JP2022546504A - 肺新生物形成を有する疑いのある対象におけるメチル化されたｄｎａ、ｒｎａ、及びタンパク質の特性決定 - Google Patents

肺新生物形成を有する疑いのある対象におけるメチル化されたｄｎａ、ｒｎａ、及びタンパク質の特性決定 Download PDF

Info

Publication number
JP2022546504A
JP2022546504A JP2022513690A JP2022513690A JP2022546504A JP 2022546504 A JP2022546504 A JP 2022546504A JP 2022513690 A JP2022513690 A JP 2022513690A JP 2022513690 A JP2022513690 A JP 2022513690A JP 2022546504 A JP2022546504 A JP 2022546504A
Authority
JP
Japan
Prior art keywords
dna
marker
max
methylation
rna
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022513690A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022546504A5 (enExample
Inventor
モーリス，スコット
マレリー，デヴィッド
ティー． アラーウィ，ハティム
ピー． リドガード，グラハム
ギアクモプロス，マリア
ダブリュー． カイザー，マイケル
エー． アールクイスト，デビッド
アール． テイラー，ウィリアム
ダブリュー． マホーニー，ダグラス
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mayo Clinic in Florida
Original Assignee
Mayo Clinic in Florida
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mayo Clinic in Florida filed Critical Mayo Clinic in Florida
Publication of JP2022546504A publication Critical patent/JP2022546504A/ja
Publication of JP2022546504A5 publication Critical patent/JP2022546504A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6844—Nucleic acid amplification reactions
    • C12Q1/6858—Allele-specific amplification
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/154—Methylation markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/158—Expression markers
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/16—Primer sets for multiplex assays

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Analytical Chemistry (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Molecular Biology (AREA)
  • Hospice & Palliative Care (AREA)
  • Biophysics (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2022513690A 2019-08-27 2020-08-27 肺新生物形成を有する疑いのある対象におけるメチル化されたｄｎａ、ｒｎａ、及びタンパク質の特性決定 Pending JP2022546504A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962892426P 2019-08-27 2019-08-27
US62/892,426 2019-08-27
PCT/US2020/048270 WO2021041726A1 (en) 2019-08-27 2020-08-27 Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia

Publications (2)

Publication Number Publication Date
JP2022546504A true JP2022546504A (ja) 2022-11-04
JP2022546504A5 JP2022546504A5 (enExample) 2023-09-01

Family

ID=74686021

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022513690A Pending JP2022546504A (ja) 2019-08-27 2020-08-27 肺新生物形成を有する疑いのある対象におけるメチル化されたｄｎａ、ｒｎａ、及びタンパク質の特性決定

Country Status (7)

Country Link
US (1) US20220403471A1 (enExample)
EP (1) EP4022093A4 (enExample)
JP (1) JP2022546504A (enExample)
KR (1) KR20220092856A (enExample)
CN (1) CN114945687A (enExample)
CA (1) CA3149601A1 (enExample)
WO (1) WO2021041726A1 (enExample)

Families Citing this family (28)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2816122A1 (en) 2008-02-15 2014-12-24 Mayo Foundation For Medical Education And Research Detecting neoplasm from a stool sample
US8361720B2 (en) 2010-11-15 2013-01-29 Exact Sciences Corporation Real time cleavage assay
CA2902916C (en) 2013-03-14 2018-08-28 Mayo Foundation For Medical Education And Research Detecting neoplasm
CN120700143A (zh) 2014-03-31 2025-09-26 梅奥医学教育和研究基金会 检测结直肠赘生物
US10184154B2 (en) 2014-09-26 2019-01-22 Mayo Foundation For Medical Education And Research Detecting cholangiocarcinoma
US10435755B2 (en) 2015-03-27 2019-10-08 Exact Sciences Development Company, Llc Detecting esophageal disorders
CN114574585A (zh) 2015-08-31 2022-06-03 梅约医药教育及研究基金会 检测胃肿瘤
CN108350485A (zh) 2015-10-30 2018-07-31 精密科学发展有限责任公司 血浆dna的多重扩增检测测定以及分离和检测
CN109563546B (zh) 2016-05-05 2022-09-09 精密科学发展有限责任公司 通过分析甲基化dna来检测肺肿瘤
KR102892245B1 (ko) 2017-01-27 2025-11-27 이그젝트 싸이언스 디블롭먼트 컴패니, 엘엘씨 메틸화된 dna 분석에 의한 결장 신조직형성의 검출
JP7277460B2 (ja) 2017-11-30 2023-05-19 マヨ ファウンデーション フォア メディカル エデュケーション アンド リサーチ 乳癌の検出
US10648025B2 (en) 2017-12-13 2020-05-12 Exact Sciences Development Company, Llc Multiplex amplification detection assay II
CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
US11898199B2 (en) 2019-11-11 2024-02-13 Universal Diagnostics, S.A. Detection of colorectal cancer and/or advanced adenomas
CN115605138A (zh) 2020-04-17 2023-01-13 精密科学公司（Us） 可摄取取样装置
WO2021231713A2 (en) 2020-05-14 2021-11-18 Ampel Biosolutions, Llc Methods and systems for machine learning analysis of single nucleotide polymorphisms in lupus
US12467096B2 (en) 2020-05-15 2025-11-11 Universal Diagnostics, S.A. Methods and systems for identifying methylation biomarkers
US12592321B2 (en) 2020-06-19 2026-03-31 University Health Network Cancer detection and classification using methylome analysis
EP4150121A1 (en) 2020-06-30 2023-03-22 Universal Diagnostics, S.A. Systems and methods for detection of multiple cancer types
EP4363612A4 (en) * 2021-07-02 2025-06-11 Enzo Biochem, Inc. Method for detecting and quantifying DNA methylation in a selected site or region of DNA
WO2023107709A1 (en) * 2021-12-10 2023-06-15 Adela, Inc. Methods and systems for generating sequencing libraries
US12606872B2 (en) 2022-11-16 2026-04-21 Universal Diagnostics, S.A. Methods for stratification and early detection of advanced adenoma and/or colorectal cancer using DNA methylation markers
WO2024233363A2 (en) * 2023-05-05 2024-11-14 Foundation Medicine, Inc. Methods and systems for isolating nucleic acids
WO2025097008A2 (en) * 2023-11-01 2025-05-08 Nucleix Ltd. Mitochondrial dna intrinsic controls for use in msre-dependent dna methylation analysis
WO2025128887A1 (en) * 2023-12-13 2025-06-19 Foundation Medicine, Inc. Methods and compositions for selective enrichment of methylation signal
KR20250161434A (ko) * 2024-05-07 2025-11-17 주식회사 포어텔마이헬스 엑손-접합부를 포함하는 암 진단용 마커 및 레퍼런스 마커
WO2026055641A1 (en) 2024-09-06 2026-03-12 Exact Sciences Corporation Methods and compositions for preparing biomolecule analytes from complex samples

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2015503356A (ja) * 2012-01-06 2015-02-02 バイオミクス, インコーポレイテッドViomics, Inc. 末梢血中で、がんによって変化したｒｎａを検出するシステムおよび方法
US20170335401A1 (en) * 2016-05-05 2017-11-23 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated dna
US20180030547A1 (en) * 2011-05-02 2018-02-01 Rheinische Friedrich-Wilhelms-Universitat Bonn Blood-based gene detection of non-small cell lung cancer

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007103541A2 (en) * 2006-03-09 2007-09-13 The Trustees Of Boston University Diagnostic and prognostic methods for lung disorders using gene expression profiles from nose epithelial cells
GB2512153B (en) * 2008-11-17 2014-11-12 Veracyte Inc Methods and compositions of molecular profiling for disease diagnostics
WO2010074924A1 (en) * 2008-12-23 2010-07-01 University Of Utah Research Foundation Identification and regulation of a novel dna demethylase system
EP2520661A1 (en) * 2011-05-02 2012-11-07 Rheinische Friedrich-Wilhelms-Universität Bonn Blood-based gene expression signatures in lung cancer
EP2813850A1 (en) * 2013-06-10 2014-12-17 INSERM (Institut National de la Santé et de la Recherche Médicale) Methods for predicting rheumatoid arthritis treatment response
ES3002715T3 (en) * 2016-04-14 2025-03-07 Guardant Health Inc Methods for early detection of cancer
CA3024744A1 (en) * 2016-05-17 2017-11-23 Genecentric Therapeutics, Inc. Methods for subtyping of lung squamous cell carcinoma
WO2020112869A1 (en) * 2018-11-27 2020-06-04 Exact Sciences Development Company, Llc Characterizing methylated dna, rna, and proteins in the detection of lung neoplasia

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20180030547A1 (en) * 2011-05-02 2018-02-01 Rheinische Friedrich-Wilhelms-Universitat Bonn Blood-based gene detection of non-small cell lung cancer
JP2015503356A (ja) * 2012-01-06 2015-02-02 バイオミクス, インコーポレイテッドViomics, Inc. 末梢血中で、がんによって変化したｒｎａを検出するシステムおよび方法
US20170335401A1 (en) * 2016-05-05 2017-11-23 Exact Sciences Corporation Detection of lung neoplasia by analysis of methylated dna

Also Published As

Publication number Publication date
EP4022093A1 (en) 2022-07-06
KR20220092856A (ko) 2022-07-04
CA3149601A1 (en) 2021-03-04
EP4022093A4 (en) 2024-05-22
AU2020336115A1 (en) 2022-04-14
CN114945687A (zh) 2022-08-26
WO2021041726A1 (en) 2021-03-04
AU2020336115A8 (en) 2022-06-02
US20220403471A1 (en) 2022-12-22

Similar Documents

Publication Publication Date Title
US20220403471A1 (en) Characterizing methylated dna, rna, and proteins in subjects suspected of having lung neoplasia
US12612664B2 (en) Detection and analysis of methylated DNA
JP7512278B2 (ja) 肺腫瘍の検出におけるメチル化ｄｎａ、ｒｎａ、及びタンパク質の特性決定
JP7670662B2 (ja) メチル化ｄｎａの分析による腫瘍の検出
JP7757338B2 (ja) 乳癌の検出
AU2020336115B2 (en) Characterizing methylated DNA, RNA, and proteins in subjects suspected of having lung neoplasia
HK40093169A (zh) 通过分析甲基化dna来检测肺肿瘤

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20221025

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230824

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230824

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20241008

A601 Written request for extension of time

Free format text: JAPANESE INTERMEDIATE CODE: A601

Effective date: 20241223

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20250408

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250729

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20251027

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20251216

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20260327

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A821

Effective date: 20260327