JP2019202939A - External preparation for lips - Google Patents

Abstract

To provide an external preparation for lips that improves the red color of the lips themselves.SOLUTION: An angiogenesis-promoting agent is contained in an external preparation for lips for improving the color. The angiogenesis-promoting agent is preferably one or more selected from the group consisting of Mori Cortex extract, Opuntia fix indica extract, Evolvulus alsinoides extract, and Gentianae Radix extract. The external preparation for lips preferably further contains a blood circulation promoter, and as the blood circulation promoter, Zanthoxylum bungeanum extract is preferable.SELECTED DRAWING: Figure 3

Description

  The present invention relates to an external preparation for lips, more specifically to an external preparation for lips for improving the color of the lips.

  Red lips are known to make women look attractive (Non-Patent Document 1), and there is a great demand for directing the red color of lips. For this reason, there are many products on the market that correct the appearance color, such as cosmetics containing pigments such as makeup cosmetics. On the other hand, it is also desired to improve the color of the lips without relying on make-up, and information on beauty methods to obtain healthy ruddy lips is transmitted, and the beauty effect on the lip color Cosmetics containing ingredients that can be expected to exist are also on the market. However, there are many consumers' voices that satisfactory effects cannot be obtained with existing beauty methods and cosmetics, and there is a need for a more effective technique for improving redness of the lips.

  One of the elements of lip color is redness due to blood. Therefore, cosmetics containing a component having a blood circulation promoting action such as capsaicin have been put on the market in order to develop a moderately red color by the blood circulation promoting action to give a healthy and youthful impression. However, a sufficient effect cannot be obtained, irritation is felt in the lips during use, and consumer satisfaction has not been achieved, and a new technique for improving the color of the lips is still desired.

Stephen ID, McKeegan AM. Perception. 2010; 39 (8): 1104-1110.

  This invention makes it a subject to provide the external preparation for lips which improves the red color of lips itself.

  As a result of intensive research, the present inventors have come up with the idea of increasing the blood vessels of the lips in order to improve the color of the lips due to redness due to blood. Then, the inventors came up with the idea of increasing the number of blood vessels, that is, containing an ingredient for promoting angiogenesis in the external preparation for lips, thereby completing the present invention.

That is, the present invention is as follows.
[1] An external preparation for lips for improving the color tone, which contains an angiogenesis promoter.
[2] The angiogenesis-promoting agent includes one or more selected from the group consisting of Soralia extract, Opuntia ficus-indica extract, morning glory extract, and gentian extract. The external preparation for lips according to [1].
[3] The external preparation for lips according to [1] or [2], further containing a blood circulation promoter.
[4] The external preparation for lips according to [3], wherein the blood circulation promoter contains a flower bud extract.
[5] A topical preparation for lips for improving the color, comprising a Sakuhakhi extract and a flower bud extract.
[6] The external preparation for lips according to any one of [1] to [5], which is a cosmetic or quasi-drug.

  According to the present invention, an external preparation for lips that can improve the red color of the lips themselves without causing irritation is provided. The external preparation for lips is suitable for cosmetics and the like, and can produce healthy and attractive lips.

The graph which shows the luminal length of a cultured human vascular endothelial cell (*: p <0.05, **: p <0.01). The graph which shows the space area between the lumina of a cultured human vascular endothelial cell (*: p <0.05, **: p <0.01). The graph which shows the variation | change_quantity of the hemoglobin value of a lip (*: p <0.05, **: p <0.01, NS: No significant difference).

The external preparation for lips of the present invention contains an angiogenesis promoter.
Angiogenesis is a physiological phenomenon in which new blood vessels are formed from existing blood vessels. An angiogenesis promoter means an agent that has an action of promoting the formation of blood vessels.
Angiogenesis can be confirmed by assessing the formation of lumens where vascular endothelial cells aggregate and adhere to form the original form of blood vessels (Arnauvova I, Kleinman HK. Nat Protoc. 2010; 5 (4). ): 628-35.). That is, a component having an action of promoting angiogenesis or suppression, using as an index the length of the connection between the vascular endothelial cells cultured on the matrix and / or the area of the space resulting from the connection between the vascular endothelial cells. The component which has an effect | action can be evaluated.

In the present invention, the angiogenesis-promoting agent is not particularly limited, but Sakuhaku extract, Opuntia fix indica extract, morning glory extract, and gentian extract are preferably mentioned, and one or two selected from the group consisting of these More than seeds can be used.
In addition, it is known that a gentian extract and a morning glory extract have an angiogenesis-promoting action, and it has been proposed to be blended into an external preparation for skin roughening or hair restoration (Japanese Patent Laid-Open No. 2000-2000). 212059, JP-A-2003-160503). In addition, the present inventors have newly found an angiogenesis-promoting action for the extract of Sakuhakuhi and Opuntia fix indica extract as shown in the experimental results described later.

  The content of the angiogenesis promoter in the lip external preparation of the present invention is a total amount with respect to the total amount of the external preparation composition, preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, More preferably, when the content is 0.01 to 0.1% by mass, a desired effect can be easily obtained, and the degree of freedom in formulation design can be secured.

The external preparation for lips of the present invention preferably further contains a blood circulation promoter.
Blood circulation promotion means increasing blood flow. A blood circulation promoter means an agent having an action of increasing blood flow.
In the present invention, the blood circulation promoter is not particularly limited, but a flower bud extract known to have a blood circulation promoting action (Japanese Patent Laid-Open No. 2008-069134) is preferably exemplified. Capsaicin is also a component known to have a blood circulation promoting action. Capsicum tincture extract containing this can also be used as a blood circulation promoting agent, but it may cause irritation during use, so its content It is preferable that the amount is 0.0001% by mass or less based on the total amount of the external preparation, or not contained.

The content of the blood circulation promoter in the lip external preparation of the present invention is a total amount with respect to the total amount of the external preparation, preferably 0.001 to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0. When the content is 0.01 to 0.1% by mass, a desired effect can be easily obtained, and the degree of freedom in formulation design can be secured.

  In the external preparation for lips of the present invention, the content of the angiogenesis promoter and the blood circulation promoter is, by mass ratio, preferably 1: 5 to 5: 1, more preferably 1: 2 to 2: 1. It is easy to obtain a desired effect.

Another aspect of the present invention is an external preparation for lips for improving the color taste, which contains an extract of Sakuhakuhi and a flower extract.
In this embodiment, the content of the extract of Sorohakuhi is a total amount with respect to the total amount of the external preparation composition, preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0.01. When the content is ˜0.1% by mass, a desired effect can be easily obtained, and a degree of freedom in formulation design can be secured. Further, the content of the floret extract is the total amount with respect to the total amount of the external preparation composition, preferably 0.001% to 10% by mass, more preferably 0.005 to 5% by mass, and still more preferably 0.01 to 0%. When the content is 1% by mass, a desired effect can be easily obtained, and a degree of freedom in formulation design can be secured. Moreover, when the content of the extract of Sakuhakuhi and the extract of flower buds is a mass ratio, preferably 1: 5 to 5: 1, more preferably 1: 2 to 2: 1, a desired effect can be easily obtained.

The external preparation for lips of the present invention can increase the blood volume of the lips by angiogenic action, and can increase the redness of the appearance due to hemoglobin in the blood. As a result, the lips themselves can be led to a natural, reddish, healthy color with a ruddy color, which is suitable for use in improving the color.
Further, as shown in the test examples described later, since the external preparation of the present invention hardly causes irritation at the time of use, it can be suitably applied to lips generally having thin skin.

Examples of the dosage form of the external preparation for lips of the present invention include a lotion type, an emulsifier type such as emulsion and cream, an oil type, a gel type, a pack, and a cleaning agent.
The form of the external preparation is not particularly limited, but preferably includes cosmetics and quasi-drugs, and is suitable for products such as lipsticks, lip balms, and lip glosses.

  In addition to the components described above, the external preparation for lips of the present invention can be widely mixed with components that are usually used in cosmetics and quasi drugs. Examples of such components include, but are not limited to, various active ingredients, oily ingredients, surfactants, polyhydric alcohols, thickeners, powders, ultraviolet absorbers, and the like.

Examples of active ingredients include whitening ingredients, wrinkle-improving ingredients, anti-inflammatory ingredients, and other animal and plant extracts.
The whitening component is not particularly limited as long as it is generally used in cosmetics. For example, 4-n-butylresorcinol, ascorbic acid glucoside, 3-O-ethylascorbic acid, tranexamic acid, arbutin, ellagic acid, kojic acid, linoleic acid, nicotinamide, 5,5′-dipropylbiphenyl-2, 2'-diol, 5'-adenylic acid disodium, cetyl tranexamic acid, 4-methoxysalicylic acid potassium salt, hydroquinone, pantothenic acid and the like.
Content of the whitening component in cosmetics is 0.01-30 mass% normally, 0.1-10 mass% is preferable and 0.3-5 mass% is more preferable.

The wrinkle improving component is not particularly limited as long as it is generally used in cosmetics. For example, sodium isopropyloxopropylaminocarbonylpyrrolidinecarbonylmethylpropylaminocarbonylbenzoylaminoacetate, nicotinamide, vitamin A or a derivative thereof (retinol, retinal, retinoic acid, tretinoin, isotretinoin, retinoic acid tocopherol, retinol palmitate And retinol acetate), ursolic acid benzyl ester, ursolic acid phosphoric acid ester, betulinic acid benzyl ester, and benzyl acid phosphoric acid ester.
Content of the wrinkle improving component in an external preparation is 0.01-30 mass% normally, 0.1-10 mass% is preferable and 1-5 mass% is more preferable.

Anti-inflammatory components include glycyrrhizic acid, glycyrrhetinic acid, allantoin, isopropylmethylphenol, clarinone, grabridine, salicylic acid, tocopherol acetate, tocopherol nicotinate, tranexamic acid, nicotinamide, pantothenic acid, pantothenyl alcohol, and these Examples thereof include glycyrrhizic acid and salts thereof, glycyrrhetinic acid and salts thereof, tranexamic acid and derivatives thereof, pantothenyl alcohol, and pantothenic acid and salts thereof.
Content of the anti-inflammatory component in an external preparation is 0.01-30 mass% normally, 0.1-10 mass% is preferable and 1-5 mass% is more preferable.

The extract derived from other animals and plants is not particularly limited as long as it is generally used in cosmetics and the like. For example, akebi extract, asunaro extract, asparagus extract, avocado extract, achacha extract, almond extract, arnica extract, aloe extract, aronia extract, apricot extract, ginkgo biloba extract, Indian mushroom extract, fennel extract, udo extract, ages extract, sorghum extract , Enmezo extract, Ogon extract, Oat extract, Auren extract, Panax ginseng extract, Hypericum extract, Adrianthus extract, Orange extract, Oyster extract, Cuckoo extract, Chamomile extract, Carrot extract, Kawara mugi extract, Kiwi extract, Cucumber extract, Guava extract, Kujin Extract, Gardenia Extract, Kumazasa Extract, Clara Extract, Walnut Extract, Grapefruit Extract, Black Rice Extract, Chlorellae , Mulberry extract, quette extract, gentian extract, gentian extract, gentian extract, tea extract, burdock extract, rice extract, rice fermented extract, fermented rice bran extract, rice germ oil, bilberry extract, salvia extract, bonito extract, sasa extract, Hawthorn extract, Sansha extract, Salamander extract, Shiitake extract, Giant extract, Shikon extract, Perilla extract, Shinobi extract, Shimotake extract, Peonies extract, Pepper extract, Ginger root extract, Birch extract, Japanese cedar extract, Stevia extract, Stevia fermented product, Pepper Kizuta extract, hawthorn extract, elderberry extract, yarrow extract, mint extract, sage extract, mallow extract, senkyu Extract, assembly extract, Sakuhakuhi extract, Diou extract, soybean extract, Tisoiso extract, thyme extract, dandelion extract, tea extract, clove extract, chimpi extract, strawberry tea extract, red pepper extract, Japanese cypress extract, eucalyptus extract, red spruce extract, spruce extract, Japanese wolfberry extract , Tomato extract, natto extract, carrot extract, garlic extract, wild rose extract, hibiscus extract, bacmond extract, lotus extract, parsley extract, birch extract, hamamelis extract, hikikoshi extract, hinoki extract, loquat extract, fukidan popo extract, fukinotou extract, bukuro extract , Butcher bloom extract, grape extract, grape seed extract, loofah extract, safflower extract, peppermint extract, bodaiju extract, Button extract, hop extract, pine extract, mayonnaise extract, maroonnier extract, mizubasho extract, mukuroji extract, melissa extract, mozuku extract, peach extract, cornflower extract, eucalyptus extract, yukinoshita extract, yuzu extract, lily extract, yookuin extract, mugwort extract, lavender extract, green tea Extracts such as extract, apple extract, rooibos tea extract, litchi extract, lettuce extract, lemon extract, forsythia extract, forsythia extract, rose extract, rosemary extract, roman chamomile extract, royal jelly extract, and bitumen extract are preferred.
Content of the plant and animal origin extract in an external preparation is 0.01-30 mass% normally, 0.1-10 mass% is preferable and 1-5 mass% is more preferable.

Examples of the oil component include polar oil and volatile hydrocarbon oil.
Polar oils include synthetic ester oils such as isopropyl myristate, cetyl octanoate, octyldodecyl myristate, isopropyl palmitate, butyl stearate, hexyl laurate, myristyl myristate, decyl oleate, hexyldecyl dimethyloctanoate, lactic acid Cetyl, myristyl lactate, lanolin acetate, 2-ethylhexyl isononanoate, isocetyl stearate, isocetyl isostearate, cholesteryl 12-hydroxystearate, ethylene glycol di-2-ethylhexanoate, dipentaerythritol fatty acid ester, monoisostearic acid N- Alkyl glycol, neopentyl glycol dicaprate, diisostearyl malate, glyceryl di-2-heptylundecanoate, tri-2-ethyl It may be mentioned hexanoic acid trimethylolpropane, trimethylolpropane triisostearate, tetra-2-ethylhexanoate pentane erythritol, tri-2-ethylhexanoate glyceryl, a trimethylolpropane triisostearate.

  Further, cetyl 2-ethylhexanoate, 2-ethylhexyl palmitate, glyceryl trimyristate, tri-2-heptylundecanoic acid glyceride, castor oil fatty acid methyl ester, oleic acid oil, cetostearyl alcohol, acetoglyceride, palmitic acid 2 -Heptylundecyl, diisobutyl adipate, N-lauroyl-L-glutamic acid-2-octyldodecyl ester, di-2-heptylundecyl adipate, ethyl laurate, di-2-ethylhexyl sebacate, 2-hexyl myristate Decyl, 2-hexyldecyl palmitate, 2-hexyldecyl adipate, diisopropyl sebacate, 2-ethylhexyl succinate, ethyl acetate, butyl acetate, amyl acetate, triethyl citrate, octylme Kishishin'nameto, etc. may also be mentioned.

  Natural oils include avocado oil, camellia oil, turtle oil, macadamia nut oil, corn oil, mink oil, olive oil, rapeseed oil, egg yolk oil, sesame oil, persic oil, wheat germ oil, sasanca oil, castor oil, flaxseed oil, Safflower oil, cottonseed oil, eno oil, soybean oil, peanut oil, tea seed oil, kaya oil, rice bran oil, cinnagari oil, Japanese kiri oil, jojoba oil, germ oil, triglycerin, glyceryl trioctanoate, glyceryl triisopalmitate Etc.

  Examples of the volatile hydrocarbon oil include isododecane and isohexadecane.

Surfactants include anionic surfactants such as fatty acid soap (sodium laurate, sodium palmitate, etc.), potassium lauryl sulfate, triethanolamine ether of alkyl sulfate, stearyltrimethylammonium chloride, benzalkonium chloride, laurylamine oxide Cationic surfactants such as betaine surfactants (alkyl betaines, amide betaines, sulfobetaines, etc.), imidazoline amphoteric surfactants (2-cocoyl-2-imidazolinium hydroxide-1-carboxyethyloxy 2) Sodium salts, etc.), amphoteric surfactants such as acylmethyltaurine,
Sorbitan fatty acid esters (such as sorbitan monostearate, sorbitan sesquioleate), glycerin fatty acid esters (such as glyceryl monostearate), propylene glycol fatty acid esters (such as propylene glycol monostearate), hydrogenated castor oil derivatives, glycerin alkyl Ether, POE sorbitan fatty acid esters (POE sorbitan monooleate, polysoxyethylene sorbitan monostearate, etc.), POE sorbite fatty acid esters (POE-sorbite monolaurate, etc.), POE glycerin fatty acid esters (POE-glycerin monoiso) Stearates, etc.), POE fatty acid esters (polyethylene glycol monooleate, POE distearate, etc.), POE alkyl ethers (POE2-O) Cutyl decyl ether, etc.), POE alkyl phenyl ethers (POE nonyl phenyl ether, etc.), Pluronic types, POE / POP alkyl ethers (POE / POP 2-decyl tetradecyl ether, etc.), Tetronics, POE castor oil / cured Castor oil derivatives (POE castor oil, POE hydrogenated castor oil, etc.), nonionic surfactants such as sucrose fatty acid ester, alkyl glucoside, and the like.

  Polyhydric alcohols include polyethylene glycol, glycerin, 1,3-butylene glycol, erythritol, sorbitol, xylitol, maltitol, propylene glycol, dipropylene glycol, diglycerin, isoprene glycol, 1,2-pentanediol, 2,4 -Hexylene glycol, 1,2-hexanediol, 1,2-octanediol and the like.

  Thickeners include guar gum, quince seed, carrageenan, galactan, gum arabic, pectin, mannan, starch, xanthan gum, curdlan, methylcellulose, hydroxyethylcellulose, carboxymethylcellulose, methylhydroxypropylcellulose, chondroitin sulfate, dermatan sulfate, glycogen, Heparan sulfate, hyaluronic acid, sodium hyaluronate, tragacanth gum, keratan sulfate, chondroitin, mucoitin sulfate, hydroxyethyl guar gum, carboxymethyl guar gum, dextran, kerato sulfate, locust bean gum, succinoglucan, caronic acid, chitin, chitosan, carboxymethyl Chitin, agar, polyvinyl alcohol, polyvinylpyrrolidone, carboxyvinyl polymer, Kill modified carboxyvinyl polymers, sodium polyacrylate, polyethylene glycol, and bentonite.

  As powders, the surface may be treated, mica, talc, kaolin, synthetic mica, calcium carbonate, magnesium carbonate, silicic anhydride (silica), aluminum oxide, barium sulfate, etc. May be treated, bengara, yellow iron oxide, black iron oxide, cobalt oxide, ultramarine, bitumen, titanium oxide, zinc oxide inorganic pigments, surface may be treated, mica titanium, fish phosphorus foil, Pearl agents such as bismuth oxychloride, red 202, red 228, red 226, yellow 4, blue 404, yellow 5, red 505, red 230, red 223 which may be raked No., Orange No. 201, Red No. 213, Yellow No. 204, Yellow No. 203, Blue No. 1, Green No. 201, Purple No. 201, Red No. 204, and the like, polyethylene powder, polymeta Methyl acrylic acid, nylon powder, organic powders such as organopolysiloxane elastomers, and the like.

Examples of the UV absorber include paraaminobenzoic acid UV absorbers, anthranilic acid UV absorbers, salicylic acid UV absorbers, cinnamic acid UV absorbers, benzophenone UV absorbers, sugar UV absorbers, 2- (2 UV absorbers such as'-hydroxy-5'-t-octylphenyl) benzotriazole, 4-methoxy-4'-t-butyldibenzoylmethane, and the like.

  EXAMPLES Hereinafter, although an Example demonstrates this invention still in detail, this invention is not limited to a following example, unless the summary is exceeded.

<Reference test example>
Using Cultured Human Vascular Endothelial Cells (HUVEC, Takara Bio Inc.), Cultrex In Vitro Angiogenesis Assay Formation Ki
Angiogenesis was induced using t (Trevigen). That is, calcein AM attached to the kit is incorporated into cultured human vascular endothelial cells and stained with green fluorescence, and then on the matrix attached to the kit, together with one of various test substances (0.1% by volume) for 10 hours. Cultured. A green fluorescent image was taken, and the length of the lumen and the space area between the lumens were measured by image analysis, and compared with the solvent control containing no test substance. It was. The length of the lumen refers to the length of the cells arranged in a mesh, and the space area between the lumens refers to the area of the black space formed outside the cells after the cells are arranged. The length of the lumen and the space area between the lumens represent the level of lumen formation that is an indicator of angiogenesis (Non-Patent Document 2).

The test substances are as follows.
Hawthorn extract (Ogi Pharmaceutical Co., Ltd.)
Hikiokoshi Extract (Maruzen Pharmaceutical Co., Ltd.)
Sohakuhi extract (Maruzen Pharmaceutical Co., Ltd.)
Gentian extract (Ichimaru Falcos Co., Ltd.)
Morning glory extract (Maruzen Pharmaceutical Co., Ltd.)
Opuntia Fixture Indica Extract (Koei Kogyo Co., Ltd.)
Crab extract (Intron)
Acerola extract (Nichirei Bioscience Co., Ltd.)
Green tea extract (Koei Kogyo Co., Ltd.)
Kiwi extract (Ichimaru Falcos Co., Ltd.)
Roman chamomile extract (Koei Kogyo Co., Ltd.)

The measurement result of the length of the lumen is shown in FIG. A statistically significant increase in lumen length was observed with respect to the solvent control in the extract of Sakuhakuhi, Gentiana, Asagakarakakusa, and Opuntiafix indica.
The measurement result of the space area between lumens is shown in FIG. Spatial spaces that are statistically significant relative to the solvent control in Sakuhakuhi extract, Gentiana extract, Asaga oakweed extract, Opuntia fix indica extract, pickaxe extract, kiwi extract, and roman chamomile extract An area increasing effect was observed.
A significant increase in both the length of the lumen and the space area between the lumens was found in the extract of Sakuha kanto extract, Gentian extract, morning glory extract, and Opuntia fixa indica extract. Presumed to have a promoting action.

<Example>
The formulation components shown in Table 1 were heated to 80 ° C. and cooled with stirring and mixing to produce a lip balm. In addition, the preparation 1 of the present invention contains a Sakuhakuhi extract as an angiogenesis promoter, and the preparation 2 of the present invention contains a Sakuhaku extract as an angiogenesis promoter and a floret extract as a blood circulation promoter. The control formulation does not contain an angiogenesis promoter or a blood circulation promoter. Comparative preparation 1 does not contain an angiogenesis promoter and contains chili pepper tincture (including capsaicin) as a blood circulation promoter. Comparative preparation 2 does not contain an angiogenesis promoter and contains a floret extract as a blood circulation promoter.

<Test Example 1>
The preparations prepared in the Examples were each used by 5 subjects, a total of 25 people, every day for 2 weeks, and the hemoglobin levels of the lips before and after continuous use were compared. Specifically, the images of the lips photographed using the Antera 3D (made by Miravex) before continuous use and the images photographed in the same manner after the continuous use are arranged, and the “upper and lower lip whole images” is displayed on the Anterra 3D image photographed before the continuous use. After selecting “Area” on the freeform as the analysis range, the analysis range was automatically matched to the image after 2 weeks of use, and data was acquired using the analysis item of the average hemoglobin level.
In this test, it is recognized that as the hemoglobin value increases, the color of the lips, more specifically, the blood color is improved.

The results are shown in FIG. Compared to the control preparation containing no angiogenesis promoting agent and no blood circulation promoting agent, both of the preparations 1 and 2 containing the angiogenesis promoting agent and / or the blood circulation promoting agent and the comparison preparations 1 and 2 have a hemoglobin value higher than that before continuous use. A tendency to increase after continuous use was observed.
However, in Comparative preparation 1 containing chili pepper tincture as a blood circulation promoter, a statistically significant blood color improvement effect was not observed with respect to the solvent control, whereas in contrast, a preparation containing Sahakuhi extract as an angiogenesis promoter In No. 1, an increase in the hemoglobin value nearly twice that of the comparative preparation 1 was observed with a statistically significant difference from the control preparation. From this, it can be seen that the lip balm containing the angiogenesis promoter is effective for improving the color of the lips.
Moreover, even in the comparative preparation 2 which does not contain an angiogenesis promoter and contains a flower bud extract as a blood circulation promoter, the hemoglobin value was statistically significantly increased as compared with the solvent control. In Formulation 2 containing the product and the flower bud extract as a blood circulation promoter, an increase in the hemoglobin value which was about two times larger was observed. This shows that a lip balm containing an angiogenesis promoter and a blood circulation promoter is more effective for improving the color of the lips.

<Test Example 2>
The preparations prepared in the Examples were each used by 5 subjects, a total of 25 people, for daily use for 2 weeks, and the redness of the lips before and after continuous use was compared. Specifically, photographs of the front face were taken before and after continuous use, and an analysis area was set in the upper lip in the photograph using Photoshop (Adobe Systems), and the average of RGB R values in the analysis area Values were calculated and compared.
The results are shown in Table 2. Compared to the control preparation containing no angiogenesis promoter and blood circulation promoter, preparations 1 and 2 containing the angiogenesis promoter and / or blood circulation promoter and comparative preparations 1 and 2 both have R values as compared to those before continuous use. A tendency to increase after continuous use was observed. Of these, Formulations 1 and 2 and Comparative Formulation 2 showed a statistically significant increase over the control formulation. In particular, in Formulation 1 containing Sakuhakuhi extract as an angiogenesis-promoting agent and Formulation 2 containing Sakuhakhi extract as angiogenesis-promoting agent and floret extract as blood circulation promoter, the R value is about twice that of the comparative formulation Showed an increase. From this, it can be seen that a lip cream containing an angiogenesis promoter is effective for improving the color of the lips, and a lip cream containing an angiogenesis promoter and a blood circulation promoter is more effective for improving the color of the lips. .

<Test Example 3>
The preparations prepared in the Examples were each used by 5 subjects, a total of 25 people, every day for 2 weeks, and after continuous use, the presence or absence of irritation during use was interviewed. Free answers to hearings.
The results are shown in Table 3. In comparative preparation 1 containing chili pepper tincture as a blood circulation promoter, all subjects complained of some kind of irritation, whereas in preparations 1 and 2 and comparative preparation 2, no complaints about irritation were obtained. From this, it can be seen that the extract of Sakuhakuhi can be suitably blended in lip balm as an angiogenesis promoter.

  According to the present invention, an external preparation for lips that can improve the red color of the lips themselves without causing irritation is provided. The topical preparation for lips is industrially useful because it is suitable for cosmetics and the like and can produce healthy and attractive lips.

Claims (6)

  An external preparation for lips for improving the color, containing an angiogenesis promoter.   The topical application for lips according to claim 1, wherein the angiogenesis-promoting agent comprises one or more selected from the group consisting of a extract of Sakuhakuhi, Opuntia fix indica extract, morning glory extract, and gentian extract. Agent.   The external preparation for lips according to claim 1 or 2, further comprising a blood circulation promoter.   The external preparation for lips according to claim 3, wherein the blood circulation promoter comprises a flower bud extract.   An external preparation for lips for improving the color, comprising a extract of Sakuhakuhi and a flower extract.   The external preparation for lips according to any one of claims 1 to 5, which is a cosmetic or a quasi-drug.

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