JP2022546717A - Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類 - Google Patents

Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類 Download PDF

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JP2022546717A
JP2022546717A JP2022514513A JP2022514513A JP2022546717A JP 2022546717 A JP2022546717 A JP 2022546717A JP 2022514513 A JP2022514513 A JP 2022514513A JP 2022514513 A JP2022514513 A JP 2022514513A JP 2022546717 A JP2022546717 A JP 2022546717A
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disease
compound
cancer
fibrosis
deficiency
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JP2022546717A5 (enExample
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ウィリアム トンプソン ポール
アンドリュー ラックハースト クリストファー
イアン ケンプ マーク
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ミッション セラピューティクス リミティド
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Publication of JP2022546717A5 publication Critical patent/JP2022546717A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/4025—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil not condensed and containing further heterocyclic rings, e.g. cromakalim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4245—Oxadiazoles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P21/00—Drugs for disorders of the muscular or neuromuscular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Psychology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Hospice & Palliative Care (AREA)
  • Emergency Medicine (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Cardiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022514513A 2019-09-04 2020-09-03 Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類 Ceased JP2022546717A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
GB1912674.7 2019-09-04
GBGB1912674.7A GB201912674D0 (en) 2019-09-04 2019-09-04 Novel compounds
PCT/EP2020/074540 WO2021043870A1 (en) 2019-09-04 2020-09-03 Substituted cyanopyrrolidines with activity as usp30 inhibitors

Publications (2)

Publication Number Publication Date
JP2022546717A true JP2022546717A (ja) 2022-11-07
JP2022546717A5 JP2022546717A5 (enExample) 2023-09-11

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JP2022514513A Ceased JP2022546717A (ja) 2019-09-04 2020-09-03 Ｕｓｐ３０阻害剤としての活性を有する置換シアノピロリジン類

Country Status (14)

Country Link
US (1) US20220315572A1 (enExample)
EP (1) EP4025573B9 (enExample)
JP (1) JP2022546717A (enExample)
KR (1) KR20220054867A (enExample)
CN (1) CN114341133B (enExample)
AU (1) AU2020340527A1 (enExample)
BR (1) BR112022003527A2 (enExample)
CA (1) CA3146040A1 (enExample)
CO (1) CO2022003608A2 (enExample)
GB (1) GB201912674D0 (enExample)
IL (1) IL290929B2 (enExample)
MX (1) MX2022002686A (enExample)
WO (1) WO2021043870A1 (enExample)
ZA (1) ZA202203775B (enExample)

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EP4218934B1 (en) 2018-10-05 2025-06-18 Forma Therapeutics, Inc. Inhibiting ubiquitin-specific protease 30 (usp30)
MX2022012578A (es) 2020-04-08 2022-11-07 Mission Therapeutics Ltd N-cianopirrolidinas con actividad como inhibidores de usp30.
KR20230016674A (ko) 2020-05-28 2023-02-02 미션 테라퓨틱스 엘티디 미토콘드리아 기능장애의 치료를 위한 usp30 억제제로서 n-(1-시아노피롤리딘-3-일)-5-(3-(트라이플루오로메틸)페닐)옥사졸-2-카복스아미드 유도체 및 상응하는 옥사다이아졸 유도체
WO2021245186A1 (en) 2020-06-04 2021-12-09 Mission Therapeutics Limited N-cyanopyrrolidines with activity as usp30 inhibitors
RS67140B1 (sr) 2020-06-08 2025-09-30 Mission Therapeutics Ltd 1-(5-(2-cijanopiridin-4-il)oksazol-2-karbonil)-4-metilheksahidropirolo[3,4-b]pirol-5(1h)-karbonitril kao usp30 inhibitor za primenu u lečenju mitohondrijske disfunkcije, kancera i fibroze
GB202016800D0 (en) 2020-10-22 2020-12-09 Mission Therapeutics Ltd Novel compounds
WO2023099561A1 (en) 2021-12-01 2023-06-08 Mission Therapeutics Limited Substituted n-cyanopyrrolidines with activity as usp30 inhibitors
EP4547247A4 (en) * 2022-06-30 2026-08-12 Dana Farber Cancer Inst Inc DESUBIQUITINASE INHIBITORS AND THEIR METHODS OF USE
KR20240132148A (ko) * 2023-02-24 2024-09-03 연세대학교 산학협력단 인덴 유도체를 유효성분으로 포함하는 섬유화의 예방 또는 치료용 조성물
GB202408928D0 (en) 2024-06-21 2024-08-07 Mission Therapeutics Ltd Novel compounds
GB202411060D0 (en) 2024-07-29 2024-09-11 Mission Therapeutics Ltd Novel compounds
GB202500610D0 (en) 2025-01-16 2025-03-05 Mission Therapeutics Ltd Novel compounds

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JP2017530960A (ja) * 2014-09-23 2017-10-19 ミッション・セラピューティクス・リミテッド 新規化合物
JP2018510183A (ja) * 2015-03-30 2018-04-12 ミッション セラピューティクス リミティド Ｕｓｐ３０阻害剤としての１−シアノ−ピロリジン化合物

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Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
JP2017528461A (ja) * 2014-09-10 2017-09-28 エピザイム インコーポレイテッド 置換ピロリジンカルボキサミド化合物
JP2017530960A (ja) * 2014-09-23 2017-10-19 ミッション・セラピューティクス・リミテッド 新規化合物
JP2018510183A (ja) * 2015-03-30 2018-04-12 ミッション セラピューティクス リミティド Ｕｓｐ３０阻害剤としての１−シアノ−ピロリジン化合物

Also Published As

Publication number Publication date
ZA202203775B (en) 2024-01-31
AU2020340527A1 (en) 2022-04-21
EP4025573B9 (en) 2024-11-20
BR112022003527A2 (pt) 2022-05-17
EP4025573A1 (en) 2022-07-13
US20220315572A1 (en) 2022-10-06
MX2022002686A (es) 2022-04-07
KR20220054867A (ko) 2022-05-03
CN114341133B (zh) 2024-02-27
EP4025573B1 (en) 2024-07-24
IL290929A (en) 2022-04-01
CA3146040A1 (en) 2021-03-11
CO2022003608A2 (es) 2022-04-19
WO2021043870A1 (en) 2021-03-11
GB201912674D0 (en) 2019-10-16
IL290929B1 (en) 2024-11-01
IL290929B2 (en) 2025-03-01
CN114341133A (zh) 2022-04-12

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