JP2022535735A - 修飾ギャップマーオリゴヌクレオチドおよび使用方法 - Google Patents

修飾ギャップマーオリゴヌクレオチドおよび使用方法 Download PDF

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JP2022535735A
JP2022535735A JP2021570299A JP2021570299A JP2022535735A JP 2022535735 A JP2022535735 A JP 2022535735A JP 2021570299 A JP2021570299 A JP 2021570299A JP 2021570299 A JP2021570299 A JP 2021570299A JP 2022535735 A JP2022535735 A JP 2022535735A
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nucleosides
hbv
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ベイゲルマン，レオニド
ケイ． パンディ，ラジェンドラ
クマル ラジワンシ，ヴィヴェク
ベルナルド スミス，デイヴィッド
ホン，ジン
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アリゴス セラピューティクス インコーポレイテッド
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    • C12N2310/341—Gapmers, i.e. of the type ===---===
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JP2021570299A 2019-05-31 2020-05-29 修飾ギャップマーオリゴヌクレオチドおよび使用方法 Pending JP2022535735A (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US201962855793P 2019-05-31 2019-05-31
US62/855,793 2019-05-31
US201962937760P 2019-11-19 2019-11-19
US62/937,760 2019-11-19
US201962943532P 2019-12-04 2019-12-04
US62/943,532 2019-12-04
PCT/US2020/035212 WO2020243490A2 (en) 2019-05-31 2020-05-29 Modified gapmer oligonucleotides and methods of use

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JP2022535735A true JP2022535735A (ja) 2022-08-10
JP2022535735A5 JP2022535735A5 (https=) 2023-05-31

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US (1) US11466274B2 (https=)
EP (1) EP3976056A2 (https=)
JP (1) JP2022535735A (https=)
KR (1) KR20220024192A (https=)
CN (1) CN113905744A (https=)
AU (1) AU2020282828A1 (https=)
BR (1) BR112021023488A2 (https=)
CA (1) CA3141874A1 (https=)
CO (1) CO2021018034A2 (https=)
IL (1) IL288259A (https=)
MX (1) MX2021014206A (https=)
PE (1) PE20220574A1 (https=)
SG (1) SG11202112741XA (https=)
TW (1) TW202113079A (https=)
WO (1) WO2020243490A2 (https=)

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US20250243491A1 (en) 2021-09-01 2025-07-31 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
CN118234862A (zh) 2021-09-08 2024-06-21 阿利戈斯治疗公司 经修饰的短干扰核酸分子(siNA)及其用途
TW202340468A (zh) 2022-01-10 2023-10-16 中國大陸商杭州浩博醫藥有限公司 B型肝炎病毒(hbv)表現之調節
KR20240158340A (ko) * 2022-03-17 2024-11-04 알리고스 테라퓨틱스 인코포레이티드 변형 갭머 올리고머 및 이의 사용 방법
WO2024182446A2 (en) 2023-02-28 2024-09-06 Aligos Therapeutics, Inc. Pnpla3-targeting short interfering rna (sirna) molecules and uses thereof
US20240352464A1 (en) 2023-03-07 2024-10-24 Aligos Therapeutics, Inc. Modified Short Interfering Nucleic Acid (siNA) Molecules and Uses Thereof
CN121175419A (zh) * 2023-04-14 2025-12-19 苏州炫景生物科技有限公司 抑制c3基因表达的化合物、药物组合物及其用途
US20250368996A1 (en) 2024-05-14 2025-12-04 Aligos Therapeutics, Inc. Modified antisense oligonucleotides for treating hepatitis b virus
CN120796266A (zh) * 2024-07-08 2025-10-17 北京悦康科创医药科技股份有限公司 一种降低hbv基因表达的反义寡核苷酸及其应用

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