JP2022540922A - ソマトスタチンモジュレーターの結晶形態 - Google Patents

ソマトスタチンモジュレーターの結晶形態 Download PDF

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Publication number
JP2022540922A
JP2022540922A JP2022502580A JP2022502580A JP2022540922A JP 2022540922 A JP2022540922 A JP 2022540922A JP 2022502580 A JP2022502580 A JP 2022502580A JP 2022502580 A JP2022502580 A JP 2022502580A JP 2022540922 A JP2022540922 A JP 2022540922A
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JP
Japan
Prior art keywords
pattern
quinolin
hydroxybenzonitrile
dimesylate
difluorophenyl
Prior art date
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Pending
Application number
JP2022502580A
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English (en)
Japanese (ja)
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JP2022540922A5 (enExample
Inventor
ピー． レッディ，ジャヤチャンドラ
ヂャオ，ユーシン
ミルメフラビ，マームード
マヨ，アレックス
コタ，マドゥカー
ダッシュ，ウッタム
ウメシュ ナイーク，ヴィジャヤクマール
クマール バンダール，パラヴィーン
ファン，ユワンチン
Original Assignee
クリネティックス ファーマシューティカルズ，インク．
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Application filed by クリネティックス ファーマシューティカルズ，インク． filed Critical クリネティックス ファーマシューティカルズ，インク．
Publication of JP2022540922A publication Critical patent/JP2022540922A/ja
Publication of JP2022540922A5 publication Critical patent/JP2022540922A5/ja
Priority to JP2025106721A priority Critical patent/JP2025141974A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2022502580A 2019-07-17 2020-07-15 ソマトスタチンモジュレーターの結晶形態 Pending JP2022540922A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025106721A JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962875285P 2019-07-17 2019-07-17
US62/875,285 2019-07-17
PCT/US2020/042119 WO2021011641A1 (en) 2019-07-17 2020-07-15 Crystalline forms of somatostatin modulators

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025106721A Division JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

Publications (2)

Publication Number Publication Date
JP2022540922A true JP2022540922A (ja) 2022-09-20
JP2022540922A5 JP2022540922A5 (enExample) 2023-07-10

Family

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Family Applications (2)

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JP2022502580A Pending JP2022540922A (ja) 2019-07-17 2020-07-15 ソマトスタチンモジュレーターの結晶形態
JP2025106721A Pending JP2025141974A (ja) 2019-07-17 2025-06-24 ソマトスタチンモジュレーターの結晶形態

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Country Status (4)

Country Link
US (1) US12617767B2 (enExample)
EP (1) EP3999509A4 (enExample)
JP (2) JP2022540922A (enExample)
WO (1) WO2021011641A1 (enExample)

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AU2017296392B2 (en) 2016-07-14 2020-09-24 Crinetics Pharmaceuticals, Inc. Somatostatin modulators and uses thereof
US12617767B2 (en) 2019-07-17 2026-05-05 Crinetics Pharmaceuticals, Inc. Crystalline forms of somatostatin modulators
WO2022055880A1 (en) * 2020-09-09 2022-03-17 Crinetics Pharmaceuticals, Inc. Formulations of a somatostatin modulator
IL314054A (en) * 2022-01-11 2024-09-01 Crinetics Pharmaceuticals Inc Uses of a somatostatin modulator for the treatment of carcinoid syndrome
EP4547654A1 (en) 2022-06-10 2025-05-07 Assia Chemical Industries Ltd. Solid state forms of paltusotine and process for preparation thereof
EP4687898A1 (en) 2023-03-28 2026-02-11 Crinetics Pharmaceuticals, Inc. Compositions and methods for administering paltusotine to patients with hepatic impairment

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Also Published As

Publication number Publication date
EP3999509A1 (en) 2022-05-25
JP2025141974A (ja) 2025-09-29
US20220267295A1 (en) 2022-08-25
WO2021011641A1 (en) 2021-01-21
EP3999509A4 (en) 2023-07-19
US12617767B2 (en) 2026-05-05

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