JP2023051578A - Brain function improving functional food - Google Patents

Abstract

To provide a brain function-improving functional food capable of generating an improvement action or effect of a brain function derived from a plant extract containing triterpenoid, and furthermore constituted such that an improvement action or effect of the brain is more remarkably exhibited compared with the case where the same plant extract is used alone.SOLUTION: A brain function improving functional food is formed by comprising three plant extracts derived from different plants, a first plant extract containing alkaloids and flavonoids, a second plant extract containing triterpenoids, and a third plant extract containing polyphenols. In addition, the first plant extract is an extract derived from a plant belonging to the Scrophulariaceae family of the Labiatae, and the second plant extract is an extract derived from a plant belonging to the genus Lagerstroemia of the family Lythraceae or the Lagerstroemia genus Lagerstroemia of the family Lythraceae.SELECTED DRAWING: Figure 1

Description

TECHNICAL FIELD The present invention relates to a functional food for improving brain function.

With the advent of an aging society in recent years, deterioration of brain function resulting from degenerative brain diseases of the elderly, particularly Alzheimer's disease, dementia with Lewy bodies, Parkinson's disease, etc., is widely regarded as a problem.

If a person suffers from such brain degenerative disease and develops dementia, it may lead to a serious situation in which even human dignity is threatened. It is

However, many of the causes of the onset of dementia remain unclear, and the development of therapeutic methods and preventive methods, let alone the development of drugs, has not yet been established.

Under such circumstances, compositions for improving brain function have been proposed that can prevent or improve these diseases by ingesting them in daily diet (see, for example, Patent Document 1).

Pharmaceuticals and food products containing such compositions for improving brain function can be safely and easily ingested by humans on a daily basis, and are effective in treating cranial nerve diseases such as dementia represented by Alzheimer's disease. It is said that it can be improved to

Japanese Patent Publication No. 2002-541194

However, the deterioration of brain function does not develop due to a single cause, but develops through a more complicated mechanism, and it is desirable to provide more improvement means through different approaches.

The present invention has been made in view of such circumstances, and is capable of producing brain function-improving actions and effects derived from plant extracts containing triterpenoids, and when the plant extracts are used alone. To provide a functional food for improving brain function, which is constituted so as to more remarkably exhibit the action and effect of improving brain function compared to .

In order to solve the above conventional problems, the functional food for improving brain function according to the present invention comprises (1) a first plant extract containing alkaloids and flavonoids, and a second plant extract containing triterpenoids; It contains three plant extracts derived from different plants and a third plant extract containing polyphenols.

In addition, the functional food for improving brain function according to the present invention also has the following characteristics.
(2) The first plant extract is an extract derived from a plant belonging to Scrophulariaceae, Labiatae.
(3) The first plant extract is an extract derived from at least one plant selected from cherry blossoms, foxgloves, bacopa monnieri, nemesia, and scrophulariosa, and contains 5 to 33 w/w% in terms of powder. Containing a corresponding amount of the first plant extract.
(4) The second plant extract is an extract derived from a plant belonging to the genus Lagerstroemia in the family Lythraceae or the genus Lagerstroemia in the family Lythraceae.
(5) The second plant extract is an extract derived from at least one plant selected from Mizumatsuba, Rotala Green, Rhododendron dilatatum, Banaba, and Crape myrtle, and corresponds to 0.0157 to 33 w/w% in terms of powder. amount of said second plant extract.
(6) The third plant extract is an extract derived from a plant belonging to the genus Skullcap of the family Labiatae or the genus Mulberry of the family Moraceae.
(7) The third plant extract is an extract derived from at least one of plants selected from the group consisting of Chimenamiki, Ezonamiki, Scutellaria baicalensis, Yamaguwa, and Black Mulberry, and corresponds to 0.0157 to 33w/w% in terms of powder. amount of said third plant extract.

The present invention also provides (8) a functional food for the purpose of including as an action or effect an improvement in brain function derived from a second plant extract containing triterpenoids, wherein the second plant extract or the brain function In the functional food in which the components of the second plant extract corresponding to the manifestation of the improvement of the above are health functional components (participating components), the first plant extract containing alkaloids and flavonoids, and the third containing polyphenols plant extract was used as an auxiliary ingredient raw material for promoting the improvement of the brain function.

According to the functional food for improving brain function according to the present invention, a first plant extract containing alkaloids and flavonoids, a second plant extract containing triterpenoids, and a third plant extract containing polyphenols are combined. Since it contains three kinds of plant extracts derived from different plants, it is possible to generate the brain function improving action and effect derived from the second plant extract containing triterpenoids, and moreover, the same plant extract. It is possible to provide a functional food for improving brain function, which is configured so that the action and effect of improving brain function are exhibited more remarkably than in the case of using the above alone.

In addition, if the first plant extract is derived from a plant belonging to Scrophulariaceae, Labiatae, the brain function-improving action and effect derived from the second plant extract are greater than when used alone. It can be expressed more steadily in making it more prominently demonstrated.

In addition, the first plant extract is an extract derived from at least one plant selected from cherry blossoms, foxgloves, bacopa monnieri, nemesia, and scrophulariosa, and is equivalent to 5 to 33 w/w% in terms of powder. If the amount of the first plant extract is contained, the brain function-improving action and effect derived from the second plant extract can be exhibited more consistently.

If the second plant extract is an extract derived from a plant belonging to the genus Lagerstroemia of the family Lythraceae or the genus Lagerstroemia of the family Lythraceae, the brain function-improving action and effect can be expressed more consistently.

In addition, the second plant extract is an extract derived from at least one plant selected from Mizumatsuba, Rotala Green, Rhododendron dilatatum, Banaba, and Lagerstroemia crape myrtle, in an amount equivalent to 0.0157 to 33 w/w% in terms of powder. By containing the second plant extract, the brain function-improving action and effect can be expressed more steadily.

If the third plant extract is an extract derived from a plant belonging to the genus Skullcap of the family Labiatae or the genus Mulberry of the family Moraceae, the brain function-improving action or effect derived from the second plant extract is used alone. It can be expressed more steadily in making it manifest more remarkably than in the case of .

In addition, the third plant extract is an extract derived from at least one plant selected from the group consisting of Pleurotus hymenamiki, Ezonamiki, Scutellaria baicalensis, Yamaguwa, and Black Mulberry, and is an amount equivalent to 0.0157 to 33 w/w% in terms of powder. By containing the third plant extract of (1), the brain function-improving action and effects derived from the second plant extract can be exhibited more consistently.

Also, a functional food for the purpose of including improvement of brain function derived from a second plant extract containing triterpenoids as an action or effect, wherein the second plant extract or the expression and response to improvement of brain function are provided. In the functional food in which the constituent components of the second plant extract are health functional components (participating components), the first plant extract containing alkaloids and flavonoids and the third plant extract containing polyphenols are combined into the above Since it is used as an auxiliary ingredient raw material that promotes improvement of brain function, it is possible to generate the brain function improving action and effect derived from the second plant extract containing triterpenoids, and the plant extract can be used alone. The functional food for improving brain function can be configured so that the action and effect of improving brain function are exhibited more remarkably than in the case of using in (1).

FIG. 10 is an explanatory diagram showing test results of a memory test; FIG. 4 is an explanatory diagram showing test results of intracerebral blood flow. FIG. 4 is an explanatory diagram showing test results of intracerebral oxygen saturation.

The present invention relates to a functional food for improving brain function, in particular, it is possible to induce brain function-improving actions and effects derived from plant extracts containing triterpenoids, and moreover, compared to the case where the plant extract is used alone. The present invention relates to a functional food for improving brain function, which is constructed so that the action and effect of improving brain function are exhibited more remarkably.

Conventionally, phospholipid tyrosine, ginkgo biloba, niacin, etc., which are called neurotransmitters, have been known as preparations for predominance of cranial nerve function.

These known ingredients are said to exhibit usefulness based on their ability to promote intracerebral blood flow. Prescription design considering route and absorption route is essential.

This is because the component produces an isomeric structure through in vivo digestion and decomposition, and therefore does not necessarily exhibit the same effect as in vitro verification.

Furthermore, it cannot be said that the effects on neuronal synapses that are different from promoting cerebral blood flow in known ingredients are sufficient, and academic verification of the restoration and improvement of cerebral nerve synapses based on oral ingestion of such ingredients, and verification of improvement effects in vivo is extremely difficult. few.

In this respect, the functional food for improving brain function according to the present embodiment uses a plant extract containing triterpenoids as a main constituent raw material for improving brain function, so it exhibits excellent brain function improving action and effect. can be made

Herein, the improvement of brain function in this specification includes normalization of excited state and sedative state, normalization of concentration, and particularly means improvement of memory. Specifically, improvement of brain function is defined as improvement of memory ability by various methods such as Wechsler memory test, which are adopted for memory test at medical institutions.

In addition, functional food is a concept that includes all foods that are said to contribute to the maintenance and promotion of health that do not contain pharmaceutical ingredients. Foods, foods with health claims such as foods for specified health uses, foods with nutrient claims, and foods with function claims are also included.

In addition, the functional food of the present application is a functional food for the purpose of including, as an action or effect, improvement of brain function derived from the second plant extract containing triterpenoids. In addition, the purpose including as an action or effect includes cases where the functional food clearly states that it is intended to improve brain function, for example, the case where it is described as an effect and efficacy. Even if it is not specified as such, if a part of the progress or result is described such as "for those who want to maintain memory" or "supports memory", it is the brain function of the present application. It corresponds to functional food for improvement.

In addition, the explanation of the functional food mentioned above is a list of examples of articles corresponding to these for the purpose of understanding the present invention, and the interpretation of each term is limited to these listed articles. isn't it. However, it does not preclude the applicant from limiting the present invention to these articles and the like in obtaining the right of the present application.

The functional food for improving brain function according to the present embodiment contains three plant extracts derived from different plants, namely a first plant extract, a second plant extract, and a third plant extract. It is characteristic in that

The first plant extract is a plant extract containing alkaloids and flavonoids, and in order to remarkably exhibit the improving action and effect of the second plant extract that functions as a main constituent raw material for improving brain function, It is one of the ingredients that play an auxiliary role together with the plant extract of 3.

This first plant extract is not particularly limited as long as it is a plant extract containing alkaloids and flavonoids. In order to exhibit the brain function-improving action and effect of the drug more remarkably than in the case of single use, it can be more consistently expressed.

In this case, the first plant extract is not particularly limited as long as it is an extract derived from a plant belonging to the family Scrophulariaceae of the order Labiatae. By using an extract derived from any one plant, the brain function-improving action and effect derived from the second plant extract can be exhibited more consistently.

In addition, when the first plant extract is an extract derived from these plants, the amount of the first plant extract contained in the functional food for improving brain function is not limited, but the intake per day is It is desirable that the dosage be 60-400mg in terms of powder. In this case, in dosage forms with low water content (hereinafter also referred to as low water dosage forms) such as tablets, granules, and powders (including cases where they are contained in enveloping materials such as capsules). It is desirable to use an amount equivalent to 5 to 33 w/w% in terms of powder.

If the intake of the first plant extract is less than 60 mg/day in terms of powder, it is not preferable because the second plant extract cannot play a sufficient supporting role in exerting the improving action and effects of the second plant extract.

In addition, there is no particular problem if the amount of intake of the first plant extract exceeds 400 mg/day in terms of powder, but even if it is added in excess, no increase in the auxiliary effect of the first plant extract is observed.

Further, when the functional food for improving brain function according to the present embodiment is prepared in a low-moisture dosage form, if the content of the first plant extract is less than 5 w/w%, The total amount of the functional food tends to increase, and when the content exceeds 33 w/w%, other constituents constituting the functional food for improving brain function, especially the second plant extract and the third It is not preferable because there is no room for containing the required amount of plant extract.

The intake of the first plant extract is 60 to 400 mg per day in terms of powder, and the content of the first plant extract in powder conversion when this drug is prepared in a low-moisture dosage form. By adjusting the amount corresponding to 5 to 33 w/w%, the supplementary effect of the first plant extract can be favorably exhibited. In addition, powder conversion means that when the plant extract is liquid, it should be considered in terms of the weight in a state where water is evaporated, and the first plant extract for the functional food for improving brain function The state is not limited to powder. That is, the first plant extract may of course be added as a liquid according to the dosage form of the functional food for improving brain function. The same applies to the second plant extract, the third plant extract, and other raw materials, which will be described later. The essence of the present invention is that the first plant extract containing alkaloids and flavonoids, the second plant extract containing triterpenoids, and the third plant extract containing polyphenols are different, regardless of the dosage form. It should be noted that the functional food for improving brain function is constituted by containing three types of plant-derived plant extracts.

The second plant extract is not particularly limited as long as it is a plant extract containing triterpenoids. For example, if it is an extract derived from a plant belonging to the genus Lagerstroemia of the family Lythraceae or the genus Lagerstroemia of the Lythraceae family, it has an effect of improving brain function. and effects can be expressed more steadily.

In this case, the second plant extract is not particularly limited as long as it is an extract derived from a plant belonging to the genus Lagerstroemia in the family Lythraceae or the genus Lagerstroemia in the family Lythraceae. By using an extract derived from at least one of the selected plants, the brain function-improving action and effects can be more consistently expressed.

In addition, when the second plant extract is an extract derived from these plants, the amount of the second plant extract contained in the functional food for improving brain function is not limited, but the intake per day is It is desirable that the dosage be 0.2 to 400 mg in terms of powder. For low-moisture dosage forms, it is desirable to use an amount equivalent to 0.0157 to 33 w/w% in terms of powder.

If the intake of the second plant extract is less than 0.2 mg/day in terms of powder, it is not preferable because the brain function-improving action and effect derived from the second plant extract cannot be obtained sufficiently.

In addition, it is not a particular problem that the intake of the second plant extract exceeds 400 mg/day in terms of powder, but even if it is added more, the brain function improving action and effect of the second plant extract will be further improved. is not seen.

In addition, when the functional food for brain function improvement is prepared in a low-water dosage form, if the content of the second plant extract is less than 0.0157 w / w%, the functional food for brain function improvement suitable for ingestion The total amount tends to increase, and when the content exceeds 33 w/w%, other constituent ingredients constituting the functional food for improving brain function, especially the first plant extract and the third plant extract are required. It is not preferable because there is no room for adding a large amount.

The intake of the second plant extract is 0.2 to 400 mg per day in terms of powder. By adjusting the amount corresponding to 0.0157 to 33 w/w%, it is possible to steadily express the action and effect of improving brain function.

The third plant extract is not particularly limited as long as it is a plant extract containing polyphenols. It is possible to express the brain function-improving action and effect derived from the above more remarkably than in the case of single use.

In this case, the third plant extract is not particularly limited as long as it is an extract derived from a plant belonging to the genus Scutellaria of the family Labiatae or the genus Mulberry of the family Moraceae. By using an extract derived from at least one of the selected plants, the brain function-improving action and effects derived from the second plant extract can be exhibited more consistently.

In addition, when the third plant extract is an extract derived from these plants, the amount of the third plant extract contained in the functional food for improving brain function is not limited, but is It is desirable that the dosage be 0.2 to 400 mg in terms of powder. For low-moisture dosage forms, it is desirable to use an amount equivalent to 0.0157 to 33 w/w% in terms of powder.

If the amount of intake of the third plant extract is less than 0.2 mg/day in terms of powder, it is not preferable because the supplementary role of the third plant extract to exert its improvement action and effect remarkably cannot be fulfilled.

In addition, there is no particular problem if the amount of intake of the third plant extract exceeds 400 mg/day in terms of powder, but even if it is added more than this, no increase in the supplementary effect of the third plant extract is observed.

In addition, when the functional food for improving brain function is prepared in a low-water dosage form, if the content of the third plant extract is less than 0.0157 w / w%, the functional food for improving brain function suitable for ingestion The total amount tends to increase, and when the content exceeds 33 w/w%, other constituent ingredients constituting the functional food for improving brain function, especially the first plant extract and the second plant extract are required. It is not preferable because there is no room for adding a large amount.

The intake of the third plant extract is 0.2 to 400 mg per day in powder conversion, and the content of the third plant extract in powder conversion when this drug is prepared in a low-moisture dosage form. By adjusting the amount corresponding to 0.0157 to 33 w/w%, the supplementary effect of the third plant extract can be favorably exhibited.

Hereinafter, the functional food for brain function improvement according to the present embodiment will be further described with reference to test results and the like.

[1. Memory improvement confirmation test]
In this test, a plurality of sample foods with different formulations were prepared, and it was confirmed whether or not improvement in memory was observed by having subjects ingest them.

(1-1. Preparation of test sample)
In conducting this test, first, 13 types of test samples were prepared. Specific formulations are shown in Table 1.

The 12 types of test samples, test samples 1 to 12, are test samples containing plant extracts. Test samples designated as Cont. are placebo samples without plant extract.

As raw materials for preparing test samples 1 to 12, the first plant extract was bacopa extract powder, the second plant extract was banaba extract powder, and the third plant extract was yamaguwa extract powder.

The bacopa extract powder is obtained by extracting the leaves or the whole plant of Bacopa monnieri with water or ethanol, and then drying the resulting extract into powder.

The banaba extract powder is obtained by extracting the leaves or the whole plant of banaba with water or ethanol, and then drying the resulting extract into powder.

The yamaguwa extract powder is obtained by extracting the leaves of yamaguwa with water or ethanol, and then drying the obtained extract to powder.

Dextrin was also used as an excipient to match the total weight of each test sample.

The test samples 1 to 12 and the placebo sample prepared were powdered formulations, each of which was packed in a pack of 3.2 g.

(1-2. Confirmation test)
Subjects were 46 years of age or older, had a Wechsler Memory Scale of less than 6, and had a Mini Mental Seat Examination of 24 or less. Seventy-eight subjects were randomly assigned, six for each test sample.

In addition, in this test, we decided to evaluate the improvement of memory by implementing the Wechsler memory test. Each subject underwent a memory test before ingestion of the test sample and after 8 weeks (2 months) of continuous ingestion. The subjects ingested one package (3.2 g) of the test sample per day during the 8-week continuous intake period. The results are shown in FIG.

FIG. 1(a) is a graph showing the total memory score before and after ingestion of each test sample, and FIG. 1(b) is a table showing significant differences between several groups with respect to the total memory score after ingestion. As can be seen from these charts shown in FIG. 1, no improvement in memory was observed in the placebo sample (Cont.); 5, 9, 10 and 11 were effective for improvement, and test sample 6 and test sample 12 were significantly effective for improvement.

In addition, in test sample 3 and test sample 9, a significant difference (P<0.05) within the group was confirmed before and after ingestion. , was shown to be able to induce brain function improving actions and effects.

In addition, although illustration is omitted, there was a significant difference (P<0.05) between test samples 4 to 6 and test sample 3 with respect to the total memory score after ingestion, and bacopa extract powder as the first plant extract or Yamaguwa extract powder as the third plant extract, or both of them in combination with the banaba extract powder as the second plant extract, brain function is improved as compared with the case where the banaba extract powder is used alone. It was shown that the actions and effects are exhibited more remarkably. In particular, when both the bacopa extract powder as the first plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, either the first or the third It was shown that the brain function-improving action and effects were exhibited more remarkably than when the plant extract was used in combination.

Similarly, in the case of lower doses, test samples 10 to 12 showed a significant difference (P<0.05) between the groups with respect to the total memory score after ingestion, and test sample 9. When one or both of the bacopa extract powder as the plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, the banaba extract powder is used alone. It was shown that the improvement action and effect of brain function are exhibited more remarkably as a result. In particular, when both the bacopa extract powder as the first plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, either the first or the third It was shown that the brain function-improving action and effects were exhibited more remarkably than when the plant extract was used in combination.

[2. Cerebral Blood Flow and Cerebral Oxygen Saturation Confirmation Test]
In this test, [1. Using the same sample food as in the memory improvement confirmation test], the cerebral blood flow and cerebral oxygen saturation were confirmed when the subject ingested the food. Specifically, as described above [1. Memory improvement confirmation test], a memory test was performed before ingestion of the test sample and 8 weeks (2 months later) after continuous ingestion. got the data. Measurement was performed using TOS-96 (manufactured by Tostec). The results are shown in FIGS. 2 and 3. FIG.

Fig. 2(a) is a graph showing the relative cerebral blood flow rate of each test sample (when the value before ingestion is taken as 100%), and Fig. 2(b) shows several relative cerebral blood flow values after ingestion. is a table showing significant differences between groups. In addition, FIG. 3(a) is a graph showing the cerebral oxygen saturation of each test sample, and FIG. 3(b) is a table showing significant differences between several groups regarding the cerebral oxygen saturation after ingestion. is.

First, as can be seen from these charts shown in FIG. 2, the placebo sample (Cont.) did not show improvement in brain function due to improvement in cerebral blood flow, but at least one of the first to third plants Test samples 1 to 12 containing the extract showed improvement in cerebral blood flow (improvement in brain function).

In addition, the improvement in cerebral blood flow was better in test sample 3 than in test samples 1 or 2, and test samples 4 and 5, which contained two types of plant extracts, contained only one type of plant extract. The test samples 1 to 3 containing no plant extracts showed good results, and the test sample 6 containing the first to third plant extracts gave better results than the test samples 1 to 5. This trend was also observed in the low-dose test samples 7-12.

Next, referring to the cerebral oxygen saturation in FIG. Test samples 1 to 12 containing the plant extract showed improvement in cerebral oxygen saturation (improvement in brain function).

In addition, test sample 3 improved brain oxygen saturation better than test samples 1 or 2, and test samples 4 and 5, which contained two types of plant extracts, contained only one type of plant extract. Test samples 1 to 3 containing no plant extracts showed better results, and test sample 6 containing the first to third plant extracts showed better results than test samples 1 to 5. This trend was also observed in the low-dose test samples 7-12.

In addition, although not shown in the drawings, there was a significant difference (P<0.05) between test samples 4 to 6 and test sample 3 with respect to the relative cerebral blood flow and cerebral oxygen saturation after ingestion. If one or both of the bacopa extract powder as the first plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, the banaba extract powder is used alone. It was shown that the improvement action and effect of brain function were exhibited more remarkably compared to the case. In particular, when both the bacopa extract powder as the first plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, either the first or the third Compared to the combined use of plant extracts, it was shown that the effect and effect of improving brain function associated with the improvement of relative cerebral blood flow and cerebral oxygen saturation are exhibited more remarkably.

Similarly, in the case of lower doses, test samples 10 to 12 showed a significant difference (P<0.05) between the groups with respect to the total memory score after ingestion, and test sample 9. When one or both of the bacopa extract powder as the plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, the banaba extract powder is used alone. It was shown that the improvement action and effect of brain function are exhibited more remarkably as a result. In particular, when both the bacopa extract powder as the first plant extract and the yamaguwa extract powder as the third plant extract are used in combination with the banaba extract powder as the second plant extract, either the first or the third Compared to the combined use of plant extracts, it was shown that the effect and effect of improving brain function associated with the improvement of relative cerebral blood flow and cerebral oxygen saturation are exhibited more remarkably.

[3. Supplement manufacturing test]
Next, in order to examine whether or not brain function can be improved with formulations closer to the product, seven supplement functional foods A1 to A7 were prepared. The formulation is shown in Table 2.

Functional foods A1 to A7 contain bacopa extract powder as the first plant extract, banaba extract powder as the second plant extract, and yamaguwa extract powder as the third plant extract, and if necessary, oligosaccharides. , with varying amounts of sweetener. Changes in the amounts of oligosaccharides and sweeteners do not affect the improvement of brain function derived from the second plant extract, banaba extract powder.

These functional foods A1 to A7 are described above [1. The improvement of brain function was investigated by the same method as the memory improvement confirmation test]. However, the intake of functional foods was 1200 mg per day. As a result, improvement in brain function was confirmed in all functional foods A1 to A7.

From these, the first plant extract has an amount equivalent to 5 to 33 w / w% in terms of powder, the second plant extract has an amount equivalent to 0.0157 to 33 w / w% in terms of powder, and the third plant extract is added in an amount corresponding to 0.0157 to 33 w / w% in terms of powder, so that the brain function improving action and effect derived from the second plant extract containing triterpenoids can be generated, and , it was shown that the plant extract can be used as a functional food for improving brain function, which is composed so that the brain function-improving action and effect are exhibited more remarkably than when the same plant extract is used alone.

In addition, the daily intake of the first plant extract is about 60 to 400 mg in powder conversion, the daily intake of the second plant extract is about 0.2 to 400 mg in powder conversion, and the third plant extract is By adjusting the blending amount of each plant extract so that the daily intake is within the range of about 0.2 to 400 mg in terms of powder, the second plant extract containing triterpenoids has the effect of improving brain function and It is possible to produce a functional food for improving brain function, which can produce an effect and is constituted so that the brain function improving action and effect can be exhibited more remarkably than when the plant extract is used alone. shown.

In addition, it is a functional food for the purpose of including improvement of brain function derived from a second plant extract containing triterpenoids as an action or effect, wherein the second plant extract or the improvement of brain function is provided. Health derived from improvement of brain function by using functional foods, such as banaba extract and corosolic acid contained therein, as health functional ingredients (participating ingredients) in which the components of the second plant extract corresponding to the expression are health functional ingredients (participating ingredients). In a functional food having an enhancement claim, if a first plant extract containing alkaloids and flavonoids and a third plant extract containing polyphenols are used as supplementary ingredient raw materials for promoting the improvement of brain function. , the brain function-improving action and effect derived from the second plant extract containing triterpenoids can be generated, and the brain function-improving action and effect can be produced compared to the case where the second plant extract is used alone. It was shown that the functional food for brain function improvement can be configured so that the effect is exhibited more remarkably.

As described above, according to the functional food for improving brain function according to the present invention, the first plant extract containing alkaloids and flavonoids, the second plant extract containing triterpenoids, and the second plant extract containing polyphenols Since it contains 3 kinds of plant extracts derived from plants different from the 3 plant extracts, it is possible to generate the brain function improving action and effect derived from the second plant extract containing triterpenoids. Moreover, it is possible to provide a functional food for improving brain function, which is composed so that the action and effect of improving brain function are exhibited more remarkably than when the same plant extract is used alone.

Finally, the description of each embodiment mentioned above is an example of this invention, and this invention is not limited to the above-mentioned embodiment. Therefore, it goes without saying that various modifications other than the above-described embodiments can be made in accordance with the design and the like within the scope not departing from the technical idea of the present invention.

Claims (8)

It comprises three plant extracts derived from different plants, a first plant extract containing alkaloids and flavonoids, a second plant extract containing triterpenoids, and a third plant extract containing polyphenols. Functional food for improving brain function. 2. The functional food for improving brain function according to claim 1, wherein the first plant extract is derived from a plant belonging to the Scrophulariaceae family of the Lamiaceae order. The first plant extract is an extract derived from at least one plant selected from cherry blossoms, redwort, bacopa monnieri, nemesia, and scrophulariosa, in an amount equivalent to 5 to 33 w/w% in terms of powder. 3. The functional food for improving brain function according to claim 2, characterized in that it contains the first plant extract of The functional food for improving brain function according to any one of claims 1 to 3, wherein the second plant extract is an extract derived from a plant belonging to the genus Lagerstroemia of the family Lythraceae or the genus Lagerstroemia in the family Lythraceae. The second plant extract is an extract derived from at least one plant selected from Mizumatsuba, Rotala Green, Rhododendron dilatatum, Banaba, and Crape myrtle, and is in an amount equivalent to 0.0157 to 33 w/w% in terms of powder. 5. The functional food for improving brain function according to claim 4, further comprising a second plant extract. The functional food for improving brain function according to any one of claims 1 to 5, wherein the third plant extract is derived from a plant belonging to the genus Skullcap of the Labiatae family or the genus Mulberry of the Moraceae family. The third plant extract is an extract derived from at least one plant selected from among cypress, edona, scutellaria baicalensis, yamaguwa, and black mulberry. 7. The functional food for improving brain function according to claim 6, further comprising a third plant extract. A functional food for the purpose of including improvement in brain function derived from a second plant extract containing triterpenoids as an action or effect, wherein said second plant extract or said functional food corresponding to the expression of improvement in brain function In a functional food in which the components of the second plant extract are health function components (participating components), the brain function of the first plant extract containing alkaloids and flavonoids and the third plant extract containing polyphenols is improved. Use as an auxiliary ingredient ingredient to facilitate improvement.

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