JP2022540567A - マイクロ流体デバイスにおける化合物分布 - Google Patents

マイクロ流体デバイスにおける化合物分布 Download PDF

Info

Publication number
JP2022540567A
JP2022540567A JP2021577975A JP2021577975A JP2022540567A JP 2022540567 A JP2022540567 A JP 2022540567A JP 2021577975 A JP2021577975 A JP 2021577975A JP 2021577975 A JP2021577975 A JP 2021577975A JP 2022540567 A JP2022540567 A JP 2022540567A
Authority
JP
Japan
Prior art keywords
gas
channel
microfluidic device
compound
experimental protocol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021577975A
Other languages
English (en)
Japanese (ja)
Other versions
JPWO2020264303A5 (https=
JP2022540567A5 (https=
Inventor
スリズ，ジョサイア
レブナー，ダニエル
ザッカーマン，ブライアン
ウェン，ノーマン
ルビンス，ジョナサン
シュロフ，タンビ
デイビッド イノホサ，クリストファー
アーン，グレース
アントンツェフ，ビクター
プエルタ，ジェファーソン
コネリアノ，デイビッド
カーンズ，エス．ジョーダン
Original Assignee
エミュレート， インコーポレイテッド
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by エミュレート， インコーポレイテッド filed Critical エミュレート， インコーポレイテッド
Publication of JP2022540567A publication Critical patent/JP2022540567A/ja
Publication of JPWO2020264303A5 publication Critical patent/JPWO2020264303A5/ja
Publication of JP2022540567A5 publication Critical patent/JP2022540567A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0031—Degasification of liquids by filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D19/00—Degasification of liquids
    • B01D19/0063—Regulation, control including valves and floats
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M23/00—Constructional details, e.g. recesses, hinges
    • C12M23/02—Form or structure of the vessel
    • C12M23/16—Microfluidic devices; Capillary tubes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00—Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/04—Filters; Permeable or porous membranes or plates, e.g. dialysis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M41/00—Means for regulation, monitoring, measurement or control, e.g. flow regulation
    • C12M41/30—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration
    • C12M41/34—Means for regulation, monitoring, measurement or control, e.g. flow regulation of concentration of gas
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q3/00—Condition responsive control processes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/06—Investigating concentration of particle suspensions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/02—Adapting objects or devices to another
    • B01L2200/026—Fluid interfacing between devices or objects, e.g. connectors, inlet details
    • B01L2200/027—Fluid interfacing between devices or objects, e.g. connectors, inlet details for microfluidic devices
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/06—Fluid handling related problems
    • B01L2200/0647—Handling flowable solids, e.g. microscopic beads, cells, particles
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/10—Integrating sample preparation and analysis in single entity, e.g. lab-on-a-chip concept
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2200/00—Solutions for specific problems relating to chemical or physical laboratory apparatus
    • B01L2200/14—Process control and prevention of errors
    • B01L2200/148—Specific details about calibrations
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/04—Closures and closing means
    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/0681—Filter
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/06—Auxiliary integrated devices, integrated components
    • B01L2300/069—Absorbents; Gels to retain a fluid
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0809—Geometry, shape and general structure rectangular shaped
    • B01L2300/0816—Cards, e.g. flat sample carriers usually with flow in two horizontal directions
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0861—Configuration of multiple channels and/or chambers in a single devices
    • B01L2300/0874—Three dimensional network
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/08—Geometry, shape and general structure
    • B01L2300/0887—Laminated structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2300/00—Additional constructional details
    • B01L2300/10—Means to control humidity and/or other gases
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L2400/00—Moving or stopping fluids
    • B01L2400/04—Moving fluids with specific forces or mechanical means
    • B01L2400/0403—Moving fluids with specific forces or mechanical means specific forces
    • B01L2400/0406—Moving fluids with specific forces or mechanical means specific forces capillary forces
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50—Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2500/00—Specific components of cell culture medium
    • C12N2500/02—Atmosphere, e.g. low oxygen conditions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N2035/00465—Separating and mixing arrangements
    • G01N2035/00534—Mixing by a special element, e.g. stirrer
    • G01N2035/00544—Mixing by a special element, e.g. stirrer using fluid flow
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
    • G01N2035/0097—Control arrangements for automatic analysers monitoring reactions as a function of time

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dispersion Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Sustainable Development (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Urology & Nephrology (AREA)
  • Toxicology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicinal Chemistry (AREA)
  • Food Science & Technology (AREA)
  • Cell Biology (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
JP2021577975A 2019-06-27 2020-06-26 マイクロ流体デバイスにおける化合物分布 Pending JP2022540567A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962867543P 2019-06-27 2019-06-27
US62/867,543 2019-06-27
PCT/US2020/039830 WO2020264303A1 (en) 2019-06-27 2020-06-26 Compound distribution in microfluidic devices

Publications (3)

Publication Number Publication Date
JP2022540567A true JP2022540567A (ja) 2022-09-16
JPWO2020264303A5 JPWO2020264303A5 (https=) 2023-07-03
JP2022540567A5 JP2022540567A5 (https=) 2023-07-03

Family

ID=74059972

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021577975A Pending JP2022540567A (ja) 2019-06-27 2020-06-26 マイクロ流体デバイスにおける化合物分布

Country Status (8)

Country Link
US (2) US12298320B2 (https=)
EP (1) EP3990186A4 (https=)
JP (1) JP2022540567A (https=)
KR (1) KR20220052911A (https=)
AU (3) AU2020303871B2 (https=)
CA (1) CA3140261A1 (https=)
GB (3) GB2621762B (https=)
WO (1) WO2020264303A1 (https=)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2621762B (en) * 2019-06-27 2024-06-05 Emulate Inc Compound distribution in microfluidic devices
MX2022004760A (es) * 2019-10-21 2022-07-21 Flaskworks Llc Sistemas y métodos para el cultivo de células.
KR102293717B1 (ko) * 2021-06-29 2021-08-26 에스디바이오센서 주식회사 플로우 커버를 포함하는 유전체 추출 장치
KR20240093662A (ko) * 2021-10-28 2024-06-24 나노카브, 엘엘씨 전기 천공 디바이스 및 세포 형질 감염 방법
WO2023085019A1 (ja) * 2021-11-09 2023-05-19 三井化学株式会社 培養容器及び培養方法
US20230375394A1 (en) * 2022-05-17 2023-11-23 Avidien Technologies, Inc. Fluid dispenser volume calibration device
US12392763B2 (en) * 2023-04-17 2025-08-19 Saudi Arabian Oil Company Hydrocarbon contaminant detection using polymer film
CN116144480B (zh) * 2023-04-20 2023-07-28 上海芯像生物科技有限公司 流体系统及其温度控制方法和流体状态监测方法
WO2025024650A1 (en) * 2023-07-25 2025-01-30 The Regents Of The University Of California Systems and apparatuses for cell culture
KR102919464B1 (ko) * 2023-10-18 2026-01-30 티케이엠에스 주식회사 미세 유체 장치, 그 미세 유체 장치의 제조방법, 그 미세 유체 장치를 이용한 미세유체 농도조합 방법 및 그 미세유체 장치를 이용한 세포의 약물반응 확인방법
WO2025132576A1 (en) * 2023-12-18 2025-06-26 Syddansk Universitet An improved anaerobic cell reactor

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134435C2 (de) * 1991-10-18 1994-06-01 Forschungszentrum Juelich Gmbh Vorrichtung zur Ermittlung der Dichteverteilung von in menschliches Gewebe gebrachten Positronen
EP1343001A1 (en) * 2002-03-04 2003-09-10 Evotec OAI AG A method for identifying the impacts of interfering effects on secondary light emission data
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
AU2003297214A1 (en) * 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
EP1547676A1 (en) * 2003-12-24 2005-06-29 Corning Incorporated Porous membrane microstructure devices and methods of manufacture
WO2006037022A2 (en) * 2004-09-24 2006-04-06 Massachusetts Institute Of Technology Microbioreactor for continuous cell culture
WO2009049252A1 (en) * 2007-10-10 2009-04-16 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
CN103635587A (zh) 2008-04-08 2014-03-12 麻省理工学院 三维微流平台和其使用方法
CN104328050B (zh) * 2008-07-16 2017-12-15 儿童医疗中心有限公司 具有微通道的器官模仿装置及其使用和制造方法
GB0814035D0 (en) * 2008-07-31 2008-09-10 Univ Heriot Watt Apparatus and method for biological sample culture or testing
JP2013534461A (ja) * 2010-05-26 2013-09-05 ザ チャールズ スターク ドレイパー ラボラトリー インク 微細加工された人工肺補助装置ならびにその使用および製造の方法
EP2618932A1 (en) * 2010-09-22 2013-07-31 Corning Incorporated Microporous microfluidic device
US9261496B2 (en) 2010-09-29 2016-02-16 Massachusetts Institute Of Technology Device for high throughput investigations of multi-cellular interactions
US10532354B2 (en) * 2013-07-16 2020-01-14 Vanderbilt University Multicompartment layered and stackable microfluidic bioreactors and applications of same
WO2013138522A2 (en) * 2012-03-16 2013-09-19 Genelux Corporation Methods for assessing effectiveness and monitoring oncolytic virus treatment
JP2016534839A (ja) * 2013-09-16 2016-11-10 ジョンソン・アンド・ジョンソン・イノベーション・エルエルシーＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｉｎｎｏｖａｔｉｏｎ ＬＬＣ 境界層分離を組み込む、マイクロ流体器官補助装置
KR102260910B1 (ko) 2014-11-11 2021-06-04 에이아이엠 바이오테크 피티이. 엘티디. 세포 기반 상호 작용 연구를 위한 마이크로 유체 플랫폼
JP6640998B2 (ja) 2015-06-05 2020-02-05 ミメタス ビー．ブイ． マイクロ流体プレート
WO2017062609A1 (en) * 2015-10-06 2017-04-13 University Of Miami Multiwell culture devices with perfusion and oxygen control
US11505773B2 (en) * 2015-12-04 2022-11-22 President And Fellows Of Harvard College Open-top microfluidic devices and methods for simulating a function of a tissue
US10773214B2 (en) * 2016-03-03 2020-09-15 Micromedics Inc. Biomimetically designed modular microfluidic-based capillaries and lymphatic units for kidney and liver dialysis systems, organ bio-reactors and bio-artificial organ support systems
GB2612206B (en) * 2018-04-02 2023-08-09 Harvard College Complex human gut microbiome cultured in an anaerobic human gut-on-a-chip
GB2621762B (en) * 2019-06-27 2024-06-05 Emulate Inc Compound distribution in microfluidic devices

Also Published As

Publication number Publication date
GB202317937D0 (en) 2024-01-10
GB2620692A (en) 2024-01-17
GB2599531A (en) 2022-04-06
AU2022215209B2 (en) 2024-03-07
AU2022215209A1 (en) 2022-09-01
EP3990186A4 (en) 2023-07-26
AU2020303871A1 (en) 2022-01-27
GB2620692B (en) 2024-07-10
WO2020264303A1 (en) 2020-12-30
US12019083B2 (en) 2024-06-25
GB202314750D0 (en) 2023-11-08
GB202117870D0 (en) 2022-01-26
US20220334139A1 (en) 2022-10-20
AU2024203591A1 (en) 2024-06-20
US12298320B2 (en) 2025-05-13
AU2020303871B2 (en) 2022-05-12
GB2621762A (en) 2024-02-21
US20220155328A1 (en) 2022-05-19
GB2621762B (en) 2024-06-05
KR20220052911A (ko) 2022-04-28
CA3140261A1 (en) 2020-12-30
EP3990186A1 (en) 2022-05-04

Similar Documents

Publication Publication Date Title
AU2022215209B2 (en) Compound distribution in microfluidic devices
US12187997B2 (en) Integrated human organ-on-chip microphysiological systems
US11680241B2 (en) Perfusion enabled bioreactors
Cimetta et al. Micro-bioreactor arrays for controlling cellular environments: design principles for human embryonic stem cell applications
Huh et al. Microengineered physiological biomimicry: organs-on-chips
Yang et al. PBPK modeling on organs-on-chips: an overview of recent advancements
US10908149B2 (en) Devices for fluid management
Miller et al. Multiorgan microfluidic platform with breathable lung chamber for inhalation or intravenous drug screening and development
Winkler et al. Sorption of neuropsychopharmaca in microfluidic materials for in vitro studies
CN107532131A (zh) 细胞培养装置及细胞培养方法
KR102273043B1 (ko) 마이크로 플레이트 랩웨어의 관류 및 환경제어 방법 및 장치
Gu et al. Compelling standardized and high-throughput micro-/millifluidic plates for biomedical research: from laboratory to market
Szmelter et al. 96-well oxygen control using a 3D-printed device
WO2023073178A1 (en) Microfluidic cell culturing device
US20160334388A1 (en) Basket for use with a fluidics device
Basak Unlocking the future: Converging multi-organ-on-a-chip on the current biomedical sciences
Gilbert et al. Computational and functional evaluation of a microfluidic blood flow device
Tian et al. Organ chips and visualization of biological systems
Sung From organ-on-a-chip towards body-on-a-chip
Wilkinson The physics and engineering of flow in organ-on-a-chip devices
Lockhart et al. A 96-WELL VALVED MICROFLUIDIC DEVICE FOR TESTING OF LIVE INTACT TUMOR CUBOIDS
Giuliano Development of tools for the precise control of biological parameters via microfluidics

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20220303

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20230623

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20230623

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20240702

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20250114

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20250708