JP2022532259A - Disposable intranasal delivery device - Google Patents

Abstract

Embodiments relate to disposable devices for delivering medication to the nasal cavity. In one embodiment, the device includes a propellant canister containing a propellant capable of propelling the compound into the nasal cavity. The propellant canister is displaceable within the device between an inoperative position and an operative position. The device further includes an actuating element having an actuating lever configured to displace the propellant canister from an inoperative position to an operative position. The device also includes a piercing element positioned to pierce the propellant canister to release propellant from the propellant canister. The device further includes a dose holding chamber containing a unit dose of the compound. The dose-retaining chamber is arranged such that the propellant flows into the dose-retaining chamber and propels the compound from the dose-retaining chamber into the nasal cavity of the user.

Description

Cross-reference to related applications This application claims the benefit of US Patent Application No. 62 / 849,735 filed May 17, 2019, which provisional application is for all purposes. The whole is incorporated herein by reference.

The present disclosure relates generally to drug delivery devices, specifically to intranasal drug delivery devices for delivering drugs to the user's nasal cavity.

Current devices often rely on the patient to regulate their breathing in order to use the device properly. This cannot be an effective drug delivery vehicle if the patient is not accustomed to using the device or if the caregiver administers the device to the patient. In addition, current devices often require priming steps prior to use that can adversely affect the efficacy and proper administration of the device.

The present embodiment relates to a disposable device for delivering a drug into the nasal cavity of a human or other mammal. The nasal cavity is considered to be a useful cavity for drug absorption. This disposable device allows a single dose of drug delivered to the nasal cavity before being discarded. In addition, the device allows patients and caregivers to use the drug in a simple, intuitive and reproducible way to deliver the drug. For example, using a disposable delivery device, the drug is delivered to the patient in a single actuation step. In addition, disposable delivery devices cannot be administered from the second time onward, thus reducing the possibility of inadvertent overdose or misuse as compared to devices that are used multiple times.

In some embodiments, the disposable device utilizes a unit dose container of propellant to push the drug into the nasal cavity. The use of propellant on the device ensures that the drug can be administered by the patient or caregiver without the patient breathing in and activating the device. In addition, the use of a propellant unit dose container eliminates the need for priming the device and the propellant usage is controlled and stable for each dose.

In one embodiment, the nasal delivery device for delivering a compound comprises a propellant canister comprising a propellant capable of propelling the compound into the user's nasal cavity. The propellant canister is displaceable between the non-working position and the working position within the housing body of the device. The device further includes a working element. The actuating element includes an actuating lever configured to displace the propellant canister from the non-actuated position to the actuated position. In embodiments, the nasal delivery device also comprises a puncture element. The puncture element can be arranged to puncture the propellant canister, thereby causing the release of propellant from the propellant canister when the propellant canister is driven from the non-actuated position to the actuated position by the propellant canister. .. In this embodiment, the device further comprises a dose holding chamber containing a unit dose of the compound. The dose holding chamber is arranged such that the propellant flows into the dose holding chamber and propells the compound from the dose holding chamber into the user's nasal cavity.

The intranasal delivery device may also include a diffuser located between the propellant canister and the dose holding chamber, which diffuses the propellant upon release of the propellant from the propellant canister. The device may also include a nozzle arranged to allow the compound to flow through the nozzle and from one or more outlet orifices of the nozzle when the compound is propelled from a dose holding chamber for delivery to the nasal cavity.

In some embodiments, the actuating lever can be an L-shaped lever. The first member of the L-shaped lever may be arranged to receive a contact force from the actuating button of the actuating element. The second member of the L-shaped lever may be perpendicular to the first member and may exert a contact force on the propellant canister when the actuation button is actuated. Further, the actuating element may include a fixed latch configured to release the actuating lever from the mating interface of the actuating element and the actuating lever upon actuation of the actuating element.

In some embodiments, the actuating element comprises an actuating button that drives the propellant canister into the puncture element when depressed, thereby puncturing the propellant canister. In addition, the actuating element is a slidable housing between a non-actuated position that allows the propellant canister to be placed in the non-actuated position and an actuated position that forces the propellant canister to be placed in the actuated position. It may include sliding elements exposed from the body. In addition, the device provides a removable cap that keeps the working element in the non-working position, a lock that keeps the working element in the working position, and / or a use indicator that provides an indication that the working element is in the working position. Can include.

FIG. 1A illustrates an isometric view of a disposable intranasal drug delivery device according to an embodiment. FIG. 1B illustrates a cross-sectional view of a disposable intranasal drug delivery device according to an embodiment. FIG. 1C illustrates a first portion of a disposable intranasal drug delivery device according to an embodiment. FIG. 1D illustrates a second partial view of a disposable intranasal drug delivery device according to an embodiment. FIG. 2A illustrates an isometric view of a disposable intranasal drug delivery device with a cap according to one embodiment. FIG. 2B illustrates a cross-sectional view of the disposable intranasal drug delivery device shown in FIG. 2A according to one embodiment. FIG. 3A illustrates an isometric view showing a variant of a disposable intranasal drug delivery device according to an embodiment. FIG. 3B illustrates a cross-sectional view of the disposable intranasal drug delivery device shown in FIG. 3A, according to one embodiment. FIG. 4 illustrates a cross-sectional view of a disposable intranasal drug delivery device with a spring-loaded actuation lever according to one embodiment. FIG. 5 illustrates actuation data from a disposable nasal drug delivery device with a short actuation lever. FIG. 6 illustrates force data from a disposable nasal drug delivery device using a long actuating lever.

The figure shows an embodiment of the present disclosure for illustration purposes only. Those skilled in the art will appreciate that, from the following description, alternative embodiments of the structures and methods described herein do not deviate from the disclosure principles described herein or the advertised advantages. You will easily recognize that it can be adopted.

Unless otherwise defined, all technical and scientific terms used herein have the same meanings commonly understood by one of ordinary skill in the art relating to the methods and compositions described. Have. As used herein, the following terms and phrases have the meanings given to them, unless otherwise specified.

As used herein, "a" or "an" may mean one or more.

"Diffuser" means and includes elements for dispersing or deflecting a compound in various directions.

"Propellant" refers to and includes compounds that function as a medium for generating propulsion or thrust.

"User" or "subject" refers to and includes humans or other animals. For example, animals can be primates or non-primates and can include rabbits, cows, horses, pigs, rats, mice, dogs, or cats.

The device can be used for human and animal therapeutic, preventive and palliative care purposes. The device can also be used for research and industrial applications. For example, the device can be used to deposit compounds in an agricultural environment.

1A-1D illustrate various diagrams of the disposable intranasal drug delivery device 100. The device 100 is designed to deliver a consistent mass of compound into the nasal cavity. For example, the compound can be an intranasal formulation in the form of a liquid or suspension, without limitation. In some embodiments, the device 100 targets a specific area of the nasal cavity, such as the upper area of the nasal cavity (eg, the middle / superior turbinate area and / or the sense of body area).

FIG. 1A illustrates a perspective view of the disposable intranasal drug delivery device 100, and FIG. 1B illustrates a cross-sectional view. The device 100 includes a housing body 105, a nozzle 110, and an actuating element having an actuating lever. In the embodiments shown, the actuating element also includes an actuating button 115, which is disclosed in detail below. In other embodiments, the working element may include a sliding element disclosed in detail with reference to FIG. The housing body 105 is designed to be held in the hand that administers the compound to the user's nasal cavity. The user activates the device 100 in one actuation step by depressing the actuation button 115. Upon activation, the compound contained within the device 100 is facilitated from the nozzle 110 and enters the user's nasal cavity. For example, the user may insert the nozzle 110 into his nasal cavity and activate the actuation button 115 to release the propellant-driven compound into the nasal cavity. Once the compound is administered, the device can be discarded.

In some embodiments, the diameter of the nozzle 110 is tapered towards the outlet orifice of the nozzle 110. This configuration can beneficially increase the rate at which the drug compound exits the outlet orifice. In addition, this configuration can be beneficial in reducing plumewise. The reduction in plume width may allow the compound to be further propelled into the nasal cavity and into the upper region of the nasal cavity (eg, the medial and superior turbinate region and / or the sensory region). In an alternative embodiment, the nozzle 110 can be cylindrical or conical.

Moreover, the design of the nozzle 110 can be optimized for a variety of compounds with different properties. For example, the diameter of the nozzle 110, the angle and / or shape of the taper, and / or the diameter of the exit orifice can be modified (eg, increased or decreased) to suitably deliver the compound to the upper nasal cavity. As an example, larger nozzles and / or nozzle outlet orifices may be used for some powdered drug compounds to prevent clogging within the nozzle 110. In addition, the number and configuration of the outlet orifices of the nozzle 110 may vary to favorably deliver the compound to the superior nasal cavity. For example, the nozzle 110 may have one or more outlet orifices (eg, one or more outlet orifices, two or more outlet orifices, three or more outlet orifices, four or more outlet orifices, five or more outlets. It may include an orifice, 6 or more outlet orifices, 7 or more outlet orifices, etc.). In some embodiments, the nozzle 110 is manufactured with a removable seal, such as a metal or plastic seal, to hold the compound within the device 100 until actuated. The removable seal can be in the form of a pull tab, or other suitable geometry to seal the outlet orifice of the nozzle 110 and provide a grippable part for the user to remove the removable seal from the nozzle 110. It can have a geometric shape.

The actuation button 115 shown is at the top of the device 100, but the actuation button 115 may be located at the bottom, sides, front, and / or back of the device 100. Further, the working element may include an electric motor (eg, a battery-powered motor), a spring mechanism, and the like. In some embodiments, the device 100 is actuated in a single actuation step. In another embodiment, the device 100 is actuated in one or more actuation steps. For example, device 100 may require a priming step to load a spring loaded actuating lever.

As shown in FIG. 1B, the housing body 105 includes an actuating lever 120, a propellant canister 125, a puncture unit 130, a diffuser 135, and a dose holding chamber 140. In the illustrated figure, the actuating button 115 is connected to the actuating lever 120 and is exposed from the housing body 105. When the actuation button 115 is pushed down, the actuation lever 120 pushes the propellant canister 125 towards the end of the nozzle 110 of the device 100, causing the propellant canister 125 to encounter the puncture unit 130. When the threshold force is achieved (device activation), the puncture unit 130 punctures the propellant canister 125, which allows the propellant contained in the propellant canister 125 to be released. The propellant flows towards and through the diffuser 135 and into the dose holding chamber 140. As the propellant flows into the dose holding chamber 140, the compound in the dose holding chamber 140 is pushed out of the nozzle 110 so that the compound exits the nozzle 110 (eg, through one or more outlet orifices of the nozzle 110). ). The propellant may follow the compound exiting the nozzle 110 or may at least partially mix with the compound present at the nozzle 110.

In some embodiments, the propellant canister 125 is welded so that the propellant remains within the propellant canister 125 until use. Welded seals can require a great deal of force to puncture or break. The actuating lever 120 determines the amount of force the user exerts on the actuation button 115 to puncture the propellant canister 125 and actuate the device 100 against a direct force sufficient to puncture the propellant canister 125. Reduce. The length of the actuating lever 120, detailed below with reference to FIG. 5-6, will vary depending on the desired amount of force from the user intended to be sufficient to actuate the device 100. It can be designed differently in embodiments. Alternatively or additionally, other suitable mechanisms such as spring mechanisms, motors, etc. may be used to reduce the force required by the user to operate the device.

The actuating lever 120 is a substantially L-shaped lever arm. The first member 145 of the actuating lever 120 is arranged to receive a contact force from the actuating button 115. The second member 150 of the actuating lever 120 is perpendicular to the first member. The second member 150 of the actuating lever 120 applies a contact force to the propellant canister 125 when the actuating button 115 is actuated. The contact force moves the propellant canister 125 from the non-actuated position to the actuated position, causing the propellant canister to come into contact with the puncture unit 130. In some embodiments, the first member 145 of the actuating lever 120 and the second member 150 of the actuating lever have a unibody structure together with the actuating button 115. In other embodiments, the first member 145 of the actuating lever 120, the second member 150 of the actuating lever, the actuating button 115, or a combination thereof may be separate and independent components. An alternative embodiment of the actuating lever will be described in detail below with reference to FIG.

FIG. 1C illustrates a first partial view of the housing body 105 with the front cover removed, and FIG. 1D shows the housing body 105 with the front cover and actuation lever 115 removed to further illustrate the actuation mechanism. A second partial view of the state is illustrated. The actuating lever 120 includes or is attached to one or more pegs 160 that guide the movement of the actuating lever 120 within the device 100. The peg 160 fits into the raised hole 165 of the housing body 105, shown in FIG. 1D, so that one or more pegs 160 can rotate freely within the hole 165 but cannot move laterally. As a result, the one or more pegs 160 serve as pivot points where the actuating lever 120 can rotate along. When the device 100 is actuated, the actuating lever 120 rotates about one or more pegs 160.

The propellant contained in the propellant canister 125 is a fluid propellant such as a liquid propellant or a gas propellant. Propellants include, but are not limited to, pharmaceutically suitable propellants such as hydrofluoroalkanes (HFA), including, but not limited to, HFA such as HFA, HFA227, HFA134a, HFA-FP, HFA-BP. Additional examples of suitable propellants include nitrogen or chlorofluorocarbons (CFCs). In addition, the propellant can be pressurized. For example, the propellant can be pressurized air (eg, ambient air), pressurized nitrogen, pressurized carbon dioxide, or pressurized argon.

The propellant canister 125 may have a capacity for distributing the propellant for a fixed number of doses. In some embodiments, the propellant canister 125 is a unit dose propellant canister 125 such that the device 100 can be a disposable device. In these embodiments, the device 100 may be discarded after a single dose and / or the propellant canister 125 may be replaced with a new canister. In some embodiments, the propellant canister 125 may include a propellant for multiple actuations of the device. The amount of propellant released during operation can be between about 5 μl and 250 μl, including the end point of the propellant.

The puncture unit 130 is designed to puncture the propellant canister 125 to form an opening in the propellant canister 125. The puncture unit 130 may have sharp points, acute angles, bladed edges, or other suitable geometry for puncturing the propellant canister 125. The puncture unit 130 may be configured to puncture the puncture area of the propellant canister 125, such as the dimples of the propellant canister 125. In some embodiments, the device 100 comprises a plurality of puncture units, each suitable for puncturing the propellant canister 125 during operation. Alternatively or additionally, the device may include one or more additional puncture units designed to puncture the dose holding chamber 140. For example, an additional puncture unit may puncture the distal end of the dose holding chamber 140 during operation. As another example, an additional puncture unit may puncture the proximal end of the dose holding chamber 140 during operation.

The diffuser 135 diffuses the propellant released from the propellant canister 125. In one aspect, most of the propellant is diffused through the diffuser 135. In another aspect, a small number of propellants are diffused through the diffuser 135. In some embodiments, the diffuser 135 is a porous member. An example of the diffuser 135 includes a frit, a plurality of frit, or a diffuser member, or a combination thereof.

The diffuser 135 can serve as a one-way check valve to keep the liquid or dry compound in the dose holding chamber 140 out of contact with the propellant canister 125. For example, the diffuser 135 may prevent the compound from moving to the propellant canister 125, while allowing the propellant to move through the diffuser and push the compound in the opposite direction towards the nozzle. The diffuser 135 can also serve to reduce the velocity and / or pressure of the propellant exiting the propellant canister 125. The diffuser 135 can also serve to raise the temperature of the propellant exiting the propellant canister 125. Additional or alternative, the diffuser 135 may convert the propellant from a liquid to a gas. For example, the diffuser 135 can expand the propellant from a liquid state to a gaseous state. The gaseous propellant can aerosolize the compound and propell the aerosolized compound through the dose holding chamber 140 from the nozzle 110. In some embodiments, the device 100 does not include a diffuser. In these embodiments, the propellant flows from the propellant canister 125 through the dose holding chamber 140 and from the nozzle 110, in the process propelling the compound from the nozzle 110.

The dose holding chamber 140 contains one or more unit doses of the compound. Compounds can treat a variety of conditions including, but not limited to, migraine, epilepsy, pain, agitation, Parkinson's disease, opioid overdose, addiction, narcolepsy, and / or sleep disorders. Examples of compounds may include, but are not limited to, olanzapine, levodopa, dihydroergotamine, sumatriptan, zolmitriptan, diazepam, midazolam, naloxone, dexmedetomidine, morphine, and / or fentanyl. In alternative embodiments, alternative or additional compounds may be used.

In some embodiments, the device 100 may include a tip 155 accommodating a nozzle 110, a diffuser 135, and a dose holding chamber 140.

2A and 2B illustrate perspective views and cross-sectional views of a disposable intranasal drug delivery device 200 with a cap 205, respectively. The cap covers the tip 155 of the device 200 and the nozzle 110. The cap 205 closes the nozzle 110 and prevents something from entering and exiting the device 200. Further, the cap 205 includes a stretching member extending through the slit of the housing body 105 to prevent the actuating button 115 from being pushed down. In this way, the cap 205 prevents the actuating lever 120 from being actuated early (eg, during manufacturing, shipping, handling, etc.). In addition, the cap 205 may provide the user with an indication that the device 100 is not activated. To activate the device 100, the user removes the cap 205 and removes the cap 205 by pulling the cap 205 away from the device 100 and / or by rotating the cap 205 along one or more threads. Unlock 120. In addition, pull tabs may be implemented to provide functionality similar to cap 205. In embodiments that include pull tabs, the user removes the pull tabs to unlock the actuating lever 120 from the non-actuated position.

The device 200 locks, such as a ratcheting lever lock, to lock the actuating lever 120 to the actuating position (or partially actuating position) after the actuating lever 120 has rotated inward by a predetermined distance during actuation. (Not shown) may be further included. The lock locks the actuating lever 120 in place after the device 200 is actuated, preventing further actuation of the device 200. The lock may be placed along various positions of the actuating lever 120. For example, the lock may include a ratchet mechanism located at the pivot point of the actuating lever 120, allowing rotation from the non-actuated position to the actuated position, but preventing rotation of the actuating lever 120 in the opposite direction. Therefore, after actuation, the lock keeps the actuating lever 120 in the actuating position. Alternatively or additionally, the lever lock may be located near the end of the actuation button 115 of the actuation lever 120. In these embodiments, when the actuation button 115 is depressed, the lock latches onto the depressed actuation button 115 to prevent the actuation lever 120 from being lifted again and thus locks the actuation lever to the actuation position. .. In addition, the device 200 may include a usage indicator (not shown). The usage indicator provides a visual indication that the device 200 has been activated. Examples of usage indicators include a cutout of the housing body 105 and / or a physical feature protruding from the housing body 105, each of which displays one color prior to the device being activated and the device being activated. After that, different colors can be displayed. The indicator used can be a colored metal, a colored plastic, an LED, and the like. Alternatively, the use indicator can be any suitable visual indicator that provides an indication that the device 200 has been activated.

3A-3B illustrate perspective views and cross-sectional views of variants of the disposable intranasal drug delivery device 300, respectively. In the illustrated embodiment, the device 300 includes a housing body 305, a nozzle 310, and an actuating element having an actuating lever. In the illustrated embodiment, the actuating element includes an actuating button 315. The housing body 305 includes an actuating lever 320, a propellant canister 325, a puncture unit 330, a diffuser 335, and a dose holding chamber 340.

Some of the components of device 300 shown have different form factors than the devices shown in FIGS. 1A-2B. For example, in the device 300, the actuating button 315 projects from the actuating lever 320 so as to extend outward of the housing body 305, while in the device 100, the surface of the actuating button 115 is a flat surface that approximates the surface of the housing body 105. Is. Further, the dose holding chamber 340 in the device 300 may have a different size and / or shape than the dose holding chamber 140 in the device 100. The device 300 may further have a housing body 305 with a general form factor different from the device 100. However, apart from these cosmetic differences, the devices 100, 300 are configured and operate substantially equivalent, and unless otherwise indicated, the components of the devices 100, 300 are functionally the same or similar. Can be.

FIG. 4 illustrates a cross-sectional view of a disposable intranasal drug delivery device 400 with a spring-loaded actuating lever 405. In the illustrated device 400, the housing body 410 includes an actuating lever 405, a spring 415, a propellant canister 420, a puncture unit 425, a diffuser 430, and a dose holding chamber 435. The device 400 further includes an actuating button 440 configured to actuate the device 400 and a nozzle 445 through which the compound contained in the dose holding chamber 435 is ejected. The device 400 may further include a cap, a lock, and / or a use indicator.

In the illustrated device 400, the actuating button 440 is a slidable element that includes a fixed latch 450, and the actuating lever 405 is urged by a spring 415. The actuating button 440 is connected to the actuating lever 405 contained within the housing body 410. When the actuating lever 405 is pushed by the compressed spring 415, the actuating lever 405 is also held in place by the actuating button 440 in the interface between the actuating lever 405 and the fixed latch 450.

When the user slides the actuating button 440 away from the nozzle 445, the actuating button 440 physically releases the actuating lever 405 at the mating interface between the actuating lever 405 and the fixed latch 450. The spring force then drives the actuating lever 405 against the propellant canister 420, urging the propellant canister against the puncture unit 425. When the puncture unit 425 punctures the propellant canister 420, the propellant contained in the propellant canister 420 is released.

The released propellant flows toward the diffuser 430, passes through the diffuser 430, enters the dose holding chamber 435, and exits the nozzle 445 (eg, through one or more outlet orifices of the nozzle 445). When the propellant enters the dose holding chamber 435, the propellant pushes the compound contained in the dose holding chamber 435 through the nozzle 445 itself.

Similar to the device shown in FIGS. 1A-3B, the propellant contained in the propellant canister 420 is a fluid propellant such as a liquid propellant or a gas propellant. The propellant contains a pharmaceutically appropriate propellant. Some examples of pharmaceutically suitable propellants include hydrofluoroalkanes (HFAs) including, but not limited to, HFAs such as HFA, HFA227, HFA134a, HFA-FP, HFA-BP. Additional examples of suitable propellants include nitrogen or chlorofluorocarbons (CFCs). In addition, the propellant can be pressurized. For example, the propellant can be pressurized air (eg, ambient air), pressurized nitrogen, pressurized carbon dioxide, or pressurized argon.

Additionally, the diffuser 430 may act to retain the liquid or dry compound in the dose holding chamber 430 and reduce the speed and / or pressure of the propellant exiting the propellant canister 420. It can act to raise the temperature of the propellant exiting the propellant canister 420 and / or act to convert the propellant from a liquid to a gas.

In some embodiments, the actuating button 440 is configured to actuate the device 400 by pushing down the actuating button 440 in a direction towards the housing body. By pushing down the actuating button 440, the actuating lever 405 is released from the non-actuated position to the actuated position. As a result, the propellant canister 420 comes into contact with the puncture unit 425 and punctures the propellant canister 420. In these embodiments, the actuating lever 405 can be spring-loaded. The activated button 440 shown is located at the top of the device 400, but the activated button 440 may be located at the bottom, sides, front, and / or back of the device 400. Further, in some embodiments, the device 400 is actuated in a single actuation step. In another embodiment, the device 400 is actuated in one or more actuation steps. For example, the device 400 may require a priming step to load the spring 415.

FIG. 5 illustrates working force data from a disposable intranasal drug delivery device with a short working lever similar to the devices shown in FIGS. 1A-D and 3A-B. As can be seen in FIG. 5, by using the actuating lever, the force required to actuate the device is 8 to 10 lbs.

FIG. 6 illustrates force data from a disposable intranasal drug delivery device using a long actuating lever similar to the devices shown in FIGS. 1A-D and 3A-B. The device used to generate the data of FIG. 6 is similar to the device used to develop the data of FIG. 5, except that it has a long actuating lever. For these devices, the amount of force required to activate the device is about 4 lbs, indicating that the actuating lever can be designed to reduce the amount of force required to actuate the device.

Additional Setting Information The above description of the embodiments of the present disclosure is presented for illustration purposes only and is not intended to be exhaustive or limited to the exact form disclosed. Those skilled in the art of the art concerned will appreciate that many modifications and variations are possible in light of the above disclosure.

The language used herein has been selected primarily for readability and description, not for clarifying the subject matter of the present invention. Accordingly, the scope of this disclosure is intended to be limited by the claims issued in the application under this specification, rather than by this detailed description. Therefore, the disclosure of the embodiments is intended to illustrate, but not limit, the scope of the disclosure described in the claims below.

Claims (21)

A device for delivering compounds to the nasal cavity
With the housing body
A propellant canister in the housing body that can contain the propellant and can be displaced between the non-actuated position and the actuated position.
A puncture element in the housing body that is arranged to puncture the propellant canister and release the propellant from the propellant canister when the propellant canister is driven to the actuating position. With the puncture element,
A diffuser in the housing body that diffuses the propellant upon discharge from the propellant canister.
A dose-holding chamber within the housing body capable of accommodating a unit dose of the compound, such that the propellant flows from the diffuser into the dose-holding chamber and propells the compound from the dose-holding chamber. Placed dose holding chamber and
A nozzle and a nozzle arranged to allow the compound to flow through the nozzle when propelled from the dose holding chamber so that the compound is delivered to the nasal cavity.
An actuating element comprising an actuating lever, wherein the actuation of the actuating lever is configured to displace the propellant canister from the non-actuated position to the actuated position.
A device equipped with. The actuating lever is an L-shaped lever arm, the first member of the actuating lever is arranged so as to receive a contact force from the actuating button, and the actuating lever perpendicular to the first member when the actuating button is actuated. The device according to claim 1, wherein the second member applies a contact force to the propellant canister. The actuating element comprises an actuating button exposed from the housing body, and when the actuating button is pushed in a direction towards the housing body, the propellant canister is driven into the puncture element, thereby causing the propellant canister to puncture. The device according to claim 1. The device of claim 1, wherein the device further comprises a removable cap configured to keep the actuating element in the non-actuated position. The device of claim 1, further comprising a lock configured to hold the actuating element in said actuating position. The device of claim 1, further comprising a use indicator configured to provide an indication that the actuating element is in the actuating position. The actuating element includes a sliding element exposed from the housing body, the sliding element has a non-actuating position in which the propellant canister can be placed in the non-actuating position, and the propellant canister in the actuating position. The device of claim 1, which is slidable to and from an actuating position urging. A device for delivering compounds to the nasal cavity
A propellant canister in the body of the housing that can contain the propellant, said propellant canister is displaceable between the non-actuated position and the actuated position.
A dose-accommodating chamber capable of accommodating a unit dose of a compound,
A nozzle and a nozzle arranged to allow the compound to flow through the nozzle when propelled from the dose holding chamber by a propellant so that the compound is delivered to the nasal cavity.
An actuating element comprising an actuating lever, wherein the actuation of the actuating lever is configured to displace the propellant canister from the non-actuated position to the actuated position.
A device equipped with. The actuating lever is an L-shaped lever arm, the first member of the actuating lever is arranged so as to receive a contact force from the actuating button, and the actuating lever perpendicular to the first member when the actuating button is actuated. 8. The device of claim 8, wherein the second member exerts a contact force on the propellant canister. The actuating element comprises an actuating button exposed from the housing body, and when the actuating button is pushed in a direction towards the housing body, the propellant canister is driven into the puncture element, thereby causing the propellant canister to puncture. The device according to claim 8. 8. The device of claim 8, wherein the device further comprises a removable cap configured to keep the actuating element in a non-actuated position. 8. The device of claim 8, further comprising a lock configured to keep the actuating element in the actuating position. 8. The device of claim 8, further comprising a use indicator configured to provide an indication that the actuating element is in the actuating position. The actuating element comprises a sliding element exposed from the housing body, the sliding element in the non-actuating position where the propellant canister can be placed in the non-actuating position and the propellant canister in the actuating position. The device of claim 8, which is slidable to and from the urging operating position. 8. Claim 8 further comprising a puncture element arranged to puncture the position of the propellant canister when the propellant canister is driven to the actuating position and to release the propellant from the propellant canister. The device described in. A device for delivering compounds to the nasal cavity
With the housing body
A propellant canister within the body of the housing, comprising a propellant, the propellant canister being displaceable between a non-working position and a working position.
A puncture element within the housing body that punctures the position of the propellant canister and is arranged to release the propellant from the propellant canister.
A diffuser in the housing body that diffuses the propellant when released from the propellant canister.
A dose-holding chamber within the housing body that houses the compound, the propellant flows from the diffuser into the dose-holding chamber, and the compound is arranged to be propelled from the dose-holding chamber. In the chamber,
A nozzle, wherein the compound is arranged to flow through the nozzle when propelled from the dose holding chamber so that the compound is delivered to the nasal cavity.
An actuating element comprising an actuating lever, wherein the actuation of the actuating lever is configured to displace the propellant canister from the non-actuated position to the actuated position.
A device equipped with. The actuating lever is an L-shaped lever arm, the first member of the actuating lever is arranged so as to receive a contact force from the actuating button, and the second member of the actuating lever perpendicular to the first member is actuated. 16. The device of claim 16, wherein a contact force is applied to the propellant canister when the button is actuated. The actuating element comprises an actuating button exposed from the housing body, and when the actuating button is pushed in a direction towards the housing body, the propellant canister is driven into the puncture element, thereby causing the propellant canister to puncture. The device of claim 16. The actuating element includes a sliding element exposed from the housing body, the sliding element has a non-actuating position in which the propellant canister can be placed in the non-actuating position, and the propellant canister in the actuating position. 16. The device of claim 16, which is slidable to and from an actuating position urging. 16. The device of claim 16, wherein the device further comprises a removable cap configured to keep the actuating element in a non-actuated position. 16. The device of claim 16, further comprising a lock configured to keep the actuating element in the actuating position.

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