JP2023148791A - Bag for heat treatment - Google Patents

Abstract

To provide a bag for heat treatment, a bag in which breakage and wrinkles can be reduced on the bag body deposited to a port member, in sterilization treatment.SOLUTION: A bag for heat treatment of the present invention includes: a seal part in which laminated films laminated with a seal layer containing a polyethylene-based resin as a main component and a barrier layer containing a cyclic polyolefin-based resin as the main component are superimposed to face each other and deposited with the mutual outer peripheral edge parts; a bag body which is defined by the laminated film and the seal part and which is provided with a housing chamber for preserving ingredients and with an opening having no deposition of the mutual outer peripheral edge parts of the oppositely facing laminated films; and a port having the deposition part deposited to the opening. The deposition part has a flat face at least in a part of a portion abutted on the opening.SELECTED DRAWING: Figure 1

Description

The present invention relates to bags for heat treatment.

A medical solution containing a drug or a nutritional supplement is stored in a heat treatment bag in a sealed state until it is used. The heat treatment bag includes a bag body formed into a bag-like body made of a plastic film, and a port that is a plastic molded product fixed to the outer periphery of the bag body. After the heat treatment bag is sterilized under moist heat, it is stored in an exterior bag or the like and shipped as a product.

As such a bag for heat treatment, for example, an infusion bag is disclosed in which the side surface of a hollow cylinder formed in an oval or boat shape is welded to the opening of a main body made of a thermoplastic plastic sheet (for example, (See Patent Document 1).

Patent No. 2791387

However, in the infusion bag of Patent Document 1, the hollow cylinder is formed in a cylindrical shape and the side surface is curved, so even if the hollow cylinder is attached to the opening of the main body, the main body is There has been a problem in that the thermoplastic sheet that makes up the opening is prone to wrinkles and folds.

In other words, when an infusion bag is sterilized, the thermoplastic sheet that makes up the main body becomes soft and easily deforms, so the thermoplastic sheet is easily bent or wrinkled, and stress is easily applied to the thermoplastic sheet. There is. If the infusion bag is cooled while the thermoplastic sheet is deformed and folded or wrinkled, stress will be applied to the folds or wrinkles due to shrinkage of the thermoplastic sheet, causing the folds or wrinkles to become larger, and the heat Breakage may occur in the resin layer that constitutes the plastic sheet.

Thermoplastic sheets are generally composed of a laminate of multiple resin layers such as polyethylene (PEP), so if there are parts where the adhesion between the resin layers is insufficient, the resin layers of the thermoplastic sheet may Breakage is likely to occur due to folds, wrinkles, etc. Since such broken portions can be seen as white in appearance, the appearance of the bag for heat treatment changes before and after sterilization, and is likely to cause poor appearance.

An object of one aspect of the present invention is to provide a bag for heat treatment that can reduce the occurrence of folds and wrinkles in the bag body welded to the port during sterilization.

One embodiment of the heat treatment bag according to the present invention is
A sealing portion in which a laminated film in which a sealing layer containing a polyethylene resin as a main component and a barrier layer containing a cyclic polyolefin resin as a main component are laminated so as to face each other and their outer peripheral edges are welded to each other; , a bag body having a storage chamber that is defined by the laminated film and the seal portion and stores the contents, and an opening in which the outer peripheral edges of the facing laminated films are not welded to each other;
a port having a welded part welded to the opening;
Equipped with
The welded portion has a flat surface in at least a portion of the portion that contacts the laminated film.

One aspect of the bag for heat treatment according to the present invention can reduce the occurrence of folds and wrinkles in the bag body welded to the port during sterilization.

BRIEF DESCRIPTION OF THE DRAWINGS It is a perspective view which shows an example of the bag for heat processing based on embodiment of this invention. FIG. 2 is a front view of the heat treatment bag shown in FIG. 1. FIG. FIG. 2 is a schematic cross-sectional view showing the structure of a laminated film. It is a schematic sectional view showing an example of other composition of a laminated film. FIG. 3 is a perspective view of a port. FIG. 3 is a bottom view of the port. FIG. 3 is an explanatory diagram showing a state where a rupture occurs in the laminated film. FIG. 2 is a partially enlarged view of the appearance of the bag body of Example 1-1. FIG. 2 is a perspective view showing an example of the configuration of a cylindrical port. FIG. 2 is a partially enlarged view of the appearance of the bag body of Comparative Example 1-1. 11 is a partially enlarged view of FIG. 10. FIG. 12 is a partially enlarged view of FIG. 11. FIG.

Embodiments of the present invention will be described in detail below. Note that in order to facilitate understanding of the explanation, the scale of each member in the drawings may be different from the actual scale. In this specification, "~" indicating a numerical range means that the lower limit and upper limit include the numerical values written before and after it, unless otherwise specified.

<Heat treatment bag>
A bag for heat treatment according to an embodiment of the present invention will be described. FIG. 1 is a perspective view showing an example of a bag for heat treatment according to an embodiment of the present invention, and FIG. 2 is a front view of the bag for heat treatment shown in FIG. 1. As shown in FIGS. 1 and 2, the heat treatment bag 1 according to the present embodiment includes a bag body 10 filled with contents, and a port 20 attached to the bag body 10.

In this embodiment, the contents include pharmaceuticals (drugs), nutritional supplements, food and drinks, cosmetics, and the like. The drug may be a substance with high adsorption or permeability to general resins, such as nitroglycerin, albumin, vitamins, trace elements, and radical scavengers, or may be a substance with high adsorption or permeability to general resins, or a pyrazolone derivative, edaravone, or a pharmaceutically acceptable salt thereof. An aqueous solution containing the same may be used. The pyrazolone derivative may have one or more substituents such as an alkyl group, an aromatic group, or a halogen atom on the carbon atom or nitrogen atom of the pyrazolone. Pyrazolone derivatives may form salts with organic acids, inorganic acids, and the like.

[Bag body]
The bag body 10 is a packaging bag (pouch) including a pair of stacked laminated films 110. The bag main body 10 includes a seal portion 11 in which a pair of laminated films 110 are overlapped so as to face each other and their outer peripheral edges are welded together, and a storage chamber 12 defined by the pair of laminated films 110 and the seal portion 11. , the pair of laminated films 110 have an opening 13 whose outer peripheral edges are not welded to each other. The storage chamber 12 is a space for storing contents. The opening 13 is an unfused gap between the opposing laminated films 110, and a port 20 is provided by welding or the like. The contents stored in the storage chamber 12 may be inserted into the opening 13 before the port 20 is welded, etc., or the contents stored in the storage chamber 12 may be inserted into the opening 13 after the port 20 is welded etc. may be inserted.

The bag main body 10 is a four-sided bag, but the form of the bag main body 10 is not particularly limited. It can be applied to large bags such as bags and drum inner bags.

(Laminated film)
The laminated film 110 includes a sealing layer containing a polyethylene resin as a main component, and a barrier layer laminated on the sealing layer and containing a cyclic polyolefin resin as a main component, such that the barrier layers of the laminated film face each other. It can be formed by overlapping and welding. The laminated film 110 may have two or more seal layers and barrier layers, or may have layers other than the seal layer and barrier layer.

-Layer structure of laminated film-
The layer structure of the laminated film 110 will be explained. FIG. 3 is a schematic cross-sectional view showing an example of the configuration of the laminated film 110. As shown in FIG. 3, the laminated film 110A may include a first seal layer 111A, a barrier layer 112, and a second seal layer 111B, which are laminated in this order from the first seal layer 111A side.

(1st seal layer)
The first sealing layer 111A includes a polyethylene (PE) resin, is preferably substantially composed of a PE resin, and is more preferably composed of a PE resin. The first seal layer 111A may contain an additive component in addition to the PE resin. Note that "substantially" means that substances that are unavoidably included other than the PE-based resin may be included.

As the polyethylene (PE) resin included in the first seal layer 111A, linear low density polyethylene (LLDPE) can be used.

The linear low-density polyethylene contained in the first sealing layer 111A is usually made by copolymerizing α-olefin having 4 or more carbon atoms and introducing short chain branches, so that the linear low-density polyethylene has fewer long chain branches and a straight chain. It has a molecular structure of Examples of the α-olefin copolymerized with linear low density polyethylene include 1-butene, 1-hexene, 4-methyl-1-pentene, 1-octene, and the like.

Examples of the type of linear low-density polyethylene included in the first seal layer 111A include resins polymerized using a Ziegler-Natta catalyst, resins polymerized using a single-site catalyst, and the like. Linear low-density polyethylene polymerized using a single-site catalyst is preferred because it has a narrow molecular weight distribution and excellent mechanical properties. Examples of single-site catalysts include metallocene catalysts. Examples of metallocene-based catalysts include catalysts containing metallocene compounds containing a ligand having a cyclopentadienyl skeleton and whose metal is zirconium, hafnium, or the like.

Specific examples of the linear low-density polyethylene included in the first sealing layer 111A include the Harmolex (registered trademark) series manufactured by Nippon Polyethylene Co., Ltd. and the Nipolon (registered trademark) Z series manufactured by Tosoh Corporation. . Specifically, Nipolon (registered trademark) Z manufactured by Tosoh Corporation
Examples include FY11, Nipolon (registered trademark) Z FY12, and the like.

The first seal layer 111A may contain one type of linear low-density polyethylene or two or more types. When using a plurality of types of linear low-density polyethylene, the plurality of linear low-density polyethylenes may be appropriately mixed in any ratio, or may be mixed in equal amounts.

The bending modulus of the linear low density polyethylene contained in the first sealing layer 111A is preferably 100 MPa to 450 MPa, more preferably 150 MPa to 420 MPa, and even more preferably 170 MPa to 360 MPa. If the flexural modulus of the linear low-density polyethylene contained in the first seal layer 111A is within the above-mentioned preferred range, the first seal layer 111A has appropriate flexibility and exhibits adhesiveness to the barrier layer 112. can.

Note that the flexural modulus can be measured by a method based on JIS K7171:2016 (ISO 178:2010).

The melt flow rate (MFR) of linear low density polyethylene is 0.9 g/10 minutes to 1 in measurements based on JIS K 7210-1:2014 (ISO 1133-1:2011) (230°C, 21N load). .5 g/10 minutes is preferred, and 1.1 g/10 minutes to 1.4 g/10 minutes is more preferred. If the MFR of the linear low-density polyethylene is within the above-mentioned preferable range, when the first sealing layer 111A is formed by extrusion molding etc., the extrudability will be relatively stable and molding defects will be suppressed, so that the film-like The first seal layer 111A can be molded stably and easily, and molding defects such as burrs can be prevented from occurring in the first sealing layer 111A during molding.

The melting point of the linear low density polyethylene is preferably 128°C to 135°C, more preferably 130°C to 132°C.

The density of the linear low density polyethylene is preferably 0.905 g/cm ³ to 0.950 g/cm ³ , more preferably 0.910 g/cm ³ to 0.940 g/cm ³ , and 0.915 g/cm ³ to 0.930 g/cm ³ is more preferred.

The content of linear low density polyethylene is preferably 40% by mass to 95% by mass, more preferably 50% by mass to 90% by mass. If the content of linear low density polyethylene is within the above preferred range, the first seal layer 111A has sufficient flexibility and can exhibit adhesiveness to the barrier layer 112.

(Barrier layer 112)
The barrier layer 112 mainly contains a cyclic olefin resin, preferably substantially consists of a cyclic polyolefin resin, and more preferably consists of a cyclic polyolefin resin.

The cyclic olefin resin contained in the barrier layer 112 is a polymer made of one or more olefin monomers or a polymer whose double bonds are hydrogenated, and at least one of the olefin monomers is a cyclic hydrocarbon. It is a cyclic olefin monomer with a skeleton. Examples of the cyclic olefin monomer include norbornene compounds. In addition, in the following description, simply "cyclic olefin resin" refers to the cyclic olefin resin contained in the barrier layer 112.

Cyclic olefin resins are polymers obtained by hydrogenating the remaining double bonds after ring-opening metathesis polymerization of norbornene compounds, addition polymers consisting of two or more types of cyclic olefin monomers, and polymers consisting of cyclic olefin monomers and acyclic olefin monomers. It includes addition polymers etc. which are copolymerized. However, homoaddition polymers containing only one type of cyclic olefin monomer are not preferred. Methods for producing cyclic olefin resins include hydrogenation of ring-opening metathesis polymers of norbornene compounds, copolymerization of two or more cyclic olefin monomers, and copolymerization of cyclic olefin monomers and α-olefins. There are several methods.

Among the cyclic olefin resins, the basic structure of a hydrogenated ring-opening metathesis polymer of a norbornene compound includes, for example, the following formula (I). That is, the polymer of the following formula (I) is described as a polymer in which cyclic skeletons and ethylene skeletons are alternately arranged. The cyclic skeleton in the following formula (1) is a 1,3-cyclopentylene skeleton. However, the ring-opening metathesis polymer of the norbornene compound itself does not need to be a copolymer.

In formula (I), n is an integer of 1 or more, and R ¹ and R ² represent a hydrogen atom or an alkyl group. R ¹ and R ² may be the same or different. R ¹ and R ² may be bonded to each other to form a ring.

In the structure shown in the above formula (I), the substituents R ¹ and R ² of the n 1,3-cyclopentylene skeletons are the same, and the ring-opening metathesis polymer of the norbornene compound is a homopolymer (homopolymer). polymer).

The structure represented by the above formula (I) may be a hydrogenated ring-opening metathesis polymer of two or more norbornene compounds. An example of such a polymer is the following formula (II).

In formula (II), m and n are integers of 1 or more, and R ¹ and R ² represent a hydrogen atom or an alkyl group. m and n may be the same or different. R ¹ and R ² may be the same or different. R ¹ and R ² may be bonded to each other to form a ring.

Specific examples of hydrogenated ring-opening metathesis polymers of norbornene compounds include ZEONEX (registered trademark) series and ZEONOR (registered trademark) series manufactured by Zeon Corporation.

Moreover, as an addition polymer obtained by copolymerizing a cyclic olefin monomer and an acyclic olefin monomer, the following formula (III) can be mentioned. The addition polymer of the following formula (III) is described as a polymer in which a cyclic skeleton and an ethylene skeleton are randomly arranged. The cyclic skeleton of the following formula (I1I) is a 2,3-norbornanylene skeleton.

In formula (III), m and n are integers of 1 or more, and R ¹ , R ² and R ³ represent a hydrogen atom or an alkyl group. m and n may be the same or different. R ¹ , R ² and R ³ may be the same or different. R ¹ and R ² may be bonded to each other to form a ring.

Examples of polymers in which R ¹ , R ² and R ³ are all hydrogen atoms include TOPAS (registered trademark) manufactured by Polyplastics Co., Ltd., and the like. Examples of polymers in which R ¹ and R ² are alkyl groups and R ³ is a hydrogen atom include, for example, APEL (registered trademark) manufactured by Mitsui Chemicals, Inc.

These cyclic olefin resins have excellent water vapor barrier properties and are easily available. As described above, the laminated film 110A can use these cyclic olefin resins as the main component of the barrier layer 112. The barrier layer 112 may contain one type of cyclic olefin resin, or may contain two or more types of cyclic olefin resin.

Here, the two or more types of cyclic olefin resins may be two or more types of cyclic olefin resins that correspond to any one of the above formulas (I) to (III), or may be two or more types of cyclic olefin resins that correspond to any one of the formulas (I) to (III) above, or ) to (III) may each have one or more cyclic olefin resins. The two or more types of cyclic olefin resins may further include cyclic olefin resins that do not correspond to the above formulas (I) to (III).

Barrier layer 112 may be the innermost layer in laminated film 110 and may be used as a sealant layer.

Commercial products of cyclic olefin resins include some of the above, but for example, ZEONEX (registered trademark) (manufactured by Nippon Zeon Co., Ltd., hydrogenated polymer of ring-opening metathesis polymer of norbornene monomer), ZEONOR (registered trademark), Trademark) (manufactured by Nippon Zeon Co., Ltd., a copolymer based on ring-opening polymerization of dicyclopentadiene and tetracyclopentadodecene), TOPAS (registered trademark) (manufactured by Polyplastics Co., Ltd., a copolymer of norbornene and ethylene), Apel (registered trademark) (manufactured by Mitsui Chemicals, Inc., a copolymer of ethylene and tetracyclododecene), Artone (registered trademark) (manufactured by JSR Corporation, a cyclic olefin containing a polar group made from dicyclopentadiene and methacrylic acid ester) resin), etc.

Barrier layer 112 may contain other resin components in addition to the cyclic olefin resin. Other resin components include polyethylene, polypropylene, polybutene, ethylene/α-olefin copolymer, ethylene/(meth)acrylic acid copolymer, ethylene/vinyl acetate copolymer, ethylene/(meth)acrylic acid ester copolymer, etc. One or more of polyolefin resins such as polymers, urethane resins, rubber resins, polyester resins, polyester urethane resins, acrylic resins, amide resins, styrene resins, silane resins, etc. It will be done. Among these, examples of the styrene resin include polystyrene, styrene acrylonitrile copolymer (SAN), and styrene elastomer. Among these, in particular, styrene-butadiene copolymer, styrene-butadiene-styrene block copolymer (SBS), styrene-isoprene copolymer, styrene-isoprene-styrene block copolymer (SIS), and hydrogenated products thereof ( For example, the barrier layer 112 preferably contains one or more components such as SEBS, SEPS, etc.), styrene-butadiene random copolymer, etc. in a range of 0.05% by mass to 20% by mass.

By containing other resin components, the barrier layer 112 improves the desired performance of the plastic container, such as impact resistance at low temperatures, maintaining transparency immediately after high-pressure steam sterilization, and improving flexibility. can be done.

The barrier layer 112 preferably contains only a cyclic olefin resin as a resin component (it may also contain non-resin additives), and may contain 100% by mass of a cyclic olefin resin (it may contain no other additives). ). When the other resin components mentioned above are included, it is preferable that the cyclic olefin resin layer has the cyclic olefin resin as a main component. That is, the barrier layer 112 preferably contains one type of cyclic olefin resin or two or more types of cyclic olefin resin in a total amount of 50% by mass or more, particularly preferably 70% by mass or more. If the composition ratio of the cyclic olefin resin is low, trace components and drug components with high affinity for plastics may be adsorbed, leading to insufficient storage stability of the drug components contained therein.

(Second seal layer)
The second sealing layer 111B, like the first sealing layer 111A, contains a PE-based resin, is preferably substantially composed of a PE-based resin, and is more preferably composed of a PE-based resin. The PE resin used in the second seal layer 111B is the same as that in the first seal layer 111A, so the details will be omitted.

The laminated film 110A may have two or more of any one of the first seal layer 111A, the barrier layer 112, and the second seal layer 111B, or may have other layers.

FIG. 4 is a schematic cross-sectional view showing an example of the structure of the laminated film 110. As shown in FIG. 4, the laminated film 110B includes a barrier layer 112, a first seal layer 111A, and a second seal layer 111B, which are laminated in this order from the barrier layer 112 side.

The laminated films 110A and 110B have three layers: a first sealing layer 111A, a second sealing layer 111B, and a barrier layer 112, but as described above, a plurality of any of these layers may be provided. For example, the laminated film 110A may include five layers in which the first seal layer 111A, the barrier layer 112, the second seal layer 111B, the barrier layer 112, and the first seal layer 111A are laminated in this order. The laminated film 110B may include five layers in which a barrier layer 112, a first seal layer 111A, a second seal layer 111B, a first seal layer 111A, and a second seal layer 111B are laminated in this order.

The materials constituting each layer constituting the laminated film 110, that is, the sealing layer, the barrier layer, etc., have safety and hygiene properties in order to improve the appearance of the container, stabilize quality, and provide other required performance. Various additives such as antioxidants, ultraviolet absorbers, antistatic agents, lubricants, and antiblocking agents may be contained within the range that does not impair the properties.

The thickness of each layer of the seal layer and the barrier layer is appropriately designed depending on the use of the container formed using the laminated film 110. For example, the thickness of the seal layer may be 90 μm to 170 μm, and the thickness of the barrier layer may be 15 μm to 30 μm.

The method for molding each layer constituting the laminated film 110 is not particularly limited, but a T-die molding method, an inflation molding method, etc. can be used. When using the T-die molding method, after T-die molding, each layer constituting the laminated film 110 may be formed into a film (sheet) or the like, and then rapidly cooled with a cooling roll. When continuously molding the films of each layer constituting the laminated film 110, it is preferable to wind up the elongated molded body such as the film of each layer constituting the laminated film 110 after molding, since productivity is excellent. .

The laminated film 110 may have other layers laminated thereon as necessary, such as a sealant layer and a base material. That is, an adhesive layer or an anchor layer may be interposed between each layer, or the layers may be laminated so that they are in direct contact with each other. As other layers, one layer or a plurality of layers such as a reinforcing layer, a gas barrier layer, a light shielding layer, a printing layer, etc. can be selected as appropriate. The sealant layer is a layer used for heat sealing, and is placed as the innermost layer of the packaging material in contact with the contents. Heat sealing is a method of bonding by melting a sealant layer, but the sealing method is not particularly limited, and examples include hot plate sealing, ultrasonic sealing, high frequency sealing, impulse sealing, and the like. The base material may be on the other outermost surface of the laminate opposite to the sealant layer, or may be laminated inside the other outermost surface.

The total thickness of the laminated film 110 can be designed as appropriate, and is preferably, for example, 150 μm to 300 μm from the viewpoint of balance between required performance (transparency, flexibility) and cost (productivity, material cost). More preferably 190 μm to 250 μm.

The method for manufacturing the laminated film 110 is not particularly limited, and each layer constituting the laminated film 110 may be appropriately laminated by an extrusion lamination method, a dry lamination method, a coextrusion method, or a combination of two or more of these methods. do it.

As shown in FIG. 4, the laminated film 110 includes a first seal layer 111A, a second seal layer 111B, and a barrier layer 112, which are laminated in this order. In this case, the thickness of the barrier layer 112 that functions as a sealant layer is appropriately designed depending on the use of the container formed using the laminated film 110, and is not particularly limited, but may be, for example, 5 μm to 150 μm, preferably 70 μm to 100 μm. It is.

When manufacturing the laminated film 110, as shown in FIGS. 3 and 4, when the laminated film 110 laminates three layers, the first sealing layer 111A, the second sealing layer 111B, and the barrier layer 112, by a co-extrusion method, these three layers They can be laminated without intervening an adhesive layer or an anchor layer.

[port]
As shown in FIGS. 5 and 6, the port 20 has a hollow port body 21, a connecting portion 22 provided on the side surface of the port body 21, and joined to the opening 13 of the bag body 10, and has an axial direction. It has a through hole 23 in it. The port body 21 and the connecting portion 22 may be integrally formed.

The port body 21 is formed into a cylindrical shape. The port main body 21 has two flange portions 211A and 211B above the side surface connection portion 22 (in the upward direction in FIG. 5), and a cap (not shown) is welded to the port body 21.

The connecting portion 22 has a flat surface in at least a portion of the portion that contacts the opening 13 . As shown in FIGS. 5 and 6, the connecting portion 22 is formed into a diamond shape when viewed from above of the port 20, and has four flat surfaces 221. As shown in FIGS.

A pair of corner portions 222 facing each other in the short axis direction may be curved. It is preferable that the pair of corners 222 have a small curvature. In other words, it is preferable that the pair of corner portions 222 be not acute, but gentle, and not sharp. If the curvature of the pair of corner parts 222 is small, it will be a gentle curve, so when the connecting part 22 and the laminated film 110 are welded together without creating a gap, and when sterilized, the laminated film 110 will be deformed and wrinkled. etc. can be made less likely to occur.

A pair of corners 223 facing each other in the long axis direction may be acute angles because these are positions where the facing laminated films 110 are bonded and sealed.

The connecting portion 22 may have a plurality of (four in FIG. 5) slits 221a on each of the four planes 221.

The port 20 can be made of synthetic resin. As a material for forming the port 20, for example, a general thermoplastic resin that can be welded to the laminated film 110 can be used.

An example of a method for manufacturing the heat treatment bag 1 will be described. The sealing layers or barrier layers serving as sealant layers of a set of laminated films 110 constituting the packaging bag are faced to each other, and the outer periphery other than the opening 13 to which the port 20 is welded is welded. It is preferable that the connecting portion 22 of the laminated film 110 and the port 20 be heat-sealed and welded using the port 20 made of a resin that can be heat-sealed to the seal layer or barrier layer of the laminated film 110. When heat-sealing the laminated film 110 and the connecting portion 22, the connecting portion 22 of the port 20 is placed in the opening 13 of the bag body 10 and heat-sealed with the inner surface of the opening of the bag body 10. Thereby, the bag 1 for heat treatment is obtained.

As described above, the heat treatment bag 1 according to the present embodiment has the bag body 10 and the port 20, and the port 20 has the connection part 22 welded to the opening 13 of the bag body 10. The connecting portion 22 has a flat surface in at least a portion of the portion that contacts the opening 13 of the bag body 10. At least a part of the connection part 22 that contacts the opening 13 is made flat, and by reducing the curved part in the part welded to the opening 13, the bag 1 for heat treatment can be connected to the opening 13 of the laminated film 110. When welding the connecting portion 22 to the opening portion 13, bending and deflection of the laminated film 110 constituting the opening portion 13 can be suppressed. As a result, even if the bag body 10 is heated and the laminated film 110 becomes soft when the bag 1 for heat treatment is sterilized, the laminated film 110 constituting the opening 13 welded to the connection part 22 will not be bent or the like. Deformation is less likely to occur, and folding and wrinkles can be suppressed. Therefore, even if the heat treatment bag 1 is cooled to room temperature and stress is applied due to shrinkage of the laminated film 110 with few or almost no folds or wrinkles occurring in the laminated film 110 forming the opening 13, Expansion of folds and wrinkles is suppressed. Therefore, the heat treatment bag 1 can reduce the occurrence of folds and wrinkles in the bag body 10 welded to the port 20 during sterilization.

Incidentally, folds and wrinkles in the laminated film 110 can be used as an indicator of the possibility of breakage (cracks) occurring in the resin layer constituting the laminated film 110, especially the barrier layer, especially if the appearance has changed to white. This can be used as an indicator to determine whether the resin layer, especially the barrier layer, is broken by observing the appearance.

When a general cylindrical port is used, the laminated film constituting the opening 13 will be bent and pasted to the port, so the laminated film constituting the opening 13 will be pasted in a bent state. It is easily bent and wrinkled. When the bag 1 for heat treatment is cooled to room temperature in a state where folds and wrinkles have occurred in the laminated film constituting the opening 13, stress is applied due to shrinkage of the laminated film 110, etc., and the folds and wrinkles expand, and, for example, As shown in FIG. 7, a portion of the barrier layer constituting the laminated film 110 tends to break.

The heat treatment bag 1 can prevent the laminated film 110 of the bag body 10 welded to the port 20 from being folded or wrinkled during sterilization. It is possible to reduce the occurrence of breakage (cracks) in the Thereby, the heat treatment bag 1 can suppress changes in appearance before and after sterilization treatment, and can maintain barrier properties.

In the bag 1 for heat treatment, the welded portion 22 can be formed in a diamond shape when viewed from above of the port 20, and a pair of opposing corners may be curved. As a result, the connecting portion 22 has four flat surfaces in the portion that contacts the opening 13, and the curved portion in the portion welded to the opening 13 can be reduced, so that the opening welded to the connecting portion 22 It is possible to make the laminated film 110 constituting the film 13 less susceptible to deformation such as bending, thereby further suppressing the occurrence of folds and wrinkles. Therefore, the heat treatment bag 1 can further reduce the occurrence of folds and wrinkles in the bag body 10 welded to the port 20 during sterilization.

The heat treatment bag 1 can have a sealing layer made of polyethylene resin. Polyethylene resin has flexibility and can have high adhesion to the cyclic polyolefin resin contained in the barrier layer, so the laminated film 110 constituting the opening 13 welded to the connection part 22 does not suffer from bending or the like. Even if deformation occurs, it is possible to prevent a gap from forming between the seal layer and the barrier layer and to prevent the seal layer from cracking, thereby further suppressing the occurrence of folds and wrinkles. Therefore, the heat treatment bag 1 can further reduce the occurrence of folds and wrinkles in the bag body 10 welded to the port 20 during sterilization.

The heat treatment bag 1 can have a barrier layer made of a cyclic polyolefin resin. The cyclic polyolefin resin has high barrier properties and can be used as the sealant layer as the innermost layer in the laminated film 110. Therefore, the heat treatment bag 1 can increase the number of layer configurations of the laminated film 110 and can reliably suppress leakage of contents to the outside.

Even if the bag 1 for heat treatment is heated during sterilization, folding and wrinkles can be reduced in the laminated film 110 that constitutes the opening 13 to which the port 20 is welded. It can be suitably used as a bag for sterilization treatment heated to .

Since the heat treatment bag 1 has the above-mentioned characteristics, it can be suitably used as a bag to be sterilized, such as a medicinal solution bag containing a medicinal solution containing a drug or nutritional supplement, an infusion solution, etc. .

In the present embodiment, the connecting portion 22 of the port 20 has a substantially rhombic shape in plan view, but may be formed in another shape such as a substantially triangular shape.

Although the embodiments have been described as above, the embodiments are presented as examples, and the present invention is not limited to the embodiments described above. The embodiments described above can be implemented in various other forms, and various combinations, omissions, substitutions, changes, etc. can be made without departing from the gist of the invention. These embodiments and their modifications are included within the scope and gist of the invention, as well as within the scope of the invention described in the claims and its equivalents.

Hereinafter, the embodiments will be described in more detail by showing examples, but the embodiments are not limited to these examples.

<Example 1>
[Preparation of heat treatment bag]
(Preparation of laminated film)
A composition for forming a first seal layer, a composition for forming a second seal layer, and a composition for forming a barrier layer, which are used to prepare each layer constituting the laminated film, were prepared.

(1) Preparation of first seal layer forming composition Metallocene-based linear low-density polyethylene (LLDPE, Nipolon-Z, manufactured by Tosoh Corporation, MFR: 1.4 g/10 min, density: 0.915 g/cm ³ , bending Elastic modulus: 170 MPa, tensile strength: 17 MPa, tensile elongation: 420%, melting peak temperature 128°C) and metallocene linear low density polyethylene (LLDPE, Nipolon-Z, manufactured by Tosoh Corporation, MFR: 1.1 g/10 min) , density: 0.930 g/cm ³ , flexural modulus: 360 MPa, tensile strength: 21 MPa, tensile elongation: 460%, melting peak temperature 130°C) in equal amounts was used as the first seal layer forming composition. Using.

(2) Preparation of second seal layer forming composition A mixture of two types of metallocene LLDPEs similar to the first seal layer forming composition was used as the second seal layer forming composition.

(3) Preparation of composition for forming barrier layer Cyclic olefin polymer (COP) 1 (ZEONOR (registered trademark), manufactured by Zeon Corporation, density 1.02 g/cm ³ , glass transition temperature: 136°C), Olefin polymer (COP) 2 (ZEONEX (registered trademark), manufactured by Zeon Corporation, density 1.02 g/cm ³ , glass transition temperature: 136°C) was blended in a ratio of 70% by mass: 30% by mass. A composition for forming a cyclic olefin resin layer was prepared.

(4) Production of laminated film Using a T-die multilayer film forming machine, the composition for forming the first seal layer, the composition for forming the second seal layer, and the composition for forming the barrier layer were coextruded into the first layer. A laminated film was produced in which a sealing layer, a barrier layer, and a second sealing layer were laminated in this order. The thicknesses of the first seal layer, barrier layer, and second seal layer were 70 μm, 25 μm, and 155 μm.

The composition of each layer of the first seal layer, barrier layer, and second seal layer constituting the laminated film is the composition for forming the first seal layer, the composition for forming the barrier layer, and the composition for forming the second seal layer, respectively. corresponds to the composition of

(Preparation of bag body)
Using the manufactured laminated film, the first sealing layer, which is the innermost layer, is superimposed on each other, and the outer periphery of the laminate is heat-sealed, excluding the opening, to create a bag body with external dimensions of 242 mm x 131 mm and volume: 310 mL. A pouch was made.

(Preparation of bag for heat treatment)
After trimming the bag body so that the outer periphery seal width is 5 mm, the port 1 having the shape shown in Fig. 5 (a molded product molded using high-density polyethylene (HDPE), approximately diamond in plan view) is placed at the opening of the bag body. A bag for heat treatment was produced by welding the welded part of the bag (with a rounded corner on the short axis side). Six heat treatment bags were produced, and the six heat treatment bags were designated as Examples 1-1 to 1-6. When the produced bags for heat treatment were evaluated in order, they were designated as Examples 1-1 to 1-6 in the order of evaluation. When the produced heat treatment bags were evaluated at the same time, Examples 1-1 to 1-6 were given in the order in which they were taken out.

[Evaluation of appearance after sterilization]
The six heat treatment bags prepared were placed in a high-pressure steam sterilizer and sterilized under the following sterilization conditions. After sterilization, remove the heat treatment bag from the high-pressure steam sterilizer, quickly lower the temperature of the pouch with cooling water, and check for folds and wrinkles near the welded part of the port of the heat treatment bag after sterilization. Each was observed and evaluated based on the following evaluation conditions. Further, FIG. 8 shows a partially enlarged view of the appearance of the bag body of Example 1-1. In addition, folds and wrinkles can be used as indicators that there is a possibility of breakage (cracks) occurring in the barrier layer that makes up the laminated film, and in particular, if the color changes to white in appearance, it is a sign that the barrier layer has broken. It can be used as an indicator.
(Sterilization conditions)
・Sterilization conditions 1: 121℃, 16 minutes (evaluation conditions)
A: There are no folds or wrinkles.
B: There are some folds and wrinkles, but the white color cannot be visually confirmed and does not affect the product.
C: There are folds and wrinkles, and the white color can be visually confirmed, which is a problem as a product.

Table 1 shows the layer structure of the package of the heat treatment bag, the type of port, and the observation results of the presence or absence of folds and wrinkles near the welded portion of the port after the heat treatment bag was sterilized.

<Example 2>
Example 1 was carried out in the same manner as in Example 1, except that sterilization condition 1 was changed to sterilization condition 2 below, and six heat treatment bags were prepared in Examples 2-1 to 2-6. did. Table 2 shows the layer structure of the package of the heat treatment bag, the type of port, and the observation results of the presence or absence of folds and wrinkles near the welded portion of the port after the heat treatment bag was sterilized.
(Sterilization conditions)
・Sterilization conditions 2: 1st time (123°C, 1 minute), 2nd time (121°C, 16 minutes)

<Example 3>
Example 1 was carried out in the same manner as in Example 1, except that sterilization condition 1 was changed to sterilization condition 3 below, and six heat treatment bags were prepared in Examples 3-1 to 3-6. did. Table 3 shows the layer structure of the package of the heat treatment bag, the type of port, and the observation results of the presence or absence of folds and wrinkles near the welded portion of the port after the heat treatment bag was sterilized.
(Sterilization conditions)
・Sterilization conditions 3: 1st time (123°C, 1 minute), 2nd time (121°C, 20 minutes)

<Example 4>
Example 1 was carried out in the same manner as in Example 1, except that sterilization condition 1 was changed to sterilization condition 4 below, and six heat treatment bags were prepared in Examples 4-1 to 4-6. did. Table 4 shows the layer structure of the package of the heat treatment bag, the type of port, and the observation results of the presence or absence of folds and wrinkles near the welded portion of the port after the heat treatment bag was sterilized.
(Sterilization conditions)
・Sterilization condition 4: 1st time (sterilization condition 2), 2nd time (sterilization condition 3)

<Comparative example 1>
In Example 1, the process was carried out in the same manner as in Example 1, except that the type of port welded to the opening of the bag body was changed from port 1 to port 2 formed in a cylindrical shape as shown in FIG. Eight bags for heat treatment were designated as Comparative Examples 1-1 to 1-8. Table 5 shows the layer structure of the package of the heat treatment bag, the type of port, and the observation results of the presence or absence of folds and wrinkles near the welded portion of the port after the heat treatment bag was sterilized. In addition, FIG. 10 shows a partially enlarged view of the external appearance of the bag body of Comparative Example 1-1, FIG. 11 shows a partially enlarged view of FIG. 10 (dotted line), and FIG. Fig. 12 shows a partially enlarged view of the part).

From Tables 1 to 4, in each Example, no folds or wrinkles were observed near the welded portion of the port of the heat treatment bag even after each sterilization treatment. Further, in any of the Examples, no folds or wrinkles were observed in the laminated films near the welded portions of the ports of the six heat treatment bags that were sterilized under the same sterilization conditions.

On the other hand, in Comparative Example 1, folds and wrinkles were observed in the laminated film near the welded parts of the ports of 4 of the 8 heat-treated bags that were sterilized under the same sterilization conditions, and Many areas were observed to have discolored to white. As a result of observing the folded and wrinkled white parts of the laminated film under a microscope, cracks in the barrier layer were confirmed.

Therefore, the bag for heat treatment of each example was made using a laminated film using LLDPE as a seal layer and COP as a barrier layer. By welding the port 1 having the adhesive portion, it is possible to reduce the rate at which folds and wrinkles occur in the laminated film near the welded portion of the port. Therefore, when the heat treatment bag of each example is used as a drug solution bag, the bag body constituting the drug solution bag can be prevented from folding or wrinkling near the welded part of the port even after sterilization. It can be said that it can be stored stably for a long period of time and maintain its function as a drug solution bag.

1 Bag for heat treatment 10 Bag body 11 Seal portion 12 Storage chamber 13 Opening portion 20 Port 21 Port body 22 Connection portion 110, 110A, 110B Laminated film 111A First seal layer 111B Second seal layer 112 Barrier layer

Claims (7)

A sealing portion in which a laminated film in which a sealing layer containing a polyethylene resin as a main component and a barrier layer containing a cyclic polyolefin resin as a main component are laminated so as to face each other and their outer peripheral edges are welded to each other. , a bag body having a storage chamber that is defined by the laminated film and the seal portion and stores the contents, and an opening in which the outer peripheral edges of the facing laminated films are not welded to each other;
a port having a welded part welded to the opening;
Equipped with
The bag for heat treatment has a flat surface in at least a part of the welded part that contacts the opening. 2. The heat treatment bag according to claim 1, wherein the welded portion is formed in a rhombic shape when viewed from the top of the port, and a pair of opposing corners are curved. The bag for heat treatment according to claim 1 or 2, wherein the sealing layer is made of polyethylene resin. The bag for heat treatment according to any one of claims 1 to 3, wherein the barrier layer is made of a cyclic polyolefin resin. The bag for heat treatment according to any one of claims 1 to 4, which is sterilized at 120°C or higher. The bag for heat treatment according to any one of claims 1 to 5, wherein the contents are pharmaceuticals. The heat treatment bag according to claim 6, wherein the heat treatment bag is a chemical solution bag.

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