JP2020015762A - Phytotoxicity reducing agent containing bactericidal compound as active ingredient, and herbicidal composition with reduced phytotoxicity containing the phytotoxicity reducing agent and a herbicidal compound - Google Patents

Abstract

To provide a phytotoxicity reducing agent that is expected to have a disease control effect derived from bactericidal activity, and can be generally used to various cultivation crops and can exhibit a good phytotoxicity reducing effect.SOLUTION: A phytotoxicity reducing agent has, as an active ingredient, at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate-methyl, isoprothiolane and amisulbrom or a salt thereof.SELECTED DRAWING: None

Description

  The present invention relates to a safener. More specifically, the present invention relates to a safener comprising a fungicidal compound as an active ingredient, and a herbicidal composition having a reduced safener comprising the safener and a herbicidal compound.

  The use of a herbicide is indispensable in crop cultivation in order to secure an appropriate yield of the crop and realize efficient cultivation of the crop. At present, the herbicides used are given selectivity for the crop, and do not cause damage to the crop except for the plant to be controlled.

  However, the crop selectivity of the herbicide is not always sufficient, and depending on the use conditions of the herbicide, growth inhibition, growth suppression, growth suppression, brown spot appearance, tiller suppression of the crop by the herbicide may be caused by the herbicide. Known or unknown undesirable phytotoxicity may occur, such as yellowing, leaf withering, withering, withering, whitening, torsion, browning, inhibition of root growth, and the like.

  Until now, in order to avoid such phytotoxicity, combined use of herbicides having different effects or combination use of a compound (Safener) having a phytotoxicity-reducing effect with a herbicide has been performed (Patent Documents 1 to 3). 4, Non-patent document 1).

  Compounds selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanatemethyl, isoprothiolane and amisulbrom are known fungicidal compounds, and each compound is listed in Table 1 below. As described in the relevant patent literature.

  In the past, it has been reported that 3-hydroxy-5-isoxazole (hereinafter, referred to as “hydroxyisoxazole”), which is a fungicidal compound, has a herbicide phytotoxicity-reducing effect in rice (Non-Patent Document 2).

  It is also known that isothiazolecarboxamides, which are resistance inducers, have a herbicide phytotoxicity-reducing effect by seed treatment and application to a nursery box (Patent Documents 16 to 18).

  Also, isoprothiolane having fungicidal activity and insecticidal activity is known to have a phytotoxicity-reducing effect on the herbicide tefuryltrione (Patent Document 19).

JP-A-2006-40235 WO2010 / 070822 WO2011 / 145318 WO2011 / 145329 Japanese Patent Publication No. 42-25660 WO2003 / 016303 JP-A-1-131163 JP-B-42-6818 US Patent 3,290,353 US Patent 3,661,176 U.S. Pat. JP-B-47-34126 Japanese Patent No. 4438919 JP 2001-187786 A JP 2005-112538 A JP-T-2001-522840 JP 2004-346030 A JP 2007-137833 A JP 2008-69091 A

Pesticide Outlook, December 2001, pp. 10-15. Studies on the effects of 3-hydroxy-5-isoxazole on growth control of crops III. Effects of flooding on rice seedlings and reduction of herbicide phytotoxicity Masami Ogawa, Yasuo Ota Jikkai Crop Science, 43, 531-537 (1974)

  However, these conventional safeners comprise a compound having herbicidal activity or a compound having no biological activity (herbicidal activity, bactericidal activity, insecticidal activity, etc.) as an active ingredient, and its target is specified. By limiting to cultivated plants, the phytotoxicity of the specific herbicide was reduced only for the specific herbicide. Therefore, the existing safeners could not be used universally for various cultivated crops (Patent Documents 1 to 4, Non-Patent Document 1).

  Specifically, with respect to hydroxyisoxazole, which is a fungicidal compound, herbicides for which the phytotoxicity-reducing effect has been confirmed include simethrin and DCPA (propanil; Dimethyl 2,3,5,6-tetrachlorobenzene-1,4-). It is mainly a photosynthesis-inhibiting herbicide such as dicarboxylate, MCC (sweep) and MCP (ethyl 2-methyl-4-chlorophenoxyacetate). Therefore, no knowledge has been obtained regarding the phytotoxicity-reducing effect of the herbicides developed in recent years.

  In addition, although isoprothiolane is known to reduce the phytotoxicity of herbicides against tefuryltrione, no knowledge has been obtained regarding the phytotoxicity-reducing effects of other herbicides.

  Furthermore, the herbicidal phytotoxic effect of fungicidal compounds having a bactericidal activity such as picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane and amisulbrom has not been elucidated at present.

  The object of the present invention is to have a biological activity other than a herbicidal effect, exhibit a phytotoxicity-reducing effect on various herbicides that exhibit different effects, and have a superior phytotoxicity-reducing effect on cultivated plants than existing phytotoxicity reducing agents, Another object of the present invention is to find a novel safener with a wide range of use that is not limited to cultivated plants.

  The present inventors have conducted various studies in order to solve the above-mentioned problems, and as a result, have found that a given fungicidal compound exhibits a herbicide phytotoxicity-reducing effect. That is, the present inventors have found that a safener comprising a predetermined fungicidal compound as an active ingredient, and a herbicidal composition containing the safener and a herbicidal compound have a good safener effect, and completed the present invention.

That is, the present invention is as follows [1] to [19].
[1] A crop containing at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanatemethyl, isoprothiolane and amisulbrom, or a salt thereof as an active ingredient. A safener.
[2] The safener according to [1], wherein the active ingredient is hydroxyisoxazole, picarbutrazox, or amisulbrom or a salt thereof.
[3] The crop is rice, wheat, barley, corn, rape, cotton, sunflower, sugar cane, potato, grape, soybean, bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, broccoli, cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris The safener according to any one of [1] and [2], wherein the agent is any of [1] and [2], which is a chrysanthemum, a fig, a citrus, a timber (a seedling), a western turf (bent grass, a ryegrass, a bluegrass) or a Japanese turf.
[4] The safener according to any one of [1] to [3], wherein the crop is rice.
[5] A herbicidal composition comprising at least one herbicidal compound or a salt thereof, and the safener for crops according to any one of [1] to [4].
[6] The herbicidal compound is at least one herbicidal compound selected from the group consisting of the following (A1) to (A6), or a salt thereof,
(A1) an ACCase-inhibiting herbicidal compound,
(A2) acetolactate synthase-inhibiting herbicidal compound,
(A3) a whitening type herbicidal compound,
(A4) a VLCFA-inhibiting herbicidal compound,
(A5) a protoporphyrinogen IX oxidase-inhibiting herbicidal compound,
(A6) a synthetic auxin-based herbicidal compound,
The herbicidal composition according to [5], wherein the active ingredient contained in the safener is at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, and amisulbrom, or a salt thereof. object.
[7] The crop is rice, wheat, barley, corn, rape, cotton, sunflower, sugar cane, potato, grape, soybean, bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana , Chinese cabbage, broccoli, cauliflower, lettuce, non-headed lettuce, tomato, cherry tomato, eggplant, pepper, pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, The herbicidal composition according to [5] or [6], which is iris, chrysanthemum, fig, citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass) or Japanese turf.
[8] The herbicidal composition according to any one of [5] to [7], wherein the crop is rice.
[9] The herbicidal compound according to any one of [5] to [8], wherein the herbicidal compound is at least one herbicidal compound or a salt thereof selected from the group consisting of the following (A2) and (A3). Herbicidal composition.
(A2) acetolactate synthase-inhibiting herbicidal compound,
(A3) A whitening type herbicidal compound.
[10] The herbicidal composition according to [9], wherein the herbicidal compound is at least one herbicidal compound or a salt thereof, selected from the group consisting of the following (A2-1) and (A3-1). .
(A2-1) a sulfonylurea-based herbicidal compound, a pyrimidinylbenzoic acid-based herbicidal compound or a triazolopyrimidine-based herbicidal compound,
(A3-1) A pyrazole herbicidal compound or a triketone herbicidal compound.
[11] A method for reducing phytotoxicity to crops by an application method selected from the group consisting of the following (B1) to (B4).
(B1) a method of mixing and applying the safener a according to any one of [1] to [4] and a herbicidal composition b not containing the safener,
(B2) a method of independently applying the safener a according to any one of [1] to [4] and the herbicidal composition b containing no safener to the same crop,
(B3) The safener a according to any one of [1] to [4] and the herbicidal composition c according to any one of [5] to [10] are independently applied to the same crop. how to,
(B4) A method of applying the herbicidal composition c according to any one of [5] to [10].
[12] The safener a, herbicidal composition b, or herbicidal composition c is applied to plants and / or seeds, or applied to soil and / or applied to roots or rhizomes of plants. , [11].
[13] The method according to [12], wherein the treatment of the seed is spraying, smearing, dipping, dressing, or spraying the seed.
[14] The method for reducing phytotoxicity according to [12], wherein the application to the soil is treatment on paddy field soil, treatment on the soil surface, irrigation to the soil, or mixing with the soil.
[15] The crop is rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, blossom, cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, capsicum, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeybee, ginger, rakkyo, tobacco, carnation, iris The method for alleviating phytotoxicity according to [11], which is selected from the group consisting of: chrysanthemum, fig, citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass) and Japanese turf.
[16] The method according to [11] or [15], wherein the crop is rice.
[17] The method of application selected from the group consisting of (B1) to (B4) is performed once or twice on the plant before transplantation, or once on the soil and / or the root or rhizome of the plant. Or the method of reducing phytotoxicity according to [11], which is performed twice.
[18] The method for application of (B2), wherein the safener a is applied once or twice to the plant before transplantation, and the herbicidal composition b containing no safener is transplanted into the soil and / or Or the method of reducing phytotoxicity according to [11] or [17], wherein the crop is rice.
[19] The safener a is hydroxyisoxazole, picarbutrazox or amisulbrom or a salt thereof, and the herbicidal composition b is selected from the group consisting of the above (A2-1) and (A3-1). The method for reducing phytotoxicity according to [11], [17] or [18], which is at least one herbicidal compound or a salt thereof.

  The present invention is based on the finding that fungicidal compounds exhibit a herbicide safening effect. That is, according to the present invention, by treating a safener having bactericidal activity before or after herbicide treatment or at the time of herbicide treatment, a disease control effect derived from bactericidal activity can be expected, and it can be universally applied to various cultivated crops. It can be effectively used and can obtain a good effect of reducing the phytotoxicity.

  Next, various terms used in this specification will be described.

  "Pharmaceutical mitigation agent" means that when agricultural materials are used in cultivated crops to control weeds and pests, growth disorders, suppression of growth, suppression of growth, appearance of brown spots, suppression of tillering on the crops. When known or unknown undesirable phytotoxicity such as yellowing, leaf withering, withering, withering, whitening, torsion, browning, inhibition of root growth, etc. is assumed, use with agricultural materials or use agricultural materials. It is a composition that reduces the phytotoxicity when used alone before and after.

  The salt of "a compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane and amisulbrom" indicates a metal salt, an acid addition salt and the like of the compound. For example, salts of alkali metals such as lithium, sodium and potassium, for example, salts of alkaline earth metals such as calcium, barium and magnesium, for example, salts of aluminum or salts of transition metals such as manganese, copper, zinc and iron, for example, Salts of hydrohalic acids such as hydrofluoric acid, hydrochloric acid, hydrobromic acid and hydroiodic acid, for example, salts of inorganic acids such as nitric acid, sulfuric acid, phosphoric acid, chloric acid and perchloric acid, for example, methane sulfone Acid, ethanesulfonic acid, trifluoromethanesulfonic acid, benzene Sulfonic acid salts such as sulfonic acid and p-toluenesulfonic acid, for example, formic acid, acetic acid, propionic acid, trifluoroacetic acid, fumaric acid, tartaric acid, oxalic acid, maleic acid, malic acid, succinic acid, benzoic acid, mandelic acid, Examples include salts of carboxylic acids such as ascorbic acid, lactic acid, gluconic acid, and citric acid, and salts of amino acids such as glutamic acid and aspartic acid.

  The “ACCase-inhibiting herbicidal compound” refers to, for example, allyloxypropionic acid-based compounds, cyclohexadione oxime-based compounds, and the like. , Cyhalofop butyl, clodinafop propargyl, diclohop methyl, phenoxaprop-P-ethyl, butroxydim, propoxydim, clethodim, tepraloxydim, tralkoxydim, sethoxydim, cycloxydim, pinoxaden and the like.

  The `` acetolactate synthase-inhibiting herbicidal compound '' refers to, for example, sulfonylurea compounds, sulfonylaminocarbonyltriazolinone compounds, pyrimidinylbenzoic acid compounds, triazolopyrimidine compounds, imidazolinone compounds, and the like. For example, amidesulfuron, azimsulfuron, trifloxysulfuron, bensulfuronmethyl, cyclosulfamuron, flupilsulfuronmethyl, forumsulfuron, chlorimuronethyl, etamethosulfuronmethyl, halosulfuronmethyl, nicosulfuron, Chlorsulfuron, ethoxysulfuron, imazosulfuron, oxasulfuron, pyrazosulfuron-ethyl, tritosulfuron, sinosulfuron, furazasulfuron, iodosulfuron-methyl, primisulfur Methyl, rimsulfuron, thifensulfuron-methyl, meso-sulfuron-methyl, metsulfuron-methyl, prosulfuron, triasulfuron, trifluorosulfuron-methyl, sulfosulfuron, tribenuron-methyl, trifloxysulfuron, flusetosulfuron, metazosulfuron, Propyrisulfuron, Flucarbazone, Propoxycarbazone, Bispyribac, Pyribenzoxime, Pyrithiobac, Pyriphthalide, Pyriminobac-methyl, Pyrimisulfan, Triafamon, Clolanthram-methyl, Dicloslam, Floraslam, Flumethoslam, Methoslam, Penoxsulam, Imazapic, Imazapill, Imazapill Metabenzmethyl, imazaquin, imazamox, imazethapyr and the like, preferably azisulfuron, benzul Ronmethyl, halosulfuronmethyl, imazosulfuron, pyrazosulfuron-ethyl, flusetosulfuron, metazosulfuron, propylisulfuron, bispyribac, pyriftalide, pyriminobac-methyl, pyrimisulfan, trifamon, penoxsulam and the like, and more preferably imazosulfuron and pyroxurum Misulfan and the like.

  The "whitening type herbicidal compound" refers to, for example, pyrazole compounds, triketone compounds, etc., for example, pyrazolate, pyrazoxifene, benzofenap, pyrasulfotole, topramesone, tolpyralate, mesotrione, sulcotrione, benzobicyclo , Tefriltrione, tembotrione, bicyclopyrone, lancotrione, cyclopyrimolate, phenquinotrione, and the like, preferably, pyrazolate, pyrazoxifene, benzofenap, mesotrione, sulcotrione, benzobicyclone, tefuryltrione. , Lancotrione, cyclopyrimolate, phenquinotrione and the like, and more preferably sulcotrione, tefuryltrione and the like.

  "VLCFA-inhibiting herbicidal compound" refers to, for example, chloroacetamide compounds and the like, for example, acetochlor, butachlor, alachlor, dimethachlor, dimethenamide, propachlor, tenylchlor, metazachlor, metolachlor, S-metolachlor. , Pretilachlor, petoxamide, mefenacet, cafenstrole, fentrazamide, ipfencarbazone, phenoxasulfone and the like.

  The `` protoporphyrinogen IX oxidase-inhibiting herbicidal compound '' includes, for example, diphenyl ether compounds, triazolinone compounds, and the like, for example, acifluofen, bifenox, fomesafen, lactofen, oxyfluorfen, carfentrazone ethyl, Sulfentrazone, pentoxazone, pyraclonil, oxadiazone, oxadialgyl and the like.

  The “synthetic auxin-based herbicidal compound” refers to, for example, a phenoxycarboxylic acid-based compound and the like, and includes, for example, clomeprop, MCPA, MCPB, 2,4-DB, florpyrauxiphenbenzyl and the like.

As used herein, the term "crop" refers to a plant that is protected and managed by humans for reproduction and growth. Crops are classified by comprehensively judging their cultivation method, commercial value, purpose of use, part used, botanical classification, etc.Generally, crops are roughly divided into agricultural crops and horticultural crops. You.
Agricultural crops are classified into food crops, craft crops, feed crops, and green manure crops according to the purpose of use. Specifically, for example, rice, wheat, barley, potato, corn, grape, apple, pear, peach, nectarine, plum, apricot, sweet cherry, oyster, quince, quince, chestnut, cute fruit, blueberry, loquat, banana, Citrus, fig, olive, papaya, akebi, oil palm, soybean, peanut, kidney bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mizuna, mibuna, cub, komatsuna, Chinese cabbage, broccoli, cauliflower, nabana, lettuce, non-heading Lettuce, tomato, eggplant, pepper, pepper, pepper, leek, onion, scallion, cucumber, bitter melon, melon, watermelon, pumpkin, zucchini, carrot, ginger, ginger, burdock, udo, taro, spinach, sugar beet, ass Lagas, okra, seri, safflower, rapeseed, honeybee, sweet potato, taro, yam, konjac, sugarcane, tobacco, tea, coffee, sunflower, tulip, carnation, basil, iris, aster, rose, kiku, cotton, pop, gentian, Lily, button, peonies, cyclamen, raccoon, pepper, garlic, butterbur, perilla, cinnamon, wasabi, taro, lotus root, sorghum, western grass (bent grass, bermuda grass, blue grass, ryegrass), Japanese grass, orchard grass, Italian ryegrass , Alfalfa, red clover, valerian mulberry, mulberry, celosia, cornflower, calendula, safflower, azalea, cherry, oak, bokeh, poplar, dogwood, ginkgo, tree, timber (sapling) etc. It is.
Above all, rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, kidney bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, flower, broccoli , Lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, fig, Citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass), Japanese turf and the like are preferable, and rice, sugar beet, western turf, Japanese turf, wheat, barley, corn, rape, cotton, sunflower, sugarcane, and d More preferably such dough, but rice is particularly preferred, but the invention is not limited thereto.

The “plant” in the present invention is a general term for all the parts constituting the “crop”, and includes, for example, stems, leaves, roots, seeds, flowers, fruits and the like.
The “seed” as used in the present invention refers to a seed that stores nutrients for germinating young plants and is used for agricultural reproduction. Specifically, for example, seeds such as corn, soybean, cotton, rice, sugar beet, wheat, barley, sunflower, tomato, cucumber, eggplant, spinach, snow peas, pumpkin, sugar cane, tobacco, peppers and oilseed rape, taro, potato, etc. , Seed potatoes such as sweet potatoes and konjac, edible lilies, bulbs such as tulips, seed balls such as raccoons, etc .; plants that are produced by artificially manipulating genes, etc., and do not naturally exist in nature. Genetically modified crops; for example, soybeans, corn, cotton, etc., which have been imparted with herbicide resistance; rice, tobacco, etc. adapted to cold regions; or seeds, such as corn, cotton, etc., which have been imparted with an insecticide-producing ability. But not limited to these. .

  Next, a safener comprising the fungicidal compound of the present invention as an active ingredient, and a herbicidal composition having reduced safener containing the safener and the herbicidal compound will be described.

First, a safener comprising the fungicidal compound of the present invention as an active ingredient will be described.
The safener according to the present invention comprises at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamide, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane and amisulbrom, or a salt thereof as an active ingredient. contains.
The active ingredients are: From the viewpoint of the effects of the present invention, hydroxyisoxazole, picarbutrazox, or amisulbrom or a salt thereof is preferable.

  The safener of the present invention may be used as it is, but it is usually used as a mixture with a carrier, and if necessary, a surfactant, a binder, a disintegrant, a stabilizer, a pH adjuster, and an antibacterial agent. Auxiliary agents such as fungicides (preservatives), thickeners, defoamers, wetting agents, fixing agents, coloring agents, etc. are added, and in accordance with ordinary methods, timely, wettable powders, flowables, wettable granules are added. , OD preparations, powders, solutions, emulsions, granules, packs and the like. The dosage form is not limited to those compositions as long as the effect is exhibited.

  The carrier used in the safener of the present invention is a synthetic or natural compound that is formulated to help the active ingredient reach the site to be treated and to facilitate storage, transportation, and handling of the active ingredient compound. Inorganic or organic substances of any kind can be used as solid or liquid as long as they are usually used for agricultural and horticultural medicines, and are not limited to specific substances.

  Examples of the solid carrier that can be used in the safener of the present invention include inorganic substances such as bentonite, montmorillonite, diatomaceous earth, clay, talc, clay; plant organic substances such as wood flour and sawdust; Can be mentioned.

  Liquid carriers that can be used in the safener of the present invention include, for example, aromatic hydrocarbons such as toluene; naphthenes; paraffinic hydrocarbons such as n-paraffin, liquid paraffin and kerosene; acetone, methyl ethyl ketone Ketones such as dioxane and diethylene glycol dimethyl ether; alcohols such as ethanol and ethylene glycol; carbonates such as ethylene carbonate; aprotic solvents such as dimethylformamide; and water.

  Furthermore, in order to enhance the efficacy of the safener of the present invention, an auxiliary agent can be used alone or in combination, depending on the purpose, depending on the purpose, in consideration of the dosage form of the preparation, the treatment method, and the like. . Examples of the auxiliary agent include a surfactant, a binder, a disintegrant, a stabilizer, a pH adjuster, a fungicide / antifungal agent, a thickener, an antifoaming agent, and an antifreezing agent.

As the surfactant that can be used in the safener of the present invention, a surfactant that is usually used for the purpose of emulsifying, dispersing, spreading, and / or wetting a pesticide formulation can be used. As such, for example, sorbitan fatty acid ester, polyoxyethylene fatty acid ester, polyoxyethylene alkyl ether, polyoxyethylene alkylphenyl ether, polyoxyethylene polyoxypropylene block polymer, alkyl polyoxyethylene polyoxypropylene block polymer Nonionic interfaces such as ethers, polyoxyethylene alkylamines, polyoxyethylene fatty acid amides, polyoxyethylene bisphenyl ethers, polyoxyalkylene adducts of higher alcohols, polyoxyethylene ethers and ester-type silicones, and fluorosurfactants Activator;
Alkyl sulfate, polyoxyethylene alkyl ether sulfate, polyoxyethylene benzyl phenyl ether sulfate, polyoxyethylene styryl phenyl ether sulfate, paraffin sulfonate, alkane sulfonate, AOS, dialkyl sulfosuccinate, alkylbenzene sulfonate, lignin sulfonate, polyoxyethylene alkylphenyl Ether sulfonate, fatty acid salt, N-methyl-fatty acid sarcosinate, polyoxyethylene alkyl ether phosphate, polyoxyethylene phenyl ether phosphate, polyoxyethylene polyoxypropylene block polymer phosphate, phosphatidylcholine, phosphatidylethanolimine, alkyl phosphate, tripoly Anionic surfactants such as sodium;
A polyanionic polymer surfactant derived from acrylic acid, acrylonitrile and acrylamidomethylpropanesulfonic acid;
Cationic surfactants such as alkyltrimethylammonium chloride, alkyldimethylbenzalkonium chloride and benzethonium chloride;
Alternatively, amphoteric surfactants such as dialkyldiaminoethylbentine and alkyldimethylbenzylbentine may be used.

  Examples of the binder include sodium alginate, polyvinyl alcohol, gum arabic, carboxymethylcellulose (hereinafter, referred to as “sodium CMC”), bentonite, and the like.

  Disintegrators include, for example, sodium CMC, croscarmellose sodium and the like.

  Examples of the stabilizer include a hindered phenol-based antioxidant; and a benzotriazole-based and hindered amine-based ultraviolet absorber.

  Examples of the pH adjuster include phosphoric acid, acetic acid, sodium hydroxide and the like.

  Examples of the fungicides and fungicides include industrial fungicides such as 1,2-benzisothiazolin-3-one and fungicides and fungicides.

  Examples of the thickener include xanthan gum, guar gum, sodium CMC, gum arabic, polyvinyl alcohol, montmorillonite and the like.

  Examples of the antifoaming agent include a silicone compound.

  Examples of the antifreeze include propylene glycol, ethylene glycol and the like.

  The auxiliaries described above are examples, and the auxiliaries of the present invention are not limited to those described above.

  The content of the active ingredient in the safener of the present invention is usually in the range of 0.1 to 100% by weight, preferably in the range of 0.1 to 90%, more preferably 1 to 90%. It is in the range of -80%, particularly preferably in the range of 5-50%.

The phytotoxicity-reducing agent of the present invention can exert an effect on various phytotoxicity to cultivated crops, for example, phytotoxicity to crops caused by herbicidal compounds, for example, growth disorders, growth suppression, growth suppression, appearance of brown spots It can reduce phytotoxicity such as suppression of tillering, yellowing, leaf withering, withering, withering, whitening, torsion, browning, and inhibition of root growth.
The phytotoxicity-reducing agent of the present invention is particularly excellent in phytotoxicity-suppressing effects on crops caused by herbicidal compounds.

The safener comprising the fungicidal compound of the present invention as an active ingredient is a safener for crops caused by the herbicidal compound, for example, growth impairment, growth suppression, growth suppression, brown point appearance, tiller suppression, yellowing, It is possible to avoid leaf withering, withering, withering, whitening, torsion, browning, root growth inhibition and the like.
As target crops, for example, rice, wheat, barley, potato, corn, grape, apple, pear, peach, nectarine, plum, apricot, cherry, oyster, quince, quince, chestnut, cui fruit, blueberry, loquat, banana, citrus , Fig, olive, papaya, akebi, oil palm, soybean, peanut, kidney bean, pea, snow pea, broad bean, adzuki, strawberry, cabbage, radish, mizuna, mibuna, turnip, komatsuna, Chinese cabbage, broccoli, cauliflower, nabana, lettuce, tomato , Eggplant, pepper, capsicum, capsicum, green onion, leek, onion, scallion, cucumber, bitter melon, melon, watermelon, pumpkin, zucchini, carrot, ginger, ginger, burdock, udo, taro, spinach, sugar beet, Spargas, okra, seri, safflower, rapeseed, honeybee, sweet potato, taro, yam, konjac, sugarcane, tobacco, tea, coffee, sunflower, tulip, carnation, basil, iris, aster, rose, kiku, cotton, pop, gentian, Lily, button, peonies, cyclamen, raccoon, pepper, garlic, butterbur, perilla, cinnamon, wasabi, taro, lotus root, sorghum, western grass (bent grass, bermuda grass, blue grass, ryegrass), Japanese grass, orchard grass, Italian ryegrass , Alfalfa, red clover, valerian mulberry, mulberry, celosia, cornflower, calendula, safflower, azalea, cherry, oak, bokeh, poplar, dogwood, ginkgo, tree, timber (sapling), etc. And the like.
Above all, rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, kidney bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, flower, broccoli , Lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, fig, Citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass) and Japanese turf are preferred, rice, sugar beet, western turf, Japanese turf, wheat, barley, corn, rape, cotton, sunflower, sugarcane, and en. More preferably such c, rice is particularly preferred

  In the present invention, rice refers to an annual plant of the genus Oryza in the family Poaceae, and is classified into two ecotypes, Japonica species (O. sativa subsp. Japonica) and Indica species (O. sativa subsp. Indica). You. In addition, starch, which is the main component of the edible portion of rice, is classified into amylose and amylopectin due to differences in molecular structure, and varieties containing about 20% amylose are obtained (non-glutinous), and the amylose content is 0% due to genetic defects. Is classified as mochi. Specific rice varieties include, for example, Koshihikari, Nipponbare, Akitakomachi, Kirara 397, Kinuhikari, Hitomebore, Nanatsuboshi, Hoshino Yume, Hanenuki, Domanaka, Sasanishiki and Hinohikari. Glutinous, Taisho glutinous, rice cake, Miyako rice cake, Asahi wax, Fujikura glue, Hiyokumochi, Himenomochi, Mochihikari, Yumenohata, Hakuchomochi, Toyohatamochi, Wataboshi etc. are low amylose varieties, for example, , Milky Queen, Dream Comfort, Ikuhikari, Milky Pearl, Himenomochi, etc. are suitable rice for sake brewing, for example, Yamada Nishiki, 500 Hyakumangoku, Miyama Nishiki, Omachi, Hattan, Hatannishiki, Ginfu, Yumesansa, Wakamizu , Incense of dreams, ferry, etc., for feed, for example, Hoshiyutaka, Hoshiaoba, Kusanohoshi, Kusayutaka, Nisiaoba And Southern Yutaka, and the like. In addition, upland rice, black rice, red rice, green rice and special varieties bred with disease resistance and insect resistance as indicators, herbicide resistance, insecticidal effect, resistance to pests by classical breeding methods or genetic modification technology Varieties that have been given sex are also included.

  In the present invention, the target crops include rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, bean, peas, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip , Nabana, Chinese cabbage, broccoli, cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, pepper, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeybee, ginger, rakkyo, tobacco, Carnation, iris, chrysanthemum, fig, citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass) or Japanese turf is preferred. The harm-reducing agent of the present invention is particularly excellent in the effect of reducing phytotoxicity caused by herbicidal compounds in these crops.

The safeners comprising the fungicidal compound of the present invention as an active ingredient can also be used for controlling plant diseases caused by the original fungicidal activity. Diseases that can be controlled include:
For example, rice blast (Magnaporthe grisea), sheath blight (Thanatephorus cucumeris), brown rot (Ceratobasidium setariae), brown sclerotium (Waitia circinata), brown rot sclerotium, and sarcoplasma Disease (Sclerotium hydrophilum), red rot (Wairea circinata), black rot (Entyloma dactylidis), pneumococcal disease (Magnaportheusalvina stomach, Corynebacterium aeruginosa) Stripe blight (Sphaerulina ory) ina), frog seedling disease (Gibberella fujikuroi), seedling blight (Pythium spp., Fusarium spp., Trichoderma spp., Rhizopus spp., Rhizoponia spore, Rhizoctonia sol. , Dictyuchus spp.), Aspergillus oryzae (Claviceps virens), Black smut (Tilletia barclayana), Brown rice (Curvularia spp., Alternaria spp.), And yellow dwarf (Sclero aprom seroa seroa seroa seroa seroa seroa xerom sprom). oryzae), brown streak (Acidovorax aven) e subsp. oryzae), strain rot (Erwinia chrysanthemi), yellow dwarf (Phytoplasma oryzae), Rice stripe tenuivirus, dwarf disease (Rice dwarf revivirus);

  Powdery mildew of wheat (Blumeria graminis f. Sp. Hordei; f. Sp. Tritici), rust (Puccinia striiformis, Puccinia graminis, Puccinia reconitia, Puccinia reconia, Puccinia reconia, Puccinia reconia, Puccinia reconitia, Puccinia reconitia) Pyrenophora teres), Fusarium zeae, Fusarium culmorum, Fusarium avenaceum, Monographella nivalis, Snow rot (Thipula inicarina, Typhula incarina sushi, Typhula incarina sushi) tilago nuda), black smut (Tilletia caries, Tilletia controversa), eye spot (Pseudocercosporella herpotrichoids), plant rot (Ceratobasidium germ) Phaeosphaeria nodorum, Fusarium spp., Pythium spp., Rhizoctonia spp., Septoria spp., Pyrenophora spp., Pyrenophora spp. . Minicola), ergot disease (Claviceps purpurea), leaf spot (Cochliobolus sativus), black clause disease (Pseudomonas syringae pv syringae);

  Corn rust (Gibberella zeae, etc.), seedling blight (Fusarium avenaceum, Penicillium spp, Pythium spp., Rhizoctonia spp., Rust blight (Puccinia sorghum), rust (Puccinia sorghum) Ustilago maydis, anthrax (Colletotrichum graminicola), northern spot (Cochliobolus carbonum), brown streak (Acidovorax avenae ssp. Zeae), bacterial wilt disease (Erwinia stewartii); downy mildew of the grape (Plasmopara viticola), rust (Physopella ampelopsidis), powdery mildew (Uncinula necotor), black rot (Ericinium serosola) and black rot (Ericonia serosol) Glomerella singulata, Colletotrichum acutatum, black rot (Guignardia bidwellii), vine disease (Phomopsis viticola), soybean scab (Zygophiala jamesicosis, gray stomach sprouts, Zygophiala jamesicosis, gray stomach) Disease (Helicobasidiu) mompa), Shiromon rot (Rosellinia necatrix), crown gall temple petitioner disease (Agrobacterium vitis);

  Powdery mildew on apples (Podsphaera leucotricha), scab (Venturia inaequalis), spotted scab (Alternaria mali), red scab (Gymnosporangium sampa, stomach sickness, Monilia et al., Mona s disease, Monia et al. Botryosphaeria berengeriana, anthrax (Colletotrichum acutatum, Glomerella singulata), soot spot disease (Zygophiala jamicensis), spotted spot disease (Gloodes apomie sipe stomach disease, Gloeodes apomesis disease) m mompa), white root rot (Rosellinia necatrix), blight blight (Phomopsis mali, Diaporthe tanakae), brown spot (Diplocarpon mali), apple burn (Erwinia amiac amiac amiac amiac amiac amiac amia amiac amiac amia amia amia amiac amia amia amia amia amia amia) ), Hair root disease (Agrobacterium rhizogenes); pear black spot (Alternaria kikuchiana), black scab (Venturia nasicicola), red scab (Gymnosporangia psia phia sargiob. Phomopsis fuk shii), bacterial wilt disease (Erwinia sp.), root canker disease (Agrobacterium tumefaciens), rust-colored blight disease (Erwinia chrysanthemi pv. chrysanthemi), and flower rot bacterial disease (Pse. Pear blight (Phytophthora actorum, Phytophthora syringae), branch blight (Erwinia sp.); Peach scab (Cladosporium carpophilum), homopsis rot (Phomopsis spores. ), Anthrax (Colletotrichum gloeosporioides), leaf blight (Taphrina deformans), perforating bacterial disease (Xhanthomonas campestris pv. Pruning ulcer) Sclerotium disease (Monilinia kusanoi), gray stalk (Monilinia fructicola), apical carcinoma (Agrobacterium tumefaciens), resin bacterial disease (Pseudomonas syringae leaf disease, charcoal disease of galleriae pv. Cercospor akaki; Mycosphaerella nawae, powdery mildew (Phyllactinia kakikora), apical carcinoma (Agrobacterium tumefaciens); black spot of citrus (Diaporthe icitica cit. Scab (Elsinoe fawcettii), brown rot (Phytophthora citrophthora), scab (Xhanthonas campestris pv. ticus), apical carcinoma (Agrobacterium tumefaciens);

  Botrytis cinerea such as tomato, cucumber, beans, strawberries, potatoes, cabbage, eggplant, lettuce; sclerotinia sclerotium such as tomato, cucumber, beans, strawberry, potato, rapeseed, cabbage, eggplant, lettuce ); Tomato, cucumber, legumes, radish, watermelon, eggplant, rapeseed, bell pepper, spinach, sugar beet, and various other types of seedling wilt (Rhizoctonia spp., Pythium spp., Fusarium spp., Phylophthroprosa sp., Etc.) Rustonia solanacearum of Solanaceae; downy mildew of cucumber (Pseudoperonospora cub); nsis), powdery mildew (Sphaerotheca fuliginea), anthracnose (Colletotrichum orbiculare), vine blight (Didymella bryoniae), Fusarium disease (Fusarium oxysporum), plague (Phytophthora parasitica, Phytophthora melonis, Phytophthora nicotianae, Phytophthora drechsleri, Phytophthora capsici Etc.), brown spot bacterial disease (Xhanthomonas campestris pv. Cucurbitae), soft rot (Erwinia carotovora subsp. Carotovora), spot bacterial disease (Pseudomo) as syringae pv. lachrymans, Pseudomonas marginalis pv. marginalis, Streptomyces sp., Hairy root disease (Agrobacterium rhizomas mosaic virus, Agrobacterium rhizogenes mosaic virus) (Alternaria solani), leaf mold disease (Fulvia fulva), plague (Phytophthora infestans), wilt (Fusarium oxysporum), root rot (Pythium myriotium, charcoal of Pythium omistrophy) Canker (Clavibacter michiganensis), stem pixel bacterial diseases (Pseudomonas corrugata), black spot bacterial diseases (Pseudomonas viridiflava), soft rot (Erwinia carotovora subsp. . Carotovora), leaf kelp disease (Crynebacterium sp), yellows disease (Phytoplasma asteris), Yellow dwarf (Tabaco leaf curl subgroup III geminivirus); eggplant powdery mildew (Sphaerotheca fuliginea, etc.), Susukabi disease (Mycovellosiella nattrassii) , late blight (Phytophthora infestans), brown rot (Phytophthora capsici), brown spot bacterial diseases (Pseudomonas cichorii), stem pixel bacterial diseases (Pseudomonas corrugata), Kukikusa bacterial diseases (Erwinia chrysanthemi), soft rot (Erwinia caroto . Ora subsp carotovora), spot bacterial disease (Pseudomonas sp).;

  Black rot of rapeseed (Alternaria brassicae), black rot (Xanthomonas campestris pv. Campestris), black rot (Pseudomonas syringae pv. Eric ab. Etc.), white spot disease (Cercosporella brassicae), root rot disease (Pharma lingam), clubroot disease (Plasmodiophora brassicae), downy mildew (Peronospora sarcoma, black rot sampa sampa samposa, black rot) Pseud monas syringae pv. maculicola, soft rot (Erwinia carotovora subsp. carotovora); cabbage root rot (Thanatephorus cucumeris), yellow rot (Fusarium oximucosa) Leek rust (Puccinia allii), black spot (Alternaria porri), white silk (Sclerotium rolfsii), white blight (Phytophthora porri), black rot (Sclerotium cepivorum scab); flac curfaciens), soft rot (Erwinia carotovora subsp. carotovora), spot bacterial disease (Pseudomonas syringae pv. syringae), rot (Erwinia rhaponica rot) (Erwinia carotovora subsp. Carotovora), spring rot (Pseudomonas marginalis pv. Marginalis); soybean purpura (Cercospora kikuchii), black scab (Elsinosa black spot (Elsinco sylphos)) ), Rhizoctonia solani, Rhizoctonia solani, Phytophthora sojae, Downy mildew (Peronospora manshurica), Rust (Phakostomacha thorch torch, Xantho rust, Xanthus disease, etc.) glycines), spot bacterial disease (Pseudomonas syringae pv. glycinea);

  Bean anthracnose (Colletotrichum lindemutianum), bacterial wilt (Ralstonia solanacearum), scab blight (Pseudomonas syringae pv. Black rot (Mycosphaerella berkeleyi), brown spot (Mycosphaerella arachidis), wilt (Ralstonia solanacearum); powdery mildew (Erysiphe pisi), downy mildew (Peronisporium, downy mildew) domonas syringae pv. pisi), vine rot (Xhanthomonas campestris pv. pisi); ), Plague (Phytophthora infestans), silver scab (Helminthosporium solani), dry scab (Fusarium oxysporum, Fusarium solani), powdery scab (Spongospora saranea Ranella rustaleanella rusteranea rustalum) Black leg disease (Erwinia carotovora subsp. Atroseptica), scab (Streptomyces scabies, Streptomyces acidiscabies), soft rot (Erwinia carotovora subsp. Carotovora), viscous rot (Crostridium spp.), Wakusabyo (Clavibacter michiganensis subsp.sepedonicus Sweetpotato wilt (Streptomyces ipomoeae); Sugar beet brown spot (Cercospora beticola), downy mildew (Peronospora schachtii), black root (Aphanomyces cochioides) ma betae), crown gall temple petitioner disease (Agrobacterium tumefaciens), scab (Streptomyces scabies), spot bacterial disease (Pseudomonas syringae pv. apata);

  Bacterial leaf blight of carrots (Alternaria dauci), club scab (Rhizobacter dauci), apical carcinoma (Agrobacterium tumefaciens), Streptomyces scab (Streptomyces spop. Powdery mildew of strawberry (Sphaerotheca aphanis var. Aphanis), plague (Phytophthora nicotiana, etc.), anthrax (Glomerella singulata, etc.), fruit rot (Pythium ultimum), bacterial rot (Stium rustum), Xanthus wilt disease, Xanthus wilt disease campest is), bacterial wilt disease (Pseudomonas marginalis pv. marginalis); net rot of tea (Exobasidium reticulatum), white scab (Elsinoe leucostila stipulae, red anthracnose, and anthrax (Colletotriche stipensis). Burn disease (Pseudomonas syringae pv. Theae), scab (Xhanthomonas campestris pv. Theeicola), goblet's sickness (Pseudomonas spiert, scab of the tobacco) Colletotrichum gloeosporioides), late blight (Phytophthora nicotianae), Wildfire Disease (Pseudomonas syringae pv.tabaci), Huang and bacterial diseases (Pseudomonas syringae pv.mellea), cavity disease (Erwinia carotovora subsp. Carotovora), damping off (Ralstonia solanacearum) , Tobacco mosaic virus; Fusarium oxysporum; Scarrotinia sclerotioorum, Xanthomonas campestris pv. malvacearum), scabs Erwinia carotovora subsp. carotovora), spot bacterial disease (Pseudomonas syringae pv. helianthi); rose scab (Diplocarpon rosae), powdery mildew (Sphaerotheca pannossa, Phytoapoa stomach, Phytoaphapus sporea, and phytophagous diseases). Agrobacterium tumefaciens; chrysanthemum rot of chrysanthemum (Septoria obesa), white rust (Puccinia horiana), plague (Phytophthora strochoa rob. Head cancer disease (Agrobacterium tumefaciens), hairy root disease (Agrobacterium rhizogenes), greening disease (Phytoplasma aurantifolia); turf brown patch disease (Rhizotonia solania solania da solania disease, Rhizotonia solani da scholaria disease) ), Rust (Puccinia zoosiae), Helmintosporium leaf blight (Cochliobolus sp.), Cloudy sickness (Rhynchosporium secalis), wilt (Gaeumannomyces graminis), anthracnose (Colleto pneumonia germ) Nuclear disease (Typhull) incarnata), snow rot black sclerotium rot (Typhula ishikariensis), snow rot sclerotium rot (Myriosclerotinia borealis), fairy ring disease (Marasmus oreades, etc.), pycium disease, etc. Is mentioned.

  Secondly, a herbicidal composition having a reduced phytotoxicity containing a safener and a herbicidal compound will be described.

  As the safener contained in the herbicidal composition containing a safener and a herbicidal compound of the present invention (hereinafter referred to as herbicidal composition), the above safener may be used. it can.

  Examples of the herbicidal compound contained in the herbicidal composition of the present invention include, in addition to the herbicidal compounds selected from the group consisting of the following (A1) to (A6) or salts thereof, for example, bromobutide, simethrin, dimethmethrin, bentazone , Dimuron, cumyluron, oxadichromemefone, esprocarb, pyributicarb, molinate, cinmethirin and the like.

From the viewpoint of the effects of the present invention, the herbicidal composition of the present invention is preferably at least one herbicidal compound selected from the group consisting of the following (A1) to (A6) or a salt thereof, More preferably, it is at least one herbicidal compound or a salt thereof selected from the group consisting of the following (A2) and (A3).
(A1) ACCase-inhibiting herbicidal compound (A2) acetolactate synthase-inhibiting herbicidal compound (A3) whitening-type herbicidal compound (A4) VLCFA-inhibiting herbicidal compound (A5) protopolyphyllinogen IX oxidase-inhibiting herbicide Compound (A6) Synthetic Auxin Herbicidal Compound

  (A2) is preferably (A2-1) a sulfonylurea-based herbicidal compound, a pyrimidinylsalicylic acid-based herbicidal compound or a triazolopyrimidine-based herbicidal compound, and (A3) is (A3-1) a pyrazole-based herbicidal compound. Compounds or triketone herbicidal compounds are preferred.

  In the present invention, at least one herbicidal compound or a salt thereof selected from the group consisting of (A2-1) and (A3-1) is more preferable.

  The herbicidal composition of the present invention can contain, in addition to these herbicidal compounds, the above-mentioned carriers and auxiliary agents exemplified in the safener.

The content of the herbicidal compound in the composition of the present invention is usually in the range of 0.1 to 90% by weight, preferably in the range of 1 to 80%, and more preferably 5 to 50%. % Range.
The total content of the safener and the herbicidal compound in the composition of the present invention is generally in the range of 0.1 to 90% by weight, preferably in the range of 1 to 80%. Preferably, it is in the range of 5 to 50%.

  In the composition of the present invention, the mixing ratio of the safener and the herbicidal compound is usually the ratio of the safener to the herbicidal compound in a weight ratio of 0.001 to 1000, preferably 0.01 to 1000. 100 ratio.

  The herbicidal composition of the present invention can be produced according to a general method for producing general pesticides. A mixture of at least two kinds of active ingredients, a bactericidal compound and a herbicidal compound, which are active ingredients of a safener, and if necessary, the above-mentioned carrier and the above-mentioned adjuvants are mixed, and both active ingredients are mixed. Or a composition containing one of a fungicidal compound and a herbicidal compound which is an active ingredient of a safener, and then adding the other to the composition. Alternatively, a herbicidal composition containing both active ingredients and having reduced phytotoxicity may be manufactured.

Usually, a mixture is preferably prepared by mixing both active ingredients to produce the herbicidal composition with reduced phytotoxicity.
The herbicidal composition of the present invention can be formulated into dosage forms such as wettable powders, flowables, wettable powders, ODs, powders, solutions, emulsions, granules, packs and the like.

  In the herbicidal composition of the present invention, from the viewpoint of the effects of the present invention, the active ingredient contained in the safener is at least one kind selected from the group consisting of hydroxyisoxazole, picarbutrazox and amisulbrom. Preferably, the compound or a salt thereof, and the herbicidal compound is at least one compound selected from the group consisting of (A1) to (A6) or a salt thereof.

  The herbicidal composition of the present invention has a bactericidal activity and can be used as a weed control due to the original herbicidal activity. Examples of weeds that can be controlled include, for example, crabgrass, ohishiba, enokorogosa, akinoenokorogusa, chinenokorogosa, oakweed, okusakikibi, texas panicum, meriken acne, seyvan sorghum, shutter cane, ginkgo biloba, oak oak, oak oak, black oak, black oak, black oat, black oak, black oat, black oat, black oat Canaryk Sayoshi, Aedes antelope, Sparrow Pod, Agra, Barnacle, Kogomegayatsuri, Hamasuge, Yellowtail, Serihigyu, Aogeto, Honagaoigaito, Ichibiki, American godzika, Sobakazura, Sanaetake, Sasaenashi, Sasaenashi, Hiratagashi , Acornus, Dogwood physalis, White-bellied Korean morning glory, Maruba morning glory, American morning glory, Ma Black-winged Morning Glory, Green-winged Morning Glory, European Convolvulus, Black-throated Gulch, White-throated Gulch, White-winged Fir, Wild Sunflower, Canine Beetle, Chamomile, Corn Marigold, Oro-Shagiku, Ragweed, Oobtaxa, Oysterfish, Florida White clover, kudzu, kara no peas, twigweed, marbats yakusa, yaegura, hakobe, wild radish, noharagarashi, nazuna, giant eastern pufferfish, fusasabasou, field pansies, wild pansies, rhododendrons, forget-me-nots, euphoridae, terrestris , Field weeds such as horsetail, horse chestnuts, sea cucumber, swordfish, stag beetle, kogomega Trees, hiderico, pine trees, inu fireflies, taiwan yamai, suzuya katsura, kuroguwai, koukiyara, shizui, konagi, azena, abnomome, kikashigusa, himemisohagi, mizohakobe, chojitade, urikawa, hera osakabe, omosakae, amosakaha, mimosa ogasawase But not limited to, paddy weeds such as, but not limited to, paddy field weeds, etc .;

Since the herbicidal composition of the present invention contains the safener of the present invention, phytotoxicity to crops caused by the herbicidal compound, for example, growth suppression, appearance of brown point, yellowing, withering, withering, etc. can be avoided. Is possible.
As the target crop, there may be mentioned the crops exemplified for the safener.

  Third, a method for reducing the phytotoxicity of crops using the phytotoxicity reducing agent of the present invention or the herbicidal composition of the present invention will be described.

In the present invention, phytotoxicity to crops can be reduced by an application method selected from the group consisting of the following (B1) to (B4).
(B1) The safener of the present invention (hereinafter referred to as safener a) is mixed with a herbicidal composition containing no safener a (hereinafter referred to as herbicidal composition b) for application. Method,
(B2) a method in which the safener a and the herbicidal composition b are independently applied to the same crop;
(B3) a method in which the safener a and the herbicidal composition of the present invention (hereinafter referred to as herbicidal composition c) are independently applied to the same crop,
(B4) A method of applying the herbicidal composition c.

The same herbicidal composition b of the present invention can be used as the herbicidal composition b except that it does not contain a safener.
In the present invention, the safener a is hydroxyisoxazole, picarbutrazox or amisulbrom or a salt thereof, and the herbicidal composition b is selected from the group consisting of the above (A2-1) and (A3-1). It is preferable to use at least one herbicidal compound or a salt thereof.

In the present invention, the application method selected from the group consisting of (B1) to (B4) is performed once or twice on the plant before transplantation, or on the soil and / or the root or rhizome of the plant. It can be performed once or twice.
The application method of the above (B2) is to apply the safener a once or twice to a plant before transplantation, and to transfer the herbicidal composition b containing no safener to the soil and / or plant after transplantation. And the crop is preferably rice.

  In these application methods, the safener a, the herbicidal composition b or the herbicidal composition c is applied to plants and / or seeds, or applied to soil and / or the roots or rhizomes of the plants. Is performed. Hereinafter, the application methods (B1) to (B4) will be described in detail.

  Examples of the method of applying the safener a, the herbicidal composition b or the herbicidal composition c in the above (B1) to (B4) include, for example, foliage application treatment to plant individuals, seedling box treatment, and paddy soil treatment. Treatment, spraying on the soil surface, soil mixing after spraying on the soil surface, injection into soil, soil mixing after injection in soil, soil irrigation, soil mixing after soil irrigation, Examples include spraying treatment on plant seeds, spreading treatment on plant seeds, immersion treatment on plant seeds, dressing treatment on plant seeds, and spraying treatment on plant seeds. It exerts sufficient efficacy in various application methods.

  In the application methods (B1) to (B4), the application rate and application concentration of the safener a, the herbicidal composition b, or the herbicidal composition c may vary depending on the target crop, the target disease, the degree of occurrence of the disease, and the amount of the compound. Although it varies depending on the dosage form, application method, various environmental conditions, etc., when spraying or irrigation, the amount of the active ingredient is suitably 50 to 1,000,000 g per hectare, preferably 100 to 500 g per hectare. 2,000 g. The amount used in the case of seed treatment is 0.001 to 50 g, preferably 0.01 to 10 g per kg of seed. When the herbicide a, the herbicidal composition b or the herbicidal composition c is subjected to foliage application to plants, application to the soil surface, injection into soil, or soil irrigation, a suitable carrier is used. After diluting to an appropriate concentration, the treatment may be performed. When it is brought into contact with a plant seed, it may be diluted to an appropriate concentration and then immersed, dressed, sprayed, sprayed or painted on the plant seed before use. The amount of the preparation used for dressing, spraying, spraying, or smearing is usually about 0.05 to 50%, more preferably 0.1 to 30% of the weight of the dried plant seeds. The appropriate amount is not limited to these ranges, and may vary depending on the form of the preparation and the type of plant seed to be treated.

  The safener a, herbicidal composition b or herbicidal composition c may be treated alone, in combination with fungicides, insecticides, acaricides, nematicides or planting agents, simultaneously or sequentially. May be processed.

  Examples of fungicides to be treated in combination include phenylamide fungicides, mitotic and mitotic inhibitors, succinate dehydrogenase inhibitors (SDHI agents), quinone external inhibitors (QoI agents), and quinone internals. Inhibitors (QiI killers), oxidative phosphorylation uncoupling inhibitors, quinone exo-stigmaterin binding subsite inhibitors (QoSI agents), amino acid biosynthesis inhibitors, protein biosynthesis inhibitors, signaling inhibitors, lipids and cell membranes Biosynthesis inhibitors, demethylation inhibitors (DMI agents), amine fungicides, 3-keto reductase inhibitors in C4 demethylation of sterol biosynthesis, squalene epoxidase inhibitors of sterol biosynthesis, cell wall growth Synthesis inhibitor, melanin biosynthesis inhibitor, host plant resistance inducer, dithiocarbamate fungicide, phthalimide fungicide, guani Emissions fungicides, multifunctional point contact active fungicides, mention may be made of other fungicides and the like. Examples of insecticides, acaricides, and nematicides that are treated in combination include carbamate acetylcholinesterase (AChE) inhibitors, organophosphorus acetylcholinesterase (AChE) inhibitors, and GABAergic chloride channel blockers. , Sodium channel modulator, nicotinic acetylcholine receptor (nAChR) competitive modulator, nicotinic acetylcholine receptor (nAChR) allosteric modulator, glutamatergic chloride channel (GluCl) allosteric modulator, juvenile hormone analog, non-specific ( Multisite) inhibitor, mite growth inhibitor, mitochondrial ATP synthase inhibitor, oxidative phosphorylation uncoupler that disrupts the proton gradient, nicotinic acetylcholine receptor (n ChR) channel blocker, chitin biosynthesis inhibitor type 0, chitin biosynthesis inhibitor type 1, flies insect molting inhibitor, molting hormone (ecdysone) receptor agonist, mitochondrial electron transport complex III inhibitor, mitochondrial electron transfer Complex I inhibitor (METI), voltage-gated sodium channel blocker, acetyl-CoA carboxylase inhibitor, mitochondrial electron transport complex IV inhibitor, mitochondrial electron transport complex II inhibitor, ryanodine receptor modulator, chordal organ Modulator Unspecified target site, other agents, and the like, and one or more of them can be used in combination, but are not limited thereto.

Fungicides include, for example, benalaxyl, benalaxyl M or quilalaxyl, furalaxyl, metalaxyl, metalaxyl M or mexaxyl-xyl, or metaxyl oxalate. Phenylamide fungicides, such as, ofurase;
Carbendazim (carbendazim), fuberidazole (fuberidazole), thiabendazole (thiabendazole), thiophanate (thiophanate), diethofencarb (diethofencarb), zoxamide (zoxamide), ethaboxam (ethaboxam), pencycuron (pencycuron), fluopicolide (fluopicolide), Fenamakuriru (phenamacril) Mitotic and mitotic inhibitors such as;
Benodanil, benzobindiflupyr, bixafen, boscarid, carboxin, fenfuram, fluopramil, fluopramil, fluopramil, fluopramil, fluopramil ), Furamepyr, isofetamide, isopyrazam, mepronil, oxycarboxin, penthiopyrad, penthrififenfent, fenfulufenfifenfent n), sedaxane, thifluzamide, pyraziflumide, isoflucypram, isoflucypram, fluindapyr enzyme, flupyrpypyramexin, etc. Agent (SDHI agent);
Azoxystrobin, cumoxystrobin, dimoxystrobin, enoxastrobin, fenoxadone, fenamidamine, fenamidamine, fenamidamine, fenamidamine, fenamidamine, fenamidamine Phenoxystrobin, fluoxastrobin, kresoxim-methyl, mandestrobin, metominostrobin, orysostrobin, orysastrobin icoxystrobin, pyraclostrobin, pyramethostrobin, pyraoxystrobin, pyribencarb, pyriclocarb, triclopyricalb, triclopyricl, trofloxy, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl, trifluoropropyl. ) And other quinone external inhibitors (QoI agents):
Oxidative phosphorylation uncoupling inhibitors such as binapacryl, meptyldinocap, dinocap, fluazinam and the like;
Quinone external stigmatelin binding subsite inhibitors (QoSI agents) such as amethoctrazine;
Amino acid biosynthesis inhibitors such as cyprodinil, mepanipyrim, pyrimethanil;
Protein biosynthesis inhibitors such as streptomycin, blasticidin-S, oxytetracycline;
Fenpiclonil, fludioxonil, quinoxyfen, quinoxyfen, proquinazide, clozolinate, dimethaclon, diproclonide, iprocionidone, dimethacrylone, diproclone ;
Edifenphos, iprobenfos, pyrazophos, biphenyl, biphenyl,
Chloroneb, dichloran, quintozene, technazene, tecclozene-methyl, tolclofos-methyl, etolidiazole (eclozolobocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbocarbopa) Lipid and cell membrane biosynthesis inhibitors of
Azaconazole, bitertanol, bromuconazole, cyproconazole, difenoconazole, diconiconzole, dinicoconazole-dinoconazole-dinoconazole-dinoconazole-dinoconazole-dinoconazole-dinoconazole Econiconazole, etaconazole, fenarimol, fenbuconazole, fluquinconazole, quinconazole, quinconazole, fluconazole, fluconazole and quinconazole. Flutriafol, hexaconazole, imazalil, imibenconazole, ipconazole, metconazol, meconazol, konconazole ), Oxpoconazole fumarate, pefurazoate, penconazole, prochloraz, propiconazole, prothionazole , Pyrifenox, pyrisoxazole, simeconazole, tebuconazole, tetraconazole, triadimetriol, triadimesol (triadifonol), triadimefol (triadifonol) Demethylation inhibitors (DMI agents) such as (triforine), triticonazole, mefentrifluconazole, ipfentrifluconazole, etc .;
Aldimorph, dodemorph, fenpropimorph, tridemorph, tridemorph, fenpropidin, piperalin, spiroxamine (spiroxamine, etc.)
3-keto reductase inhibitors in C4 demethylation of sterol biosynthesis such as fenhexamide, fenpyrazamine, etc .;
Squalene epoxidase inhibitors of sterule biosynthesis, such as pyributicarb, [b-15.2] naftifine, [b-15.3] terbinafine (terbinafine);
Polyoxin compound (polyoxins), dimethomorph (Dimethomorph), flumorph (flumorph), Pirimorufu (pyrimorph), benthiavalicarb (benthiavalicarb), benthiavalicarb-isopropyl (benthivalicarb-isopropyl), iprovalicarb (iprovalicarb), mandipropamid (mandipropamid), Cell wall biosynthesis inhibitors such as varifenalate;
Phthalide or phthalide, pyroquilone, tricyclazole, carpropamide, diclocymet, fenoxanil, fenoxanil, etc.
Host plant resistance inducers such as acibenzolar-S-methyl, probenazole, thiazinil, tiadinil, isotianil, laminarin, dichlobenaziox, etc .;
Mancozeb, manzezeb or manzeb, maneb (maneb), metiram (metiram), propineb (propineb), thiuram (thiram), zineb (zineb), ziram (ziram), ferbamate (ferbicam, etc.) ;
Captan, captafol, phorpet, fluorofolpet, etc .;
Phthalimide fungicides:
Guanidine fungicides such as guazatin, iminoctadine, iminoctadine albesilate, iminoctadine triacetate, and the like;
Basic copper chloride (copper oxychloride), cupric hydroxide (copper (II) hydroxide), basic copper sulfate (copper hydroxysulfate), organic copper compound (organocopper compound), dodecylbenzenesulfonate bisethylenediamine copper complex ] (Dodecylbenzenesulphonic acid bisethylenediamine copper [II] salt, DBEDC), sulfur (sulfur), fluoroimide (thionil), dichlorofluanid, dilfluanid, thifluanid Multi-action contact active fungicides such as onato (chinomethionat or quinomethionate), extract from cotyledon of the seedling of lupine (BLAD);
Diclobenthiazox, fenpicoxamid, dipymetitron, bupirimate, dimethylimol, dimethirimol, ethirimol, enthitrimol acetate, triphenyltin acetate fentin chloride, triphenyltin hydroxide, oxolinic acid, hymexazol, octilinone, fosetyl, sodium phosphorous acid, and phosphorous acid sodium salt. (Sodiu phosphite), ammonium salts of phosphorous acid (ammonium phosphite), potassium phosphite (potassium phosphite), tecloftalam (tecloftalam), triazoxide (triazoxide), flusulfamide (flusulfamide), Jikuromejin (diclomezine), silthiofam (silthiofam), Diflumetorim, methasulfocarb, cyflufenamide, metrafenone, pyriophenone, doriine, [fluthianil] mzone), oxathiapiprolin, tebuflokin, validamycins, valoxamycins, cymoxanil, quinofumeline, fenpicoxamide, fenpicoxamide, pyrimicoxamide And other fungicides such as (pyridachlometyl), ipflufenoquin, fluopimomide, and florylpicoxamide.

Examples of the insecticide include phosphocarb, alanycarb, butocarboxim, butoxycarboxym, thiodicarb, thiodicarbob, and thiofandicarb. , Benfuracarb, carbaryl, carbofuran, carbosulfan, ethiofencarb, fenobcarb, fenobutathiobate, formetafurate carbafuran b), isoprocarb, methiocarb, methomyl, oxamyl, oxamyl, pirimicarb, propoxur, propoxur, trimethacarb, lymethcarb, ylmcyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl, albyl. alloxycarb, aldoxycarb, bufencarb, butacarb, butacarb, carbanolate, metolcarb, metolcarb, xylylcarbocarboxyl, carboxylate, xylylcarbocarboxyl, carboxylate, xylylcarbocarbyl, carboxylcarboxylate, xylylcarbocarbylcarboxylate, xylylcarbocarbylcarboxylate, xylylcarbocarbylcarboxylate, xylylcarbocarbylcarboxylate. b), carbamates acetylcholinesterase such as bendiocarb (bendiocarb) (AChE) inhibitor;
Acephate, azamethiphos, azinphos-methyl, azinphos-ethyl, ethefon, cadsafos, chlorofosphos, chlorofosphos, chlorefosphos, chlorethosphos, chlorethoxys chlorfenvinphos), Kurorumehosu (chlormephos), chlorpyrifos (chlorpyrifos), chlorpyrifos - methyl (chlorpyrifos-methyl), Coumaphos (coumaphos), cyanophos (cyanophos), demeton -S- methyl (demeton-S-methyl), diazinon (diazinon), The Lofenthion, dichlorvos, dicrothophos, dimethoate, dimethylvinphos, disulfotone, O-ethylphospho-thiophenate O-4-nitrophenyl phenylphosphonothioate, ethion, ethoprophos, famfur, fenamiphos, fenamiphos, fenitrothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, thiothion, etc. Heptenophos, isofenphos-methyl, isocarbobophos, isoxathion, malathion, malathion, methamidomion, methamidephos Monocrotophos, nared, omethoate, oxydemethon-methyl, parathions, parathion-methyl, phentothate e), phosphate, phosphonale, phosphomet, phosmet, phosphamidon, phoxim, pirimiphos-methyl, pirimiphosophthophos, profenophosophospho, phosphofos trophofos, profenophosophospho, propofotrophos, profenophosophospho, phosfofos, phosfofos, phosfofos) ), Pyraclofos, pyridaphenthion, quinalphos, sulhotep, sulfotep, tebupirimfos, tefofos, tefofos (terfos), terbufos (tefofo) iazophos, trichlorfon, vamidothion, chlorothion, bromfenvinfos, bromophosothiopheno, bromophosothiobos, and bromophosothiobos-thiophos. ), Chlorphoxim, sulprofos, diamidafos, tetrachlorvinphos, propaphos, propaphos, mesulfenfosd, disufenfosd, disulfide fofos), etrimfos, oxydeprofos, formothion, fensulfothion, isazofos, isazofos, imiciafos, imiciafos (isimifos), imiciafos (isimifos), imiciafos (thimichos) An organophosphorus acetylcholinesterase (AChE) inhibitor;
Chloridene, endosulfan, lindane, dienochlor, ethiprole, fipronil, [GABA-operating chloride channel such as acetoprole;
Acrinathrin, aresulin [(1R) -isomer] (allethrin [(1R) -isomer]), bifenthrin, bioallthrin, bioarethrin S-cyclopentenyl isomeric (biosiale) Bioresmethrin, cycloprothrin, cyfluthrin, beta-cyfluthrin, cyhalothrin, gamma-thalamothrin, gamma-cham-thalamine thrin), cypermethrin, alpha-cypermethrin, beta-cypermethrin, beta-cypermethrin, theta-cypermethrin, zeda-cypermethrin, zeda-cypermethrin, Phenothrin [(1R) -trans-isomer] (cyphenothrin [(1R) -trans-isomer]), deltamethrin (deltamethrin), empentrin [(EZ)-(1R) -isomer] (empenthrin [(EZ)-(1R)) -Isomer]), esfenvalerate, ethofenprox (ethofen) rox), fenpropathrin, fenvalerate, flucitrinate, flumethrin, tau-fluvalinate, tau-fluvalinate, halfenprox, halfenprox, halphenprox Methothrin, metofluthrin, epsilon-methofluthrin, monfluorothrin, epsilon-monfluorothrin, epsilon-montromethrin, perfluoromethrin [(1R) -trans-isomer] (phenothrin [(1R) -trans-isomer]), praletrin (resalthrin), resmethrin (resmethrin), cadetrin (kadethrin), silafluofen (tetrafluthrin), tefluthrin (tetrafluthrin) tetramethrin, tetramethrin [(1R) -isomer], tetralomethrin, transfluthrin, ZXI8901 (3- (4-bromophenoxy-phenoxy-phenypheny-phyy-phenypheny-phenypheny-phenypheny-phenoxy) -phenythrionic-phenoxy-phenoxy-phenythrionic-phenoxy-phenoxy difluoromethyoxy) -α- (1- methylethyl) benzeneacetate), Bio permethrin (biopermethrin), furamethrin (furamethrin), profluthrin (profluthrin), full Bro Shi tri sulphonate (flubrocythrinate), dimefluthrin (dimefluthrin), DDT (dichloro-diphenyl-trichloroethane), methoxychlor (methoxychlor), phenothrin ( sodium channel modulators such as phenothrin, fluvalinate;
Acetamiprid (acetamiprid), clothianidin (clothianidin), dinotefuran (dinotefuran), imidacloprid (imidacloprid), nitenpyram (nitenpyram), thiacloprid (thiacloprid), thiamethoxam (thiamethoxam), nicotine (nicotine), nicotine (nicotine sulfate) sulfate, Suruhokisafuroru (sulfoxaflor ), Nicotinic acetylcholine receptor (nAChR) competitive modulators, such as flupyradifurone, triflumezopyrim;
Nicotinic acetylcholine receptor (nAChR) allosteric modulators such as spinosad, spinetoram;
Glutamatergic chloride channel (GluCl) allosteric modulators, such as abamectin, emamectin benzoate, lepimectin, milbemectin, etc .;
Juvenile hormone analogs such as hydroprene, kinoprene, methoprene, phenoxycarb, pyriproxyfen and the like;
Methyl bromide, chloropicrin, cryolite, sulfuryl fluoride, borax, boric acid, disodium octabodate Non-specific (multi-site) inhibitors such as sodium metaborate, tartar ematic, dazomet, metham, carbam sodium, and the like;
String organ TRPV channel modulators such as pymetrozine, pyrifluquinazone;
Mite growth inhibitors such as clofentezine, diflovidazin, hexythiazox, ethoxazole, etc .;
Mitochondria A of mitochondria such as diafenthiuron, azocyclotin, cyhexatin, fenbutatin oxide, propargite, tetradifon, etc .;
Oxidative phosphorylation uncoupling agents that disrupt the proton gradient, such as chlorfenapyr, DNOC (dinitro-ortho-cresol), binapacacryl, sulfluramid;
Nicotinic acetylcholine receptor (nAChR) channel blockers such as bensultap, cartap hydrochloride, thiocyclam, monosultap;
Bistrifluron, chlorfluazuron, diflubenzuron, flucycloxuron, flufenoxuron, hexonflonuron, hexonflonuron, hexonflonuron, hexonflonurone ), Chitin biosynthesis inhibitors type 0 such as noviflumuron, teflubenzuron, triflumuron, etc .;
Chitin biosynthesis inhibitor type 1 such as buprofezin;
Fly moth inhibitors such as cyromazine;
Molting hormone (ecdysone) receptor agonists such as chromafenozide, halofenozide, methoxyfenozide, tebufenozide and the like;
Octopamine receptor agonists such as amitraz;
Mitochondrial electron transfer system complex III inhibitors such as hydramethylnonon, acequinocyl, fluacrylyprim, bifenazate and the like;
Fenazaquin, fenpyroximate, pyridaben, pyrimidifene, tebufenpyrad, tolfenpyrad (tolfenpyrad), a transmission agent such as tofenonepyride (tolenpyrone), and the like.
Voltage-gated sodium channel blockers such as indoxacarb, metaflumizone;
Acetyl CoA carboxylase inhibitors such as spirodiclofen, spiromesifen, spirotetramat and the like;
Aluminum phosphide (aluminum phosphide), calcium phosphide (calcium phosphide), hydrogen phosphide (phosphine), zinc phosphide (zinc phosphide), calcium cyanide (calcium cyanide), sodium cyanide (potassium cyanide (potassium cyanide), potassium cyanide (potassium cyanide)) mitochondrial electron transport system complex IV inhibitors such as cyanide);
Mitochondrial electron transport system complex II inhibitors such as cyenopyrafen, cyflumetofen, and pyflubumide;
Ryanodine receptor modulators such as chlorantraniliprole, [c cyantraniprole, flubendiamide, etc .;
Chord organ modulators such as flonicamid Target site not specified;
Azadirachtin, benzoximate, phenisobromolate, quinomethionat, dicofol, pyridaryl, citramyl, bromopropylate, bromopropylate, bromopropylate, bromopropylate, bromopropylate, propylate, propylate, propylate, propylate, propylate, propylate, propylate, propylate, and bromopropylate. ), Dinobuton, dinocap, hydrogen cyanide, methyl iodide, karanjin,] mercury chloride, methyl isothiocyanate thiocyanate), pentachlorophenol (pentachlorophenol), phosphine (phosphine), piperonyl butoxide (piperonyl butoxide), polynactin complex (polynactins), Sabadira (sabadilla), Surukofuron salt (Surukofuron - sodium (sulcofuron-sodium)), tribufos (Tribufos ), Aldrin, amidithione, amidothioate, aminocarb, aminocarb, amiton, aramite,] athidate, azothate, azotoate, azothate, azotoate, azotoate Barium polysulphide, benclothiaz, 5- (1,3-benzodioxol-5-yl) -3-hexylcyclohexa-2-enone (5- (1,3-benzodioxole-5) -Yl) -3-hexylcyclohexa-2-enone), 1,1-bis (4-chlorophenyl) -2-ethoxyethanol (1,1-bis (4-chlorophenyl) -2-ethoxyethoxyl), butonate, Butopyronoxyl, 2- (2-butoxyethoxy) ethyl thiocyanate (2- (2-butoxyethoxy) ethyl thiocyanate), camphechlor (camphech) lor), chlorbenside, chlordecone, chlordimeform, chlorphenethol, chlorfenson, chlorfenson, fluazuron, deahalphide, alhaphide, alhaphide, alhabaldehyde (Levamisol), amidoflumet, pyrafluprole, pyriprole, pyriprole, tralopyril, flupirazofos, diophenolane (dichlorobenolate) benzilate, flufenzine, benzomate, flufenerim, flubendazole, albendazole, oxybendazole, fenbendazole, fenbendazole, fenbendazole, fenbendazole, fenbendazole, fenbendazole, fenbendazole, fenbendazole, and fenbendazole. -Dichloropropene (1,3-dichloropropene), flomethoquin, cyclaniliprol, tetraraniprole, brofranilide, dichloromezzozide, dichloromezzozide Len dibromide, acrylonitrile, bis (2-chloroethyl) ether, 1-bromo-2-chloroethane, 3-bromo-1-chloropropane -1-ene (3-bromo-1-chloroprop-1-ene), bromocyclen, carbon disulfide, carbon tetrachloride, tetrachloromethane, nemadectin, and simazole calcium (cymizol). calcium polysulfide, cytokinin, 2- (octane) Ruthio) ethanol, potassium oleate, sodium oleate, machine oil, tar oil, anabasine, morantel tartrate, insecticide (Pyrethrum)), rapeseed oil (rape seed oil), soybean lecithin, starch (starch), hydroxypropyl starch (hydroxypropyloilstarch), fatty acid glyceride fatty acid glyceride (decanoyloctyloglycolyl ester) ester), diatomite. Afoxolaner (afoxolaner), fluazaindolizine (fluazaindolizine), aphidopiropen (afidopyropen), cyhalodiamide (cyhalodiamide), thioxazafen (tioxalufen, flumexa, flunafla, flumexa) Rolls (tetrachlorantraniprole), saloraner (sarolaner), lotilaner (lotilaner), cycloxapride (cycloxapride), fluensulfone (fluensulfone), TPIC (tripropylisocyanurate), D-D (1,3-Dichloropropene), peroxocarbonate (peroxocarbonate), MB-599 (verbutin), bis (2,3,3,3-tetrachloropropyl) ether (bis (2,3,3,3-tetrachloropropyl)) ether), DCIP (bis (2-chloro-1-methylethyl) ether), ENT-8184 (N- (2-Ethylhexyl) bicyclohept-5-ene-2,3-dicarboximide), Bayer 22408 (O, O-diethyl) O-naphthalimidophosphorothioate), Bayer 32394 (tris (1-dodecyl-3-methyl-2-phenyl) Enzimidazolium hexacyanoferrate), benzpyrimoxan, acynonapyr, flupyrimine (flupyrimin), ticlopyrazofurol, tyropyrazofluor, etc. Can be

  Hereinafter, a safener comprising the fungicidal compound of the present invention as an active ingredient, and a formulation example, a test example, and an application example of a safer herbicidal composition containing the safener and the herbicidal compound, The present invention will be specifically described, but the present invention is not limited thereto.

  In addition, the mixing parts of each component described in the following formulation examples all mean parts by weight.

<Reference Example 1 (Synthesis of Picarbutrazox)>
According to the method described in Production Example 24 of Patent Document 6,
3.46 g of (1-methyl-1H-5-tetrazolyl) -phenyl-methanone oxime and t-butyl benzoyl- (6- (bromomethyl) pyridin-2-yl) carbamate [CAS No. 1334119-10-6] From 13.69 g, t-butyl benzoyl- {6-((Z)-(1-methyl-1H-5-tetrazolyl) phenylmethylene-aminooxymethyl) -2-pyridyl is a synthetic intermediate. After 2.47 g of｝ carbamate was obtained, it was reacted with a 20% aqueous solution of NaOH in a methanol solvent to obtain 1.68 g of picarbutrazox.
_{^{1 H-NMR (CDCl 3)}} δ: 7.86 (1H, d, J = 8.3 Hz), 7.65 (1H, t, J = 8.0 Hz), 7.51 (2H, t, J = 4.3 Hz), 7.44 (1H, dd, J = 8.4, 6.3 Hz), 7.38 (2H, t, J = 7.5 Hz), 7.22 (1H, s), 6.93 (1H, d, J = 7.3 Hz), 5.25 (2H, s), 3.98 (3H, s), 1.52 (9H, s).

<Formulation example 1 (picarbutrazox wettable powder)>
Picalbutrazox: 10 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, Radiolite (registered trademark) : 0.8 part, H fine powder: balance, 100 parts in total were pulverized and mixed to obtain a wettable powder.

<Formulation Example 2 (Hydroxyisoxazole / Pirimisulfan wettable powder)>
Hydroxyisoxazole: 30 parts, Pyrimisulfan: 2 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts , Radiolite: 0.8 part, H fine powder: balance, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation Example 3 (Amisulbrom / Imazosulfuron wettable powder)>
Amisulbrom: 20 parts, imazosulfuron: 1 part, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, Radiolite (registered) (Trademark): 0.8 part, H fine powder: balance, 100 parts in total were pulverized and mixed to obtain a wettable powder.

<Formulation Example 4 (Ciazofamid / Imazosulfuron wettable powder)>
Cyazofamid: 10 parts, imazosulfuron: 0.5 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, radiolite (Registered trademark): 0.8 part, H fine powder: balance, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation Example 5 (Kasugamycin / pyrazolate wettable powder)>
Kasugamycin: 1 part, pyrazolate: 50 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, Radiolite (registered) (Trademark): 0.8 part, H fine powder: balance, 100 parts in total were pulverized and mixed to obtain a wettable powder.

<Formulation example 6 (chlorothalonil sulcotrione wettable powder)>
30 parts of chlorothalonil, 10 parts of sulcotrione, 0.5 part of Neogen Powder (registered trademark), 0.5 part of Carplex (registered trademark), 0.2 part of Gohsenol (registered trademark), 0.2 parts of radiolite ( (Registered trademark): 0.8 part, H fine powder: remaining part, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation Example 7 (Benomyl / tenylchlor wettable powder)>
Benomyl: 20 parts, Tenylchlor: 5 parts: 50 parts, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, radio Light (registered trademark): 0.8 part, H fine powder: balance, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation Example 8 (thiophanate methyl / pyrimisulfan wettable powder)>
Thiophanate methyl: 40 parts, pyrimisulfan: 3 parts, Neogen powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts, radiolite (Registered trademark): 0.8 part, H fine powder: balance, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation Example 9 (picarbutrazox / pyrimisulfan wettable powder)>
Picalbutrazox: 10 parts, Pyrimisulfan: 1 part, Neogen Powder (registered trademark): 0.5 parts, Carplex (registered trademark): 0.5 parts, Gohsenol (registered trademark): 0.2 parts , Radiolite (registered trademark): 0.8 part, H fine powder: balance, and a total of 100 parts were pulverized and mixed to obtain a wettable powder.

<Formulation example 10 (picarbutrazox / pyrimisulfan granules)>
Picalbutrazox: 3 parts, pyrimisulfan: 0.3 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 64.5 parts, talc 27.7 parts After uniformly pulverized and mixed, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation example 11 (hydroxyisoxazole / pyrimisulfan granule)>
Hydroxyisoxazole: 5 parts, pyrimisulfan: 0.2 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, sodium CMC 3 parts, clay 62.6 parts, talc 27.7 parts After uniformly pulverized and mixed, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 12 (Amisulbrom / Imazosulfuron granules)>
Amisulbrom: 5 parts, imazosulfuron: 0.4 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, sodium CMC 3 parts, clay 56.4 parts, talc 33.7 parts Then, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 13 (Cyazofamid / Imazosulfuron granules)>
Cyazofamid: 2.5 parts, imazosulfuron: 0.2 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, sodium CMC 3 parts, clay 59.1 parts, talc 33.7 parts After mixing, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 14 (Kasugamycin / pyrazolate granule)>
Kasugamycin: 0.1 part, pyrazolate: 20 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 53.7 parts, talc 21.7 parts Then, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 15 (chlorothalonil sulcotrione granules)>
Chlorothalonil: 4 parts, sulcotrione: 1 part, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 65.8 parts, talc 33.7 parts Water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 16 (Benomyl / tenylchlor granules)>
Benomyl: 5 parts, tenylchlor: 1 part, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 68.8 parts, talc 29.7 parts Was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 17 (thiophanate methyl / pyrimisulfan granule)>
Thiophane methyl: 5 parts, pyrimisulfan: 0.4 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 62.4, talc 27.7 parts Thereafter, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

<Formulation Example 18 (isoprothiolane / pyrimisulfan granules)>
Isoprothiolane: 12 parts, pyrimisulfan: 0.4 parts, polyoxyethylene / polyoxypropylene condensate 1.5 parts, CMC sodium 3 parts, clay 55.4, talc 27.7 parts Thereafter, water was added and kneaded, and the mixture was granulated and dried to obtain granules.

Reagent (B1) hydroxyisoxazole solution (trade name / Tatigalene (registered trademark) solution, active ingredient hydroxyisoxazole, 30% by weight, manufactured by Mitsui Chemicals Agro Co., Ltd.)
(B2) Picarbutrazox wettable powder obtained in Formulation Example 1 (B3) Amisulbrom wettable powder (trade name / Oracle (registered trademark) wettable powder, active ingredient amisulbrom, 50% by weight, Nissan Chemical Industries (Made by Corporation)
(B4) Cyazofamid wettable powder (trade name / Ranman (registered trademark) flowable, active ingredient cyazofamid, 9.4% by weight, manufactured by Ishihara Bioscience Co., Ltd.)
(B5) Kasugamycin solution (trade name / Kasmin (registered trademark) solution, active ingredient kasugamycin, 2% by weight, manufactured by Hokko Chemical Industry Co., Ltd.)
(B6) Chlorothalonil wettable powder (trade name / Daconil (registered trademark) 1000 wettable powder, active ingredient chlorothalonil, 40% by weight, manufactured by DS Biotech Co., Ltd.)
(B7) Benomyl wettable powder (trade name / Benlate (registered trademark) wettable powder, active ingredient benomyl, 50% by weight, manufactured by Sumitomo Chemical Co., Ltd.)
(B8) Thiophanate methyl wettable powder (trade name / Topgin (registered trademark) M wettable powder, active ingredient thiophanate methyl, 70% by weight, manufactured by Nippon Soda Co., Ltd.)
(B9) Isoprothiolane granules (trade name / Fujiwan (registered trademark) granules, active ingredient isoprothiolane, 12% by weight, manufactured by Nippon Agrochemical Co., Ltd.)
(B10) Hydroxyisoxazole powder (trade name / Tatigaren (registered trademark) powder, active ingredient hydroxyisoxazole, 4% by weight, manufactured by Mitsui Chemicals Agro Co., Ltd.)

<Test Example 1>
The chemical solutions (B1) to (B8) were diluted to concentrations of 600 ppm, 100 ppm, 250 ppm, 94 ppm, 5000 ppm, 800 ppm, 1000 ppm, and 1000 ppm, respectively (500 times, 1000 times, 2000 times, 1000 times, 4 times, respectively). , 500 times, 500 times and 700 times), irrigate the soil (B1, B2, B3, B4, B6, B7, B8; 500 ml / equivalent of nursery box, B5; 50 ml / equivalent of nursery box), or (B9 ) Was treated at 50 g / seedling raising box and (B10) at 6 g / seedling raising box, and then a test crop (rice variety: Koshihikari) was sown. To the seedlings (about 2.1 leaf stage) cultivated in a greenhouse at 26 ° C. for 17 days, the chemical solutions (B1) to (B8) diluted to a predetermined concentration were again irrigated with soil or (B9) at 50 g / After treatment in a nursery box, it was treated as a chemical treatment and transplanted.

Into a container (30 × 30 cm) containing paddy soil that had been scraped, two seedlings were transplanted, one for each of the two seedlings at a transplanting depth of 1.5 cm. . Four days after transplantation, while maintaining the water depth at 2 cm, an equivalent of 20 kg / ha of pyrimisulfan 0.67% granules (trade name / Best Partner (registered trademark) granules, manufactured by Kumiai Chemical Industry Co., Ltd.) was treated. did. As a control, in order to eliminate the effect of weeds on paddy rice, a complete weeding plot with only weeds removed was established.
Twenty-one days after the chemical treatment, the plant was sampled.
In addition, the dry weight measured the weight which cut | disconnected the above-ground part and the root part, and dried at 100 degreeC 1 hour and 80 degreeC 2 days.
Compared to the complete weeding plot, phytotoxicity was observed in the dry matter weight above the ground and the dry matter weight in the root part in the granule treated with 0.67% of pyrimisulfan. With respect to the section in which phytotoxicity was confirmed, the above-mentioned fungicide-treated section had higher dry weight at the aerial part and dry matter at the root compared to the above-mentioned section without treatment with the bactericide, and it was confirmed that the section had a phytotoxicity-reducing effect.

<Test Example 2>
The hydroxyisoxazole solution (B1), picarbutrazox wettable powder (B2), and amisulbrom wettable powder (B3) were diluted to a concentration of 600 ppm, 100 ppm and 250 ppm, respectively (500 times, 1000 times and 2000 times). After irrigating the soil (500 ml / equivalent to a nursery box), a test crop (rice variety: Koshihikari) was sown. To the seedlings (about 2.1 leaf stage) cultivated in a greenhouse at 26 ° C. for 17 days, the chemical solutions (B1) to (B3) diluted to a predetermined concentration were again irrigated into the soil, and treated with a chemical-treated / transplanted seedling. And

Into a container (30 × 30 cm) containing paddy soil that had been scraped, two seedlings were transplanted, one for each of the two seedlings at a transplanting depth of 1.5 cm. . Four days after transplantation, 0.8% oxadiclomephone and 3% tefuryltrione granules (trade name / A-one (registered trademark) granules, manufactured by Hokuko Chemical Industry Co., Ltd.) at a water depth of 2 cm, equivalent to 20 kg / ha Amount processed. In another container, pyrimisulfan 0.67% granules were treated at an amount equivalent to 20 kg / ha. As a control, in order to eliminate the effect of weeds on paddy rice, a complete weeding plot with only weeds removed was established.
Twenty-six days after the chemical treatment, the plant was sampled and inspected.
In addition, the dry weight measured the weight which cut | disconnected the above-ground part and the root part, and dried at 100 degreeC 1 hour and 80 degreeC 2 days.

  Compared to the complete weeding plot, phytotoxicity was observed in the above-ground dry matter weight and root dry matter weight in the oxadiclomefone 0.8%, tefuryltrione 3% granule-treated section and the pyrimisulfan 0.67% granule-treated section. With respect to the area where phytotoxicity was confirmed, the dry weight of the above-ground part and the dry weight of the root increased in the hydroxyisoxazole solution-treated area compared to the non-treated area of hydroxyisoxazole solution, and it was possible to have a phytotoxicity-reducing effect. confirmed.

  Compared to the complete weeding plot, phytotoxicity was observed in the above-ground dry matter weight and root dry matter weight in the oxadiclomefone 0.8%, tefuryltrione 3% granule-treated section and the pyrimisulfan 0.67% granule-treated section. In the plots in which phytotoxicity was confirmed, the dry matter weight of the above-ground part and the dry weight of the roots increased in the treated section with picarbutrazox wettable powder compared with the non-treated section with picarbutrazox wettable powder. It was confirmed to have.

  Compared to the complete weeding plot, phytotoxicity was observed in the above-ground dry matter weight and root dry matter weight in the oxadiclomefone 0.8%, tefuryltrione 3% granule-treated section and the pyrimisulfan 0.67% granule-treated section. With respect to the section in which phytotoxicity was confirmed, the dry weight of the aerial part and the dry weight of the root were increased in the group treated with amisulbrom granule wettable powder as compared with the group not treated with amisulbrom granule wettable powder, and it was possible to have a phytotoxicity reducing effect. confirmed.

<Test Example 3>
After diluting the hydroxyisoxazole solution (B1) to a concentration of 600 ppm (500-fold), the seedlings (rice cultivar: from Sagabi) grown for 21 days were irrigated (500 ml / equivalent to a nursery box). .

Three seedlings were transplanted to a paddy field (Yasu City, Shiga Prefecture, Mitsui Chemicals Agro Co., Ltd., Agricultural Chemistry Research Institute), which had been treated with a drug and transplanted, and three transplanted seedlings were not treated with the drug. Five days after transplantation, oxadiclomephone 0.8% and tefuryltrione 3% granules were treated at an amount equivalent to 20 kg / ha while maintaining the water depth at 5 cm. In another container, pyrimisulfan 0.67% granules were treated at an amount equivalent to 20 kg / ha. As a control, in order to eliminate the effect of weeds on paddy rice, a complete weeding plot with only weeds removed was established.
Thirty days after the herbicide treatment, plant height, number of stems, and sampling of plants were examined.
In addition, the dry weight measured the weight which cut | disconnected the above-ground part and the root part, and dried at 100 degreeC 1 hour and 80 degreeC 2 days.

  Compared to the complete weeding plot, oxadiclomefone 0.8%, tefuryltrione 3% granule double-treated area, and pyrimisulfan 0.67% granule double-treated area, plant height, number of stems, above-ground dry matter, root Chemical damage was confirmed in dry matter. In the plots where phytotoxicity was confirmed, the number of stems, aerial dry weight and root dry weight increased in the hydroxyisoxazole solution-treated group compared to the hydroxyisoxazole solution-untreated section, and the phytotoxicity reduction effect was increased. It was confirmed to have.

  ADVANTAGE OF THE INVENTION According to this invention, compared with the existing safener, the safener which can be used universally for various cultivated crops and which is good, and the safener including the safener and the herbicidal compound was reduced. A herbicidal composition can be obtained.

  This application claims priority based on Japanese Patent Application No. 2018-030986 filed on Feb. 23, 2018 and incorporates the entire disclosure thereof.

Claims (19)

  A safener for crops containing at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, cyazofamid, kasugamycin, chlorothalonil, benomyl, thiophanate methyl, isoprothiolane and amisulbrom or a salt thereof as an active ingredient, a safener for crops. .   The safener according to claim 1, wherein the active ingredient is hydroxyisoxazole, picarbutrazox, or amisulbrom or a salt thereof.   The crop is rice, wheat, barley, corn, rape, cotton, sunflower, sugar cane, potato, grape, soybean, kidney bean, peas, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, broccoli. , Cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, capsicum, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, The safener according to claim 1, which is a fig, a citrus, a timber (a seedling), a western turf (a bentgrass, a ryegrass, a bluegrass) or a Japanese turf.   The safener according to any one of claims 1 to 3, wherein the crop is rice.   A herbicidal composition comprising at least one herbicidal compound or a salt thereof, and the safener for crops according to any one of claims 1 to 4. The herbicidal compound is at least one herbicidal compound selected from the group consisting of the following (A1) to (A6) or a salt thereof;
(A1) an ACCase-inhibiting herbicidal compound,
(A2) acetolactate synthase-inhibiting herbicidal compound,
(A3) a whitening type herbicidal compound,
(A4) a VLCFA-inhibiting herbicidal compound,
(A5) a protoporphyrinogen IX oxidase-inhibiting herbicidal compound,
(A6) a synthetic auxin-based herbicidal compound,
The herbicidal composition according to claim 5, wherein the active ingredient contained in the safener is at least one compound selected from the group consisting of hydroxyisoxazole, picarbutrazox, and amisulbrom, or a salt thereof. object.   The crop is rice, wheat, barley, corn, rapeseed, cotton, sunflower, sugarcane, potato, grape, soybean, bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, Broccoli, cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, capsicum, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum The herbicidal composition according to claim 5, wherein the herbicidal composition is selected from the group consisting of: fig, citrus, timber (sapling), western turf (bent grass, ryegrass, bluegrass) and Japanese turf.   The herbicidal composition according to any one of claims 5 to 7, wherein the crop is rice. The herbicidal composition according to any one of claims 5 to 8, wherein the herbicidal compound is at least one herbicidal compound selected from the group consisting of the following (A2) and (A3) or a salt thereof. Composition.
(A2) acetolactate synthase-inhibiting herbicidal compound,
(A3) A whitening type herbicidal compound. The herbicidal composition according to claim 9, wherein the herbicidal compound is at least one herbicidal compound selected from the group consisting of the following (A2-1) and (A3-1) or a salt thereof.
(A2-1) a sulfonylurea-based herbicidal compound, a pyrimidinylbenzoic acid-based herbicidal compound or a triazolopyrimidine-based herbicidal compound,
(A3-1) A pyrazole herbicidal compound or a triketone herbicidal compound. A method for reducing phytotoxicity to crops by an application method selected from the group consisting of the following (B1) to (B4).
(B1) a method of mixing and applying the safener a according to any one of claims 1 to 4, and a herbicidal composition b containing no safener,
(B2) a method of independently applying the safener a according to any one of claims 1 to 4 and the herbicidal composition b containing no safener to the same crop,
(B3) The safener a according to any one of claims 1 to 4 and the herbicidal composition c according to any one of claims 5 to 10 are independently applied to the same crop. how to,
(B4) A method for applying the herbicidal composition c according to any one of claims 5 to 10.   12. The method according to claim 11, wherein the safener a, the herbicidal composition b or the herbicidal composition c is applied to plants and / or seeds, or applied to soil and / or applied to roots or rhizomes of plants. A method for reducing the phytotoxicity described in the above.   The method for reducing phytotoxicity according to claim 12, wherein the treatment of the seed is spraying, smearing, dipping, dressing, or spraying the seed.   13. The method for reducing phytotoxicity according to claim 12, wherein the application to soil is treatment on paddy soil, treatment on soil surface, irrigation or admixture with soil.   The crop is rice, wheat, barley, corn, rape, cotton, sunflower, sugarcane, potato, grape, soybean, kidney bean, pea, broad bean, adzuki, strawberry, cabbage, radish, mibuna, mizuna, turnip, nabana, Chinese cabbage, broccoli. , Cauliflower, lettuce, non-head lettuce, tomato, cherry tomato, eggplant, pepper, capsicum, onion, cucumber, melon, watermelon, pumpkin, spinach, sugar beet, okra, honeysuckle, ginger, rakkyo, tobacco, carnation, iris, chrysanthemum, The method for reducing the chemical injury according to claim 11, which is a fig, a citrus, a timber (a seedling), a western turf (a bentgrass, a ryegrass, a bluegrass) or a Japanese turf.   The method for reducing phytotoxicity according to claim 11 or claim 15, wherein the crop is rice.   The application method selected from the group consisting of (B1) to (B4) is performed once or twice on the plant before transplantation, or once or twice on the soil and / or the root or rhizome of the plant. The method for reducing phytotoxicity according to claim 11, which is performed.   The method for applying (B2) is that the safener a is applied once or twice to the plant before transplantation, and the herbicidal composition b containing no safener is transplanted into the soil and / or the plant after transplantation. The method for reducing phytotoxicity according to claim 11 or claim 17, wherein the crop is rice.   The safener a is hydroxyisoxazole, picarbutrazox or amisulbrom or a salt thereof, and the herbicidal composition b is at least one selected from the group consisting of the above (A2-1) and (A3-1). 19. The method for reducing phytotoxicity according to claim 11, 17 or 18, wherein the method is a herbicidal compound or a salt thereof.