JP2022540567A - マイクロ流体デバイスにおける化合物分布 - Google Patents

マイクロ流体デバイスにおける化合物分布 Download PDF

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JP2022540567A
JP2022540567A JP2021577975A JP2021577975A JP2022540567A JP 2022540567 A JP2022540567 A JP 2022540567A JP 2021577975 A JP2021577975 A JP 2021577975A JP 2021577975 A JP2021577975 A JP 2021577975A JP 2022540567 A JP2022540567 A JP 2022540567A
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gas
channel
microfluidic device
compound
experimental protocol
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JP2022540567A5 (https=
Inventor
スリズ，ジョサイア
レブナー，ダニエル
ザッカーマン，ブライアン
ウェン，ノーマン
ルビンス，ジョナサン
シュロフ，タンビ
デイビッド イノホサ，クリストファー
アーン，グレース
アントンツェフ，ビクター
プエルタ，ジェファーソン
コネリアノ，デイビッド
カーンズ，エス．ジョーダン
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エミュレート， インコーポレイテッド
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    • G—PHYSICS
    • G01—MEASURING; TESTING
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    • G01N35/00—Automatic analysis not limited to methods or materials provided for in any single one of groups G01N1/00 - G01N33/00; Handling materials therefor
    • G01N35/00584—Control arrangements for automatic analysers
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    • B01L3/502—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
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    • B01D19/0063—Regulation, control including valves and floats
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    • B01L3/5027—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads or physically stretching molecules
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    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
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    • B01L2300/046—Function or devices integrated in the closure
    • B01L2300/048—Function or devices integrated in the closure enabling gas exchange, e.g. vents
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    • B01L3/502707—Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip characterised by the manufacture of the container or its components
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  • Proteomics, Peptides & Aminoacids (AREA)
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  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
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JP2021577975A 2019-06-27 2020-06-26 マイクロ流体デバイスにおける化合物分布 Pending JP2022540567A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962867543P 2019-06-27 2019-06-27
US62/867,543 2019-06-27
PCT/US2020/039830 WO2020264303A1 (en) 2019-06-27 2020-06-26 Compound distribution in microfluidic devices

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JP2022540567A true JP2022540567A (ja) 2022-09-16
JP2022540567A5 JP2022540567A5 (https=) 2023-07-03

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US (2) US12298320B2 (https=)
EP (1) EP3990186A4 (https=)
JP (1) JP2022540567A (https=)
KR (1) KR20220052911A (https=)
AU (3) AU2020303871B2 (https=)
CA (1) CA3140261A1 (https=)
GB (3) GB2621762B (https=)
WO (1) WO2020264303A1 (https=)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20220052911A (ko) * 2019-06-27 2022-04-28 에뮬레이트, 인크. 미세유체 장치 내 화합물 분배
CN114901799A (zh) * 2019-10-21 2022-08-12 弗拉斯沃克斯有限责任公司 用于细胞培养的系统和方法
KR102293717B1 (ko) * 2021-06-29 2021-08-26 에스디바이오센서 주식회사 플로우 커버를 포함하는 유전체 추출 장치
KR20240093662A (ko) * 2021-10-28 2024-06-24 나노카브, 엘엘씨 전기 천공 디바이스 및 세포 형질 감염 방법
EP4431592A4 (en) * 2021-11-09 2025-10-29 Mitsui Chemicals Inc CULTIVATION CONTAINER AND CULTIVATION METHOD
CN120077249A (zh) * 2022-05-17 2025-05-30 艾维迪恩科技有限责任公司 流体分配器体积校准装置
US12392763B2 (en) * 2023-04-17 2025-08-19 Saudi Arabian Oil Company Hydrocarbon contaminant detection using polymer film
CN116144480B (zh) * 2023-04-20 2023-07-28 上海芯像生物科技有限公司 流体系统及其温度控制方法和流体状态监测方法
WO2025024650A1 (en) * 2023-07-25 2025-01-30 The Regents Of The University Of California Systems and apparatuses for cell culture
KR102919464B1 (ko) * 2023-10-18 2026-01-30 티케이엠에스 주식회사 미세 유체 장치, 그 미세 유체 장치의 제조방법, 그 미세 유체 장치를 이용한 미세유체 농도조합 방법 및 그 미세유체 장치를 이용한 세포의 약물반응 확인방법
WO2025132576A1 (en) * 2023-12-18 2025-06-26 Syddansk Universitet An improved anaerobic cell reactor
US20260110605A1 (en) * 2024-10-22 2026-04-23 Texas Tech University System Rapid passive sampling kit for measuring dissolved hydrophobic chemicals in sediment porewater

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE4134435C2 (de) * 1991-10-18 1994-06-01 Forschungszentrum Juelich Gmbh Vorrichtung zur Ermittlung der Dichteverteilung von in menschliches Gewebe gebrachten Positronen
EP1343001A1 (en) * 2002-03-04 2003-09-10 Evotec OAI AG A method for identifying the impacts of interfering effects on secondary light emission data
AU2003297214A1 (en) * 2002-12-16 2004-07-22 Cytodiscovery, Inc. Microfluidic system with integrated permeable membrane
US20050266582A1 (en) * 2002-12-16 2005-12-01 Modlin Douglas N Microfluidic system with integrated permeable membrane
EP1547676A1 (en) * 2003-12-24 2005-06-29 Corning Incorporated Porous membrane microstructure devices and methods of manufacture
WO2006037022A2 (en) * 2004-09-24 2006-04-06 Massachusetts Institute Of Technology Microbioreactor for continuous cell culture
CA2702116C (en) * 2007-10-10 2021-01-05 Optiscan Biomedical Corporation Fluid component analysis system and method for glucose monitoring and control
WO2009126524A2 (en) 2008-04-08 2009-10-15 Massachusetts Institute Of Technology Three-dimensional microfluidic platforms and methods of use thereof
ES2672201T3 (es) * 2008-07-16 2018-06-13 Children's Medical Center Corporation Dispositivo de imitación de órganos con microcanales y métodos de uso
GB0814035D0 (en) * 2008-07-31 2008-09-10 Univ Heriot Watt Apparatus and method for biological sample culture or testing
WO2011150216A1 (en) * 2010-05-26 2011-12-01 The Charles Stark Draper Laboratory, Inc. Microfabricated artificial lung assist device, and methods of use and manufacture thereof
WO2012039994A1 (en) * 2010-09-22 2012-03-29 Corning Incorporated Microporous microfluidic device
WO2012050981A1 (en) 2010-09-29 2012-04-19 Massachusetts Institute Of Technology Device for high throughput investigations of cellular interactions
US10532354B2 (en) * 2013-07-16 2020-01-14 Vanderbilt University Multicompartment layered and stackable microfluidic bioreactors and applications of same
US20140087362A1 (en) * 2012-03-16 2014-03-27 Aladar A. Szalay Methods for assessing effectiveness and monitoring oncolytic virus treatment
JP2016534839A (ja) * 2013-09-16 2016-11-10 ジョンソン・アンド・ジョンソン・イノベーション・エルエルシーＪｏｈｎｓｏｎ ＆ Ｊｏｈｎｓｏｎ Ｉｎｎｏｖａｔｉｏｎ ＬＬＣ 境界層分離を組み込む、マイクロ流体器官補助装置
WO2016076795A1 (en) 2014-11-11 2016-05-19 Aim Biotech Pte. Ltd. Microfluidic platform for investigating cell-based interactions
JP6640998B2 (ja) 2015-06-05 2020-02-05 ミメタス ビー．ブイ． マイクロ流体プレート
WO2017062609A1 (en) * 2015-10-06 2017-04-13 University Of Miami Multiwell culture devices with perfusion and oxygen control
WO2017096285A1 (en) * 2015-12-04 2017-06-08 President And Fellows Of Harvard College Open-top microfluidic devices and methods for simulating a function of a tissue
US10773214B2 (en) * 2016-03-03 2020-09-15 Micromedics Inc. Biomimetically designed modular microfluidic-based capillaries and lymphatic units for kidney and liver dialysis systems, organ bio-reactors and bio-artificial organ support systems
GB2612206B (en) * 2018-04-02 2023-08-09 Harvard College Complex human gut microbiome cultured in an anaerobic human gut-on-a-chip
KR20220052911A (ko) * 2019-06-27 2022-04-28 에뮬레이트, 인크. 미세유체 장치 내 화합물 분배

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