JP2023011549A5 - - Google Patents

Info

Publication number

JP2023011549A5

JP2023011549A5 JP2022143256A JP2022143256A JP2023011549A5 JP 2023011549 A5 JP2023011549 A5 JP 2023011549A5 JP 2022143256 A JP2022143256 A JP 2022143256A JP 2022143256 A JP2022143256 A JP 2022143256A JP 2023011549 A5 JP2023011549 A5 JP 2023011549A5

Authority

JP

Japan

Prior art keywords

medicament according

salt

compound

dose

cell proliferative

Prior art date

2022-09-08

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003814 drug Substances 0.000 claims 18
• 150000001875 compounds Chemical class 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 11
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
• 230000002062 proliferating effect Effects 0.000 claims 8
• 201000010099 disease Diseases 0.000 claims 7
• 206010028980 Neoplasm Diseases 0.000 claims 4
• 201000011510 cancer Diseases 0.000 claims 4
• 206010069755 K-ras gene mutation Diseases 0.000 claims 3
• 230000003442 weekly effect Effects 0.000 claims 3
• CMSMOCZEIVJLDB-UHFFFAOYSA-N Cyclophosphamide Chemical compound ClCCN(CCCl)P1(=O)NCCCO1 CMSMOCZEIVJLDB-UHFFFAOYSA-N 0.000 claims 2
• 102100039788 GTPase NRas Human genes 0.000 claims 2
• 101000744505 Homo sapiens GTPase NRas Proteins 0.000 claims 2
• 239000004480 active ingredient Substances 0.000 claims 2
• 229960004397 cyclophosphamide Drugs 0.000 claims 2
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 2
• 229960003957 dexamethasone Drugs 0.000 claims 2
• 230000035772 mutation Effects 0.000 claims 2
• 229940127084 other anti-cancer agent Drugs 0.000 claims 2
• QOFFJEBXNKRSPX-ZDUSSCGKSA-N pemetrexed Chemical compound C1=N[C]2NC(N)=NC(=O)C2=C1CCC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 QOFFJEBXNKRSPX-ZDUSSCGKSA-N 0.000 claims 2
• 229960005079 pemetrexed Drugs 0.000 claims 2
• UEJJHQNACJXSKW-UHFFFAOYSA-N 2-(2,6-dioxopiperidin-3-yl)-1H-isoindole-1,3(2H)-dione Chemical compound O=C1C2=CC=CC=C2C(=O)N1C1CCC(=O)NC1=O UEJJHQNACJXSKW-UHFFFAOYSA-N 0.000 claims 1
• 208000034578 Multiple myelomas Diseases 0.000 claims 1
• ZDZOTLJHXYCWBA-VCVYQWHSSA-N N-debenzoyl-N-(tert-butoxycarbonyl)-10-deacetyltaxol Chemical compound O([C@H]1[C@H]2[C@@](C([C@H](O)C3=C(C)[C@@H](OC(=O)[C@H](O)[C@@H](NC(=O)OC(C)(C)C)C=4C=CC=CC=4)C[C@]1(O)C3(C)C)=O)(C)[C@@H](O)C[C@H]1OC[C@]12OC(=O)C)C(=O)C1=CC=CC=C1 ZDZOTLJHXYCWBA-VCVYQWHSSA-N 0.000 claims 1
• 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940041181 antineoplastic drug Drugs 0.000 claims 1
• VSRXQHXAPYXROS-UHFFFAOYSA-N azanide;cyclobutane-1,1-dicarboxylic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OC(=O)C1(C(O)=O)CCC1 VSRXQHXAPYXROS-UHFFFAOYSA-N 0.000 claims 1
• GXJABQQUPOEUTA-RDJZCZTQSA-N bortezomib Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)B(O)O)NC(=O)C=1N=CC=NC=1)C1=CC=CC=C1 GXJABQQUPOEUTA-RDJZCZTQSA-N 0.000 claims 1
• 229960001467 bortezomib Drugs 0.000 claims 1
• 229960004562 carboplatin Drugs 0.000 claims 1
• 208000035475 disorder Diseases 0.000 claims 1
• 229960003668 docetaxel Drugs 0.000 claims 1
• 239000002955 immunomodulating agent Substances 0.000 claims 1
• 229940121354 immunomodulator Drugs 0.000 claims 1
• 239000003112 inhibitor Substances 0.000 claims 1
• 229960004942 lenalidomide Drugs 0.000 claims 1
• GOTYRUGSSMKFNF-UHFFFAOYSA-N lenalidomide Chemical compound C1C=2C(N)=CC=CC=2C(=O)N1C1CCC(=O)NC1=O GOTYRUGSSMKFNF-UHFFFAOYSA-N 0.000 claims 1
• 229960001924 melphalan Drugs 0.000 claims 1
• SGDBTWWWUNNDEQ-LBPRGKRZSA-N melphalan Chemical compound OC(=O)[C@@H](N)CC1=CC=C(N(CCCl)CCCl)C=C1 SGDBTWWWUNNDEQ-LBPRGKRZSA-N 0.000 claims 1
• 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 1
• XAEFZNCEHLXOMS-UHFFFAOYSA-M potassium benzoate Chemical compound [K+].[O-]C(=O)C1=CC=CC=C1 XAEFZNCEHLXOMS-UHFFFAOYSA-M 0.000 claims 1
• 229960003433 thalidomide Drugs 0.000 claims 1
• 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 1