JP2022532423A5 - - Google Patents

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Publication number
JP2022532423A5
JP2022532423A5 JP2021568564A JP2021568564A JP2022532423A5 JP 2022532423 A5 JP2022532423 A5 JP 2022532423A5 JP 2021568564 A JP2021568564 A JP 2021568564A JP 2021568564 A JP2021568564 A JP 2021568564A JP 2022532423 A5 JP2022532423 A5 JP 2022532423A5
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JP
Japan
Prior art keywords
prs
gene variants
cad
reference population
gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2021568564A
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English (en)
Japanese (ja)
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JP2022532423A (ja
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Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/033315 external-priority patent/WO2020236670A1/en
Publication of JP2022532423A publication Critical patent/JP2022532423A/ja
Publication of JP2022532423A5 publication Critical patent/JP2022532423A5/ja
Priority to JP2025229455A priority Critical patent/JP2026062658A/ja
Pending legal-status Critical Current

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JP2021568564A 2019-05-17 2020-05-16 心血管系リスクを減らすためのゲノムに基づく方法 Pending JP2022532423A (ja)

Priority Applications (1)

Application Number Priority Date Filing Date Title
JP2025229455A JP2026062658A (ja) 2019-05-17 2025-12-04 心血管系リスクを減らすためのゲノムに基づく方法

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962849670P 2019-05-17 2019-05-17
US62/849,670 2019-05-17
US201962933181P 2019-11-08 2019-11-08
US62/933,181 2019-11-08
PCT/US2020/033315 WO2020236670A1 (en) 2019-05-17 2020-05-16 Genome-based methods for reducing cardiovascular risk

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2025229455A Division JP2026062658A (ja) 2019-05-17 2025-12-04 心血管系リスクを減らすためのゲノムに基づく方法

Publications (2)

Publication Number Publication Date
JP2022532423A JP2022532423A (ja) 2022-07-14
JP2022532423A5 true JP2022532423A5 (https=) 2023-05-22

Family

ID=70978651

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2021568564A Pending JP2022532423A (ja) 2019-05-17 2020-05-16 心血管系リスクを減らすためのゲノムに基づく方法
JP2025229455A Pending JP2026062658A (ja) 2019-05-17 2025-12-04 心血管系リスクを減らすためのゲノムに基づく方法

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2025229455A Pending JP2026062658A (ja) 2019-05-17 2025-12-04 心血管系リスクを減らすためのゲノムに基づく方法

Country Status (6)

Country Link
US (2) US12264366B2 (https=)
EP (2) EP3969620B1 (https=)
JP (2) JP2022532423A (https=)
CA (1) CA3139943A1 (https=)
MX (1) MX2021014015A (https=)
WO (1) WO2020236670A1 (https=)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN116171161A (zh) 2020-08-25 2023-05-26 雷杰纳荣制药公司 用pcsk9和ldlr调节剂治疗败血症
GB2634837A (en) 2022-06-07 2025-04-23 Scribe Therapeutics Inc Compositions and methods for the targeting of PCSK9

Family Cites Families (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2008057459A2 (en) 2006-11-07 2008-05-15 Merck & Co., Inc. Antagonists of pcsk9
EP2158330A2 (en) * 2007-05-11 2010-03-03 Tufts Medical Center Polynucleotides associated with age-related macular degeneration and methods for evaluating patient risk
JOP20080381B1 (ar) 2007-08-23 2023-03-28 Amgen Inc بروتينات مرتبطة بمولدات مضادات تتفاعل مع بروبروتين كونفيرتاز سيتيليزين ككسين من النوع 9 (pcsk9)
AR070315A1 (es) 2008-02-07 2010-03-31 Merck & Co Inc Anticuerpos 1b20 antagonistas de pcsk9
JP5526122B2 (ja) 2008-04-18 2014-06-18 クリティカル ケア ダイアグノスティクス インコーポレイテッド 主要有害心イベントのリスクを予測する方法
JO3672B1 (ar) 2008-12-15 2020-08-27 Regeneron Pharma أجسام مضادة بشرية عالية التفاعل الكيماوي بالنسبة لإنزيم سبتيليسين كنفرتيز بروبروتين / كيكسين نوع 9 (pcsk9).
CN102596249A (zh) 2009-10-30 2012-07-18 默沙东公司 Ax1和ax189 pcsk9拮抗剂和变体
AR079336A1 (es) 2009-12-11 2012-01-18 Irm Llc Antagonistas de la pro-proteina convertasa-subtilisina/quexina tipo 9 (pcsk9)
JP5932670B2 (ja) 2010-03-11 2016-06-08 ライナット ニューロサイエンス コーポレイション ｐＨ依存性の抗原結合を有する抗体
SG192117A1 (en) 2011-01-28 2013-08-30 Sanofi Sa Human antibodies to pcsk9 for use in methods of treating particular groups of subjects
AR087715A1 (es) 2011-09-16 2014-04-09 Lilly Co Eli Anticuerpos anti pcsk9 y usos de los mismos
JP2015507205A (ja) * 2012-02-12 2015-03-05 ビージー メディシン，インコーポレイテッド 有害事象のリスク因子および予測
US9255154B2 (en) 2012-05-08 2016-02-09 Alderbio Holdings, Llc Anti-PCSK9 antibodies and use thereof
EP2861624A1 (en) 2012-06-15 2015-04-22 F. Hoffmann-La Roche AG Anti-pcsk9 antibodies, formulations, dosing, and methods of use
US9540449B2 (en) 2012-08-13 2017-01-10 Regeneron Pharmaceuticals, Inc. Anti-PCSK9 antibodies with pH-dependent binding characteristics
JP6450679B2 (ja) 2012-08-21 2019-01-09 クリティカル ケア ダイアグノスティクス インコーポレイテッド マルチマーカーリスク層別化
CN105473141A (zh) 2013-03-15 2016-04-06 实发生物医学公司 治疗和/或预防心血管疾病的抗pcsk9化合物和方法
US8883157B1 (en) 2013-12-17 2014-11-11 Kymab Limited Targeting rare human PCSK9 variants for cholesterol treatment
US10337070B2 (en) * 2017-01-12 2019-07-02 Cardioforecast Ltd. Methods and kits for treating cardiovascular disease
US20190017119A1 (en) * 2017-07-12 2019-01-17 The General Hospital Corporation Genetic Risk Predictor

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