JP2022530920A - 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー - Google Patents

核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー Download PDF

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JP2022530920A
JP2022530920A JP2021565022A JP2021565022A JP2022530920A JP 2022530920 A JP2022530920 A JP 2022530920A JP 2021565022 A JP2021565022 A JP 2021565022A JP 2021565022 A JP2021565022 A JP 2021565022A JP 2022530920 A JP2022530920 A JP 2022530920A
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chain reaction
polymerase chain
nucleic acid
sequence
oligonucleotide primer
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フランシス バラニー
マニー ディー． バコロド
ジャンミン ファン
アーシク エイチ． ミルザ
フィリップ ビー． フェインベルク
サラ エフ． ギアルディナ
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Cornell University
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    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
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    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
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    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
JP2021565022A 2019-05-03 2020-05-01 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー Pending JP2022530920A (ja)

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JP2025091539A JP2026002789A (ja) 2019-05-03 2025-06-02 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー

Applications Claiming Priority (3)

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US201962843032P 2019-05-03 2019-05-03
US62/843,032 2019-05-03
PCT/US2020/031044 WO2020227100A1 (en) 2019-05-03 2020-05-01 Markers for identifying and quantifying of nucleic acid sequence mutation, expression, splice variant, translocation, copy number, or methylation changes

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JP2025091539A Division JP2026002789A (ja) 2019-05-03 2025-06-02 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー

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JP2022530920A true JP2022530920A (ja) 2022-07-04
JP2022530920A5 JP2022530920A5 (enExample) 2023-03-13

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JP2025091539A Pending JP2026002789A (ja) 2019-05-03 2025-06-02 核酸配列の変異、発現、スプライスバリアント、転座、コピー数、またはメチル化変化を特定及び定量するためのマーカー

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US (1) US20220243263A1 (enExample)
EP (1) EP3963095A4 (enExample)
JP (2) JP2022530920A (enExample)
CN (1) CN115244188A (enExample)
AU (1) AU2020268885A1 (enExample)
BR (1) BR112021022084A2 (enExample)
CA (1) CA3135726A1 (enExample)
IL (1) IL287804A (enExample)
SG (1) SG11202112246UA (enExample)
WO (1) WO2020227100A1 (enExample)

Families Citing this family (13)

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CA3127329A1 (en) 2019-01-24 2020-07-30 Mayo Foundation For Medical Education And Research Detecting endometrial cancer
US11702704B2 (en) 2019-10-31 2023-07-18 Mayo Foundation For Medical Education And Research Detecting ovarian cancer
EP4267763B1 (en) * 2020-12-24 2025-07-23 Life Technologies Corporation Compositions and methods for highly sensitive detection of target sequences in multiplex reactions
CA3211005A1 (en) * 2021-03-05 2022-09-09 Mayo Foundation For Medical Education And Research Detecting cervical cancer
WO2022246000A1 (en) * 2021-05-19 2022-11-24 City Of Hope Compositions and methods for determining dna methylation level in cancer
WO2023017001A1 (en) * 2021-08-09 2023-02-16 Epigenomics Ag Improved methods for detecting colorectal cancer
CA3268032A1 (en) * 2022-09-23 2024-03-28 Flagship Pioneering Innovations Vi, Llc NUCLEIC ACID AMPLIFICATION PROCESSES
WO2024154075A1 (en) * 2023-01-18 2024-07-25 Pixelgen Technologies Ab Gap-fill ligation and primer extension reactions employing exonuclease-resistant or capture moiety means
AU2024263920A1 (en) * 2023-04-24 2025-11-13 Saga Diagnostics Ab Detection of variants
WO2024259135A1 (en) 2023-06-13 2024-12-19 Intellia Therapeutics, Inc. Assays for analysis of ribonucleic acid (rna) molecules
CN117305312B (zh) * 2023-10-19 2024-08-20 西南大学 一个家蚕专一取食桑叶的决定基因Zfh3及其应用
US20250223652A1 (en) * 2024-01-05 2025-07-10 Harbinger Health, Inc. Tiered testing for high risk populations
CN118986863A (zh) * 2024-10-18 2024-11-22 四川新泌学生物科技有限公司 一种外阴用外泌体凝胶及其制备方法

Citations (3)

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WO2015023285A1 (en) * 2013-08-15 2015-02-19 Xia Xueliang James Biomarkers for use in colorectal cancer
JP2018520672A (ja) * 2015-06-24 2018-08-02 ユーシーエル ビジネス パブリック リミテッド カンパニー 膀胱がんを診断する方法
WO2019068082A1 (en) * 2017-09-29 2019-04-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Dna methylation biomarkers for cancer diagnosing

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ATE342378T1 (de) * 1999-03-19 2006-11-15 Cornell Res Foundation Inc Verfahren das auf den gekoppelten reactionen der polymerase-kettenreaktion (pcr)-verdauung mit restriktionsenzymen und ligasenachweis basiert
EP2386654A1 (en) * 2005-05-02 2011-11-16 University of Southern California DNA Methylation markers associated with the CpG island methylator phenotype (cimp) in human colorectal cancer
EP2129796B1 (en) * 2007-02-21 2013-10-23 Oslo Universitetssykehus HF New markers for cancer
SG11201404899VA (en) * 2012-02-14 2014-10-30 Univ Cornell Method for relative quantification of nucleic acid sequence, expression, or copy changes, using combined nuclease, ligation, and polymerase reactions
SI4056712T1 (sl) * 2012-09-20 2024-10-30 The Chinese University Of Hong Kong Neinvazivno določanje metiloma tumorja iz plazme
PT3204520T (pt) * 2014-10-08 2020-04-16 Univ Cornell Método de identificação e quantificação da expressão de ácidos nucleicos, variantes de splicing, translocação, número de cópias ou alterações de metilação
US10030272B2 (en) * 2015-02-27 2018-07-24 Mayo Foundation For Medical Education And Research Detecting gastrointestinal neoplasms
US10829804B2 (en) * 2015-03-23 2020-11-10 The University Of North Carolina At Chapel Hill Method for identification and enumeration of nucleic acid sequences, expression, splice variant, translocation, copy, or DNA methylation changes using combined nuclease, ligase, polymerase, terminal transferase, and sequencing reactions
ES2835866T5 (es) * 2015-05-12 2024-12-02 Hoffmann La Roche Procedimientos terapéuticos y de diagnóstico para el cáncer
WO2018087129A1 (en) * 2016-11-08 2018-05-17 Region Nordjylland, Aalborg University Hospital Colorectal cancer methylation markers

Patent Citations (3)

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Publication number Priority date Publication date Assignee Title
WO2015023285A1 (en) * 2013-08-15 2015-02-19 Xia Xueliang James Biomarkers for use in colorectal cancer
JP2018520672A (ja) * 2015-06-24 2018-08-02 ユーシーエル ビジネス パブリック リミテッド カンパニー 膀胱がんを診断する方法
WO2019068082A1 (en) * 2017-09-29 2019-04-04 Arizona Board Of Regents On Behalf Of The University Of Arizona Dna methylation biomarkers for cancer diagnosing

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IL287804A (en) 2022-01-01
EP3963095A4 (en) 2023-01-25
WO2020227100A1 (en) 2020-11-12
SG11202112246UA (en) 2021-12-30
WO2020227100A8 (en) 2022-01-13
BR112021022084A2 (pt) 2022-02-08
EP3963095A1 (en) 2022-03-09
AU2020268885A1 (en) 2021-12-02
CA3135726A1 (en) 2020-11-12
JP2026002789A (ja) 2026-01-08
CN115244188A (zh) 2022-10-25
US20220243263A1 (en) 2022-08-04

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