JP2022540585A - カンナビノイド誘導体 - Google Patents

カンナビノイド誘導体 Download PDF

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Publication number
JP2022540585A
JP2022540585A JP2022500797A JP2022500797A JP2022540585A JP 2022540585 A JP2022540585 A JP 2022540585A JP 2022500797 A JP2022500797 A JP 2022500797A JP 2022500797 A JP2022500797 A JP 2022500797A JP 2022540585 A JP2022540585 A JP 2022540585A
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Japan
Prior art keywords
methyl
biphenyl
alkyl
oxy
pentyl
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Pending
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JP2022500797A
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Japanese (ja)
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JPWO2021007662A5 (https=
JP2022540585A5 (https=
Inventor
アラン オメーラ，ジェフリー
ワーナー ポールズ，ハインツ
Original Assignee
キャノピー グロウス コーポレイション
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Publication of JP2022540585A publication Critical patent/JP2022540585A/ja
Publication of JPWO2021007662A5 publication Critical patent/JPWO2021007662A5/ja
Publication of JP2022540585A5 publication Critical patent/JP2022540585A5/ja
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6581—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and nitrogen atoms with or without oxygen or sulfur atoms, as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/40—Esters thereof
    • C07F9/4071—Esters thereof the ester moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4084—Esters with hydroxyaryl compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/06—Phosphorus compounds without P—C bonds
    • C07F9/08—Esters of oxyacids of phosphorus
    • C07F9/09—Esters of phosphoric acids
    • C07F9/12—Esters of phosphoric acids with hydroxyaryl compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/28—Phosphorus compounds with one or more P—C bonds
    • C07F9/38—Phosphonic acids [RP(=O)(OH)2]; Thiophosphonic acids ; [RP(=X1)(X2H)2(X1, X2 are each independently O, S or Se)]
    • C07F9/44—Amides thereof
    • C07F9/4461—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic
    • C07F9/4465—Amides thereof the amide moiety containing a substituent or a structure which is considered as characteristic of aliphatic amines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65742—Esters of oxyacids of phosphorus non-condensed with carbocyclic rings or heterocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6571—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and oxygen atoms as the only ring hetero atoms
    • C07F9/6574—Esters of oxyacids of phosphorus
    • C07F9/65746—Esters of oxyacids of phosphorus the molecule containing more than one cyclic phosphorus atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6564—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms
    • C07F9/6578—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having phosphorus atoms, with or without nitrogen, oxygen, sulfur, selenium or tellurium atoms, as ring hetero atoms having phosphorus and sulfur atoms with or without oxygen atoms, as ring hetero atoms

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pulmonology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2022500797A 2019-07-12 2020-07-10 カンナビノイド誘導体 Pending JP2022540585A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962873562P 2019-07-12 2019-07-12
US62/873,562 2019-07-12
US201962934937P 2019-11-13 2019-11-13
US62/934,937 2019-11-13
PCT/CA2020/050968 WO2021007662A1 (en) 2019-07-12 2020-07-10 Cannabinoid derivatives

Publications (3)

Publication Number Publication Date
JP2022540585A true JP2022540585A (ja) 2022-09-16
JPWO2021007662A5 JPWO2021007662A5 (https=) 2023-07-13
JP2022540585A5 JP2022540585A5 (https=) 2023-07-13

Family

ID=74209626

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2022500797A Pending JP2022540585A (ja) 2019-07-12 2020-07-10 カンナビノイド誘導体

Country Status (4)

Country Link
US (1) US12252503B2 (https=)
EP (1) EP3997098A4 (https=)
JP (1) JP2022540585A (https=)
WO (1) WO2021007662A1 (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2021007663A1 (en) 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives
JP2022540586A (ja) 2019-07-12 2022-09-16 キャノピー グロウス コーポレイション カンナビノイド誘導体
WO2021062559A1 (en) 2019-10-02 2021-04-08 Canopy Growth Corporation Cannabinoid derivatives
EP4065554A4 (en) 2019-11-26 2024-01-10 Canopy Growth Corporation CANNABIGEROL DERIVATIVES AND THEIR USE AS CANNABINOID RECEPTOR MODULATORS
WO2021228150A1 (zh) * 2020-05-13 2021-11-18 成都百裕制药股份有限公司 大麻素衍生物及其制备方法和在医药上的应用
KR20240096817A (ko) 2020-05-19 2024-06-26 사이빈 아이알엘 리미티드 중수소화된 트립타민 유도체 및 사용 방법
CN115315418B (zh) * 2021-04-06 2023-03-21 山东绿叶制药有限公司 大麻二酚前药及其药物组合物和应用
CN116253671B (zh) * 2021-12-10 2025-07-04 德义制药有限公司 一种大麻二酚衍生物及其制备方法和应用

Citations (4)

* Cited by examiner, † Cited by third party
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JP2013503206A (ja) * 2009-08-31 2013-01-31 オールトランツ インコーポレイティド マイクロ針を用いた局所及び経皮投与におけるカンナビジオールプロドラッグの使用
WO2018096504A1 (en) * 2016-11-28 2018-05-31 Kalytera Therapeutics, Inc Cbd prodrugs, compositions, and methods of administering cbd and cbd prodrugs
JP2019515031A (ja) * 2016-04-22 2019-06-06 レセプター・ライフ・サイエンシズ・インコーポレイテッド 即効性の植物由来医薬化合物及び栄養補給剤
JP2022539523A (ja) * 2019-06-24 2022-09-12 ダイヴァース バイオテック， インコーポレイテッド カンナビノイド抱合分子

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US4391827A (en) 1980-09-08 1983-07-05 Pfizer Inc. 3-(2-Hydroxy-4-(substituted)phenyl)-cycloalkanone and cycloalkanol analgesic agents and intermediates therefor
US5205852A (en) * 1991-11-12 1993-04-27 Imperial Chemical Industries Plc Alkylphosphonamidate herbicides
KR101286484B1 (ko) * 2005-09-14 2013-07-16 다이하치 카가쿠 고교 가부시키가이샤 인 화합물, 그의 용도 및 난연성 폴리에스테르 섬유
JP4716954B2 (ja) 2006-08-17 2011-07-06 富士フイルム株式会社 ｏ−ビフェニルジフェニルホスフェートおよびトリフェニルホスフェートの混合物の製造方法。
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EP3994129A4 (en) 2019-07-04 2023-01-04 Canopy Growth Corporation CANNABINOID DERIVATIVES
JP2022539400A (ja) 2019-07-04 2022-09-08 キャノピー グロウス コーポレイション カンナビノイド誘導体
WO2021007663A1 (en) 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives
US20220259221A1 (en) 2019-07-12 2022-08-18 Canopy Growth Corporation Cannabinoid derivatives
WO2021007659A1 (en) 2019-07-12 2021-01-21 Canopy Growth Corporation Cannabinoid derivatives
JP2022540586A (ja) 2019-07-12 2022-09-16 キャノピー グロウス コーポレイション カンナビノイド誘導体
EP4038058A4 (en) 2019-10-02 2023-10-25 Canopy Growth Corporation Cannabinoid derivatives
WO2021062559A1 (en) 2019-10-02 2021-04-08 Canopy Growth Corporation Cannabinoid derivatives
US20230122510A1 (en) 2019-11-26 2023-04-20 Canopy Growth Corporation Cannabinoid derivatives
EP4065554A4 (en) 2019-11-26 2024-01-10 Canopy Growth Corporation CANNABIGEROL DERIVATIVES AND THEIR USE AS CANNABINOID RECEPTOR MODULATORS
WO2021113958A1 (en) 2019-12-09 2021-06-17 Canopy Growth Corporation Cannabinoid derivatives
JP2023505517A (ja) 2019-12-09 2023-02-09 キャノピー グロウス コーポレイション カンナビノイド誘導体
CN113087741B (zh) * 2020-01-08 2023-04-28 成都百裕制药股份有限公司 大麻二酚衍生物及其制备方法和在医药上的应用

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2013503206A (ja) * 2009-08-31 2013-01-31 オールトランツ インコーポレイティド マイクロ針を用いた局所及び経皮投与におけるカンナビジオールプロドラッグの使用
JP2019515031A (ja) * 2016-04-22 2019-06-06 レセプター・ライフ・サイエンシズ・インコーポレイテッド 即効性の植物由来医薬化合物及び栄養補給剤
WO2018096504A1 (en) * 2016-11-28 2018-05-31 Kalytera Therapeutics, Inc Cbd prodrugs, compositions, and methods of administering cbd and cbd prodrugs
JP2022539523A (ja) * 2019-06-24 2022-09-12 ダイヴァース バイオテック， インコーポレイテッド カンナビノイド抱合分子

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EP3997098A1 (en) 2022-05-18
US12252503B2 (en) 2025-03-18
US20220259233A1 (en) 2022-08-18
WO2021007662A1 (en) 2021-01-21
EP3997098A4 (en) 2023-10-11

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