JP2022552329A - 化合物の塩及びその結晶形態 - Google Patents

化合物の塩及びその結晶形態 Download PDF

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JP2022552329A
JP2022552329A JP2022522343A JP2022522343A JP2022552329A JP 2022552329 A JP2022552329 A JP 2022552329A JP 2022522343 A JP2022522343 A JP 2022522343A JP 2022522343 A JP2022522343 A JP 2022522343A JP 2022552329 A JP2022552329 A JP 2022552329A
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cancer
salt
iii
solvent
water
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Japanese (ja)
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JP2022552329A5 (https=
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ウェンチー リー
リン フォン
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ハチソン メディファルマ リミテッド
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/225—Saturated compounds having only one carboxyl group and containing keto groups containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022522343A 2019-10-14 2020-10-13 化合物の塩及びその結晶形態 Pending JP2022552329A (ja)

Priority Applications (1)

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JP2025106308A JP2025143319A (ja) 2019-10-14 2025-06-24 化合物の塩及びその結晶形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910973785 2019-10-14
CN201910973785.3 2019-10-14
PCT/CN2020/120594 WO2021073494A1 (en) 2019-10-14 2020-10-13 The salts of a compound and the crystalline forms thereof

Related Child Applications (1)

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JP2025106308A Division JP2025143319A (ja) 2019-10-14 2025-06-24 化合物の塩及びその結晶形態

Publications (2)

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JP2022552329A true JP2022552329A (ja) 2022-12-15
JP2022552329A5 JP2022552329A5 (https=) 2023-10-17

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JP2022522343A Pending JP2022552329A (ja) 2019-10-14 2020-10-13 化合物の塩及びその結晶形態
JP2025106308A Pending JP2025143319A (ja) 2019-10-14 2025-06-24 化合物の塩及びその結晶形態

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US (1) US12559472B2 (https=)
EP (1) EP4045484A4 (https=)
JP (2) JP2022552329A (https=)
KR (1) KR20220088712A (https=)
CN (3) CN119751422A (https=)
AR (1) AR120202A1 (https=)
AU (1) AU2020367905A1 (https=)
BR (1) BR112022007035A2 (https=)
CA (1) CA3154064A1 (https=)
IL (1) IL292206B2 (https=)
MX (1) MX2022004274A (https=)
TW (1) TWI895290B (https=)
UA (1) UA129777C2 (https=)
WO (1) WO2021073494A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7736357B2 (ja) * 2021-12-13 2025-09-09 アビスコ セラピューティクス カンパニー リミテッド Ｆｇｆｒ４阻害剤酸性塩およびその製造方法と使用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013512956A (ja) * 2009-12-07 2013-04-18 ノバルティス アーゲー ３−（２，６−ジクロロ−３，５−ジメトキシ−フェニル）−１−｛６−［４−（４−エチル−ピペラジン−１−イル）−フェニルアミノ］−ピリミジン−４−イル｝−１−メチル−尿素の結晶形態およびその塩
JP2016510774A (ja) * 2013-03-15 2016-04-11 ハチソン メディファーマ リミテッド 新規なピリミジン及びピリジン化合物並びにその利用
JP2018511635A (ja) * 2015-04-14 2018-04-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性ｆｇｆｒ４阻害剤化合物およびその使用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018099451A1 (zh) 2016-12-01 2018-06-07 和记黄埔医药（上海）有限公司 化合物的晶型

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013512956A (ja) * 2009-12-07 2013-04-18 ノバルティス アーゲー ３−（２，６−ジクロロ−３，５−ジメトキシ−フェニル）−１−｛６−［４−（４−エチル−ピペラジン−１−イル）−フェニルアミノ］−ピリミジン−４−イル｝−１−メチル−尿素の結晶形態およびその塩
JP2016510774A (ja) * 2013-03-15 2016-04-11 ハチソン メディファーマ リミテッド 新規なピリミジン及びピリジン化合物並びにその利用
JP2018511635A (ja) * 2015-04-14 2018-04-26 エーザイ・アール・アンド・ディー・マネジメント株式会社 結晶性ｆｇｆｒ４阻害剤化合物およびその使用

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
薬剤学, vol. 72(3), JPN6024036937, 2012, pages 154 - 158, ISSN: 0005416622 *

Also Published As

Publication number Publication date
CN114555558A (zh) 2022-05-27
US20230121346A1 (en) 2023-04-20
TWI895290B (zh) 2025-09-01
UA129777C2 (uk) 2025-07-30
AU2020367905A1 (en) 2022-04-21
EP4045484A1 (en) 2022-08-24
IL292206B2 (en) 2026-03-01
CN114555558B (zh) 2024-12-17
US12559472B2 (en) 2026-02-24
TW202128669A (zh) 2021-08-01
AR120202A1 (es) 2022-02-02
EP4045484A4 (en) 2023-09-06
CN119462616A (zh) 2025-02-18
MX2022004274A (es) 2022-05-06
WO2021073494A1 (en) 2021-04-22
CA3154064A1 (en) 2021-04-22
JP2025143319A (ja) 2025-10-01
KR20220088712A (ko) 2022-06-28
IL292206A (en) 2022-06-01
IL292206B1 (en) 2025-11-01
CN119751422A (zh) 2025-04-04
BR112022007035A2 (pt) 2022-06-28

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