JP2022540922A - ソマトスタチンモジュレーターの結晶形態 - Google Patents

ソマトスタチンモジュレーターの結晶形態 Download PDF

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Publication number
JP2022540922A
JP2022540922A JP2022502580A JP2022502580A JP2022540922A JP 2022540922 A JP2022540922 A JP 2022540922A JP 2022502580 A JP2022502580 A JP 2022502580A JP 2022502580 A JP2022502580 A JP 2022502580A JP 2022540922 A JP2022540922 A JP 2022540922A
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JP
Japan
Prior art keywords
pattern
quinolin
hydroxybenzonitrile
dimesylate
difluorophenyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2022502580A
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English (en)
Japanese (ja)
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JP2022540922A5 (https=
Inventor
ピー． レッディ，ジャヤチャンドラ
ヂャオ，ユーシン
ミルメフラビ，マームード
マヨ，アレックス
コタ，マドゥカー
ダッシュ，ウッタム
ウメシュ ナイーク，ヴィジャヤクマール
クマール バンダール，パラヴィーン
ファン，ユワンチン
Original Assignee
クリネティックス ファーマシューティカルズ，インク．
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by クリネティックス ファーマシューティカルズ，インク． filed Critical クリネティックス ファーマシューティカルズ，インク．
Publication of JP2022540922A publication Critical patent/JP2022540922A/ja
Publication of JP2022540922A5 publication Critical patent/JP2022540922A5/ja
Priority to JP2025106721A priority Critical patent/JP2025141974A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Dermatology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2022502580A 2019-07-17 2020-07-15 ソマトスタチンモジュレーターの結晶形態 Pending JP2022540922A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025106721A JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875285P 2019-07-17 2019-07-17
US62/875,285 2019-07-17
PCT/US2020/042119 WO2021011641A1 (en) 2019-07-17 2020-07-15 Crystalline forms of somatostatin modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025106721A Division JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Publications (2)

Publication Number Publication Date
JP2022540922A true JP2022540922A (ja) 2022-09-20
JP2022540922A5 JP2022540922A5 (https=) 2023-07-10

Family

ID=74211310

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2022502580A Pending JP2022540922A (ja) 2019-07-17 2020-07-15 ソマトスタチンモジュレーターの結晶形態
JP2025106721A Pending JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025106721A Pending JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Country Status (3)

Country Link
EP (1) EP3999509A4 (https=)
JP (2) JP2022540922A (https=)
WO (1) WO2021011641A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL264178B2 (en) 2016-07-14 2024-05-01 Crinetics Pharmaceuticals Inc Somatostatin modulators and uses thereof
CA3191084A1 (en) * 2020-09-09 2022-03-17 Gerald Burke Formulations of a somatostatin modulator
WO2023137018A1 (en) * 2022-01-11 2023-07-20 Crinetics Pharmaceuticals, Inc. Uses of a somatostatin modulator for the treatment of carcinoid syndrome
EP4547654A1 (en) 2022-06-10 2025-05-07 Assia Chemical Industries Ltd. Solid state forms of paltusotine and process for preparation thereof

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009520690A (ja) * 2005-12-05 2009-05-28 ゼノポート，インコーポレーテッド レボドパプロドラッグメシラート、その組成物、およびその使用法
US20180016252A1 (en) * 2016-07-14 2018-01-18 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102011113749A1 (de) * 2011-09-14 2013-03-14 Aicuris Gmbh & Co. Kg Sulfonsäuresalze Heterocyclylamid-substituiertr Imidazole
MX2019000246A (es) * 2016-07-07 2019-05-27 Plantex Ltd Formas en estado solido del dimesilato de palbociclib.

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009520690A (ja) * 2005-12-05 2009-05-28 ゼノポート，インコーポレーテッド レボドパプロドラッグメシラート、その組成物、およびその使用法
US20180016252A1 (en) * 2016-07-14 2018-01-18 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Ｃ．Ｇ．ＷＥＲＭＵＴＨ編, 最新 創薬化学 下巻, vol. p.347-365, JPN6014029314, 1999, ISSN: 0005641357 *
厚生省医薬安全局審査管理課長: "医薬品の残留溶媒ガイドラインについて", 医薬審, JPN6014031669, 1998, ISSN: 0005641359 *
平山令明, 有機化合物結晶作製ハンドブック, JPN6014035600, 2008, pages 17 - 23, ISSN: 0005641358 *

Also Published As

Publication number Publication date
JP2025141974A (ja) 2025-09-29
EP3999509A4 (en) 2023-07-19
EP3999509A1 (en) 2022-05-25
WO2021011641A1 (en) 2021-01-21
US20220267295A1 (en) 2022-08-25

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