JP2023087017A - Composition for scalp and hair - Google Patents

Abstract

To provide compositions for scalp and hair.SOLUTION: Provided is a composition for scalp and hair, the composition containing (A) Aloe extract, and (B) Hypericum erectum extract, or containing (A) Aloe extract, (B)Hypericum erectum extract, and (C) Zingiber officinale extract.SELECTED DRAWING: None

Description

The present invention relates to a scalp and hair composition.

Aloe extract has been known to have many actions. In particular, as effects of aloe extract on the scalp and hair, dermal papilla activating action (Patent Document 1), VEGF production promoting action (Patent Documents 2 and 3), etc. are conventionally known. is expected. In particular, aloe extract is a plant-derived component that has been applied to the skin for a long time and has been confirmed to be safe for the human body.

JP-A-11-240823 JP 2013-144650 A JP 2015-34157 A

An object of the present invention is to provide a scalp and hair composition. An object of the present invention is to provide a scalp and hair composition in which the hair growth promoting effect of an aloe extract, preferably prepared from one type of aloe plant, is enhanced. More specifically, the object of the present invention is to provide a scalp and hair composition that has a hair growth promoting effect, an anti-hair loss effect, an anti-dandruff effect and/or an effect of moisturizing the scalp.

The inventors of the present invention have made intensive studies to solve the above problems, and found that the hair growth promoting effect of the aloe extract was further enhanced by combining the aloe extract with the Hypericum perforatum extract, which is also a plant-derived component. Furthermore, it was found that the effect is further enhanced by using an aloe extract prepared from two or more kinds of aloe plants as the aloe extract and/or by using it in combination with a ginger extract. , have completed the present invention. The present invention has been completed based on these findings, and includes the following embodiments.

(I) Scalp and hair composition (I-1) Scalp and hair containing (A) aloe extract and (B) hypericum perforatum extract, or (A) aloe extract, (B) hypericum perforatum extract and (C) ginger extract composition.
(I-2) The scalp and hair according to (I-1), wherein the (A) aloe extract is an extract of at least one aloe plant selected from the group consisting of aloe vera, aloe vera, and aloe tormentosa. composition.
(I-3) The (A) aloe extract is an extract of at least two aloe plants selected from the group consisting of aloe vera, aloe vera, and aloe tormentosa (I-1) or (I-2) ).
(I-4) Used for at least one application selected from the group consisting of hair growth promotion (including hair nourishing and hair growing), hair loss prevention, dandruff prevention, and scalp moisturizing, (I- 1) A composition for scalp and hair according to any one of (I-3).

(II) Method for imparting or enhancing action such as hair growth promoting action to composition for scalp and hair (II-1) (A) Aloe extract and (B) Hypericum perforatum extract, or (A) Aloe extract and (B) Hypericum perforatum extract, and (C) ginger extract, selected from the group consisting of hair growth promoting action, hair loss preventing action, dandruff preventing action, and scalp moisturizing action on the scalp and hair composition, which has a step of blending the ginger extract with the composition for scalp and hair. method of imparting at least one action to be obtained or enhancing said at least one action possessed by said composition for scalp and hair.
(II-2) The method according to (II-1), wherein the (A) aloe extract is an extract of at least one aloe plant selected from the group consisting of aloe vera, aloe vera, and aloe tormentosa.
(II-3) The (A) aloe extract is an extract of at least two aloe plants selected from the group consisting of aloe vera, aloe vera, and aloe tormentosa (II-1) or (II-2) ).

INDUSTRIAL APPLICABILITY According to the present invention, it is possible to provide a scalp and hair composition that has a hair growth promoting effect and is friendly to the human body. In particular, the scalp and hair composition of the present invention containing an aloe extract prepared from two or more kinds of aloe plants and a Hypericum perforatum extract exerts an excellent effect of promoting hair growth, and an effect of lengthening and/or thickening the hair. and can contribute to increasing the volume of hair. Furthermore, according to the composition for scalp and hair of the present invention, which further contains ginger extract in addition to these, in addition to the effect of promoting hair growth, the effect of preventing hair loss, the effect of preventing dandruff, and/or the effect of imparting moisture to the scalp is excellent. ing. The composition for scalp and hair of the present invention is useful as a hair-restoring or hair-nourishing composition for those who are concerned about thinning hair at present or in the future.

The results of the questionnaire evaluation conducted in Test Example 3 are shown. Box plots (quartiles) showing the effects of the composition for scalp and hair of the present invention (Example 3) on (a) overall hair volume, (b) hair loss, (c) scalp moisture, and (d) dandruff number). In each figure, the top of the whiskers is the maximum value of the questionnaire evaluations of all 24 subjects, the bottom of the whiskers is the minimum value of the questionnaire evaluations of all the subjects, and the top of the box (third quartile) is 3/4 of all the subjects. part (75th percentile), the center of the box (2nd quartile) is 2/4 of the total (50th percentile), the bottom of the box (1st quartile) is 1/4 of all ( 25th percentile).

(I) Composition for Scalp and Hair The composition for scalp and hair of the present invention contains (A) aloe extract and (B) hypericum perforatum extract, or (A) aloe extract, (B) hypericum perforatum extract, and (C) ) characterized by containing ginger extract. These components are described below.

(A) Aloe extract The aloe plant used as a raw material for the aloe extract used in the present invention is not particularly limited as long as it exhibits the effects of the present invention. In addition to the effects of the present invention, for reasons such as safety, ease of cultivation, availability, and approval for use in the Japanese Pharmacopoeia, Aloe vera (scientific name: Aloe arborescens) and Aloe Vera (scientific name: Aloe vera), Aloe tomentosa, Aloe eru, Aloe cameronii, Aloe kedongensis, Aloe Ferox (scientific name: Aloe ferox), Aloe africana (scientific name: Aloe africana), Aloe andongensis (scientific name: Aloe andongensis), etc. can be mentioned. In addition, these aloe plants include similar species and improved species of the plant. One of these plants can be used as a raw material for an aloe extract, but two or more of them are preferably used in combination. Preferable aloe plants are aloe vera, aloe vera, and aloe tormentosa. In particular, it is preferable to use a combination of two or more arbitrarily selected from among these three types of aloe plants as a raw material for an aloe extract. Preferred combinations are aloe vera and aloe vera, aloe vera and aloe tomentosa, and aloe vera and aloe tomentosa.

For the preparation of the aloe extract, the whole aloe plant described above may be used as it is. Alternatively, the outer skin of an aloe leaf may be used, or the jelly inside the leaf may be used. Although not limited, it is preferable to use the whole aloe plant to prepare the aloe extract because it is easy to prepare.

For the preparation of an aloe extract, the whole or part of an aloe plant (e.g., leaves, stems, roots, etc.) may be fresh (undried), dried (dried), or frozen. (Frozen) can be used. In addition, undried, dried or frozen aloe plants can also be pulverized into a suitable size and powdered.

Methods for preparing an aloe extract include, but are not limited to, a method combining an extraction step and a separation step, and a method combining the above method with a fractionation step.

The extraction step is a step of extracting components necessary as an aloe extract from the aloe plant using an extraction solvent, and the extraction method and extraction conditions are not particularly limited.

The type of extraction solvent is not particularly limited as long as the effects of the present invention can be obtained, but examples include water, organic solvents, and mixed solvents thereof. Here, the water includes water at all temperatures such as cold water, room temperature water, hot water, hot water and steam, and may be sterilized, ion exchanged, osmotically adjusted or buffered. As the organic solvent, a hydrophilic organic solvent is preferable. Propylene glycol, 1,3-butylene glycol, etc.), esters (methyl acetate, etc.), ketones (acetone, etc.), etc. can be used. These organic solvents may be used alone or in combination of two or more.

In the present invention, it is preferable to use at least one extraction solvent selected from the group consisting of water, ethanol, and 1,3-butylene glycol from the viewpoint of safety and extraction efficiency of the active ingredient. Suitable extraction solvents include a mixture of water and ethanol and a mixture of water and 1,3-butylene glycol. When using these water-containing mixtures, the ratio of ethanol or 1,3-butylene glycol in the water-containing mixture is not limited, but in the case of ethanol, it is about 5 to 95% by mass, preferably about 50 to 90% by mass. , and more preferably about 60 to 80% by mass. In the case of 1,3-butylene glycol, it is about 5 to 70% by mass, preferably about 10 to 60% by mass, more preferably about 10 to 50% by mass.

As an extraction method, a conventional method can be used, and examples thereof include immersion extraction, stirring extraction, reflux extraction, shaking extraction, ultrasonic extraction and the like. Also, as extraction conditions, conventional methods can be used, and examples thereof include room temperature extraction, heating extraction (also referred to as heating extraction), pressurized extraction, supercritical extraction, and the like. Room temperature or heat extraction is preferred. Extraction time is not particularly limited. Also, the pH may be adjusted during the extraction. The above extraction operation may be performed once, or may be performed by repeating extraction of the extraction residue obtained after performing the extraction operation a plurality of times. Furthermore, before and after the extraction step, a solid-liquid separation treatment such as filtration, which will be described later, may be performed as necessary.

The separation step is a solid-liquid separation method for separating the extract and the insoluble matter, which is the extraction residue, from the extract obtained above. A method such as chromatography or the like using an adsorbent or an absorbent may be used. The extract separated from the liquid extract may be used as it is, or may be further purified by fractionation or the like, if necessary.

The fractionation step is a method of fractionating, purifying and concentrating fractions that exhibit the effect of the present invention from the extract obtained above. Methods used in the fractionation step include chromatography using activated carbon, anion exchange resin, cation exchange resin, silica gel, polystyrene resin that adsorbs aromatic compounds, etc. as a carrier, dialysis, molecular sieve, vacuum concentration, Examples include, but are not limited to, methods such as freeze-drying. Furthermore, after this step, a step of recovering the supernatant by centrifugation or the like may be performed as necessary.

In addition, before and after each of the above steps, a treatment such as filtration may be performed as necessary. Gauze, a filtration filter, a commercially available filter, or the like can be used for filtration. Moreover, sterilization treatment etc. can be performed as needed.

The aloe extract prepared by the above method may have a liquid form as it is, but is then subjected to a drying process such as spray drying, vacuum drying, or freeze drying so as to have a solid form. can be prepared. Furthermore, by performing pulverization treatment or granulation treatment as necessary, it can be prepared so as to have a powdery or granular form.

The content of the aloe extract contained in the composition for scalp and hair of the present invention can be appropriately selected from the range of 0.01 to 80% by mass as the extract so as to exhibit the effects of the present invention. It is preferably 0.1 to 70% by mass, more preferably 1 to 20% by mass, particularly preferably 1 to 10% by mass. The dry solid content is 0.0001 to 0.8% by mass, preferably 0.001 to 0.7% by mass, more preferably 0.01 to 0.2% by mass, particularly preferably 0.01 to 0.01% by mass. .1% by mass can be exemplified.

(B) Hypericum perforatum extract The Hypericum perforatum plant as a raw material for the Hypericum perforatum extract used in the present invention is not particularly limited as long as the effects of the present invention are exhibited. As with the aloe plant described above, in addition to the effects of the present invention, it is safe, easy to cultivate, easy to obtain, and is approved for use in the Japanese Pharmacopoeia. (Hypericum erectum) or Hypericum perforatum (Hypericum perforatum). St. John's wort is preferred. These Hypericum perforatum plants include allogeneic species and improved species of the plant. One of these plants can be used as a raw material for the Hypericum perforatum extract, but two or more of them can also be used in combination, if necessary.

For the preparation of the Hypericum perforatum extract, the whole Hypericum perforatum plant described above may be used as it is. Hypericum perforatum flowers may also be used.

For the preparation of the Hypericum perforatum extract, the whole or part of the Hypericum perforatum plant (e.g., flowers) in a fresh state (undried matter), dried (dried matter), or frozen (frozen matter) can be used. In addition, undried, dried or frozen products of Hypericum perforatum can also be pulverized into a suitable size and powdered.

Methods for preparing the Hypericum perforatum extract include, but are not limited to, a method in which an extraction step and a separation step are combined, a method in which the above method is further combined with a fractionation step, and the like. The details are the same as the method for preparing the aloe extract described above. The Hypericum perforatum extract thus prepared may have a liquid form as it is, but is then subjected to a drying process such as spray drying, vacuum drying, or freeze drying so as to have a solid form. can be prepared. Furthermore, by performing pulverization treatment or granulation treatment as necessary, it can be prepared so as to have a powdery or granular form.

The content of the Hypericum perforatum extract contained in the composition for scalp and hair of the present invention can be appropriately selected and set from the range of 0.0001 to 40% by mass as the extract so as to exhibit the effects of the present invention. It is preferably 0.001 to 35% by mass, more preferably 0.001 to 20% by mass, and particularly preferably 0.001 to 10% by mass. The dry solid content is 0.000001 to 0.4% by mass, preferably 0.00001 to 0.35% by mass, more preferably 0.00001 to 0.2% by mass, particularly preferably 0.00001 to 0.00001% by mass. It is 0.1% by mass. The ratio of (B) Hypericum perforatum extract to 1 part by mass of (A) aloe extract contained in the composition for scalp and hair can be in the range of 0.00000125 to 4000 parts by mass in terms of extract/solid.

(C) Ginger Extract As a ginger plant that is a raw material for the ginger extract used in the present invention, Zingiber officinale (scientific name: Zingiber officinale) can be mentioned. The ginger plant includes similar species and improved species of the plant as long as the effect of the present invention is exhibited. These plants can be used singly as raw materials for the ginger extract, but if necessary, they can be used in combination of two or more.

For the preparation of the ginger extract, the whole ginger plant described above may be used as it is. Ginger roots, rhizomes, stems or leaves can also be used.

For the preparation of ginger extract, whole or part of the ginger plant (e.g., rhizomes or stems and leaves) may be fresh (undried), dried (dried), or frozen (frozen). things) can be used. Alternatively, undried, dried or frozen ginger plants may be pulverized into a suitable size and powdered.

Methods for preparing the ginger extract include, but are not limited to, a method combining an extraction step and a separation step, and a method combining the above method with a fractionation step. The details are the same as the method for preparing the aloe extract described above. Extracts prepared by extracting dried ginger rhizomes with ethanol or hydrous ethanol are called ginger tinctures. The ginger tincture is a preferred embodiment of the ginger extract targeted by the present invention.

The ginger extract thus prepared may have a liquid form as it is, but is then subjected to a drying process such as spray drying, vacuum drying, or freeze drying so as to have a solid form. can be prepared. Furthermore, by performing pulverization treatment or granulation treatment as necessary, it can be prepared so as to have a powdery or granular form.

The content of the ginger extract contained in the composition for scalp and hair of the present invention can be appropriately selected from the range of 0.001 to 15% by mass as the extract so as to exhibit the effects of the present invention. It is preferably 0.01 to 10% by mass, more preferably 0.05 to 10% by mass, and particularly preferably 0.05 to 5% by mass. The dry solid content is 0.00001 to 0.1
5% by mass, preferably 0.0001 to 0.1% by mass, more preferably 0.005 to 0.1% by mass, particularly preferably 0.0005 to 0.05% by mass. The ratio of (C) ginger extract to 1 part by mass of (A) aloe extract contained in the composition for scalp and hair can be in the range of 0.000000016 to 150 parts by mass in terms of extract/solid.

(D) Other Ingredients The composition for scalp and hair according to the present invention may contain the above-mentioned (A) and (B) or (A), (B) and (C) as long as the effects of the present invention are exhibited. In addition, it can contain optional ingredients that are conventionally blended in compositions for external use (compositions for transdermal administration), preferably compositions for scalp and hair. For example, as a base, water, lower alcohols, polyhydric alcohols, and fats and oils can be appropriately selected and used according to the form. Lower alcohols include alcohols having 1 to 7 carbon atoms such as methanol, ethanol, n-propyl alcohol, isopropyl alcohol, 1,3-butyl alcohol, sec-butyl alcohol, isobutyl alcohol, tert-butyl alcohol and benzyl alcohol. It can be exemplified without limitation. Polyhydric alcohols include glycerin, diglycerin, BG (1,3-butylene glycol), propanediol, PG
(propylene glycol), pentylene glycol, dipropylene glycol (DPG),
Sorbitol (sorbit), sodium DL-pyrrolidonecarboxylate and the like can be exemplified without limitation. Fats and oils include avocado oil, almond oil, fennel oil, perilla oil, olive oil, orange oil, orange rough oil, sesame oil, cacao butter, chamomile oil, carrot oil, cucumber oil, beef fatty acid, kukui nut oil, safflower oil, Shea butter, soybean oil, camellia oil, corn oil, rapeseed oil, persic oil, castor oil, cottonseed oil, peanut oil, turtle oil, mink oil, egg yolk oil, palm oil, palm kernel oil, Japanese wax, coconut oil, beef tallow, horse Oil, lard or hydrogenated products of these fats and oils, beeswax, carnauba wax, whale wax, lanolin, liquid lanolin, reduced lanolin, hard lanolin, candelilla wax, montan wax, shellac wax, rice wax, squalene, squalane, pristane, liquid paraffin, Non-limiting examples include vaseline, paraffin, ozokeride, ceresin, and microcrystalline wax.

When used as an external composition, the pH is preferably in the range of 4 to 8 for the purpose of reducing irritation to the skin. pH adjustment can be performed using a basic substance or an acidic substance. Examples of basic substances include inorganic bases such as sodium hydroxide and potassium hydroxide; organic amines such as triethanolamine and diisopropanolamine; basic amino acids such as arginine, lysine and ornithine. Examples of acidic substances include inorganic acids such as hydrochloric acid, nitric acid, methasulfonic acid, sulfuric acid, p-toluenesulfonic acid, phosphoric acid, citric acid, malic acid, tartaric acid, and succinic acid, organic acids, and salts thereof. can.

When used as a composition for external use, it is also possible to blend a pharmacologically effective adjuvant as another component. Pharmaceutical efficacy adjuvants include cooling agents such as camphor, turpentine oil, mint oil, menthol and its derivatives, eucalyptus oil, and menthyl lactate; local stimulants such as nonanoic acid vanillylamide and capsaicin; anti-inflammatory agents such as glycyrrhizic acid; antihistamines such as imidazole, diphenhydramine and its salts, and chlorpheniramine maleate; blood circulation promoters such as tocopheryl acetate and benzyl nicotinate; , Japanese pepper extract, hot pepper extract, and the like. In addition to the above ingredients, suitable active ingredients that can be used in combination (e.g., blood circulation promoter, hair follicle activator, antiseborrheic agent, antibacterial agent, etc.), thickeners, preservatives, preservatives, antioxidants, stabilizers Additives that are commonly used in compositions for transdermal administration, such as agents, chelating agents, perfumes, dyes and coloring agents, can be used as appropriate.

Form/Usage The composition for scalp and hair of the present invention can be prepared in the form of a composition for transdermal administration. Specific examples of such forms include ointments, gels, pastes, mousses, creams, lotions, sprays (sprays, aerosols), solutions, suspensions, and emulsions. (emulsion), a sheet-like agent impregnated with a liquid agent, and the like. The composition for scalp and hair of the present invention having these forms includes, for example, hair tonic, hair liquid, hair rinse, hair conditioner, hair treatment, hair lotion, hair pack, hair cream, conditioning mousse, hair mousse, hair spray, shampoo, It can also be in the form of a product such as a leave-on treatment. The composition for scalp and hair of the present invention may belong to any category of pharmaceuticals, quasi-drugs or cosmetics.

The composition for scalp and hair of the present invention can be prepared as a preparation for external use and topically administered (scalp administration). The dosage varies depending on the subject's age, gender, scalp and hair conditions (e.g., thinning hair), and cannot be uniformly specified, but as a result, it promotes hair growth and hair extension. and/or the effect of making the hair thicker can be exhibited. The dosage of the composition for scalp and hair of the present invention is preferably 0.00001 to 1 g, more preferably 0.0001 as a daily dose for adults in terms of the dry weight of (A) aloe extract contained therein. It is desirable that the amount is about 0.1 g. The administration can also be individually changed according to the condition of the scalp and hair, for example, the daily dose can be divided into several administrations.

Effect As shown in Test Examples 1 and 2 to be described later, the composition for scalp and hair of the present invention has an effect of promoting hair growth, and when applied to the scalp, it accelerates hair growth and/or And it exhibits the effect of thickening the thickness of the hair. Moreover, as shown in Test Example 3 to be described later, the composition for scalp and hair of the present invention has an action of promoting hair growth and an action of increasing the proportion of hair in the growing phase. By applying it, the percentage of hair loss is reduced and the hair thickening effect is exhibited. Thus, according to the composition for scalp and hair of the present invention, thinning hair can be prevented or improved by promoting hair growth and/or preventing hair loss. Therefore, the composition for scalp and hair of the present invention is useful as a hair nourishing agent or a hair restorer for those who are concerned about thinning hair now or in the future, regardless of gender such as male and female. Furthermore, as shown in Test Example 3 to be described later, the scalp and hair composition of the present invention is excellent in the effects of suppressing dandruff and imparting moisture to the scalp. Therefore, according to the composition for scalp and hair of the present invention, it is possible to obtain effects such as prevention of itching and prevention of dandruff in addition to hair growth and hair nourishing effects.

(II) Method for imparting or enhancing action such as hair growth promoting action to composition for scalp and hair As described above, a combination of (A) aloe extract and (B) Hypericum perforatum extract, or (A) aloe extract and (B) ) The combination of Hypericum perforatum extract and (C) Ginger extract has a hair growth promoting effect. Therefore, by adding these components to the composition for scalp and hair, the hair growth promoting effect can be imparted to the composition for scalp and hair. Moreover, when the composition for scalp and hair has a hair growth promoting action, the action can be enhanced. Here, the hair growth promoting action includes the hair elongation action evaluated by the method described in Test Example 1 and/or the hair thickening action evaluated by the method described in Test Example 2. be

(A) Aloe extract, (B) Hypericum perforatum extract, and (C) Plant bodies used as raw materials for ginger extract, method for preparing extracts from them, content ratio of each component in final composition for scalp and hair is as described in (I) above, and the description thereof can be incorporated herein. The target scalp and hair composition to which these ingredients are added and blended may be one that is applied to the scalp, such as ointments, gels, pastes, mousses, creams, lotions, sprays (sprays , aerosols), solutions, suspensions, emulsions, sheets impregnated with liquid agents, and the like. Specifically, it has product forms such as hair tonics, hair liquids, hair rinses, hair conditioners, hair treatments, hair lotions, hair packs, hair creams, conditioning mousses, hair mousses, hair sprays, shampoos, and leave-on treatments. may

Moreover, as shown in Test Example 3, the combination of (A) aloe extract, (B) hypericum perforatum extract, and (C) ginger extract, in particular, has the effect of promoting hair growth and increasing the proportion of hair in the growing phase. By applying it to the scalp, it is possible to reduce the rate of hair loss and achieve a hair-throwing effect. Therefore, by adding these components to the composition for scalp and hair, it is possible to provide the composition for scalp and hair with a hair loss prevention effect in addition to a hair growth promoting effect. In addition, when the composition for scalp and hair has a hair loss prevention action, the action can be enhanced.

Moreover, as shown in Test Example 3, the combination of (A) aloe extract, (B) hypericum perforatum extract, and (C) ginger extract, in addition to the above effects, has antidandruff action and/or scalp moisturizing action. have. Therefore, by adding these ingredients to the composition for scalp and hair, in addition to the hair growth promoting action and hair loss preventing action, the scalp and hair composition has an antidandruff action and/or a scalp moisturizing action. can be granted. Moreover, when the composition for scalp and hair has these actions, the actions can be enhanced.

As used herein, the terms "include" and "contain" include the meanings of "consisting of" and "consisting essentially of".

Hereinafter, the present invention will be described using experimental examples in order to facilitate understanding of the configuration and effects of the present invention. However, the present invention is not limited by these experimental examples. Unless otherwise specified, the following experiments were performed at room temperature (25±5° C.) and atmospheric pressure conditions. "%" means "% by mass" unless otherwise specified.

The samples used in the following experimental examples are as follows:
(1) Kidachi aloe extract:
Water-containing ethanol extract of Kidachi aloe leaves (trade name: Aloe extract <Kidachi>, manufacturer: Maruzen Pharmaceutical Co., Ltd.) (solid content 1.2%)
(2) Aloe Tormentosa Extract:
Aloe tomentosa leaves (1 kg of fresh plant body) were finely chopped and dried. After stirring for hours, filtering, and concentrating, a water-containing ethanol extract of aloe tomentosa leaves was prepared (solid content: 1%).
(3) Aloe vera extract:
Aloe vera leaf extract from a mixture of water and 1,3-butylene glycol (trade name: Biocell Act Aloe Vera B, manufacturer: Ichimaru Farcos Co., Ltd.) (solid content 0.5%)
(4) Hypericum extract:
Water-containing ethanol extract of Hypericum perforatum flowers, leaves, and stems (product name: Hypericum perforatum extract-J, manufacturer: Maruzen Pharmaceutical Co., Ltd.)
(5) Hair growth drug containing 5% minoxidil:
Product name: RiUP X5 Plus, Distributor: Taisho Pharmaceutical Co., Ltd. (6) Ginger extract:
Extract obtained by extracting dried ginger rhizome with ethanol (trade name: ginger tincture, manufacturer: Maruzen Pharmaceutical Co., Ltd.) (solid content 1%)

Test Example 1 Hair elongation effect mice (C57BL6/N mice) (female, 7-8 weeks old) were used to evaluate the hair elongation effect of various test samples.

(1) Test method
1. Mice were divided into 7 groups (Examples 1 and 2, Comparative Examples 1 and 3, and Reference Examples 1 and 2: n = 6 in each group), and hair was removed from the dorsal skin (approximately 2 cm x 3 cm) of each mouse. , reset the hair cycle of the skin to the early growth period.
2. Each test sample shown in Table 1 was applied once a day at a rate of 0.1 mL to the hair-pulled area (approximately 2 cm x 3 cm) of each group of mice for 21 days.
3. Among the hairs that grew on the 21st day after application, a few randomly selected hairs were pulled out from the hair roots using tweezers, and the collected hairs were observed using an optical microscope (manufactured by Keyence). After the image was taken, the distance from the end of the hair root to the tip of the hair shaft was measured as "hair length" by multi-point distance measurement using software (Keyence VHX-2000). The average value of the lengths of several pulled hairs was taken as the "hair length" of the mouse.

(2) Test results The results are also shown in Table 1. The measured value (μm) shown in Table 1 means the average value (n=6) of “hair length” obtained from individual mice. The length of the obtained hair shaft was compared with the result of Reference Example 1 (drug for hair growth containing 5% minoxidil), and the case longer than that was evaluated as "○: Exhibits excellent hair extension effect". , and a case shorter than that was evaluated as "x".

As shown in Table 1, with the aloe extract alone (Comparative Examples 1 and 2) and the Hypericum perforatum extract alone (Comparative Example 3), the degree of hair elongation was lower than that of Reference Example 1, but the combined use of the aloe extract and the hypericum perforatum extract Thus (Examples 1 and 2), compared with Reference Example 1, it was confirmed that the degree of hair elongation was further increased. From these results, it was found that the scalp and hair composition using both the aloe extract and the Hypericum perforatum extract is superior in not only the hair growth effect but also the hair growth promoting effect compared to the aloe extract alone or the hypericum perforatum extract alone. .

Test Example 2 Hair Thickening Effect Mice (C57BL6/N mice) (female, 7 to 8 weeks old) were used to evaluate the hair thickening effect of various test samples.

(1) Test method
1. Divide the mice into 3 groups (Example 3, Comparative Example 4, and Reference Example 1: n = 6 in each group), remove hair from the dorsal skin (2 cm x 3 cm) of each mouse, and measure the hair cycle of the skin. was reset at the beginning of the growing season.
2. Each test sample shown in Table 2 was applied once a day at a rate of 0.1 mL to the hair-pulled area (2 cm x 3 cm) of each group of mice for 21 days.
3. Among the hairs grown on the 21st day after application, a few randomly selected hairs were pulled out from the hair roots using tweezers, and the collected hairs were observed using an optical microscope (manufactured by Thermo Fisher Scientific). Then, after taking the image, print the taken image (with a scale), measure it with a ruler on paper (measure three places at random and calculate the average value), measure by scale conversion, and measure the thickness of the hair was measured. The average value of the thickness of several plucked hairs was taken as the "hair thickness" of the mouse.

(2) Test results The results are also shown in Table 2. The measured value (μm) shown in Table 2 means the average value (n=6) of “hair thickness” obtained from individual mice. The thickness of the obtained hair was compared with the results of Reference Example 1 (medicine for hair growth containing 5% minoxidil), and thicker than that was evaluated as "○: excellent in hair thickening effect". , and a case thinner than that was evaluated as "x".

As shown in Table 2, with the aloe extract alone (Comparative Example 4), the hair grown was thinner than in Reference Example 1. It was confirmed that by using the Hypericum perforatum extract and the ginger extract (Gingerweed tincture) in combination (Example 3), the thickness of the hair becomes thicker than in Reference Example 1. From these results, it can be seen that the composition for scalp and hair using a combination of aloe extract and hypericum perforatum extract, particularly the composition for scalp and hair using a combination of aloe extract, hypericum perforatum extract and ginger extract, has a higher hair growth effect and hair growth than the aloe extract alone. It was found to be excellent not only in the elongation effect but also in the effect of thickening the hair, that is, it was comprehensively excellent in the effect of promoting hair growth.

Test Example 3 Test on Human Subjects The test sample of Example 3, whose hair growth promoting effect was confirmed in Test Example 2, was applied to the human scalp, and the hair growth promoting effect was evaluated by the phototrichogram method and the questionnaire method. evaluated. These tests were conducted on 24 subjects (14 females (average age 52.1 years), 10 males (average age 46.4 years)). These test subjects are a group of people who are aware of thinning hair and who are judged to have thinning hair according to the hair loss classification by a doctor.

(A) Phototricogram method (1) Test method
1. A section of hair (1 cm x 1 cm) was shaved, and immediately after shaving and 3 days after that, the shaved section was photographed with a digital microscope (images taken before using the test sample).
2. Twice a day, after washing the hair, apply 1.25 mL of the test sample to the entire scalp including the above-mentioned shaved area, and massage the entire scalp centering on the measurement area for 24 weeks. rice field.
3. After 24 weeks of use, the same section as the section shaved before application was shaved again, and immediately after shaving and 3 days after that, the section was photographed with a digital microscope (image taken after using the test sample ).
4. From images taken before using the test sample (immediately after shaving and 3 days after) and images taken after using the test sample (immediately after shaving and 3 days after), the following two items were analyzed.

(2) Test results Table 4 shows the results.

As shown in Table 4, by applying the test sample (Example 3) to the scalp, the hair growth rate (mm/day) and anagen hair rate (%) were significantly increased compared to the case of not applying it. confirmed to rise. From these results, it was found that the composition for scalp and hair of the present invention not only has a hair elongating effect, but also has an excellent hair thickening effect by exerting an action of activating the hair in the telogen phase to the anagen phase. confirmed.

(B) Questionnaire evaluation 24 subjects (14 females, 10 males) were given their own hair (hair loss, total Volume) and the condition of the scalp (dandruff, moisture) were evaluated on an 11-point scale from 0 to 10 (0 being the worst and 10 being the best). The results are shown in FIG.
As shown in FIG. 1, by applying the test sample (Example 3) to the scalp, the volume of the entire hair increased (Fig. 1 (a)) and hair loss decreased (Fig. 1 ( b)), an increase in the moisture content of the scalp (Fig. 1(c)), and a reduction in dandruff (Fig. 1(d)) were observed. From these results, it was confirmed that the composition for scalp and hair of the present invention (Example 3) not only has an effect of promoting hair growth, but also has an excellent effect of suppressing the occurrence of dandruff by imparting moisture to the scalp. was confirmed.

By blending each component according to the formulation shown in Table 5, the composition for scalp and hair (pH 5.5) of the present invention can be prepared.

Claims (5)

A composition for scalp and hair containing (A) aloe extract and (B) hypericum perforatum extract, or (A) aloe extract, (B) hypericum perforatum extract and (C) ginger extract. 2. The composition for scalp and hair according to claim 1, wherein the (A) aloe extract is an extract of at least one aloe plant selected from the group consisting of aloe vera, aloe vera, and aloe tomentosa. 3. The composition for scalp and hair according to claim 1 or 2, which is used for at least one application selected from the group consisting of promoting hair growth, preventing hair loss, preventing dandruff and moisturizing the scalp. (A) Aloe extract and (B) Hypericum perforatum extract, or (A) Aloe extract, (B) Hypericum perforatum extract, and (C) Ginger extract. imparting at least one action selected from the group consisting of hair growth promoting action, hair loss preventing action, antidandruff action and scalp moisturizing action to the product, or imparting said at least one action possessed by said composition for scalp and hair. How to strengthen. 5. The method according to claim 4, wherein the (A) aloe extract is an extract of at least one aloe plant selected from the group consisting of aloe vera, aloe vera, and aloe tormentosa.

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