CA3154064A1 - The salts of a compound and the crystalline forms thereof - Google Patents

The salts of a compound and the crystalline forms thereof Download PDF

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Publication number
CA3154064A1
CA3154064A1 CA3154064A CA3154064A CA3154064A1 CA 3154064 A1 CA3154064 A1 CA 3154064A1 CA 3154064 A CA3154064 A CA 3154064A CA 3154064 A CA3154064 A CA 3154064A CA 3154064 A1 CA3154064 A1 CA 3154064A1
Authority
CA
Canada
Prior art keywords
compound
crystalline forms
salts
same
present
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3154064A
Other languages
English (en)
French (fr)
Inventor
Wenji Li
Ling Feng
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Hutchmed Ltd
Original Assignee
Hutchison Medipharma Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hutchison Medipharma Ltd filed Critical Hutchison Medipharma Ltd
Publication of CA3154064A1 publication Critical patent/CA3154064A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/185—Saturated compounds having only one carboxyl group and containing keto groups
    • C07C59/225—Saturated compounds having only one carboxyl group and containing keto groups containing —CHO groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
CA3154064A 2019-10-14 2020-10-13 The salts of a compound and the crystalline forms thereof Pending CA3154064A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN201910973785 2019-10-14
CN201910973785.3 2019-10-14
PCT/CN2020/120594 WO2021073494A1 (en) 2019-10-14 2020-10-13 The salts of a compound and the crystalline forms thereof

Publications (1)

Publication Number Publication Date
CA3154064A1 true CA3154064A1 (en) 2021-04-22

Family

ID=75537486

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3154064A Pending CA3154064A1 (en) 2019-10-14 2020-10-13 The salts of a compound and the crystalline forms thereof

Country Status (14)

Country Link
US (1) US12559472B2 (https=)
EP (1) EP4045484A4 (https=)
JP (2) JP2022552329A (https=)
KR (1) KR20220088712A (https=)
CN (3) CN119751422A (https=)
AR (1) AR120202A1 (https=)
AU (1) AU2020367905A1 (https=)
BR (1) BR112022007035A2 (https=)
CA (1) CA3154064A1 (https=)
IL (1) IL292206B2 (https=)
MX (1) MX2022004274A (https=)
TW (1) TWI895290B (https=)
UA (1) UA129777C2 (https=)
WO (1) WO2021073494A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP7736357B2 (ja) * 2021-12-13 2025-09-09 アビスコ セラピューティクス カンパニー リミテッド Ｆｇｆｒ４阻害剤酸性塩およびその製造方法と使用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR079257A1 (es) * 2009-12-07 2012-01-04 Novartis Ag Formas cristalinas de 3-(2,6-dicloro-3-5-dimetoxi-fenil)-1-{6-[4-(4-etil-piperazin-1-il)-fenil-amino]-pirimidin-4-il}-1-metil-urea y sales de las mismas
WO2014139145A1 (en) * 2013-03-15 2014-09-18 Hutchison Medipharma Limited Novel pyrimidine and pyridine compounds and usage thereof
KR102548229B1 (ko) * 2015-04-14 2023-06-27 에자이 알앤드디 매니지먼트 가부시키가이샤 결정질 fgfr4 억제제 화합물 및 그의 용도
WO2018099451A1 (zh) 2016-12-01 2018-06-07 和记黄埔医药（上海）有限公司 化合物的晶型

Also Published As

Publication number Publication date
CN114555558A (zh) 2022-05-27
US20230121346A1 (en) 2023-04-20
TWI895290B (zh) 2025-09-01
UA129777C2 (uk) 2025-07-30
AU2020367905A1 (en) 2022-04-21
EP4045484A1 (en) 2022-08-24
IL292206B2 (en) 2026-03-01
CN114555558B (zh) 2024-12-17
US12559472B2 (en) 2026-02-24
TW202128669A (zh) 2021-08-01
AR120202A1 (es) 2022-02-02
EP4045484A4 (en) 2023-09-06
CN119462616A (zh) 2025-02-18
MX2022004274A (es) 2022-05-06
WO2021073494A1 (en) 2021-04-22
JP2025143319A (ja) 2025-10-01
KR20220088712A (ko) 2022-06-28
IL292206A (en) 2022-06-01
JP2022552329A (ja) 2022-12-15
IL292206B1 (en) 2025-11-01
CN119751422A (zh) 2025-04-04
BR112022007035A2 (pt) 2022-06-28

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