JP2022548777A5 - - Google Patents
Info
- Publication number
- JP2022548777A5 JP2022548777A5 JP2022518208A JP2022518208A JP2022548777A5 JP 2022548777 A5 JP2022548777 A5 JP 2022548777A5 JP 2022518208 A JP2022518208 A JP 2022518208A JP 2022518208 A JP2022518208 A JP 2022518208A JP 2022548777 A5 JP2022548777 A5 JP 2022548777A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- amino acid
- acid sequence
- chain variable
- variable region
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201962904272P | 2019-09-23 | 2019-09-23 | |
| US62/904,272 | 2019-09-23 | ||
| PCT/US2020/052121 WO2021061708A1 (en) | 2019-09-23 | 2020-09-23 | Monoclonal antibody against canine fibroblast activation protein that cross-reacts with mouse and human fibroblast activation protein (fap) |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2022548777A JP2022548777A (ja) | 2022-11-21 |
| JP2022548777A5 true JP2022548777A5 (https=) | 2023-09-06 |
| JP7603670B2 JP7603670B2 (ja) | 2024-12-20 |
Family
ID=74881697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2022518208A Active JP7603670B2 (ja) | 2019-09-23 | 2020-09-23 | マウスおよびヒト線維芽細胞活性化タンパク質（ｆａｐ）と交差反応するイヌ線維芽細胞活性化タンパク質に対するモノクローナル抗体 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US12139550B2 (https=) |
| EP (1) | EP4041290A4 (https=) |
| JP (1) | JP7603670B2 (https=) |
| KR (1) | KR20220066090A (https=) |
| CN (1) | CN114761036B (https=) |
| AU (1) | AU2020352986A1 (https=) |
| BR (1) | BR112022005404A2 (https=) |
| CA (1) | CA3151438A1 (https=) |
| IL (1) | IL291341A (https=) |
| MX (1) | MX2022003465A (https=) |
| WO (1) | WO2021061708A1 (https=) |
| ZA (1) | ZA202203460B (https=) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2019067425A1 (en) | 2017-09-26 | 2019-04-04 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR TREATING CARDIAC DISEASE BY REDIRECTED T-CELL IMMUNOTHERAPIES |
| US12116418B2 (en) | 2019-09-23 | 2024-10-15 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| MX2022003465A (es) | 2019-09-23 | 2022-06-16 | Univ Pennsylvania | Anticuerpo monoclonal contra proteína de activación de fibroblasto canino de reacción cruzada con proteína de activación de fibroblasto (fap) de ratón y humana. |
| US20240199762A1 (en) * | 2021-04-23 | 2024-06-20 | Philogen S.P.A | Anti-fibroblast activation protein antibodies |
| US20250002998A1 (en) * | 2023-06-29 | 2025-01-02 | Edge Animal Health, Inc. | Urine pcr assay and use thereof to diagnose and stage feline chronic kidney disease |
| US20250144234A1 (en) | 2023-11-02 | 2025-05-08 | Capstan Therapeutics Inc. | RNA for In vivo Transfection with Increased Expression |
| US20250332281A2 (en) | 2023-12-15 | 2025-10-30 | Capstan Therapeutics, Inc. | Humanized anti-cd8 antibodies and uses thereof |
| US20250302763A1 (en) | 2024-02-22 | 2025-10-02 | Capstan Therapeutics, Inc. | Immune engineering amplification |
| CN118388652B (zh) * | 2024-06-21 | 2025-03-04 | 杭州新东澳生物科技有限公司 | 抗成纤维细胞活化蛋白的单克隆抗体及其应用 |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1728800A (en) | 1998-11-18 | 2000-06-05 | Genentech Inc. | Antibody variants with higher binding affinity compared to parent antibodies |
| CA2412494C (en) | 2000-06-22 | 2012-10-23 | Genentech, Inc. | Agonist anti-trk-c monoclonal antibodies |
| CA2533593A1 (en) | 2003-07-26 | 2005-02-10 | Biogen Idec Ma Inc. | Altered antibodies having improved antigen-binding affinity |
| KR20100110864A (ko) | 2008-01-24 | 2010-10-13 | 노보 노르디스크 에이/에스 | 인간화된 항-인간 ｎｋｇ2ａ 모노클로날 항체 |
| CA2776037A1 (en) * | 2009-10-02 | 2011-04-07 | Ludwig Institute For Cancer Research Ltd | Anti-fibroblast activation protein antibodies and methods and uses thereof |
| CA2806021C (en) * | 2010-08-13 | 2019-05-21 | Roche Glycart Ag | Anti-fap antibodies and methods of use |
| GB201202319D0 (en) | 2012-02-10 | 2012-03-28 | Orbsen Therapeutics Ltd | Stromal stem cells |
| WO2014055442A2 (en) | 2012-10-01 | 2014-04-10 | The Trustees Of The University Of Pennsylvania | Compositions and methods for targeting stromal cells for the treatment of cancer |
| US20160136272A1 (en) | 2013-05-14 | 2016-05-19 | Innate Pharma | Methods for restoring corticosteroid sensitivity |
| SG11201601424PA (en) | 2013-08-28 | 2016-03-30 | Stemcentrx Inc | Site-specific antibody conjugation methods and compositions |
| AU2014317009A1 (en) | 2013-09-05 | 2016-03-10 | Aduro Biotech Holdings, Europe B.V. | CD70-binding peptides and method, process and use relating thereto |
| EP3087101B1 (en) | 2013-12-20 | 2024-06-05 | Novartis AG | Regulatable chimeric antigen receptor |
| ES2857226T3 (es) | 2014-03-15 | 2021-09-28 | Novartis Ag | Receptor de antígeno quimérico regulable |
| MA40861A (fr) | 2014-10-31 | 2017-09-05 | Biogen Ma Inc | Anticorps anti-glycoprotéines iib/iiia |
| GB201500875D0 (en) * | 2015-01-19 | 2015-03-04 | Philogen Spa | Antibodies for treatment and diagnosis |
| RU2757314C2 (ru) | 2016-01-22 | 2021-10-13 | Мерк Шарп И Доум Корп. | Антитела против фактора свертывания xi |
| CN109715808A (zh) | 2016-04-15 | 2019-05-03 | 诺华股份有限公司 | 用于选择性蛋白质表达的组合物和方法 |
| JP2018035137A (ja) * | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーＭａｂｉｍｍｕｎｅ Ｄｉａｇｎｏｓｔｉｃｓ Ａｇ | 新規な抗線維芽細胞活性化タンパク質（ｆａｐ）結合薬剤およびその使用 |
| CN107663240B (zh) | 2016-07-29 | 2021-01-12 | 中国人民解放军第四军医大学 | 高度糖基化cea特异性结合的单链抗体及其在检测和治疗上的应用 |
| WO2018105560A1 (ja) | 2016-12-07 | 2018-06-14 | 国立大学法人大阪大学 | Ｃｌａｕｄｉｎ ５抗体、及びその抗体を含有する医薬 |
| JP7227912B2 (ja) | 2017-02-08 | 2023-02-24 | ダナ－ファーバー キャンサー インスティテュート，インコーポレイテッド | キメラ抗原受容体の調節 |
| WO2019067425A1 (en) * | 2017-09-26 | 2019-04-04 | The Trustees Of The University Of Pennsylvania | COMPOSITIONS AND METHODS FOR TREATING CARDIAC DISEASE BY REDIRECTED T-CELL IMMUNOTHERAPIES |
| CN109796532B (zh) | 2017-11-17 | 2024-09-10 | 恺兴生命科技(上海)有限公司 | 靶向成纤维激活蛋白α的结合单元及其应用 |
| MA51428A (fr) | 2017-12-22 | 2020-11-04 | Bluebird Bio Inc | Récepteur d'antigène chimérique multivalent |
| EP3762030A4 (en) * | 2018-03-09 | 2022-01-05 | Phanes Therapeutics, Inc. | ANTI-CD73 ANTIBODIES AND USES THEREOF |
| MX2022003465A (es) | 2019-09-23 | 2022-06-16 | Univ Pennsylvania | Anticuerpo monoclonal contra proteína de activación de fibroblasto canino de reacción cruzada con proteína de activación de fibroblasto (fap) de ratón y humana. |
| US12116418B2 (en) | 2019-09-23 | 2024-10-15 | The Trustees Of The University Of Pennsylvania | Disrupting tumor tissues by targeting fibroblast activation protein (FAP) |
| WO2022081694A1 (en) | 2020-10-13 | 2022-04-21 | The Trustees Of The University Of Pennsylvania | In vivo targeting of fibrosis by anti-cd5-targeted fap-car t mrna-lnp |
-
2020
- 2020-09-23 MX MX2022003465A patent/MX2022003465A/es unknown
- 2020-09-23 CN CN202080079394.8A patent/CN114761036B/zh active Active
- 2020-09-23 KR KR1020227011620A patent/KR20220066090A/ko active Pending
- 2020-09-23 BR BR112022005404A patent/BR112022005404A2/pt unknown
- 2020-09-23 JP JP2022518208A patent/JP7603670B2/ja active Active
- 2020-09-23 WO PCT/US2020/052121 patent/WO2021061708A1/en not_active Ceased
- 2020-09-23 US US17/029,284 patent/US12139550B2/en active Active
- 2020-09-23 CA CA3151438A patent/CA3151438A1/en active Pending
- 2020-09-23 EP EP20869609.6A patent/EP4041290A4/en active Pending
- 2020-09-23 AU AU2020352986A patent/AU2020352986A1/en active Pending
-
2022
- 2022-03-14 IL IL291341A patent/IL291341A/en unknown
- 2022-03-24 ZA ZA2022/03460A patent/ZA202203460B/en unknown
-
2024
- 2024-02-28 US US18/589,804 patent/US20240384004A1/en active Pending
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