JP2023152525A - Water-in-oil emulsion composition - Google Patents

Abstract

To suppress foreign odors from the combined use of a tranexamic acid and D-pantothenyl alcohol, and to provide cosmetics that do not give stickiness and offer a moist and refreshing feeling.SOLUTION: A water-in-oil emulsion composition contains following components (A), (B) and (C), with its aqueous phase having a pH of 4-7: (A) a tranexamic acid or a derivative thereof or salts thereof; (B) D-pantothenyl alcohol; and (C) a poly(oxyethylene oxypropylene) methylpolysiloxane copolymer.SELECTED DRAWING: None

Description

Patent Act Article 30, Paragraph 2 application filed Publication date: March 30, 2020 Online new product presentation via zoom webinar Distribution date: March 2020 Distribution of free samples Publication date: 2020 March 30th POLA Corporation Homepage News release and product introduction page Website address https://www. pola. co. jp/company/news/po20220330/index. html https://www. pola. co. jp/company/news/po20220330/un1llu000000fzu7-att/po20220330. pdf https://www. pola. co. jp/brand/whiteshot/products/index. html

The present invention relates to a water-in-oil emulsion composition suitable for cosmetics.

Skin care cosmetics are also required to have a good feel on the skin during and after application.
For example, the formulation can be made into a water-in-oil emulsifier to suppress stickiness (Patent Documents 1, 2, etc.), or the ethanol content can be increased to give a refreshing feel (Patent Document 3). Proposed. Furthermore, it has been proposed to use specific silicones in water-in-oil emulsified cosmetics to create a feeling of overflowing water (Patent Documents 4 and 5).

Skin care cosmetics usually contain active ingredients such as whitening agents and anti-wrinkle agents, and a combination of a plurality of them is also used (for example, Patent Document 6).
Tranexamic acid is a component known as a whitening agent and anti-inflammatory agent, and D-pantothenyl alcohol is a component known as a whitening agent and anti-wrinkle agent.

Japanese Patent Application Publication No. 2015-205372 Japanese Patent Application Publication No. 2015-211375 Patent No. 4732638 Patent No. 3782914 Japanese Patent Application Publication No. 2020-083763 International Publication No. 2015/152384

The present inventors noticed that when tranexamic acids and D-pantothenyl alcohol are combined as ingredients in cosmetics, a strange odor similar to that of a solvent may be produced, and this may cause discomfort when the cosmetics are applied. We focused on the issues that arise.
An object of the present invention is to suppress the off-flavor that occurs when tranexamic acids and D-pantothenyl alcohol are used in combination. Another object of the present invention is to provide a cosmetic that does not feel sticky and gives a fresh and refreshing feel.

The present inventors have conducted extensive research to solve the above problems, and found that in a water-in-oil emulsion composition, tranexamic acids and D-pantothenyl alcohol are contained in the aqueous phase, and the pH of the aqueous phase is adjusted to neutral. We came up with the idea that it is possible to suppress unpleasant odors by making the area Furthermore, the inventors have come up with the idea that a fresh and refreshing feeling can be provided by using polyoxyalkylene-modified silicone when forming a water-in-oil emulsifier, and have completed the present invention.

That is, the present invention is as follows.
[1] A water-in-oil emulsion composition containing the following components (A), (B), and (C), and the pH of the aqueous phase is 4 to 7.
(A) Tranexamic acid or its derivative or salt thereof (B) D-pantothenyl alcohol (C) Poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer [2] The content of component (A) is The composition according to [1], which is 0.1 to 10% by weight of the total.
[3] The composition according to [1] or [2], wherein the content of component (B) is 0.1 to 10% by weight of the entire composition.
[4] Component (C) is PEG/PPG-18/18 dimethicone, PEG/PPG-19/19 dimethicone, cetyl PEG/PPG-10/1 dimethicone, lauryl PEG/PP
The composition according to any one of [1] to [3], which is one or more selected from G-18/18 methicone.
[5] The composition according to any one of [1] to [4], wherein the content of component (C) is 0.4 to 10% by weight of the entire composition.
[6] The weight ratio of the total content of components (A) and (B) to the content of component (C) ((A+B)/C) is 0.1 to 10, [1] to [5] ] The composition according to any one of.
[7] The composition according to any one of [1] to [6], containing component (D) one or more selected from citric acid, succinic acid, phosphoric acid, and salts thereof.
[8] The composition according to any one of [1] to [7], further containing component (E) a polyhydric alcohol.
[9] The composition according to [8], wherein component (E) is diglycerin.
[10] The composition according to any one of [1] to [9], wherein the internal phase ratio is 50% by weight or more of the entire composition.
[11] The composition according to any one of [1] to [10], which has a hardness of 15 to 50 g at 40°C.
[12] The composition according to any one of [1] to [11], which is an external preparation for skin.

ADVANTAGE OF THE INVENTION The present invention provides a water-in-oil emulsion composition that allows tranexamic acids and D-pantothenyl alcohol to be used together while preventing the generation of off-flavors, and provides a fresh and refreshing feel as if water is flowing out. be done.

The water-in-oil emulsion composition of the present invention contains the following components (A), (B), and (C).
(A) Tranexamic acid or its derivative or salt thereof (B) D-pantothenyl alcohol (C) Poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer

(A) Tranexamic acids In the present invention, tranexamic acid, its derivatives, or its salts are referred to as "tranexamic acids".
Tranexamic acid refers to trans-4-aminomethylcyclohexane-1-carboxylic acid.
Examples of derivatives of tranexamic acid include esters and amides; esters of tranexamic acid include tranexamic acid lauryl ester, tranexamic acid hexadecyl ester, tranexamic acid cetyl ester, and tranexamic acid amides include tranexamic acid lauryl ester, tranexamic acid hexadecyl ester, tranexamic acid cetyl ester, etc. Examples include tranexamic acid methylamide.

Salts of tranexamic acid or its derivatives include alkali metal salts such as sodium salts and potassium salts; alkaline earth metal salts such as calcium salts and magnesium salts; zinc salts; iron salts; ammonium salts; arginine, histidine, and lysine. and salts with basic amino acids such as ornithine; salts with amines such as monoethanolamine, diethanolamine, and triethanolamine.

The content of tranexamic acids in the composition of the present invention is not particularly limited, but is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, and 1.0% by weight or more based on the entire composition. More preferred. Further, it is preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 3% by weight or less. Moreover, the range may be a range of combinations of these upper and lower limits that do not contradict each other. By containing in such a range, it becomes easier to exhibit the anti-inflammatory (skin roughness suppression) and whitening (pigmentation suppression) effects exhibited by tranexamic acids.

(B) D-pantothenyl alcohol D-pantothenyl alcohol is a compound represented by the following structural formula (1).

D-pantothenyl alcohol is used as a material for external skin preparations such as cosmetics, and there is no difficulty in obtaining it, and commercially available products can be used as appropriate.

The content of D-pantothenyl alcohol in the composition of the present invention is not particularly limited, but is preferably 0.1% by weight or more, more preferably 0.5% by weight or more, and 1.0% by weight based on the entire composition. % or more is more preferable. Further, it is preferably 10% by weight or less, more preferably 5% by weight or less, and even more preferably 3% by weight or less. Moreover, the range may be a range of combinations of these upper and lower limits that do not contradict each other. By containing D-pantothenyl alcohol in this range, it becomes easier to exhibit the whitening (pigmentation suppression) and anti-wrinkle effects that D-pantothenyl alcohol exhibits.

(C) Poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer Poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer is a poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer in which some methyl groups of methylpolysiloxane, which may be alkyl-modified, are , refers to those substituted with polyoxyethylene and polyoxypropylene. The methylpolysiloxane chain may be straight chain or branched, but straight chain is preferred. When the methylpolysiloxane is alkyl-modified, it may be modified with a straight or branched alkyl chain having 2 to 20 carbon atoms. The average degree of polymerization of polyoxyethylene is preferably from 10 to 30, more preferably from 15 to 25, even more preferably from 15 to 20. The average degree of polymerization of polyoxypropylene is preferably from 1 to 30, more preferably from 10 to 25, even more preferably from 15 to 20.
The poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer may be used alone or in combination of two or more.

The poly(oxyethylene-oxypropylene) methylpolysiloxane copolymer acts as a surfactant to form a water-in-oil emulsion. By using this as a surfactant, an aqueous phase can be stably formed, and an emulsified composition can be stabilized even when the proportion of the aqueous phase is high, that is, the internal phase is high. When the emulsified composition has a high internal phase, it can give a fresher feel when applied to the skin, and can give a refreshing feel without a sticky feeling. It can also provide a good moisturizing feeling.

The poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer preferably has a low HLB, and specifically those with an HLB of 1 to 4 are preferable from the viewpoint of ease of forming a water-in-oil emulsion with a high internal phase. preferable. Note that HLB (Hydrophilic-Lypophilic Balance) here refers to a value calculated from Griffin's formula.

As the poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer, commercially available products can be used, specifically PEG/PPG-18/18 dimethicone ("5200"; manufactured by Dow Corning Toray Co., Ltd.). ), PEG/PPG-19/19 Dimethicone (“BY11-030”; manufactured by Dow Corning Toray), Cetyl PEG/PPG-10/
1 dimethicone (“Abil EM-90”; Goldschmidt Chemical Company), lauryl PEG/PPG-18/18 methicone (“5200 Formulation Aid”; manufactured by Toray Dow Corning), PEG/PPG-20/20 dimethicone (“ PEG/PPG-30/10 dimethicone (“BY25-339”; manufactured by Dow Corning), PEG/PPG-15/15 dimethicone (“5330 Fluid”; manufactured by Toray Dow Corning Silicones) manufactured by Dow Corning Co., Ltd.), PEG/PPG-2
Preferred examples include, but are not limited to, 0/22 butyl ether dimethicone (“KF-6012”; manufactured by Shin-Etsu Chemical Co., Ltd.). Among these, PEG/PPG-18/18 dimethicone, PEG/PPG-19/19 dimethicone, cetyl PEG/PPG-10/1 dimethicone, and lauryl PEG/PPG-18/18 methicone are particularly preferred.

The total content of the poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer in the composition of the present invention is not particularly limited, but is preferably 0.4 to 10% by weight, and 0.6% by weight based on the entire composition. It is more preferably 6% by weight, even more preferably 0.8% to 5% by weight, particularly preferably 1.0% to 4% by weight. By using the composition within this range, when applied to the skin, a sensation as if water is overflowing from the aqueous phase (splash sensation) is likely to be obtained. Furthermore, if the content is less than 0.4% by mass, it may be difficult to form a water-in-oil emulsion, and if the content is greater than 10% by mass, the composition may become sticky when applied. .

In the present invention, the weight ratio of the total content of components (A) and (B) to the content of component (C) ((A+B)/C) is preferably 0.1 to 10, more preferably is from 0.2 to 5, more preferably from 0.5 to 3.
If it is smaller than this range, the composition may not give a refreshing feeling when applied, and if it is larger than this range, the stability of the composition over time may be impaired.

The composition of the present invention has a water-in-oil (W/O) emulsion structure. That is, it has a structure in which a water phase (W phase) is included in an oil phase (O phase).
In the present invention, the aqueous phase is usually composed of water and an aqueous component. Here, the aqueous component may be any component that dissolves in water at 25 to 65°C.
In the present invention, the oil phase is usually composed of an oily component. The oil component here is usually an oil agent, but is not limited thereto, and may also include a component that phase separates from water after being suspended in water at 25 to 65° C. and left standing for one hour.
The internal phase ratio (mass ratio of the aqueous phase) in the composition of the present invention is preferably 50% by weight or more, more preferably 60% or more, and still more preferably 70% by weight or more. The upper limit is usually 90% by weight or less. When the emulsified composition has a high internal phase, it becomes easier to obtain a feeling of disintegration (splash feeling) as if the internal aqueous phase is bursting during use.

In the present invention, components (A) and (B) are present in the aqueous phase. By adjusting the pH of this aqueous phase to a neutral range, specifically 4 to 7, preferably 5 to 6.5, more preferably 5.5 to 6, components (A) and (B) coexist. It can suppress the odor that sometimes occurs.
In order to adjust the pH of the aqueous phase, the composition of the present invention preferably contains component (D) a pH adjuster. Preferred examples of the pH adjuster include one or more selected from citric acid, succinic acid, phosphoric acid, and salts thereof. Examples of the salt include sodium salt, potassium salt, calcium salt, and the like. Among these, citric acid and/or sodium citrate are particularly preferred.
The content of the pH adjuster in the composition of the present invention is not particularly limited, but is preferably 0.05 to 1% by weight, more preferably 0.1 to 0.5% by weight, and 0.05 to 1% by weight based on the entire composition. More preferably 1 to 0.5% by weight, particularly preferably 1.5 to 4% by weight.

It is preferable that the composition of the present invention further contains component (E) a polyhydric alcohol, since the stability of the emulsified composition can be improved.
Such polyhydric alcohols include glycerin, diglycerin, sugar alcohol, polyethylene glycol, 1,3-butylene glycol, propylene glycol, dipropylene glycol, isoprene glycol, 1,2-pentanediol, 2,4-hexanediol, 1 , 2-hexanediol, 1,2-octanediol, etc. Among these, glycerin, diglycerin, and sugar alcohol are more preferred, and diglycerin is particularly preferred. Examples of sugar alcohols include sorbitol, erythritol, xylitol, maltitol, and the like.

The content of polyhydric alcohol in the present invention is preferably 3 to 40% by weight, more preferably 8 to 30% by weight, and even more preferably 10 to 20% by weight based on the entire composition. Within this range, the stability of the composition is more likely to be improved.

The composition of the present invention preferably has an appropriate hardness so that when it is applied to the skin, it can easily give a feeling of water overflowing (splash feeling). Specifically, we used a digital card meter (Curdmeter MAX ME-500 manufactured by I.techno Engineering) to
The hardness when measured under g load, φ20 mm, and 40° C. is preferably 15 to 50 g, more preferably 20 to 40 g, and even more preferably 25 to 30 g. If the hardness is too small, the splash feeling tends to be weak, and if the hardness is too large, the feel during use may be impaired.

When the composition of the present invention is applied to the skin, it produces the feeling of water overflowing, gives a fresh feel without feeling sticky, and can also give a refreshing feeling to the skin after application. . Therefore, it is preferable to take the form of an external preparation for the skin, and more preferably to take the form of a cosmetic (including quasi-drugs).

In addition to the above-mentioned components, the cosmetic of the present invention may optionally contain any components used in ordinary cosmetics as long as they do not impair the effects of the present invention.
Such ingredients include, for example, macadamia nut oil, avocado oil, corn oil, olive oil, rapeseed oil, sesame oil, castor oil, safflower oil, cottonseed oil, jojoba oil, coconut oil, palm oil, liquid lanolin, hydrogenated coconut oil, hydrogenated oil. , Japanese wax, hydrogenated castor oil, beeswax, candelilla wax, carnauba wax, privet wax, lanolin, reduced lanolin, hard lanolin, jojoba wax, and other oils and waxes; liquid paraffin, squalane, pristane, ozokerite, paraffin, ceresin, petrolatum, microcrystalline Hydrocarbons such as wax; Higher fatty acids such as oleic acid, isostearic acid, lauric acid, myristic acid, palmitic acid, stearic acid, behenic acid, undecylenic acid; cetyl alcohol, stearyl alcohol, isostearyl alcohol, behenyl alcohol, octyl dodeca Higher alcohols such as alcohol, myristyl alcohol, cetostearyl alcohol, etc.; cetyl isooctanoate, isopropyl myristate, hexyldecyl isostearate, diisopropyl adipate, di-2-ethylhexyl sebacate, cetyl lactate, diisostearyl malate, di- Ethylene glycol 2-ethylhexanoate, neopentyl glycol dicaprate, glycerin di-2-heptylundecanoate, glycerin tri-2-ethylhexanoate, trimethylolpropane tri-2-ethylhexanoate, trimethylolpropane triisostearate, Synthetic ester oils such as pentane erythritol tetra-2-ethylhexanoate; chain polysiloxanes such as dimethylpolysiloxane, methylphenylpolysiloxane, diphenylpolysiloxane; octamethylcyclotetrasiloxane, decamethylcyclopentasiloxane, dodecamethyl Cyclic polysiloxanes such as cyclohexanesiloxane; Oils such as silicone oils such as modified polysiloxanes such as amino-modified polysiloxanes, polyether-modified polysiloxanes, alkyl-modified polysiloxanes, and fluorine-modified polysiloxanes;

Anionic surfactants such as fatty acid soaps (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, alkyl sulfate triethanolamine ether; cationic surfactants such as stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide, etc. Class; imidazoline type amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy disodium salt, etc.), betaine type surfactants (alkylbetaine, amidobetaine, sulfobetaine, etc.), acyl Amphoteric surfactants such as methyltaurine; sorbitan fatty acid esters (sorbitan monostearate, sorbitan sesquioleate, etc.), glycerin fatty acids (glyceryl monostearate, etc.), propylene glycol fatty acid esters (propylene glycol monostearate, etc.) ), hydrogenated castor oil derivatives, glycerin alkyl ethers, POE sorbitan fatty acid esters (POE sorbitan monooleate, polyoxyethylene sorbitan monostearate, etc.), POE sorbitan fatty acid esters (POE-sorbitan monolaurate, etc.), POE glycerin Fatty acid esters (POE-glycerin monoisostearate, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-octyl dodecyl ether, etc.), POE alkylphenyl ethers (POE nonyl) phenyl ether, etc.), Pluronic types, POE/POP alkyl ethers (POE/POP2-decyltetradecyl ether, etc.), Tetronics, POE castor oil/hydrogenated castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.) , nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside;

Powders such as mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silica anhydride, aluminum oxide, barium sulfate, etc., which may have their surfaces treated. , red iron oxide, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine blue, navy blue, titanium oxide, zinc oxide inorganic pigments, surface-treated pearls such as mica titanium, fish phosphorus foil, bismuth oxychloride, etc. agents, Red No. 202, Red No. 228, Red No. 226, Yellow No. 4, Blue No. 404, Yellow No. 5, Red No. 505, Red No. 230, Red No. 223, Orange No. 201, which may be laked; Organic pigments such as Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, polyethylene powder, polymethyl methacrylate, nylon powder, organopolysiloxane elastomer, etc. Organic powders;

Para-aminobenzoic acid-based UV absorbers; Anthranilic acid-based UV absorbers; Salicylic acid-based UV absorbers; Cinnamic acid-based UV absorbers; Benzophenone-based UV absorbers; Sugar-based UV absorbers; 2-(2'-hydroxy-5' UV absorbers such as -t-octylphenyl)benzotriazole and 4-methoxy-4'-t-butyldibenzoylmethane;

Lower alcohols such as ethanol and isopropanol; vitamin A or its derivatives, vitamin B ₆ hydrochloride, vitamin B ₆ tripalmitate, vitamin B ₆ dioctanoate, vitamin B ₂ or its derivatives, vitamin B ₁₂ , vitamin B ₁₅ or its derivatives B vitamins such as α-tocopherol, β-tocopherol, γ-tocopherol, vitamin E such as vitamin E acetate, vitamins such as vitamin D, vitamin H, pantothenic acid, pantethine, pyrroloquinoline quinone, etc.; glycyrrhizinic acid anti-inflammatory agents such as derivatives, glycyrrhetinic acid derivatives, salicylic acid derivatives, hinokitiol, zinc oxide, and allantoin; anti-wrinkle agents such as retinol, ascorbic acid, tocopherol, or farnesyl acetate; various extracts (e.g. , Japanese cabbage, birch, sage, loquat, carrot, aloe, mallow, iris, grape, lily, loofah, lily, saffron, nebula, scarlet, hypericum, ononis, garlic, chili pepper, chimpi, trumpet, seaweed, etc.); royal jelly, Activators such as photosensors and cholesterol derivatives; blood circulation promoters such as nonylic acid warenylamide, capsaicin, zingerone, and tannic acid; antiseborrhea agents such as sulfur and thianthol; anti-inflammatory agents such as thiotaurine and hypotaurine; collagen, hyaluronic acid, etc. water-soluble polymer; etc.

In addition, various active ingredients, humectants, preservatives, antibacterial agents, antioxidants/antioxidant aids, etc. can also be optionally blended into the cosmetic composition of the present invention.

Active ingredients other than tranexamic acids and D-pantothenyl alcohol include whitening ingredients, wrinkle-improving ingredients, anti-inflammatory ingredients, and extracts derived from plants and animals.
Whitening ingredients include 4-n-butylresorcinol, ascorbic acid glucoside, 3-O-ethyl ascorbic acid, arbutin, ellagic acid, kojic acid, linoleic acid, nicotinic acid amide, 5,5'-dipropylbiphenyl-2, Examples include 2'-diol, disodium 5'-adenylate, potassium 4-methoxysalicylate, and hydroquinone.

The wrinkle-improving ingredient is not particularly limited as long as it is commonly used in cosmetics. For example, isopropyloxopropylaminocarbonylpyrrolidine carbonyl trifluoride, sodium methylpropylaminocarbonylbenzoylaminoacetate, nicotinamide, vitamin A or its derivatives (retinol, retinal, retinoic acid, tretinoin, isotretinoin, tocopherol retinoate, retinol palmitate). , retinol acetate, etc.), benzyl ursolic acid ester, ursolic acid phosphoric ester, betulinic acid benzyl ester, and benzylic acid phosphoric ester.

Examples of anti-inflammatory ingredients include clarinone, glabridin, glycyrrhizinic acid, glycyrrhetinic acid, pantothenyl alcohol, etc., and preferred are glycyrrhizic acid and its salts, alkyl glycyrrhetinate and its salts, and glycyrrhetinic acid and its salts.

Extracts derived from animals and plants are not particularly limited as long as they are commonly used in medicines, cosmetics, foods, etc. For example, akebia extract, asunaro extract, asparagus extract, avocado extract, amacha extract, almond extract, arnica extract, aloe extract, aronia extract, apricot extract, ginkgo biloba extract, indokino extract, fennel extract, oud extract, elegiac extract, eleuthero extract , Scutellaria extract, Scutellaria extract, Scutellaria extract, Orientalis extract, Panax ginseng extract, Hypericum perforatum extract, Dead nettle extract, Orange extract, Perforatum extract, Cucumber extract, Chamomilla extract, Carrot extract, Artemisia annua extract, Licorice extract, Kiwi extract, Cucumber extract, Guava extract, Kujin extract, Gardenia extract, Kumazasa extract, Clara extract, Walnut extract, Grapefruit extract, Black rice extract, Chlorella extract, Mulberry extract, Keiketou extract, Cucumber extract, Gentiana extract, Gennoshouko extract, Black tea extract, Burdock extract, Rice extract, Fermented rice extract, fermented rice bran extract, rice germ oil, lingonberry extract, salvia extract, soapwort extract, bamboo grass extract, hawthorn extract, santia extract, sansho extract, shiitake extract, rhododendron extract, perilla extract, perilla extract, linden extract, meadowsweet extract, peony Extract, ginger extract, calamus root extract, birch extract, horsetail extract, stevia extract, stevia fermented product, Ivy extract, hawthorn extract, elderberry extract, yarrow extract, mentha extract, sage extract, mallow extract, neem Extract, Jasperia japonica extract, Rhubarb extract, Rhubarb extract, Soybean extract, Japanese turmeric extract, Thyme extract, Dandelion extract, Tea extract, Clove extract, Chimpi extract, Tien tea extract, Capsicum extract, Angelica extract, Calendula extract, Trifolium extract, Trifolium extract, Spruce extract, Heutyami extract , tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacterium extract, lotus extract, parsley extract, birch extract, hamamelis extract, hikiokoshi extract, cypress extract, loquat extract, coltsfoot extract, coltsfoot extract, butterbur extract , butcher bloom extract, grape extract, grape seed extract, loofah extract, safflower extract, peppermint extract, bodega extract, button extract, hop extract, pine extract, mayonnaise extract, horse chestnut extract, skunk cabbage extract, sapinum extract, melissa extract, mozuku extract, peach extract , cornflower extract, eucalyptus extract, saxifrage extract, yuzu extract, lily extract, yokuinin extract, mugwort extract, lavender extract, green tea extract, apple extract, rooibos tea extract, reishi extract, lettuce extract, lemon extract, forsythia extract, astragalus extract, rose extract Preferable examples include extracts such as , rosemary extract, Roman chamomile extract, royal jelly extract, and Roman chamomile extract.

Moisturizers include polyethylene glycol, propylene glycol, glycerin, 1,3-butylene glycol, xylitol, sorbitol, maltitol, chondroitin sulfate, hyaluronic acid, mucoitin sulfate, caronic acid, atelocollagen, cholesteryl-12-hydroxystearate, lactic acid. , sodium lactate, bile salts, dl-pyrrolidone carboxylic acid salts, short chain soluble collagen, diglycerin (EO) PO adduct, Izayoirara extract, Yarrow extract, Melilot extract, and the like.
Examples of pH adjusters include buffers such as lactic acid-sodium lactate, citric acid-sodium citrate, and succinic acid-sodium succinate.
Examples of preservatives include methylparaben, ethylparaben, butylparaben, and phenoxyethanol.
Preferred antibacterial agents include synthetic ones such as 1,3-butylene glycol and paraoxybenzoic acid ester, as well as natural antibacterial substances such as caprylyl glycol, glyceryl caprylate, ethylhexylglycerin, and caprylic hydroxamic acid.
Examples of the antioxidant include tocopherols, dibutylhydroxytoluene, butylhydroxyanisole, gallic acid esters, and the like. Examples of the antioxidant aid include phosphoric acid, citric acid, ascorbic acid, maleic acid, malonic acid, succinic acid, fumaric acid, cephalin, hexametaphosphate, phytic acid, and ethylenediaminetetraacetic acid.

EXAMPLES Hereinafter, the present invention will be explained in more detail with reference to examples, but the present invention is not limited to the following examples unless it exceeds the gist thereof.

<Manufacturing example>
Emulsified compositions of Examples and Comparative Examples were manufactured according to the formulations shown in Table 1 below. That is, components A, B, and E were mixed uniformly, and the pH at 25° C. was adjusted to 5.7 (however, in Comparative Example 3, the pH was set to 3.09). This was heated to 75°C, and separately, components C and D were heated to 75°C and mixed uniformly, gradually added, stirred to emulsify, and then cooled to room temperature to form a W/O emulsion. I got something.

<Test example>
The following items were evaluated for each emulsified composition.
(1) Splash feeling: An experienced evaluator evaluated the feeling of the internal water phase splashing out when an appropriate amount was applied to the arm on the following four scales. The results are also shown in Table 1.
◎: I feel it enough ○: I feel it a little △: I don't feel it very much ×: I don't feel it at all

(2) Refreshing feeling: An experienced evaluator evaluated the refreshing feeling on the skin after applying an appropriate amount to the arm on the following four scales. The results are also shown in Table 1.
◎: I feel it enough ○: I feel it a little △: I don't feel it very much ×: I don't feel it at all

(3) Stability over time: The emulsion composition was placed in a standard glass bottle and stored at 50°C for one month. A skilled evaluator visually observed whether there was any change in the appearance after storage from immediately after production, and evaluated it on the following four scales. The results are also shown in Table 1.
◎: No change ○: Slight change △: Change ×: Obvious change

(4) Hardness: The hardness of the emulsified composition on the day after preparation was measured using a digital card meter (Curdmeter MAX ME-500 manufactured by I.techno Engineering) under the conditions of 100 g load, φ20 mm, and 40°C. The results are also shown in Table 1.

(5) Smell: An experienced evaluator directly smelled the emulsion composition and evaluated the presence or absence of odor.
Only in Comparative Example 3, an unusual odor like a solvent odor was observed.

ADVANTAGE OF THE INVENTION The present invention provides a water-in-oil emulsion composition that allows tranexamic acids and D-pantothenyl alcohol to be used together while preventing the generation of off-flavors, and provides a fresh and refreshing feel as if water is flowing out. and is very useful industrially.

Claims (12)

A water-in-oil emulsion composition containing the following components (A), (B), and (C), and the pH of the aqueous phase is 4 to 7.
(A) Tranexamic acid or its derivative or salt thereof (B) D-pantothenyl alcohol (C) Poly(oxyethylene/oxypropylene) methylpolysiloxane copolymer The composition according to claim 1, wherein the content of component (A) is 0.1 to 10% by weight of the entire composition. The composition according to claim 1, wherein the content of component (B) is 0.1 to 10% by weight of the entire composition. Component (C) is PEG/PPG-18/18 dimethicone, PEG/PPG-19/19 dimethicone, cetyl PEG/PPG-10/1 dimethicone, lauryl PEG/PPG-
The composition according to claim 1, which is one or more selected from 18/18 methicone. The composition according to claim 1, wherein the content of component (C) is 0.4 to 10% by weight of the entire composition. The composition according to claim 1, wherein the weight ratio ((A+B)/C) of the total content of components (A) and (B) to the content of component (C) is 0.1 to 10. The composition according to any one of claims 1 to 6, containing component (D) one or more selected from citric acid, succinic acid, phosphoric acid, and salts thereof. The composition according to any one of claims 1 to 6, further comprising component (E) a polyhydric alcohol. 9. The composition according to claim 8, wherein component (E) is diglycerin. The composition according to any one of claims 1 to 6, wherein the internal phase ratio is 50% by weight or more of the entire composition. The composition according to any one of claims 1 to 6, having a hardness of 15 to 50 g at 40°C. The composition according to any one of claims 1 to 6, which is an external preparation for skin.