JP2022536806A - エマルサンの増進生産のための、粘液細菌およびアシネトバクターの共培養 - Google Patents
エマルサンの増進生産のための、粘液細菌およびアシネトバクターの共培養 Download PDFInfo
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Abstract
Description
本願は、その全体が参照により本明細書に組み入れられる、2019年6月20日に出願された米国仮特許出願第62/864,113号からの優先権を主張する。
微生物、例えば細菌、酵母および真菌の培養は、幅広い様々な有用なバイオ調製物の生産に重要である。微生物は、例えば、食品産業、医薬、農業、油およびガス回収、鉱業、環境修復、および廃棄物運用において重要な役割を果たすが、微生物由来生産物の商業化を制限する要因の1つは、これらの生産物の大規模生産が非常に高価でありかつ/または実現可能でないことである。
本発明は、微生物およびそれらの成長副産物を生産する方法を提供する。有利には、本発明の微生物由来生産物および方法は、環境に優しく、運用が容易であり、かつ費用対効果が高い。
本明細書で使用される場合、「バイオフィルム」は、微生物、例えば細菌の、複雑な凝集物であって、細胞が細胞外多糖マトリクスを用いて相互におよび/または表面に接着しているものである。バイオフィルム内の細胞は、液体培地中を浮遊または遊泳することができる単一の細胞である同じ生物の浮遊細胞とは生理学的に区別される。
本発明は、バイオマス(例えば、生存能力のあるもしくは不活性な細胞物質)、細胞外代謝産物、および/または細胞内成分の生産のための物質および方法を提供する。好ましい態様において、本発明は、発酵リアクタ内で2つまたはそれ以上の異なる微生物を共培養する工程を含む、1つまたは複数の微生物成長副産物を生産するための改善された方法を提供する。
本発明のシステムおよび方法にしたがい生育される微生物は、例えば、細菌、酵母および/または真菌であり得る。これらの微生物は、天然または遺伝子改変微生物であり得る。例えば、微生物は、特定の特徴を示す特定の遺伝子によって形質転換され得る。微生物はまた、所望の株の変異体であり得る。本明細書で使用される場合、「変異体」は、参照微生物と比較して1つまたは複数の遺伝的バリエーション(例えば、点変異、ミスセンス変異、非センス変異、欠失、重複、フレームシフト変異または反復伸長)を有する、参照微生物の株、遺伝的変種またはサブタイプを意味する。変異体を作成する手順は、微生物学分野で周知である。例えば、UV変異誘発およびニトロソグアニジンがこの目的で広く使用されている。
本発明の方法およびシステムは、1つまたは複数の有用な微生物成長副産物、例えば、バイオポリマーおよび/または他の微生物代謝産物を含む組成物を生産するために使用され得る。
本発明は、微生物由来生産物、ならびに、例えば、農業、増進した油回収、バイオレメディエーション、製薬、および美容を含む様々な用途におけるそれらの使用を提供する。
本発明の組成物は、様々な目的で使用され得る。1つの態様において、組成物は、農業で使用され得る。例えば、害虫および/もしくは病気を処置するならびに/またはその伝播を防止するために、本発明にしたがい生産される組成物を植物および/またはその環境に適用する方法が提供される。組成物はまた、土壌における水の分散および吸収を増進するため、ならびに植物の根を通じた土壌からの栄養分の吸収を増進する、植物の健康を促進する、採集高を増加させる、および土壌の通気を管理するために有用であり得る。
本発明の好ましい態様において、微生物成長設備は、関心対象の、新鮮な、高密度の微生物および/または微生物成長副産物を所望の規模で生産する。微生物成長設備は、適用場所またはその付近に設置され得る。設備は、高密度の微生物由来組成物を、バッチ、準連続、または連続培養で生産する。
A.ベネティアヌスを小規模リアクタ内で少なくとも48時間生育し、3.0%の接種物を生成する。S.オーランティアカを小規模リアクタ内で少なくとも4日間生育し、1.0%の接種物を生成する。純度を試験するため、3日後にS.オーランティアカ接種物をサンプル採取し、スライド画線を用いて試験することができる。
Claims (26)
第1の微生物が粘液細菌であり、第2の微生物がアシネトバクター(Acinetobacter)属の株であり、
第1および第2の微生物が個別に培養されたときに達成されるよりも高い、1つまたは複数の微生物成長副産物の濃度が達成される、方法。
液体栄養培地を含む発酵リアクタに第1の微生物を接種すること、および該発酵リアクタに第2の微生物を接種すること;
該リアクタ内の第1および第2の微生物を、成長および1つまたは複数の微生物成長副産物の生産に好ましい条件下でインキュベートすること;
該リアクタから1つまたは複数の成長副産物を抽出すること;ならびに、任意で、
該1つまたは複数の成長副産物を精製すること
を含む、請求項1記載の方法。
微生物が、スティグマテラ・オーランティアカ(Stigmatella aurantiaca)およびアシネトバクター・ベネティアヌス(Acinetobacter venetianus)を含み、1つまたは複数の微生物成長副産物が少なくとも1つのバイオポリマーを含む、組成物。
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