JP2022543555A - ｍｉＲＮＡ－１９３ａに関する新たな処置 - Google Patents

ｍｉＲＮＡ－１９３ａに関する新たな処置 Download PDF

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JP2022543555A
JP2022543555A JP2022505487A JP2022505487A JP2022543555A JP 2022543555 A JP2022543555 A JP 2022543555A JP 2022505487 A JP2022505487 A JP 2022505487A JP 2022505487 A JP2022505487 A JP 2022505487A JP 2022543555 A JP2022543555 A JP 2022543555A
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mirna
cancer
use according
pten
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JP2022543555A5 (enExample
Inventor
サナズ イェヒェネジャド，
ブライオニー ジェーン テルフォード，
デン ボシュ， マリオン ティナ ジョリアン ファン
ミール ファルシード アレムデイ，
ガンスト， マテウス マリア デ
ピンクステレン， ローレンス アドリアヌス ヘンドリクス ファン
ルーラント クイリーヌス ジョゼフ シャープフェルト，
ミシェル ジャニコ，
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Interna Technologies BV
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Interna Technologies BV
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Publication of JP2022543555A5 publication Critical patent/JP2022543555A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]
    • C12N2310/141—MicroRNAs, miRNAs
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2320/00—Applications; Uses
    • C12N2320/30—Special therapeutic applications
    • C12N2320/31—Combination therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biotechnology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
JP2022505487A 2019-08-12 2020-03-06 ｍｉＲＮＡ－１９３ａに関する新たな処置 Pending JP2022543555A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
EP19191222.9 2019-08-12
EP19191222 2019-08-12
EP20160235 2020-02-28
EP20160235.6 2020-02-28
PCT/EP2020/055965 WO2021028081A1 (en) 2019-08-12 2020-03-06 New treatments involving mirna-193a

Publications (2)

Publication Number Publication Date
JP2022543555A true JP2022543555A (ja) 2022-10-13
JP2022543555A5 JP2022543555A5 (enExample) 2023-03-10

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JP2022505487A Pending JP2022543555A (ja) 2019-08-12 2020-03-06 ｍｉＲＮＡ－１９３ａに関する新たな処置

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US (1) US20220275368A1 (enExample)
EP (1) EP4013869A1 (enExample)
JP (1) JP2022543555A (enExample)
CN (1) CN114729358A (enExample)
AU (1) AU2020327537A1 (enExample)
CA (1) CA3148713A1 (enExample)
WO (1) WO2021028081A1 (enExample)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020245822A1 (en) * 2019-06-03 2020-12-10 Carmel Haifa University Economic Corporation Ltd. Human head and neck cancer treatment
AU2020327537A1 (en) * 2019-08-12 2022-03-03 Interna Technologies B.V. New treatments involving miRNA-193a
CN114672558B (zh) * 2021-12-29 2023-08-04 河北医科大学第三医院 肝癌药物仑伐替尼耐药机制的研究方法
WO2023162872A1 (ja) * 2022-02-22 2023-08-31 株式会社 レオロジー機能食品研究所 抗がん剤及び抗がん剤のスクリーニング方法
EP4529562A2 (en) * 2022-05-23 2025-04-02 Empirico Inc. Treatment of sos2 related diseases and disorders
CN116850289B (zh) * 2022-07-29 2025-10-28 东北大学 Plk4靶向药物在治疗对铂类药物耐药型肿瘤中的应用
CN117144008B (zh) * 2023-08-31 2024-03-08 武汉科技大学 三阴性乳腺癌生物标志物及其应用
WO2025111565A1 (en) * 2023-11-22 2025-05-30 Empirico Inc. Treatment of sos2 related diseases and disorders
WO2025155574A1 (en) * 2024-01-16 2025-07-24 University Of Houston System, Board Of Regents Modulation of akap12 signalosome
CN118671343B (zh) * 2024-06-25 2025-04-29 南昌大学第一附属医院 一种头颈鳞状细胞癌分子标记物及其应用
WO2026013165A1 (en) * 2024-07-10 2026-01-15 Université Libre de Bruxelles Combination of ship2 inhibitor and plk1 inhibitor for use in the treatment of cancer
CN118987030B (zh) * 2024-07-16 2025-05-30 广东医科大学附属医院 干预嗜碱性粒细胞exosc3在制备预防或治疗狼疮性肾炎药物中的应用
CN119015428B (zh) * 2024-10-29 2024-12-20 中国人民解放军总医院第三医学中心 一种敲低tmem91诱导肾癌细胞死亡和肿瘤免疫治疗肾癌的应用
CN120989248B (zh) * 2025-10-23 2025-12-23 山东第二医科大学 一种检测lncRNA标志物表达量的试剂在制备口腔鳞状细胞癌诊断产品或预后判断产品中的应用
CN122168762B (zh) * 2026-05-13 2026-07-31 山东第一医科大学附属肿瘤医院(山东省肿瘤防治研究院、山东省肿瘤医院) Ubald2作为标志物在肝细胞癌诊断产品中的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120295832A1 (en) * 2011-05-17 2012-11-22 Arrowhead Research Corporation Novel Lipids and Compositions for Intracellular Delivery of Biologically Active Compounds
JP2021513508A (ja) * 2018-02-12 2021-05-27 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 抗がんマイクロｒｎａ及びその脂質製剤

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU1089600A (en) 1998-05-15 2000-01-17 Tcs Engineering Services, Inc. Enhanced aircraft cockpit configuration
US7220410B2 (en) 2003-04-18 2007-05-22 Galaxy Biotech, Llc Monoclonal antibodies to hepatocyte growth factor
EA015363B1 (ru) 2003-07-18 2011-06-30 Эмджен Инк. Агенты, специфически связывающие фактор роста гепатоцитов, и их применение
FR2872704B1 (fr) 2004-07-12 2007-11-02 Laurent Schwartz Pluritherapie contre le cancer
AR059922A1 (es) 2006-04-01 2008-05-07 Galaxy Biotech Llc Anticuerpos monoclonales humanizados para el factor de crecimiento de hepatocitos
MX2008015138A (es) 2006-06-02 2009-01-28 Aveo Pharmaceuticals Inc Proteinas de union al factor de crecimiento de hepatocitos (fch).
US7649083B2 (en) 2006-06-02 2010-01-19 Aveo Pharmaceuticals, Inc. Hepatocyte growth factor (HGF) binding antibody
JP4933548B2 (ja) 2006-07-20 2012-05-16 パナソニック株式会社 超音波探触子
WO2009091982A1 (en) 2008-01-18 2009-07-23 Alnylam Pharmaceuticals, Inc. Mir-122 agonist
TW200948380A (en) 2008-04-11 2009-12-01 Galaxy Biotech Llc Combination of HGF inhibitor and PTEN agonist to treat cancer
EP2591106A1 (en) * 2010-07-06 2013-05-15 InteRNA Technologies B.V. Mirna and its diagnostic and therapeutic uses in diseases or conditions associated with melanoma, or in diseases or conditions associated with activated braf pathway
EP3369818B1 (en) 2011-12-22 2021-06-09 InteRNA Technologies B.V. Mirna for treating head and neck cancer
WO2015022545A2 (en) * 2013-08-14 2015-02-19 Reneuron Limited Stem cell microparticles and mirna
WO2017180587A2 (en) * 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
WO2019106605A1 (en) 2017-12-01 2019-06-06 Board Of Regents, The University Of Texas System Combination treatment for cancer
AU2020327537A1 (en) * 2019-08-12 2022-03-03 Interna Technologies B.V. New treatments involving miRNA-193a
US20230136088A1 (en) * 2020-02-28 2023-05-04 Interna Technologies B.V. miRNA-193a for Promoting Immunogenic Cell Death

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120295832A1 (en) * 2011-05-17 2012-11-22 Arrowhead Research Corporation Novel Lipids and Compositions for Intracellular Delivery of Biologically Active Compounds
JP2021513508A (ja) * 2018-02-12 2021-05-27 インテアールエヌエー テクノロジーズ ビー．ヴイ．ＩｎｔｅＲＮＡ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｂ．Ｖ． 抗がんマイクロｒｎａ及びその脂質製剤

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
BLOOD, vol. 121, no. 3, JPN6024007916, 2013, pages 499 - 509, ISSN: 0005426600 *

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Publication number Publication date
US20220275368A1 (en) 2022-09-01
CA3148713A1 (en) 2021-02-18
AU2020327537A1 (en) 2022-03-03
EP4013869A1 (en) 2022-06-22
WO2021028081A1 (en) 2021-02-18
CN114729358A (zh) 2022-07-08

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