JP2022548943A - 複数標的化エフェクター細胞およびその使用 - Google Patents

複数標的化エフェクター細胞およびその使用 Download PDF

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JP2022548943A
JP2022548943A JP2022517799A JP2022517799A JP2022548943A JP 2022548943 A JP2022548943 A JP 2022548943A JP 2022517799 A JP2022517799 A JP 2022517799A JP 2022517799 A JP2022517799 A JP 2022517799A JP 2022548943 A JP2022548943 A JP 2022548943A
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cells
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derived
car
bcma
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JP2022548943A5 (enExample
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バラマール,バーラム
ビョーダール,リャン
グッドリッジ,ジョーデ
リー,トム,トング
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フェイト セラピューティクス,インコーポレイテッド
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JP2022517799A 2019-09-25 2020-09-25 複数標的化エフェクター細胞およびその使用 Pending JP2022548943A (ja)

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US201962906046P 2019-09-25 2019-09-25
US62/906,046 2019-09-25
US201962944187P 2019-12-05 2019-12-05
US62/944,187 2019-12-05
PCT/US2020/052890 WO2021062281A2 (en) 2019-09-25 2020-09-25 Multi-targeting effector cells and use thereof

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US (1) US20220378831A1 (enExample)
EP (1) EP4034638A4 (enExample)
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KR (1) KR20220085779A (enExample)
CN (1) CN114867846A (enExample)
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Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US12642852B1 (en) * 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
US11629340B2 (en) 2017-03-03 2023-04-18 Obsidian Therapeutics, Inc. DHFR tunable protein regulation
CN112119093A (zh) * 2018-02-20 2020-12-22 蜻蜓治疗公司 结合cd33、nkg2d和cd16的多特异性结合蛋白和使用方法
EP4097220A4 (en) * 2020-01-30 2024-03-20 ImmunityBio, Inc. ELIMINATION OF BCMA-POSITIVE MALIGNANCIES BY CAR-EXPRESSING NK CELLS
US11459372B2 (en) 2020-11-30 2022-10-04 Crispr Therapeutics Ag Gene-edited natural killer cells
EP4271798A1 (en) 2020-12-30 2023-11-08 CRISPR Therapeutics AG Compositions and methods for differentiating stem cells into nk cells
JP2024522756A (ja) * 2021-06-18 2024-06-21 オーエヌケイ セラピューティクス リミテッド ダブルノックアウトナチュラルキラー細胞
KR20240051112A (ko) 2021-07-01 2024-04-19 인답타 세라뷰틱스 인코포레이티드 조작된 자연 살해(nk) 세포 및 관련 방법
US20240307540A1 (en) * 2021-07-02 2024-09-19 Fate Therapeutics, Inc. Protected effector cells and use thereof for allogeneic adoptive cell therapies
GB202110363D0 (en) * 2021-07-19 2021-09-01 Celyad S A NKG2D CAR cells expressing IL-18 for adoptive cell therapy
CA3228865A1 (en) * 2021-08-18 2023-02-23 Bahram Valamehr Off-the-shelf ipsc-derived car-nk cell as monotherapy and in combination with antibody
JP2024539013A (ja) * 2021-10-20 2024-10-28 フェイト セラピューティクス,インコーポレイティド 固形腫瘍における同種異系養子細胞療法のためのエフェクター細胞及びその使用
US20250018034A1 (en) * 2021-11-08 2025-01-16 Fate Therapeutics, Inc. Engineered effector cells and methods of enhancing ubiquitous targeting of solid tumors
KR20250004622A (ko) 2022-04-08 2025-01-08 페이트 세러퓨틱스, 인코포레이티드 종양 표적화를 위한 키메라 항원 수용체
KR20250005097A (ko) * 2022-04-08 2025-01-09 페이트 세러퓨틱스, 인코포레이티드 고형 종양 표적화 골격을 갖는 세포 및 이의 용도
WO2024004814A1 (en) * 2022-06-27 2024-01-04 Kyoto University A METHOD FOR PRODUCING iPS CELL -DERIVED NATURAL KILLER CELLS
US20250375524A1 (en) 2022-06-30 2025-12-11 Indapta Therapeutics, Inc. Combination of engineered natural killer (nk) cells and antibody therapy and related methods
EP4593868A1 (en) * 2022-09-26 2025-08-06 Institut Curie Myeloid cells expressing il-2 and uses thereof for quick anticancer therapy
CN120092090A (zh) * 2022-11-07 2025-06-03 上海先博生物科技有限公司 工程化嵌合抗原受体免疫细胞及其应用
JP2026525671A (ja) * 2023-07-26 2026-07-31 ビーアールエル メディシン (シャンハイ) カンパニー リミテッド 疾患を治療するための方法及び組成物
WO2025109493A1 (en) * 2023-11-21 2025-05-30 National University Of Singapore Chimeric Receptors with Binding Capacity for Antibodies

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130156770A1 (en) * 2011-11-15 2013-06-20 Boehringer Ingelheim International Gmbh Binding molecules for bcma and cd3
WO2019075395A1 (en) * 2017-10-12 2019-04-18 Icell Gene Therapeutics, Llc COMPOUND CHIMERIC ANTIGEN RECEPTOR (CCAR) TARGETING MULTIPLE ANTIGENS AND METHODS OF USE THEREOF
WO2019112899A2 (en) * 2017-12-08 2019-06-13 Fate Therepeutics, Inc. IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3789487A1 (en) * 2013-04-03 2021-03-10 Memorial Sloan Kettering Cancer Center Effective generation of tumor-targeted t-cells derived from pluripotent stem cells
BR112016024546A2 (pt) * 2014-04-30 2018-01-23 Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft anticorpo ou fragmento de anticorpo, anticorpo ou fragmento de anticorpo isolado, conjugado de anticorpo-fármaco, molécula de ácido nucleico, célula hospedeira, e, composição farmacêutica
US10383929B2 (en) * 2014-12-12 2019-08-20 Bluebird Bio, Inc. BCMA chimeric antigen receptors
US12642852B1 (en) * 2015-11-04 2026-06-02 Fate Therapeutics, Inc. Genomic engineering of pluripotent cells
US12048718B2 (en) * 2016-06-07 2024-07-30 Max-Delbrück-Centrum für Molekulare Medizin in der Helmholtz-Geminschaft Chimeric antigen receptor and CAR-T cells that bind BCMA
BR112020011017A2 (pt) * 2017-12-22 2020-11-17 Fate Therapeutics, Inc. células efetoras imunes intensificadas e uso das mesmas

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130156770A1 (en) * 2011-11-15 2013-06-20 Boehringer Ingelheim International Gmbh Binding molecules for bcma and cd3
WO2019075395A1 (en) * 2017-10-12 2019-04-18 Icell Gene Therapeutics, Llc COMPOUND CHIMERIC ANTIGEN RECEPTOR (CCAR) TARGETING MULTIPLE ANTIGENS AND METHODS OF USE THEREOF
WO2019112899A2 (en) * 2017-12-08 2019-06-13 Fate Therepeutics, Inc. IMMUNOTHERAPIES USING ENHANCED iPSC DERIVED EFFECTOR CELLS

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