafop, quizalofop, haloxyfop, fluazifop butyl, fluazifop-P-butyl , cyhalofop butyl, clodinafop propargyl, diclofop methyl, fenoxaprop-P-ethyl, butroxydim, profoxydim, clethodim, tepraloxydim, tralkoxydim, setoxydim, cycloxydim, pinoxaden, and the like.

"Acetolactate synthase inhibiting herbicidal compounds" include, for example, sulfonylurea compounds, sulfonylaminocarbonyltriazolinone compounds, pyrimidinylbenzoic acid compounds, triazolopyrimidine compounds, imidazolinone compounds, etc. , for example, amidosulfuron, azimsulfuron, trifloxysulfuron, bensulfuron methyl, cyclosulfamuron, flupyrsulfuron methyl, forumsulfuron, chlorimuron ethyl, etamethosulfuron methyl, halosulfuron methyl, nicosulfuron, Chlorsulfuron, ethoxysulfuron, imazosulfuron, oxasulfuron, pyrazosulfuron ethyl, tritosulfuron, sinosulfuron, flazasulfuron, iodosulfuron methyl, primisulfuron methyl, rimisulfuron, thifensulfuron methyl, mesosulfuron methyl , metsulfuron methyl, prosulfuron, triasulfuron, triflusulfuron methyl, sulfosulfuron, tribenuron methyl, trifloxysulfuron, flucetosulfuron, metazosulfuron, propyrisulfuron, flucarbazone, propoxycarbazone, bispyribac, pyribenzoxime , pyrithiobac, pyrifthalide, pyriminobac-methyl, pyrimisulfan, triafamone, chloransulam methyl, diclosulam, florasulam, flumetosulam, metosulam, penoxsulam, imazapic, imazapyr, imazametabenzmethyl, imazaquin, imazamox, imazetapyr, etc. Preferably, azimsulfuron, bensulfuron methyl, halosulfuron methyl, imazosulfuron, pyrazosulfuron ethyl, flucetosulfuron, metazosulfuron, propyrisulfuron, bispyribac, pyrifthalide, pyriminobac methyl, pyrimisulfan, triafamone, penoxsulam, etc. Among them, imazosulfuron, pyrimisulfan, etc. are more preferred.

"Whitening herbicidal compounds" include, for example, pyrazole compounds, triketone compounds, etc., such as pyrazolate, pyrazoxifene, benzofenap, pyrasulfotol, topramesone, tolpirate, mesotrione, sulcotrione, benzobiccyclo pyrazolate, pyrazoxifene, benzofenap, mesotrione, sulcotrione, benzobiciclone, tefuryltrione, and the like. , lankotrione, cyclopyrimoleate, fenquinotrione, etc., and more preferably sulkotrione, tefuryltrione, etc.

"VLCFA-inhibiting herbicidal compounds" refer to, for example, chloroacetamide compounds, such as acetochlor, butachlor, alachlor, dimethachlor, dimethenamide, propachlor, tenylchlor, metazachlor, metolachlor, S-metolachlor. , pretilachlor, petoxamide, mefenacet, cafenstrol, fentrazamide, ipfencarbazone, fenoxasulfone, etc.

"Protoporphyrinogen IX oxidase-inhibiting herbicidal compounds" include, for example, diphenyl ether compounds, triazolinone compounds, etc., such as acifluofen, bifenox, fomesafen, lactofen, oxyfluorfen, carfentrazone ethyl, These include sulfentrazone, pentoxazone, pyraclonil, oxadiazone, and oxadiargyl.

The "synthetic auxin herbicidal compound" refers to, for example, a phenoxycarboxylic acid compound, such as clomeprop, MCPA, MCPB, 2,4-DB, florpyrauxifenbenzyl, and the like.

The term "crops" as used in the present invention refers to plants whose reproduction and growth are protected and managed by humans. Crops are classified based on a comprehensive judgment of their cultivation methods, commercial value, purpose of use, parts used, botanical classification, etc. Generally, crops are broadly divided into agricultural crops and horticultural crops. Ru.
Agricultural crops are divided into food crops, craft crops, fodder crops, and green manure crops depending on the purpose of use. Specifically, for example, rice, wheat, barley, potato, corn, grape, apple, pear, peach, nectarine, plum, apricot, cherry, persimmon, quince, quince, chestnut, cui fruit, blueberry, loquat, banana, Citrus, fig, olive, papaya, akebia, oil palm, soybean, groundnut, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, mizuna, Japanese cabbage, turnip, Japanese cabbage, Chinese cabbage, broccoli, cauliflower, nabana, lettuce, non-heading Lettuce, tomato, eggplant, green pepper, chili pepper, chili pepper, green onion, onion, spring onion, cucumber, bitter melon, melon, watermelon, pumpkin, zucchini, carrot, ginger, ginger, burdock, cloud, cod, spinach, sugar beet, asparagus, okra , parsley, safflower, rapeseed, honeysuckle, sweet potato, taro, yam, konnyaku, sugar cane, tobacco, tea, coffee, sunflower, tulip, carnation, basil, iris, aster, rose, chrysanthemum, cotton, pop, gentian, lily, button , peonies, cyclamen, rakkyo, pepper, garlic, butterbur, perilla, cinnamon, wasabi, taranoki, lotus root, sorghum, western grass (bent grass, bermuda grass, blue grass, rye grass), Japanese grass, orchard grass, Italian rye grass, alfalfa, Examples include red clover, valerian, mulberry, celosia, brooms, calendula, safflower, rhododendrons, cherry blossoms, oaks, bokeh, poplar, boxwood, boxwood, trees, lumber (seedlings), and the like.
Among them, rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugar cane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, mizuna, turnip, Chinese cabbage, Chinese cabbage, broccoli, and cauliflower. , lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, fig, Citrus, lumber (seedlings), Western grass (bentgrass, ryegrass, bluegrass), Japanese grass, etc. are preferred; rice, sugar beet, Western grass, Japanese grass, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, pea, etc. is more preferred, and rice is particularly preferred, but is not limited to these.

The term "plant" as used in the present invention is a general term for all parts constituting the "crop", and includes, for example, stems, leaves, roots, seeds, flowers, fruits, and the like.
The term "seed" as used in the present invention refers to a seed that stores nutrients for seedlings to germinate and is used for agricultural propagation. Specifically, for example, seeds such as corn, soybean, cotton, rice, sugar beet, wheat, barley, sunflower, tomato, cucumber, eggplant, spinach, snow pea, pumpkin, sugar cane, tobacco, green pepper, and canola, taro, and potato. , sweet potatoes, seed potatoes such as konjac, bulbs of edible lilies, tulips, seed bulbs of rakkyo, etc. Furthermore, these are plants created by artificially manipulating genes, etc., and do not naturally exist in the natural world. Genetically modified crops; for example, herbicide-resistant soybean, corn, cotton, etc. adapted to cold regions, such as rice, tobacco; or insecticide-producing ability, such as corn, cotton, etc. seeds, potatoes These include, but are not limited to, tubers and the like.

Next, a phytotoxicity reducing agent containing the fungicidal compound of the present invention as an active ingredient, and a herbicidal composition with reduced phytotoxicity containing the phytotoxicity reducing agent and a herbicidal compound will be described.

First, a drug damage reducing agent containing the fungicidal compound of the present invention as an active ingredient will be explained.
The drug harm reducer of the present invention contains as an active ingredient at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane, and amisulbrome, or a salt thereof. contains.
The active ingredient is. From the viewpoint of the effects of the present invention, hydroxyisoxazole, picarbutrazox, amisulbrome, or a salt thereof is preferable.

The drug harm reducer of the present invention may be used as it is, but it is usually mixed with a carrier, and if necessary, surfactants, binders, disintegrants, stabilizers, pH adjusters, antibacterial agents, etc. Add auxiliary agents such as anti-mold agents (preservatives), thickeners, antifoaming agents, wetting agents, fixing agents, coloring agents, etc., and prepare hydrating agents, flowable agents, and hydrated granules according to conventional methods. , OD preparations, powders, liquids, emulsions, granules, packs, and other dosage forms. The dosage form is not limited to those compositions as long as the effect is exhibited.

The carrier used in the drug safety agent of the present invention refers to a synthetic or natural carrier that is blended to help the active ingredient reach the area to be treated and to facilitate the storage, transportation, and handling of the active ingredient compound. It means an inorganic or organic substance, and as long as it is normally used in agricultural and horticultural chemicals, it can be used in either solid or liquid form, and is not limited to a specific substance.

Examples of solid carriers that can be used in the drug-toxicity reducing agent of the present invention include inorganic substances such as bentonite, montmorillonite, diatomaceous earth, white clay, talc, and clay; vegetable organic substances such as wood flour and sawdust; or urea. can be mentioned.

Examples of liquid carriers that can be used in the drug safety agent of the present invention include aromatic hydrocarbons such as toluene; naphthenes; paraffinic hydrocarbons such as n-paraffin, liquid paraffin, and kerosene; acetone, methyl ethyl ketone; ethers such as dioxane and diethylene glycol dimethyl ether; alcohols such as ethanol and ethylene glycol; carbonates such as ethylene carbonate; aprotic solvents such as dimethylformamide; and water.

Furthermore, in order to enhance the efficacy of the drug harm reducer of the present invention, adjuvants may be used alone or in combination depending on the purpose, taking into consideration the dosage form of the preparation, processing method, etc. . Examples of the auxiliary agents include surfactants, binders, disintegrants, stabilizers, pH adjusters, antibacterial and antifungal agents, thickeners, antifoaming agents, antifreeze agents, and the like.

As the surfactant that can be used in the drug-toxicity reducing agent of the present invention, surfactants that are normally used for the purpose of emulsifying, dispersing, spreading, and/or wetting agricultural chemical formulations can be used. Such substances include, for example, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkyl phenyl ether, polyoxyethylene polyoxypropylene block polymer, alkyl polyoxyethylene polyoxypropylene block polymer. Nonionic interfaces such as ether, polyoxyethylene alkylamine, polyoxyethylene fatty acid amide, polyoxyethylene bisphenyl ether, polyoxyalkylene adduct of higher alcohol, polyoxyethylene ether, ester type silicone, and fluorine surfactant. Activator;
Alkyl sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene benzyl phenyl ether sulfate, polyoxyethylene styrylphenyl ether sulfate, paraffin sulfonate, alkanesulfonate, AOS, dialkyl sulfosuccinate, alkylbenzene sulfonate, lignin sulfonate, polyoxyethylene alkylphenyl Ether sulfonate, fatty acid salt, N-methyl-fatty acid sarcosinate, polyoxyethylene alkyl ether phosphate, polyoxyethylene phenyl ether phosphate, polyoxyethylene polyoxypropylene block polymer phosphate, phosphatidylcholine, phosphatidylethanolimine, alkyl phosphate, sodium tripolyphosphate, etc. anionic surfactant;
Polyanionic polymer surfactant derived from acrylic acid, acrylonitrile, and acrylamide methylpropanesulfonic acid;
Cationic surfactants such as alkyltrimethylammonium chloride, alkyldimethylbenzalkonium chloride, benzethonium chloride;
Alternatively, amphoteric surfactants such as dialkyldiaminoethylbentine and alkyldimethylbenzylbentine may be mentioned.

Examples of the binder include sodium alginate, polyvinyl alcohol, gum arabic, carboxymethyl cellulose (hereinafter referred to as "CMC sodium"), bentonite, and the like.

Examples of the disintegrant include CMC sodium, croscarmellose sodium, and the like.

Examples of the stabilizer include hindered phenol-based antioxidants; benzotriazole-based and hindered amine-based ultraviolet absorbers.

Examples of the pH adjuster include phosphoric acid, acetic acid, and sodium hydroxide.

Examples of the antibacterial and fungicidal agent include industrial fungicides such as 1,2-benzisothiazolin-3-one, and antibacterial and antifungal agents.

Examples of thickeners include xanthan gum, guar gum, sodium CMC, gum arabic, polyvinyl alcohol, and montmorillonite.

Examples of antifoaming agents include silicone compounds.

Examples of antifreeze agents include propylene glycol, ethylene glycol, and the like.

The adjuvants described above are examples, and the adjuvants of the present invention are not limited to the above-mentioned ones.

The content of the active ingredient in the drug harm reducer of the present invention is usually in the range of 0.1 to 100%, preferably in the range of 0.1 to 90%, more preferably in the range of 1 to 100% by weight. 80%, particularly preferably 5 to 50%.

The phytotoxicity reducing agent of the present invention can be effective against various phytotoxicity to cultivated crops, such as phytotoxicity to crops caused by herbicidal compounds, such as growth disorder, growth inhibition, growth inhibition, and appearance of brown spots. It is possible to reduce chemical damage such as tillering inhibition, yellowing, leaf withering, withering, withering, whitening, twisting, browning, and inhibition of root growth.
The phytotoxicity reducing agent of the present invention is particularly excellent in suppressing phytotoxicity to crops caused by herbicidal compounds.

The phytotoxicity reducing agent containing the fungicidal compound of the present invention as an active ingredient can prevent phytotoxicity to crops caused by herbicidal compounds, such as growth failure, growth inhibition, growth inhibition, appearance of brown spots, tillering inhibition, yellowing, It is possible to avoid leaf withering, withering, wilting, whitening, twisting, browning, inhibition of root growth, etc.
Target crops include, for example, rice, wheat, barley, potato, corn, grape, apple, pear, peach, nectarine, plum, apricot, cherry, persimmon, quince, quince, chestnut, cui fruit, blueberry, loquat, banana, and citrus. , figs, olives, papaya, akebia, oil palm, soybeans, groundnuts, green beans, peas, snow peas, fava beans, azuki beans, strawberries, cabbage, radish, mizuna, mibuna, turnip, komatsuna, Chinese cabbage, broccoli, cauliflower, nabana, lettuce, tomato , eggplant, bell pepper, chili pepper, chili pepper, green onion, onion, spring onion, cucumber, bitter melon, melon, watermelon, pumpkin, zucchini, carrot, Japanese ginger, ginger, burdock, cloud, cod, spinach, sugar beet, asparagus, okra, Japanese parsley, Safflower, rapeseed, honeysuckle, sweet potato, taro, yam, konnyaku, sugar cane, tobacco, tea, coffee, sunflower, tulip, carnation, basil, iris, aster, rose, chrysanthemum, cotton, pop, gentian, lily, button, peonies, Cyclamen, rakkyo, pepper, garlic, butterbur, perilla, cinnamon, wasabi, taranoki, lotus root, sorghum, western grass (bent grass, bermuda grass, blue grass, rye grass), Japanese grass, orchard grass, Italian rye grass, alfalfa, red clover, Examples include valerian, mulberry, celosia, broomstick, calendula, safflower, rhododendron, cherry, oak, bokeh, poplar, boxwood, ginkgo, trees, lumber (seedlings), and the like.
Among them, rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugar cane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, mizuna, turnip, Chinese cabbage, Chinese cabbage, broccoli, and cauliflower. , lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, fig, Citrus, lumber (seedlings), Western grass (bentgrass, ryegrass, bluegrass), Japanese grass are preferred, and rice, sugar beet, Western grass, Japanese grass, wheat, barley, corn, rapeseed, cotton, sunflower, sugar cane, peas, etc. More preferred, especially rice

In the present invention, rice refers to an annual plant of the Poaceae family, the genus Oryza, and is classified into two ecotypes: O. sativa subsp. japonica and O. sativa subsp. indica. Ru. In addition, starch, which is the main component of the edible part of rice, is divided into amylose and amylopectin due to differences in molecular structure, and some varieties contain about 20% amylose (Uruchi), while others have 0% amylose content due to genetic defects. Some varieties are classified as mochi (glue). Specific glutinous varieties include Koshihikari, Nipponbare, Akitakomachi, Kirara 397, Kinuhikari, Hitomebore, Nanatsuboshi, Hoshino Yume, Haenuki, Domannaka, Sasanishiki, and Hinohikari; examples of mochi varieties include Habutae Low amylose varieties include glutinous, Taisho glutinous, Koganemochi, Miyakoganemochi, Asahi glutinous, Fujizo glutinous, Hiyokumochi, Himenomochi, Mochihikari, Yume no Hatamochi, Hakuchomochi, Toyohatamochi, Wataboshi, etc. , Milky Queen, Yumegokochi, Ikuhikari, Milky Pearl, and Himenomochi are suitable for sake brewing, such as Yamada Nishiki, Gohyakumangoku, Miyama Nishiki, Omachi, Hattan, Hattan Nishiki, Ginpu, Yumesansa, and Wakamizu. , Yume no Kaori, Ferry, etc., and for feed use include, for example, Hoshi Yutaka, Hoshi Aoba, Kusanohoshi, Kusayutaka, Nishi Aoba, and Minami Yutaka. In addition, upland rice, black rice, red rice, green rice, and special varieties bred for disease resistance and insect resistance, as well as herbicide resistance, insecticidal effect, and resistance to pests and diseases using classical breeding methods or genetic modification techniques. This also includes varieties that have been given sex.

In the present invention, target crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, broad bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Japanese radish, Mizuna, and turnip. , Chinese cabbage, broccoli, cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honey beet, ginger, rakkyo, tobacco, Preferably, it is carnation, iris, chrysanthemum, fig, citrus, lumber (sapling), Western grass (bentgrass, ryegrass, bluegrass) or Japanese grass. The phytotoxicity reducing agent of the present invention is particularly effective in reducing phytotoxicity caused by herbicidal compounds in these crops.

The phytotoxicity reducing agent containing the fungicidal compound of the present invention as an active ingredient can also be used to control plant diseases due to its inherent fungicidal activity. Diseases that can be controlled include:
For example, rice blast (Magnaporthe grisea), sheath blight (Thanatephorus cucumeris), brown sclerotium (Ceratobasidium setariae), brown small-grain sclerotium (Waitea circinata), brown sheath blight (Tha natephorus cucumeris), spherical sclerotia Sclerotium hydrophilum, Wairea circinata, Entyloma dactylidis, Magnaporthe salvinii, Ceratobasidium cornigerum), sesame leaf blight (Cochliobolus miyabeanus), Row blight (Sphaerulina oryzina), Gibberella fujikuroi, Seedling damping off (Pythium spp., Fusarium spp., Trichoderma spp., Rhizopus spp., Rhizoctonia solani, Mucor sp.), seedling rot ( Pythium spp., Achlya spp., Dictyuchus spp.), rice mildew (Claviceps virens), black smut (Tilletia barclayana), brown rice (Curvularia spp., Alternari) a spp.), Sclerophthora macrospora, Xanthomonas oryzae pv. oryzae, Acidovorax avenae subsp. avenae, Erwinia ananas, Burkholderia pv. lantarii), Burkholderia glumae, Pseudomonas fuscovaginae, Pseudomonas syringae pv. oryzae, Erwinia chrysanthemi, Phytoplasma oryzae ), Rice stripe tenuivirus, Rice dwarf reovirus);

Powdery mildew (Blumeria graminis f.sp.hordei; f.sp.tritici), rust (Puccinia striiformis, Puccinia graminis, Puccinia recondita, Puc) of wheat cinia hordei), spotted leaf disease (Pyrenophora graminea), web spot disease ( Pyrenophora teres), Gibberella zeae, Fusarium culmorum, Fusarium avenaceum, Monographella nivalis, snow rot (Typhula incarna) ta, Typhula ishikariensis, Monographella nivalis), naked smut (Ustilago nuda), slug smut (Tilletia caries, Tilletia controversa), Pseudocercosporella herpotrichoides, Ceratobasidium gramineum, Rhynchosporium secalis, Septoria tritici, Phaeosphaeria nodorum, Fusarium spp. ., Pythium spp., Rhizoctonia spp., Septoria spp., Pyrenophora spp.), damping-off (Gaeumannomyces graminis), anthracnose (Colletotrichum grami) nicola), ergot disease (Claviceps purpurea), spot disease (Cochliobolus sativus), black knot disease (Pseudomonas syringae pv. syringae);

Fusarium head blight (Gibberella zeae, etc.), seedling damping-off (Fusarium avenaceum, Penicillium spp, Pythium spp., Rhizoctonia spp.), and rust (Puccinia spp.) of corn ), sesame leaf blight (Cochliobolus heterostrophus), smut ( Ustilago maydis), anthrax (Colletotrichum graminicola), northern spot disease (Cochliobolus carbonum), brown streak disease (Acidovorax avenae subsp. avenae), streak bacterial disease ( Burkholderia andropogonis), bacterial lodging disease (Erwinia chrysanthemi pv. zeae), Bacterial wilt (Erwinia stewartii); Grape downy mildew (Plasmopara viticola), Rust (Physopella ampelopsidis), Powdery mildew (Uncinula necator), Black rot (Elsinoe am.) pelina), late rot (Glomerella cingulata, Colletotrichum) acutatum), black rot (Guignardia bidwellii), vine split disease (Phomopsis viticola), soot spot disease (Zygophiala jamaicensis), gray mold (Botrytis cinerea), bud blight ( Diaporthe medusaea), Helicobasidium mompa ), Rosellinia necatrix, Agrobacterium vitis;

Apple powdery mildew (Podosphaera leucotricha), Venturia inaqualis, leaf spot (Alternaria mali), red star disease (Gymnosporangium yamadae), Monilia disease (Monil) inia mali), rot disease (Valsa ceratosperma), ringworm disease ( Botryosphaeria berengeriana), anthrax (Colletotrichum acutatum, Glomerella cingulata), soot spot disease (Zygophiala jamaicensis), sooty spot disease (Gl oeodes pomigena), black spot (Mycosphaerella pomi), purple spot (Helicobasidium mompa), white spot (Helicobasidium mompa) (Rosellinia necatrix), Phomopsis mali, Diaporthe tanakae, Diplocarpon mali, apple fire blight (Erwinia amylovora), Agrobacterium blight (Diaporthe tanakae) Agrobacterium rhizogenes), hair root disease (Agrobacterium rhizogenes) Pear black spot (Alternaria kikuchiana), black star disease (Venturia nashicola), red star disease (Gymnosporangium asiaticum), ring spot disease (Botryosphaeria berengeriana f.s) P. piricola), Phomopsis fukushii, bacterial branch blight (Erwinia sp.), Agrobacterium tumefaciens, Erwinia chrysanthemi pv. chrysanthemi, Pseudomonas syringae pv. Phytophthora cactorum; Phytophthora syringae), bacterial branch blight (Erwinia sp.); peach scab (Cladosporium carpophilum), homopsis rot (Phomopsis sp.), late blight (Phytophthora sp.). ), Anthracnose (Colletotrichum gloeosporioides), Taphrina deformans, Xhanthomonas campestris pv. pruni, Agrobacter anthracnose (Glomerella cingulata), young fruit Monilinia kusanoi, Monilinia fructicola, Agrobacterium tumefaciens, Pseudomonas syringae pv. syringae ; Oyster anthracnose (Glomerella cingulata), leaf fall disease ( Cercospora kaki; Mycosphaerella nawae), powdery mildew (Phyllactinia kakikora), tumefaciens (Agrobacterium tumefaciens); citrus black spot (Diaporthe c itri), Penicillium digitatum, Penicillium italicum, Elsinoe fawcettii, Phytophthora citrophthora, Xhanthomonas campestris pv. citri, Pseudomonas syringae pv. syringae), greening disease (Liberibactor asiaticus), radicular carcinoma Agrobacterium tumefaciens;

Botrytis cinerea on tomatoes, cucumbers, beans, strawberries, potatoes, cabbage, eggplants, lettuce, etc.; Sclerotinia sclerotiorum on tomatoes, cucumbers, beans, strawberries, potatoes, rapeseed, cabbage, eggplants, lettuce, etc. ); Seedling damping-off of tomatoes, cucumbers, beans, radish, watermelon, eggplant, rapeseed, green pepper, spinach, sugar beet, etc. (Rhizoctonia spp., Pythium spp., Fusarium spp., Phythophthora spp., Sclerotinia spp. clerotiorum etc.) Ralstonia solanacearum; downy mildew of cucurbits (Pseudoperonospora cubensis), powdery mildew (Sphaerotheca fuliginea), anthracnose (Colletotrichum o) bryoniae), vine blight (Didimella bryoniae), vine split disease (Fusarium oxysporum), Phytophthora parasitica, Phytophthora melonis, Phytophthora nicotianae, Phytophthora drechsleri, Phytophthora phthora capsici etc.), bacterial brown spot disease (Xhanthomonas campestris pv. cucurbitae), soft rot disease (Erwinia carotovora subsp. carotovora), bacterial spot disease ( Pseudomonas syringae pv. lachrymans), Pseudomonas marginalis pv. marginalis, Streptomyces sp., Agrobacterium rhizogenes), Cucumber mosaic virus; ring spot disease of tomato (Alternaria solani), leaf mold (Fulvia fulva), late blight (Phytophthora infestans), wilt (Fusarium oxysporum), root rot (Pythium myriotylum, Pythium dissotocum), anthrax (Colletotrichum gloeosporioides), canker disease (Clavibacter michiganensis) , Pseudomonas corrugata, Pseudomonas viridiflava, Erwinia carotovora subsp. carotovora), leaf curl (Crynebacterium sp.), yellowing disease (Phytoplasma asteris), yellowing leaf curl subgroup III geminivirus (Tabaco leaf curl subgroup III geminivirus); eggplant powdery mildew (Sp. haerotheca fuliginea etc.), sooty mold (Mycovellosiella nattrassii) , Phytophthora infestans, Phytophthora capsici, Pseudomonas cichorii, Pseudomonas corrugata, Erwini a chrysanthemi), soft rot (Erwinia carotovora subsp. carotovora), bacterial spot disease (Pseudomonas sp.);

Alternaria brassicae, Xhanthomonas campestris pv. campestris, Pseudomonas syringae pv. maculicola, soft rot of rapeseed winia carotovora); black spot of cruciferous vegetables (Alternaria brassicae) etc.), white spot (Cercosporella brassicae), root rot (Phoma lingam), clubroot (Plasmodiophora brassicae), downy mildew (Peronospora parasitica), black rot (Xhanthom) onas campestris pv. campestris), black spot bacterial disease ( Pseudomonas syringae pv. maculicola), soft rot (Erwinia carotovora subsp. carotovora); Rhizoctonia solani, Verticillium dahliae ); Allium rust (Puccinia allii), black spot (Alternaria porri), white silk rot (Sclerotium rolfsii), white late blight (Phytophthora porri), black rot sclerotium (Sclerotium cepivoru) m); Onion canker disease (Curtobacterium flaccumfaciens), soft rot (Erwinia carotovora subsp. carotovora), bacterial spot (Pseudomonas syringae pv. syringae), rot (Erwinia rhapontici), Burkholderia gladioli, Phytoplasma asteris; Soft rot of garlic (Erwinia carotovora subsp. carotovora), spring rot (Pseudomonas marginalis pv. marginalis); soybean purpura (Cercospora kikuchii), black millet (Elsinoe g. lycines), black spot (Diaporthe phaseolorum), Rhizoctonia root rot (Rhizoctonia solani) ), stem blight (Phytophthora sojae), downy mildew (Peronospora manshurica), rust (Phakopsora pachyrhizi), anthracnose (Colletotrichum truncatum, etc.), leaf scorch disease (Xhanthomonas campestris pv. glycine), bacterial spot disease (Pseudomonas syringae pv. glycinea);

Green bean anthracnose (Colletotrichum lindemuthianum), bacterial wilt (Ralstonia solanacearum), canopy blight (Pseudomonas syringae pv. phaseolicola), brown spot bacterial disease (Pseud omonas viridiflava), leaf blight (Xhanthomonas campestris pv. phaseoli); Mycosphaerella berkeleyi, brown spot (Mycosphaerella arachidis), bacterial wilt (Ralstonia solanacearum); pea powdery mildew (Erysiphe pisi), downy mildew (Peron) ospora pisi), Pseudomonas syringae pv pisi), vine rot bacterial disease (Xhanthomonas campestris pv. pisi); downy mildew of broad beans (Peronospora viciae), late blight (Phytophthora nicotianae); summer blight of potato (Alternaria s olani), black bruise (Thanatephorus cucumeris), late blight (Phytophthora infestans), silver scab (Helminthosporium solani), dry rot (Fusarium oxysporum, Fusarium solani), powdery scab (Spongospora subterranee) a), Ralstonia solanacearum, Erwinia carotovora subsp. atroseptica), Streptomyces scabies, Streptomyces acidiscabies, Erwinia carotovora subsp. um spp.), ring rot (Clavibacter michiganensis subsp. sepedonicus); damping-off of sweet potato (Clavibacter michiganensis subsp. Streptomyces ipomoeae); Cercospora beticola, Peronospora schachtii, Aphanomyces cochioides, Phoma beta e), Agrobacterium tumefaciens, scab disease (Streptomyces scabies), bacterial spot disease (Pseudomonas syringae pv. aptata);

Carrot black leaf blight (Alternaria dauci), clubroot (Rhizobacter dauci), tumefaciens (Agrobacterium tumefaciens), Streptomyces spp., soft rot (Erwi) nia carotovora subsp. carotovora); Strawberry powdery mildew (Sphaerotheca aphanis var. aphanis), late blight (Phytophthora nicotianae, etc.), anthracnose (Glomerella cingulata, etc.), fruit rot disease (Pythium ultimum) ), bacterial wilt (Ralstonia solanacearum), bacterial horn spot disease (Xhanthomonas campestris), bacterial shoot blight (Pseudomonas marginalis pv. marginalis); tea net blast (Exobasidium reticulatum), white star disease (Elsinoe leucospila), anthracnose (Col letotrichum theae-sinensis), Pestalotiopsis longiseta, red Pseudomonas syringae pv. theae, canker disease (Xhanthomonas campestris pv. theicola), Pseudomonas sp. nata), powdery mildew (Erysiphe cichoracearum), anthrax (Colletotrichum) gloeosporioides), late blight (Phytophthora nicotianae), wildfire disease (Pseudomonas syringae pv. tabaci), yellow bacterium disease (Pseudomonas syringae pv. mellea), cavities disease (Erwinia carotovora subsp. carotovora), damping-off disease (Ralstonia solanacearum), Tobaco mosaic virus; Cotton damping-off (Fusarium oxysporum); Sunflower Sclerotinia sclerotiorum, Xhanthomonas campestris pv. malvacearum), cavitation Erwinia carotovora subsp. carotovora), bacterial spot disease (Pseudomonas syringae pv. megasperma), downy mildew (Peronospora sparsa), radicular carcinoma Agrobacterium tumefaciens; chrysanthemum septoria obesa, white rust (Puccinia horiana), late blight (Phytophthora cactorum), bacterial spot (Pseudomonas ci) chorii), soft rot (Erwinia carotovora subsp. carotovora), root Agrobacterium tumefaciens, Agrobacterium rhizogenes, Phytoplasma aurantifolia; brown patch disease of grass (Rhizoctonia solani) ), dollar spot disease (Sclerotinia homoeocarpa), Curvularia leaf blight (Curvularia sp. ), rust (Puccinia zoysiae), Cochliobolus sp., rhynchosporium secalis, damping-off (Gaeumannomyces graminis), anthracnose (Collet) otrichum sp.), small snow-brown fungus Typhula incarnata, snow rot small black sclerotia (Typhula ishikariensis), snow rot large sclerotinia borealis, fairy ring disease (Marasmius oreades etc.), Pythium disease (Py thium aphanidermatum, etc.), blast disease ( Pyricularia grisea) and the like.

Second, a herbicidal composition with reduced phytotoxicity containing a phytotoxicity reducing agent and a herbicidal compound will be described.

The herbicidal composition with reduced herbicidal damage containing a herbicidal compound and a herbicidal compound (hereinafter referred to as a herbicidal composition) of the present invention may include the above-mentioned herbicidal harm reducer. can.

The herbicidal compounds contained in the herbicidal composition of the present invention include, for example, bromobutide, cymetrine, dimethamethrine, bentazone, in addition to herbicidal compounds selected from the group consisting of (A1) to (A6) below, or salts thereof. , Daimeron, Cumiluron, Oxadiclomefon, Esprocarb, Pyributicarb, Molinate, Cinmethylline and the like.

From the viewpoint of the effects of the present invention, the herbicidal composition of the present invention preferably contains at least one herbicidal compound or a salt thereof selected from the group consisting of (A1) to (A6) below: More preferably, it is at least one herbicidal compound or a salt thereof selected from the group consisting of (A2) and (A3) below.
(A1) ACCase inhibitory herbicidal compound (A2) Acetolactate synthase inhibitory herbicidal compound (A3) Whitening herbicidal compound (A4) VLCFA inhibitory herbicidal compound (A5) Protoporphyrinogen IX oxidase inhibitory herbicidal compound Synthetic auxin herbicidal compound (A6)

(A2) is preferably (A2-1) a sulfonylurea herbicidal compound, a pyrimidinylsalicylic acid herbicidal compound, or a triazolopyrimidine herbicidal compound, and (A3) is preferably (A3-1) a pyrazole herbicidal compound. and triketone herbicidal compounds are preferred.

In the present invention, it is more preferably at least one herbicidal compound selected from the group consisting of (A2-1) and (A3-1) or a salt thereof.

The herbicidal composition of the present invention can contain, in addition to these herbicidal compounds, the carrier and the auxiliary agent exemplified in the phytotoxicity reducer.

The content of the herbicidal compound in the composition of the present invention is usually in the range of 0.1 to 90% by weight, preferably in the range of 1 to 80%, more preferably in the range of 5 to 50%. % range.
The total content of the herbicidal compound and the herbicidal compound in the composition of the present invention is usually in the range of 0.1 to 90% by weight, preferably in the range of 1 to 80%, and Preferably, it is in the range of 5 to 50%.

The mixing ratio of the herbicidal compound to the herbicidal compound in the composition of the present invention is usually such that the weight ratio of the herbicidal compound to the herbicidal compound is 0.001 to 1000, preferably 0.01 to 1000. The ratio is 100.

The herbicidal composition of the present invention can be manufactured according to conventional methods for manufacturing general agricultural chemicals. At least two types of active ingredients, a fungicidal compound and a herbicidal compound, which are the active ingredients of a drug damage reducer, are mixed, and if necessary, the above-mentioned carrier and the above-mentioned auxiliary agent, etc. are mixed, and both active ingredients are mixed. or, after first producing a composition containing either a fungicidal compound or a herbicidal compound, which are the active ingredients of the safener, the other is added thereto. , a herbicidal composition with reduced phytotoxicity containing both active ingredients may be produced.

Usually, preferably, a mixture of both active ingredients is prepared to produce the herbicidal composition with reduced phytotoxicity.
The herbicidal composition of the present invention can be formulated into dosage forms such as wettable powders, flowable powders, wettable powder powders, OD powders, powders, liquids, emulsions, granules, and packs.

From the viewpoint of the effects of the present invention, the herbicidal composition of the present invention is characterized in that the active ingredient contained in the drug harm reducer contains at least one type selected from the group consisting of hydroxyisoxazole, picarbutrazox, and amisulbrome. The herbicidal compound is preferably at least one compound selected from the group consisting of (A1) to (A6) or a salt thereof.

The herbicidal composition of the present invention has fungicidal activity and can also be used for weed control due to its inherent herbicidal activity. Weeds that can be controlled include, for example, crabgrass, foxtail grass, hackberry grass, golden foxtail grass, golden foxtail grass, golden locust, Japanese grass millet, Texas panicum, Japanese corn millet, Seiban sorghum, shutter cane, silver grass, oat, common wheat, black grass, horseweed grass, horseweed, and Japanese sorghum. Canary bushweed, European staghorn, sycamore, grasshopper, staghorn snail, Japanese snail, yellow snail, purslane, blue staghorn, Japanese staghorn staghorn, Japanese staghorn staghorn, freckle violet, staghorn staghorn, American staghorn staghorn, husk knot, staghorn snail, Japanese knotweed, Japanese knotweed, white staghorn, broom Gi , Japanese knotweed, Japanese Physalis, White-bellied morning glory, Mulva morning glory, American morning glory, Mulva American morning glory, Japanese morning glory, St. convolvulus, Japanese sycamore, Hotokenoza, Japanese fir, wild sunflower, dog's chamomile, chamomile, corn marigold, stagweed, ragweed, giant ragweed, Japanese wormwood, Mugwort, European stingray, American hornwort, Ebisu weed, Florida beggarweed, white clover, kudzu, crow's pea, daywort, bumbleweed, japonica, chickweed, wild radish, field mustard, shepherd's purse, shepherd's puffer, flowering plant, field pansy, wild pansy, poppy , field weeds such as forget-me-nots, milkweeds, spurges, cornweeds, American grasshoppers, Dutch grasshoppers, and horsetails; Azena, Japanese aphrodisiac, Japanese aphrodisiac, Japanese aphrodisiac, Japanese japonica, Japanese chickweed, Japanese knotweed, Japanese apricot, Japanese chickweed, Japanese aphrodisiac, Japanese aphrodisiac, Japanese azalea, Japanese parsley, water chickweed, Japanese red pepper, American azaena, Japanese aphrodisiac, Japanese japonica, Japanese apricot, Japanese japonica, Japanese azalea, bamboo azaena, Japanese aphrodisiac, Japanese aphrodisiac Japanese grasshopper, taucogi, American melium, and staghorn Examples include, but are not limited to, paddy field weeds such as , American hornwort, azalea, and algae.

Since the herbicidal composition of the present invention contains the phytotoxicity reducer of the present invention, it avoids phytotoxicity to crops caused by herbicidal compounds, such as growth suppression, appearance of brown spots, yellowing, withering, and wilting. is possible.
Target crops include those exemplified in the phytotoxicity reducer.

Thirdly, a method for reducing phytotoxicity on crops using the phytotoxicity reducing agent of the present invention or the herbicidal composition of the present invention will be explained.

In the present invention, phytotoxicity to crops can be reduced by an application method selected from the group consisting of (B1) to (B4) below.
(B1) Mixing and applying the herbicidal composition which does not contain the herbicidal composition b (hereinafter referred to as herbicidal composition b) which does not contain the herbicidal composition b, which does not contain the herbicidal composition b, which does not contain the herbicidal composition b. Method,
(B2) A method of independently applying phytotoxicity reducer a and herbicidal composition b to the same crop,
(B3) A method of independently applying the phytotoxicity reducer a and the herbicidal composition of the present invention (hereinafter referred to as herbicidal composition c) to the same crop,
(B4) Method of applying herbicidal composition c.

As the herbicidal composition b, the same one as the herbicidal composition of the present invention can be used except that it does not contain a phytotoxicity reducer.
In the present invention, the herbicidal composition b is selected from the group consisting of (A2-1) and (A3-1) above, where the drug damage reducer a is hydroxyisoxazole, picarbutrazox, or amisulbrome or a salt thereof. At least one herbicidal compound or a salt thereof is preferred.

In the present invention, the application method selected from the group consisting of (B1) to (B4) is applied once or twice to the plant before transplanting, or to the soil and/or the roots or underground stems of the plant. This can be done once or twice.
In the application method (B2), the herbicidal composition b, which does not contain the phytotoxicity reducer, is applied once or twice to the plant before transplanting, and the herbicidal composition b, which does not contain the phytotoxicity reducer, is applied to the soil and/or the plant after transplantation. In this method, the crop is preferably applied to rice.

In these application methods, the phytotoxicity reducer a, the herbicidal composition b, or the herbicidal composition c is applied to the plant body and/or seeds, or is applied to the soil and/or to the roots or underground rhizomes of the plant body. Processing is performed. Below, the application methods of the above (B1) to (B4) will be explained in detail.

In (B1) to (B4) above, the method of applying the chemical harm reducer a, the herbicidal composition b, or the herbicidal composition c includes, for example, foliar spraying treatment on individual plants, seedling box treatment, and application to paddy soil. treatment, spraying treatment on the soil surface, soil mixing after spraying on the soil surface, injection treatment into the soil, soil mixing after injection treatment in the soil, soil irrigation treatment, soil mixing after soil irrigation treatment, Examples include spraying on plant seeds, smearing on plant seeds, dipping on plant seeds, powder coating on plant seeds, and spraying on plant seeds. It exhibits sufficient efficacy in various application methods.

In the application methods (B1) to (B4) above, the application amount and concentration of the herbicidal harm reducer a, herbicidal composition b, or herbicidal composition c are determined depending on the target crop, the target disease, the degree of occurrence of the disease, and the concentration of the compound. Although it varies depending on the dosage form, application method, various environmental conditions, etc., when spraying or irrigation, the appropriate amount of active ingredient is 50 to 1,000,000 g per hectare, preferably 100 to 500 g per hectare. ,000g. Further, in the case of seed treatment, the amount used is 0.001 to 50 g, preferably 0.01 to 10 g per 1 kg of seeds. When phytotoxicity reducer a, herbicidal composition b, or herbicidal composition c is sprayed on individual plants, sprayed on the soil surface, injected into the soil, or irrigated, an appropriate carrier is used. The treatment may be carried out after diluting it to an appropriate concentration. When contacting with plant seeds, it may be diluted to an appropriate concentration and then dipped, coated, sprayed, sprinkled, or smeared on the plant seeds. When applying powder, spraying, spraying, or smearing, the appropriate amount of the preparation is usually about 0.05 to 50%, more preferably 0.1 to 30% of the weight of dry plant seeds. The amount used is not limited to these ranges, and may vary depending on the form of the preparation and the type of plant seeds to be treated.

The phytotoxicity reducer a, herbicidal composition b, or herbicidal composition c may be treated alone, or in combination with a fungicide, insecticide, acaricide, nematicide, or plant preparation agent, simultaneously or sequentially. May be processed.

Fungicides to be treated in combination include, for example, phenylamide fungicides, mitotic and cell division inhibitors, succinate dehydrogenase inhibitors (SDHI agents), quinone external inhibitors (QoI agents), quinone internal inhibitors (QiI killers), oxidative phosphorylation uncoupling inhibitors, quinone external stigmatellin binding subsite inhibitors (QoSI agents), amino acid biosynthesis inhibitors, protein biosynthesis inhibitors, signal transduction inhibitors, lipids and cell membranes Biosynthesis inhibitor, demethylation inhibitor (DMI agent), amine fungicide, 3-keto reductase inhibitor in C4 demethylation of sterol biosynthesis, squalene epoxidase inhibitor in sterol biosynthesis, cell wall biosynthesis Synthesis inhibitors, melanin biosynthesis inhibitors, host plant resistance inducers, dithiocarbamate fungicides, phthalimide fungicides, guanidine fungicides, multi-point contact active fungicides, other fungicides, etc. I can do it. Insecticides, acaricides, and nematocides that are treated in combination include, for example, carbamate acetylcholinesterase (AChE) inhibitors, organophosphate acetylcholinesterase (AChE) inhibitors, and GABAergic chloride channel blockers. , sodium channel modulator, nicotinic acetylcholine receptor (nAChR) competitive modulator, nicotinic acetylcholine receptor (nAChR) allosteric modulator, glutamatergic chloride channel (GluCl) allosteric modulator, juvenile hormone analog, nonspecific ( multisite) inhibitor, mite growth inhibitor, mitochondrial ATP synthase inhibitor, oxidative phosphorylation uncoupler that disrupts proton gradient, nicotinic acetylcholine receptor (nAChR) channel blocker, chitin biosynthesis inhibitor type 0 , chitin biosynthesis inhibitor type 1, fly insect molting inhibitor, ecdysone receptor agonist, mitochondrial electron transport chain complex III inhibitor, mitochondrial electron transport system complex I inhibitor (METI), voltage dependent Drugs include: sodium channel blockers, acetyl-CoA carboxylase inhibitors, mitochondrial electron transport chain complex IV inhibitors, mitochondrial electron transport chain complex II inhibitors, ryanodine receptor modulators, chordotonal organ modulators, target sites unspecified, and other agents. One or more types can be used in combination, but the invention is not limited thereto.

As fungicides, examples include benalaxyl, benalaxyl-M or kiralaxyl, furaxyl, metalaxyl, metalaxyl-M or mefenoxyl. oxam), oxadixyl , phenylamide fungicides such as ofurace;
carbendazim, fuberidazole, thiabendazole, thiophanate, diethofencarb, zoxamide, ethaboxam, pencycuron, fluopicolide, phenamacryl Mitotic and cell division inhibitors such as;
benodanil, benzovindiflupyr, bixafen, boscalid, carboxin, fenfuram, fluopyram, flutolanil tolanil), fluxapyroxad (fluxapyroxad) ), furametpyr, isofetamide, isopyrazam, mepronil, oxycarboxin, penthiopyrad, penflufen , pydiflumetofen, sedaxane ), thifluzamide, pyraziflumid, isoflucypram, fluindapyr, inpyrfluxam, pyrapropoyne, etc. succinate dehydrogenase inhibitor (SDHI agent);
Azoxystrobin, coumoxystrobin, dimoxystrobin, enoxastrobin, famoxadone, fenamidone, fena Minstrobin (fenaminstrobin), full phenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobin, metominostrobin, orysastrobin astrobin), picoxystrobin, pira Clostrobin, pyrametostrobin, pyraoxystrobin, pyribencarb, triclopyricarb, trifloxys quinones such as trobin, methyltetraprol, etc. External inhibitors (QoI agents):
Oxidative phosphorylation uncoupling inhibitors such as binapacryl, meptyldinocap, dinocap, fluazinam;
Quinone external stigmatellin binding subsite inhibitors (QoSI agents) such as ametoctradin;
Amino acid biosynthesis inhibitors such as cyprodinil, mepanipyrim, and pyrimethanil;
Protein biosynthesis inhibitors such as streptomycin, blasticidin-S, and oxytetracycline;
Fenpiclonil, fludioxonil, quinoxyfen, proquinazid, chlorozolinate, dimethachlone, Signal transduction inhibitors such as iprodione, procymidone, and vinclozolin ;
edifenphos, iprobenfos, pyrazophos, biphenyl,
Chloroneb, dicloran, quintozene, tecnazene, tolclofos-methyl, echlomezol or etridiazo le), iodocarb, propamocarb, prothiocarb, etc. lipid and cell membrane biosynthesis inhibitor;
azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diniconazole nazole), diniconazole-M, [b-12.8] epoxy epoxiconazole, etaconazole, fenarimol, fenbuconazole, fluquinconazole, quinconazole zole), flusilazole, flutriafol, hexaco hexaconazole, imazalil, imibenconazole, ipconazole, metconazole, myclobutanil, nuarimol, oxpoconazole, oxpoconazole fumar Oxpoconazole fumarate, pefurazoate, penconazole, prochloraz, propiconazole, prothioconazole ioconazole), pyrifenox, pyrisoxazole, simeconazole ( simeconazole, tebuconazole, tetraconazole, triadimefon, triadimenol, triflumizole, triforine (triforine), triticonazole, mefentrifluconazole Demethylation inhibitors (DMI agents) such as (mefentrifluconazole) and ipfentrifluconazole (ipfentrifluconazole);
aldimorph, dodemorph, fenpropimorph, tridemorph, fenpropidin, piperalin, spiroxamine, etc. Amine fungicides;
3-keto reductase inhibitors in C4 demethylation of sterol biosynthesis, such as fenhexamide and fenpyrazamine;
squalene epoxidase inhibitors of sterol biosynthesis such as pyributicarb, [b-15.2] naftifine, [b-15.3] terbinafine;
polyoxins, dimethomorph, flumorph, pyrimorph, benthiavalicarb, benthivalicarb-isopropy l), iprovalicarb, mandipropamide, Cell wall biosynthesis inhibitors such as valifenalate;
Phthalide or fthalide, pyroquilone, tricyclazole, carpropamide, diclocymet, fenoxanil, tol Melanin biosynthesis inhibitors such as tolprocarb;
Acibenzolar-S-methyl, probenazole, tiadinil, isotianil, laminarin, dichlobentiazox, etc. host plant resistance inducer;
Mancozeb, mancozeb or manzeb, maneb, metiram, propineb, thiram, zineb, ziram, ferbam, etc. dithiocarbamate fungicides ;
Captan, captafol, folpet, fluorofolpet, etc.;
Phthalimide fungicide:
Guanidine fungicides such as guazatine, iminoctadine, iminoctadine albesilate, iminoctadine triacetate;
Basic copper oxychloride, copper(II) hydroxide, basic copper hydroxide sulfate, organocopper compound, dodecylbenzenesulfonic acid Bisethylenediamine copper complex salt [II ] (Dodecylbenzenesulfonic acid bisethylenediamine copper [II] salt, DBEDC), sulfur, fluoroimide, dichlofluanide (dichloflu anid), tolylfluanid, anilazine, dithianon, chinomethionate ( multi-site contact active fungicides such as chinomethionat or quinomethionate), extract from the cotyledons of balsam bean seedlings (BLAD);
dichlorobentiazox, fenpicoxamide, dipimetitrone, bupirimate, dimethirimol, ethirimol, triacetate Phenyltin (fentin acetate), triphenyltin chloride ( fentin chloride, fentin hydroxide, oxolinic acid, hymexazol, octilinone, fosetyl, phos phorous acid), sodium salt of phosphorous acid (sodium phosphite), ammonium phosphite, potassium salt of phosphorous acid (potassium phosphite), tecloftalam, triazoxide, flusulfamide (flu sulfamide), diclomezine, silthiofam ), diflumetrim, methasulfocarb, cyflufenamide, metrafenone, pyriofenone, dodine, [fluti anil), ferimzone, oxathiapiproline ( oxathiapiprolin), tebufloquin, validamycins, cymoxanil, quinofumelin, fenpicoxamide, aminopyrifene (am inopyrifen), pyridachlomethyl, ipflufenoquine Other fungicides include ipflufenoquin, fluopimomide, florylpicoxamide, and the like.

Insecticides include phosphocarb, alanycarb, butocarboxim, butoxycarboxim, thiodicarb, thiofanox, aldicarb. (aldicarb), bendiocarb , benfuracarb, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobucarb, formetanate , furathiocarb, isoprocarb, methiocarb ( methiocarb), methomyl, oxamyl, pirimicarb, propoxur, trimethacarb, XMC (3,5-xylyl methylcarbamate), allyxycarb, aldoxycarb, bufencarb, butacarb, carbanolate, metolcarb, xylylcarb, phenothiocarb, xylylcarb, bendiocarb Carbamate acetylcholinesterase (bendiocarb, etc.) AChE) inhibitor;
acephate, azamethiphos, azinphos-methyl, azinphos-ethyl, ethephon, cadusafos, chlorethoxy chlorethoxyfos, chlorfenvinphos ( chlorfenvinphos, chlormephos, chlorpyrifos, chlorpyrifos-methyl, coumaphos, cyanophos, demeton-S-methyl ( demeton-S-methyl), diazinon, Dichlorofenthion, dichlorvos, dicrotophos, dimethoate, dimethylvinphos, disulfoton, O-ethyl O- 4-Nitrophenyl phenylphosphonotioate (O-ethyl O -4-nitrophenyl phenylphosphonothioate, ethion, ethoprophos, famphur, fenamiphos, fenitrothion, fen fenthion, fosthiazate, heptenophos, isofenphos-methyl (isofenphos-methyl), isocarbophos, isoxathion, malathion, mecarbam, methamidophos, methidathion ion), mevinphos, monocrotophos, naled ), omethoate, oxydemeton-methyl, parathions, parathion-methyl, phenthoate, phorate, phos alone), phosmet, Phosphamidon, phoxim, pirimiphos-methyl, profenofos, propetamphos, prothiofos, pyraclof os), pyridaphenthion, quinalphos, sulfotep (sulfotep), tebupirimfos, temephos, terbufos, thiometon, triazophos, trichlorfon, vamidothion (vamido) thion), chlorthion, bromfenvinfos ), bromophos, bromophos-ethyl, butathiofos, carbophenothion, chlorphoxim, sulprofos, diamidaphos (diamidafos), tetrachlorvinphos (tetrachlorvinphos) , propaphos, mesulfenfos, dioxabenzofos, etrimfos, oxydeprofos, formothion, fensulfothion thion), isazofos, imicyafos , organophosphorus acetylcholinesterase (AChE) inhibitors such as isamidofos, thionazin, fosthietan;
GABAergic chloride channel blockers such as chlordane, endosulfan, lindane, dienochlor, ethiprole, fipronil, [acetoprole] ;
acrinathrin, allethrin [(1R)-isomer], bifenthrin, bioallethrin, bioallethrin S-cyclopentenyl isomer S-cyclopentenyl isomer), bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-cyha lothrin), lambda-cyhalothrin, cyhalothrin Permethrin, alpha-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeta-cypermethrin permethrin), cyphenothrin [(1R )-trans-isomer] (cyphenothrin [(1R)-trans-isomer]), deltamethrin (deltamethrin), empenthrin [(EZ)-(1R)-isomer] (empenthrin [(EZ)-(1R)-isomer]) , esfenvalerate, ethofenprox, fenpropathrin, fenvalerate, flucythrinate, flumethrin, tau-fluvalinate tau-fluvalinate, halfenprox, imiprothrin, methothrin, metofluthrin, epsilon-methofluthrin, momfluoro thrin), epsilon-momfluorothrin, permethrin (permethrin), phenothrin [(1R)-trans-isomer], pralletthrin, resmethrin, cadethrin, silafluofen (silaf) luofen), tefluthrin ), tetramethrin, tetramethrin [(1R)-isomer], tralomethrin, transfluthrin, ZXI8901 (3-(4-b) romophenoxy) phenyl]- cyanomethyl 4-(difluoromethoxy)-α-(1-methylethyl)benzeneacetate), biopermethrin, furamethrin, profluthrin n), flubrocythrinate, dimefluthrin, DDT (dichloro- Sodium channel modulators such as diphenyl-trichloroethane, methoxychlor, phenothrin, fluvalinate;
acetamiprid, clothianidin, dinotefuran, imidacloprid, nitenpyram, thiacloprid, thiamethoxam amethoxam), nicotine, nicotine sulfate, sulfoxaflor ), flupyradifurone, triflumezopyrim, nicotinic acetylcholine receptor (nAChR) competitive modulators;
Nicotinic acetylcholine receptor (nAChR) allosteric modulators such as spinosad, spinetoram;
Glutamatergic chloride channel (GluCl) allosteric modulators such as abamectin, emamectin benzoate, lepimectin, milbemectin;
Juvenile hormone analogs such as hydroprene, kinoprene, methoprene, fenoxycarb, pyriproxyfen;
Methyl bromide, chloropicrin, cryolite, sulfuryl fluoride, borax, boric acid, disodium octaborate um octaborate), non-specific (multisite) inhibitors such as sodium metaborate tartar emetic, dazomet, metam, metham sodium;
Chord tone organ TRPV channel modulators such as pymetrozine and pyrifluquinazone;
Mite growth inhibitors such as clofentezine, diflobidazin, hexythiazox, etoxazole;
Mitochondrial A such as diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon, etc. TP synthase inhibitor;
Oxidative phosphorylation uncouplers that disrupt the proton gradient, such as chlorfenapyl, DNOC (dinitro-ortho-cresol), binapacryl, sulfuramide;
Nicotinic acetylcholine receptor (nAChR) channel blockers such as bensultap, cartap hydrochloride, thiocyclam, monosultap;
bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexaflumuron umuron), lufenuron, novaluron ), chitin biosynthesis inhibitor type 0 such as noviflumuron, teflubenzuron, triflumuron;
Chitin biosynthesis inhibitor type 1 such as buprofezin;
Inhibitors of molting of fly insects such as cyromazine;
ecdysone receptor agonists such as chromafenozide, halofenozide, methoxyfenozide, tebufenozide;
Octopamine receptor agonists such as amitraz;
Mitochondrial electron transport system complex III inhibitors such as hydramethylnon, acequinocyl, fluacrypyrim, bifenazate;
fenazaquin, fenpyroximate, pyridaben, pyrimidifen, tebufenpyrad, tolfenpyrad, rotenone Mitochondrial electron transport chain complex I inhibitors (METI) such as
Voltage-dependent sodium channel blockers such as indoxacarb and metaflumizone;
Acetyl-CoA carboxylase inhibitors such as spirodiclofen, spiromesifen, spirotetramat;
Aluminum phosphide, calcium phosphide, phosphine, zinc phosphide, calcium cyanide, potassium cyanide anide), potassium cyanide (sodium mitochondrial electron transport chain complex IV inhibitors such as cyanide);
Mitochondrial electron transport system complex II inhibitors such as cyenopyrafen, cyflumetofen, and pyflubumide;
ryanodine receptor modulators such as chlorantraniliprole, [ccyantraniliprole, flubendiamide;
Choronic organ modulators such as flonicamid Target site unspecified;
Azadirachtin, benzoximate, phenisobromolate, chinomethionat, dicofol, pyridalyl, bromopropylene Bromopropylate, triazamate, dicyclanil ), dinobuton, dinocap, hydrogen cyanide, methyl iodide, karanjin, mercury chloride, methyl isothiocyanate thyl isothiocyanate), pentachlorophenol (pentachlorophenol), phosphine, piperonyl butoxide, polynactins, sabadilla, sulcofuron salt (sulcofuron-sodium) dium), tribufos, aldrin , amidithion, amidothioate, aminocarb, amiton, aramite, ] athidathion, azothoate, polysulfide barium polysulfide, benclothiaz , 5-(1,3-benzodioxol-5-yl)-3-hexylcyclohex-2-enone (5-(1,3-benzodioxole-5-yl)-3-hexylcyclohexa-2-enone) , 1,1-bis(4-chlorophenyl)-2-ethoxyethanol, butonate, butopyronoxyl, 2-(2-butoxyethoxy) ) Ethyl thiocyanate (2-(2-butoxyethoxy)ethyl thiocyanate), camphechlor, chlorbenside, chlordecone, chlordimeform , chlorfenethol, chlorfenson, fluazuron (fluazuron), metaldehyde (metaldehyde), bialaphos (bialaphos), levamisole hydrochloride (levamisol), amidoflumet (amidoflumet), pyrafluprole (pyrafluprole), pyriprole (pyriprole), tralo Pyryl (tralopyril), flupyrazofos (flupyrazofos), geophenolan ( diofenolan), chlorobenzilate, flufenzine, benzomate, flufenerim, albendazole, oxibend azole), fenbendazole, metam sodium -sodium), 1,3-dichloropropene, flometoquin, cyclaniliprole, tetraniliprole, broflanilide de), dichloromezothiaz , ethylene dibromide, acrylonitrile, bis(2-chloroethyl)ether, 1-bromo-2-chloroethane, 3 - Bromo-1-chloroprop-1-ene (3-bromo-1-chloroprop-1-ene), bromocyclen, carbon disulfide, tetrachloromethane, nemadectin in), Simiazole ( cymazole) calcium polysulfide, cytokinin, 2-(octylthio)ethanol, potassium oleate, sodium oleate, machine oil l),] tar oil ), anabasine, morantel tartrate, pyrethrum, rape seed oil, soybean lecithin, starch , hydroxypropyl starch, fatty acid glycerides (decanoyloctanoylglycerol), propylene glycol monofatty acid ester, diatomite. afoxolaner, fluazindolizine, afidopyropen, cyhalodiamide, tioxazafene, fluhe xafon), fluralaner, fluxametamide, tetrachlorantranilip tetrachlorantraniliprole, sarolaner, lotilaner, cycloxaprid, fluensulfone, TPIC (tripropyl isocyan) urate), DD (1,3-Dichloropropene), peroxocarbonate, MB-599 (verbutin), bis(2,3,3,3-tetrachloropropyl) ether, DCIP(bis(2-chloro-1-methylethyl) ether), ENT-8184 (N-(2-Ethylhexyl)bicyclohept-5-ene-2,3-dicarboximide), Bayer 22408 (O,O-diethyl O-naphthalimido phosphorothi oate), Bayer 32394 (tris(1-dodecyl- 3-methyl-2-phenylbenzimidazolium hexacyanoferrate), benzpyrimoxan, acynonapyr, flupyrimin, ticlopyrazoflor (tyclopyrazoflor), oxazosulfyl, spiropidion, etc. Other agents include.

Below, formulation examples, test examples, and application examples of a herbicidal harm reducing agent containing the fungicidal compound of the present invention as an active ingredient, and a herbicidal composition with reduced herbicidal damage containing the herbicidal harm reducing agent and a herbicidal compound are shown. The present invention will be specifically explained, but the present invention is not limited thereto.

In addition, all the blended parts of each component described in the following formulation examples mean parts by weight.

<Reference Example 1 (Synthesis of picarbutrazox)>
According to the method described in Production Example 24 of Patent Document 6,
3.46 g of (1-methyl-1H-5-tetrazolyl)-phenyl-methanone oxime and t-butyl benzoyl-(6-(bromomethyl)pyridin-2-yl)carbamate [CAS No. 1334119-10-6] Synthesis intermediate t-butyl benzoyl-{6-((Z)-(1-methyl-1H-5-tetrazolyl)phenylmethylene-aminooxymethyl)-2-pyridyl from 13.69g }After obtaining 2.47 g of carbamate, it was reacted with a 20% NaOH aqueous solution in methanol solvent to obtain 1.68 g of picarbutrazox.
^1H -NMR ( _CDCl3 ) δ: 7.86 (1H, d, J = 8.3 Hz), 7.65 (1H, t, J = 8.0 Hz), 7.51 (2H, t, J = 4.3 Hz), 7.44 (1H, dd, J = 8.4, 6.3 Hz), 7.38 (2H, t, J = 7.5 Hz), 7.22 (1H, s), 6.93 (1H, d, J = 7.3 Hz), 5.25 (2H, s), 3.98 (3H, s), 1.52 (9H, s).

<Formulation example 1 (picalbutrazox wettable powder)>
Picalbutrazox: 10 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radiolite (registered trademark) : 0.8 part, H fine powder: remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation example 2 (hydroxyisoxazole/pyrimisulfan hydrating agent)>
Hydroxyisoxazole: 30 parts, Pyrimisulfan: 2 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part , radiolite: 0.8 parts, and H fine powder: the remainder, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation example 3 (amisulbrome/imazosulfuron wettable powder)>
Amisulbrome: 20 parts, Imazosulfuron: 1 part, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radiolite (registered trademark) Trademark): 0.8 part, H fine powder: the remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation example 4 (cyazofamid/imazosulfuron wettable powder)>
Cyazofamid: 10 parts, Imazosulfuron: 0.5 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, Radiolite (registered trademark): 0.8 parts, H fine powder: the remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation Example 5 (kasugamycin/pyrazolate wettable powder)>
Kasugamycin: 1 part, Pyrazolate: 50 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radiolite (registered trademark) Trademark): 0.8 part, H fine powder: the remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation example 6 (chlorothalonil sulcotrione hydrating agent)>
Chlorothalonil: 30 parts, Sulcotrione: 10 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radiolite ( (registered trademark): 0.8 part, H fine powder: the remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation example 7 (benomyl/tenyl chloride hydrating agent)>
Benomyl: 20 parts, Tenylchlor: 5 parts: 50 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radio Light (registered trademark): 0.8 part, H fine powder: remainder, a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation example 8 (thiophanate methyl pyrimisulfan hydrating agent)>
Thiophanate methyl: 40 parts, Pyrimisulfan: 3 parts, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part, Radiolite (registered trademark): 0.8 parts, H fine powder: the remainder, and a total of 100 parts were ground and mixed to obtain a wettable powder.

<Formulation example 9 (picarbutrazox/pyrimisulfan hydrating agent)>
Picarbutrazox: 10 parts, Pyrimisulfan: 1 part, Neogen Powder (registered trademark): 0.5 part, Carplex (registered trademark): 0.5 part, Gohsenol (registered trademark): 0.2 part , Radiolite (registered trademark): 0.8 parts, H fine powder: the remainder, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation example 10 (picarbutrazox pyrimisulfan granules)>
Picarbutrazox: 3 parts, pyrimisulfan: 0.3 parts, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 64.5 parts, talc 27.7 parts, and the above. After uniformly pulverizing and mixing, water was added and kneaded, followed by granulation and drying to obtain granules.

<Formulation Example 11 (Hydroxyisoxazole/pyrimisulfan granules)>
Hydroxyisoxazole: 5 parts, pyrimisulfan: 0.2 parts, polyoxyethylene polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 62.6 parts, talc 27.7 parts, the above After uniformly pulverizing and mixing, water was added and kneaded, followed by granulation and drying to obtain granules.

<Formulation example 12 (amisulbrome/imazosulfuron granules)>
Amisulbrome: 5 parts, imazosulfuron: 0.4 parts, polyoxyethylene polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 56.4 parts, talc 33.7 parts, after uniformly pulverizing and mixing the above. , water was added, kneaded, and granulated and dried to obtain granules.

<Formulation Example 13 (cyazofamid/imazosulfuron granules)>
Cyazofamid: 2.5 parts, Imazosulfuron: 0.2 parts, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 59.1 parts, talc 33.7 parts, and the above were pulverized uniformly. After mixing, water was added and kneaded, followed by granulation and drying to obtain granules.

<Formulation example 14 (kasugamycin/pyrazolate granules)>
Kasugamycin: 0.1 part, pyrazolate: 20 parts, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 53.7 parts, talc 21.7 parts. After uniformly pulverizing and mixing the above. , water was added, kneaded, and granulated and dried to obtain granules.

<Formulation example 15 (chlorothalonil sulcotrione granules)>
Chlorothalonil: 4 parts, sulcotrione: 1 part, polyoxyethylene polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 65.8 parts, talc 33.7 parts. After uniformly pulverizing and mixing the above, Water was added and kneaded, followed by granulation and drying to obtain granules.

<Formulation example 16 (benomyl/tenylchlor granules)>
Benomyl: 5 parts, tenylchlor: 1 part, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 68.8 parts, talc 29.7 parts. After uniformly pulverizing and mixing the above, water was added. was added, kneaded, and granulated and dried to obtain granules.

<Formulation example 17 (thiophanate methyl pyrimisulfan granules)>
Thiophanate methyl: 5 parts, pyrimisulfan: 0.4 parts, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 62.4 parts, talc 27.7 parts, and the above were uniformly ground and mixed. Thereafter, water was added and kneaded, followed by granulation and drying to obtain granules.

<Formulation example 18 (isoprothiolane/pyrimisulfan granules)>
Isoprothiolane: 12 parts, pyrimisulfan: 0.4 parts, polyoxyethylene/polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 55.4 parts, talc 27.7 parts, and the above were uniformly ground and mixed. Thereafter, water was added and kneaded, followed by granulation and drying to obtain granules.

Test drug (B1) Hydroxyisoxazole solution (trade name/Tatigaren (registered trademark) solution, active ingredient hydroxyisoxazole, 30% by weight, manufactured by Mitsui Chemicals Agro Co., Ltd.)
(B2) Picalbutrazox hydrating powder obtained in Formulation Example 1 (B3) Amisulbrome granule hydrating powder (trade name/Oracle (registered trademark) granule hydrating powder, active ingredient amisulbrome, 50% by weight, Nissan Chemical Industries, Ltd. Co., Ltd.)
(B4) Cyazofamid wettable powder (trade name/Lanman (registered trademark) Flowable, active ingredient Cyazofamid, 9.4% by weight, manufactured by Ishihara Bioscience Co., Ltd.)
(B5) Kasugamycin solution (trade name/Kasugamycin (registered trademark) solution, active ingredient kasugamycin, 2% by weight, manufactured by Hokuko Chemical Industry Co., Ltd.)
(B6) Chlorothalonil hydrating powder (trade name/Daconil (registered trademark) 1000 hydrating powder, active ingredient chlorothalonil, 40% by weight, manufactured by SDS Biotech Co., Ltd.)
(B7) Benomyl hydrating agent (trade name/Benlate (registered trademark) hydrating agent, active ingredient benomyl, 50% by weight, manufactured by Sumitomo Chemical Co., Ltd.)
(B8) Thiophanate methyl hydrating agent (trade name/Topgin (registered trademark) M hydrating agent, active ingredient thiophanate methyl, 70% by weight, manufactured by Nippon Soda Co., Ltd.)
(B9) Isoprothiolane granules (trade name/Fujiwan (registered trademark) granules, active ingredient isoprothiolane, 12% by weight, manufactured by Nihon Nohyaku Co., Ltd.)
(B10) Hydroxyisoxazole powder (trade name/Tatigaren (registered trademark) powder, active ingredient hydroxyisoxazole, 4% by weight, manufactured by Mitsui Chemicals Agro Co., Ltd.)

<Test Example 1>
The chemical solutions (B1) to (B8) were diluted to a concentration of 600 ppm, 100 ppm, 250 ppm, 94 ppm, 5000 ppm, 800 ppm, 1000 ppm, and 1000 ppm, respectively (respectively, 500 times, 1000 times, 2000 times, 1000 times, 4 500 times, 500 times, and 700 times), irrigating the soil (B1, B2, B3, B4, B6, B7, B8; 500 ml/equivalent amount of seedling box, B5; 50 ml/equivalent amount of seedling box), or (B9 ) was treated with 50 g/seedling box and (B10) was treated with 6 g/seedling box, and then the test crop (rice variety: Koshihikari) was sown. Seedlings (approximately 2.1 leaf stage) grown in a greenhouse at 26°C for 17 days were again sprinkled with the chemical solutions (B1) to (B8) diluted to the specified concentrations, or 50 g/g of (B9) was added to the soil. After being treated in a seedling box, the seedlings were treated with chemicals and transplanted.

Chemically treated and transplanted seedlings and non-chemically treated transplanted seedlings were transplanted into a container (30 x 30 cm) containing paddy soil that had been plowed, at a transplant depth of 1.5 cm, and 10 plants each, with two plants counted as one plant, were transplanted. . Four days after transplanting, the water was maintained at a depth of 2 cm, and an amount equivalent to 20 kg/ha of pyrimisulfan 0.67% granules (trade name/Best Partner (registered trademark) granules, manufactured by Kumiai Chemical Industry Co., Ltd.) was treated. did. As a control, we set up a completely weeded area where only weeds were removed to eliminate the influence of weeds on rice.
Twenty-one days after the chemical treatment, the plants were sampled and investigated.
The dry weight was measured by cutting the above-ground part and root part and drying them at 100°C for 1 hour and at 80°C for 2 days.
Compared to the completely weeded area, phytotoxicity was confirmed in the area treated with 0.67% pyrimisulfan granules in terms of aboveground dry weight and root dry weight. Regarding the plots where phytotoxicity was confirmed, the above-mentioned fungicide-treated plots had increased above-ground dry weight and root dry weight compared to the above-mentioned fungicide-untreated plots, confirming that the fungicide-treated plots had an effect of reducing phytotoxicity.

<Test Example 2>
Hydroxyisoxazole solution (B1), picarbutrazox wettable powder (B2), and amisulbrome granule wettable powder (B3) were diluted to concentrations of 600 ppm, 100 ppm, and 250 ppm, respectively (500 times, 1000 times, and 2000 times). After irrigating the soil (equivalent to 500 ml/seedling box), a test crop (rice variety: Koshihikari) was sown. Seedlings (approximately 2.1 leaf stage) grown in a greenhouse at 26°C for 17 days were once again irrigated with the chemical solutions (B1) to (B3) diluted to a predetermined concentration into the soil, and the seedlings were treated with chemicals and transplanted. And so.

Chemically treated and transplanted seedlings and non-chemically treated transplanted seedlings were transplanted into a container (30 x 30 cm) containing paddy soil that had been plowed, at a transplant depth of 1.5 cm, and 10 plants each, with two plants counted as one plant, were transplanted. . Four days after transplantation, while maintaining the water depth at 2 cm, add 0.8% oxadiclomefon and 3% tefuryltrione granules (trade name/A-One (registered trademark) granules, manufactured by Hokuko Chemical Industry Co., Ltd.) equivalent to 20 kg/ha. processed amount. In addition, in another container, an amount equivalent to 20 kg/ha of pyrimisulfan 0.67% granules was treated. As a control, we set up a completely weeded area where only weeds were removed to eliminate the influence of weeds on rice.
Twenty-six days after the chemical treatment, sampling of the plants was conducted.
The dry weight was measured by cutting the above-ground part and root part and drying them at 100°C for 1 hour and at 80°C for 2 days.

Compared to the completely weeded area, chemical damage was confirmed in the aboveground dry weight and root dry weight in the area treated with oxadiclomefon 0.8%, tefuryltrione 3% granule, and pyrimisulfan 0.67% granule. Regarding the plots where phytotoxicity was confirmed, in the plot treated with hydroxyisoxazole liquid, the dry weight of aboveground parts and the dry weight of roots increased compared to the plot not treated with hydroxyisoxazole liquid, indicating that it has the effect of reducing phytotoxicity. confirmed.

Compared to the completely weeded area, chemical damage was confirmed in the aboveground dry weight and root dry weight in the area treated with oxadiclomefon 0.8%, tefuryltrione 3% granule, and pyrimisulfan 0.67% granule. Regarding plots where phytotoxicity was confirmed, in the plots treated with picarbutrazox wettable powders, the dry weight of aboveground parts and root dry weight increased compared to the plots not treated with picarbutrazox wettable powders, indicating the effect of reducing drug damage. It was confirmed that the

Compared to the completely weeded area, chemical damage was confirmed in the aboveground dry weight and root dry weight in the area treated with oxadiclomefon 0.8%, tefuryltrione 3% granule, and pyrimisulfan 0.67% granule. Regarding plots where phytotoxicity was confirmed, in the plot treated with amisulbrome granule wettable powder, the dry weight of aboveground parts and root dry weight increased compared to the plot not treated with amisulbrome granule wettable powder, indicating that it has the effect of reducing drug damage. confirmed.

<Test Example 3>
Hydroxyisoxazole solution (B1) was diluted (500 times) to a concentration of 600 ppm, and then young seedlings (rice variety: Sagabiyori) grown for 21 days were irrigated (500 ml/equivalent to a seedling box). .

Chemically treated and transplanted seedlings and non-chemically treated transplanted seedlings were transplanted into a paddy field (inside the Agricultural Chemical Research Institute of Mitsui Chemicals Agro Co., Ltd., Yasu City, Shiga Prefecture) that had been plowed. Five days after transplantation, the plants were treated with 0.8% oxadiclomefon and 3% tefuryltrione granules at an amount equivalent to 20 kg/ha while keeping the water at a depth of 5 cm. In addition, in another container, an amount equivalent to 20 kg/ha of pyrimisulfan 0.67% granules was treated. As a control, we set up a completely weeded area where only weeds were removed to eliminate the influence of weeds on rice.
Thirty days after the herbicide treatment, plant height, number of stems, and sampling of plants were investigated.
The dry weight was measured by cutting the above-ground part and root part and drying them at 100°C for 1 hour and at 80°C for 2 days.

Compared to the completely weeded plot, plant height, number of stems, dry weight of aboveground parts, and roots were significantly reduced in the plots treated with oxadiclomefon 0.8%, tefuryltrione 3% granules, and pyrimisulfan 0.67% granules. Phytotoxicity was confirmed in terms of dry weight. Regarding plots where phytotoxicity was confirmed, in the hydroxyisoxazole solution treated plot, the number of stems, above ground dry weight, and root dry weight increased compared to the plot not treated with hydroxyisoxazole solution, indicating that the phytotoxicity reducing effect was increased. It was confirmed that it has.

According to the present invention, compared to existing phytotoxicity reducing agents, there is provided a phytotoxicity reducing agent that is universally usable and good for various cultivated crops, and a phytotoxicity reducing agent containing the phytotoxicity reducing agent and a herbicidal compound. A herbicidal composition can be obtained.

Claims (19)

A phytotoxic agent for crops containing as an active ingredient at least one compound or a salt thereof selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane, and amisulbrome. . The drug harm reducer according to claim 1, wherein the active ingredient is hydroxyisoxazole, picarbutrazox, amisulbrome, or a salt thereof. The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Japanese cabbage, Japanese cabbage, turnip, Chinese cabbage, Chinese cabbage, and broccoli. , cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, The drug damage reducer according to claim 1 or 2, which is a fig, citrus, lumber (seedling), Western grass (bentgrass, ryegrass, bluegrass), or Japanese grass. The drug damage reducer according to any one of claims 1 to 3, wherein the crop is rice. A herbicidal composition containing at least one type of herbicidal compound or a salt thereof and the phytotoxicity reducing agent for crops according to any one of claims 1 to 4. The herbicidal compound is at least one herbicidal compound or a salt thereof selected from the group consisting of the following (A1) to (A6),
(A1) ACCase inhibitory herbicidal compound,
(A2) acetolactate synthase inhibiting herbicidal compound,
(A3) bleaching herbicidal compound,
(A4) VLCFA inhibitory herbicidal compound,
(A5) protoporphyrinogen IX oxidase inhibitory herbicidal compound,
(A6) synthetic auxin herbicidal compound,
The herbicidal composition according to claim 5, wherein the active ingredient contained in the drug harm reducer is at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, and amisulbrome, or a salt thereof. thing. The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Mizuna, Mizuna, turnip, Chinese cabbage, Chinese cabbage, Broccoli, cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum , fig, citrus, lumber (sapling), Western grass (bentgrass, ryegrass, bluegrass), or Japanese grass, the herbicidal composition according to claim 5 or 6. The herbicidal composition according to any one of claims 5 to 7, wherein the crop is rice. The herbicidal compound according to any one of claims 5 to 8, wherein the herbicidal compound is at least one herbicidal compound selected from the group consisting of the following (A2) and (A3) or a salt thereof. Composition.
(A2) acetolactate synthase inhibiting herbicidal compound,
(A3) Whitening type herbicidal compound. The herbicidal composition according to claim 9, wherein the herbicidal compound is at least one herbicidal compound or a salt thereof selected from the group consisting of (A2-1) and (A3-1) below.
(A2-1) a sulfonylurea herbicidal compound, a pyrimidinylbenzoic acid herbicidal compound, or a triazolopyrimidine herbicidal compound,
(A3-1) Pyrazole herbicidal compound or triketone herbicidal compound. A method of reducing phytotoxic damage to crops using an application method selected from the group consisting of (B1) to (B4) below.
(B1) A method of mixing and applying the phytotoxicity reducing agent a according to any one of claims 1 to 4 and the herbicidal composition b that does not contain the phytotoxicity reducing agent,
(B2) A method of independently applying the phytotoxicity reducing agent a according to any one of claims 1 to 4 and the herbicidal composition b not containing the phytotoxicity reducing agent to the same crop;
(B3) The phytotoxicity reducer a according to any one of claims 1 to 4 and the herbicidal composition c according to any one of claims 5 to 10 are applied independently to the same crop. how to,
(B4) A method of applying the herbicidal composition c according to any one of claims 5 to 10. Claim 11, wherein the phytotoxicity reducer a, herbicidal composition b, or herbicidal composition c is applied to plants and/or seeds, or applied to soil and/or applied to roots or rhizomes of plants. Methods for reducing drug damage described in . 13. The method for reducing phytotoxicity according to claim 12, wherein the treatment of the seeds includes spraying, smearing, dipping, dusting, or spraying the seeds. 13. The method for reducing phytotoxicity according to claim 12, wherein the application to soil is treatment to paddy soil, treatment to soil surface, irrigation to soil, or mixing to soil. The crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, green bean, pea, fava bean, adzuki bean, strawberry, cabbage, radish, Japanese radish, Japanese cabbage, Japanese cabbage, turnip, Chinese cabbage, Chinese cabbage, Chinese radish , cauliflower, lettuce, non-heading lettuce, tomato, cherry tomato, eggplant, green pepper, chili pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, The method for reducing chemical damage according to claim 11, which is a fig, citrus, lumber (sapling), Western grass (bentgrass, ryegrass, bluegrass), or Japanese grass. The method for reducing phytotoxicity according to claim 11 or 15, wherein the crop is rice. The application method selected from the group consisting of (B1) to (B4) is applied once or twice to the plant before transplanting, or once or twice to the soil and/or the roots or rhizomes of the plant. The method for reducing drug damage according to claim 11. In the application method (B2), the herbicidal composition b, which does not contain the phytotoxicity reducer, is applied once or twice to the plant before transplanting, and the herbicidal composition b, which does not contain the phytotoxicity reducer, is applied to the soil and/or the plant after transplantation. 18. The method for reducing phytotoxicity according to claim 11 or 17, wherein the crop is applied to rice. The herbicidal composition b is at least one selected from the group consisting of (A2-1) and (A3-1), wherein the drug harm reducer a is hydroxyisoxazole, picarbutrazox, or amisulbrome or a salt thereof. 19. The method for reducing drug damage according to claim 11, claim 17, or claim 18, which is a herbicidal compound or a salt thereof.