JP2022543112A - Ｄｕｘ４発現細胞およびそれらの使用 - Google Patents

Ｄｕｘ４発現細胞およびそれらの使用 Download PDF

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JP2022543112A
JP2022543112A JP2022506729A JP2022506729A JP2022543112A JP 2022543112 A JP2022543112 A JP 2022543112A JP 2022506729 A JP2022506729 A JP 2022506729A JP 2022506729 A JP2022506729 A JP 2022506729A JP 2022543112 A JP2022543112 A JP 2022543112A
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cells
cell
dux4
hla
gene
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JP2022543112A5 (https=
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エー． コーワン，チャド
エス． マッケイド，ライアン
シュレプファー，ソーニャ
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サナ バイオテクノロジー，インコーポレイテッド
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
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    • C12N5/0602—Vertebrate cells
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    • C12N5/0646—Natural killers cells [NK], NKT cells
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    • A61K40/00—Cellular immunotherapy
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    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/86—Viral vectors
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    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/90—Stable introduction of foreign DNA into chromosome
    • C12N15/902—Stable introduction of foreign DNA into chromosome using homologous recombination
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    • C12N9/14—Hydrolases (3)
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    • C12N9/22—Ribonucleases [RNase]; Deoxyribonucleases [DNase]
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    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
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    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/15011—Lentivirus, not HIV, e.g. FIV, SIV
    • C12N2740/15041—Use of virus, viral particle or viral elements as a vector
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    • C12N2840/00—Vectors comprising a special translation-regulating system
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JP2022506729A 2019-08-01 2020-07-31 Ｄｕｘ４発現細胞およびそれらの使用 Pending JP2022543112A (ja)

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US201962881840P 2019-08-01 2019-08-01
US62/881,840 2019-08-01
PCT/US2020/044635 WO2021022223A1 (en) 2019-08-01 2020-07-31 Dux4 expressing cells and uses thereof

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JP2022543112A true JP2022543112A (ja) 2022-10-07
JP2022543112A5 JP2022543112A5 (https=) 2023-08-08

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