JP2022530018A - 脂質ナノ粒子 - Google Patents

脂質ナノ粒子 Download PDF

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Publication number
JP2022530018A
JP2022530018A JP2021562869A JP2021562869A JP2022530018A JP 2022530018 A JP2022530018 A JP 2022530018A JP 2021562869 A JP2021562869 A JP 2021562869A JP 2021562869 A JP2021562869 A JP 2021562869A JP 2022530018 A JP2022530018 A JP 2022530018A
Authority
JP
Japan
Prior art keywords
lipid
moiety
peg
nanoparticle according
nucleic acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
JP2021562869A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022530018A5 (enExample
Inventor
ヘイズ,ジェイムズ
ジャッジ,アダム
モン ラム,キエウ
ディー マーティン,アラン
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Genevant Sciences GmbH
Original Assignee
Genevant Sciences GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Genevant Sciences GmbH filed Critical Genevant Sciences GmbH
Publication of JP2022530018A publication Critical patent/JP2022530018A/ja
Publication of JP2022530018A5 publication Critical patent/JP2022530018A5/ja
Abandoned legal-status Critical Current

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers
    • A61K9/1272—Non-conventional liposomes, e.g. PEGylated liposomes or liposomes coated or grafted with polymers comprising non-phosphatidyl surfactants as bilayer-forming substances, e.g. cationic lipids or non-phosphatidyl liposomes coated or grafted with polymers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5123—Organic compounds, e.g. fats, sugars
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nanotechnology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Optics & Photonics (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
JP2021562869A 2019-04-26 2020-04-24 脂質ナノ粒子 Abandoned JP2022530018A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962839452P 2019-04-26 2019-04-26
US62/839,452 2019-04-26
US201962867098P 2019-06-26 2019-06-26
US62/867,098 2019-06-26
PCT/US2020/029907 WO2020219941A1 (en) 2019-04-26 2020-04-24 Lipid nanoparticles

Publications (2)

Publication Number Publication Date
JP2022530018A true JP2022530018A (ja) 2022-06-27
JP2022530018A5 JP2022530018A5 (enExample) 2023-04-27

Family

ID=72941858

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021562869A Abandoned JP2022530018A (ja) 2019-04-26 2020-04-24 脂質ナノ粒子

Country Status (8)

Country Link
US (1) US20220168222A1 (enExample)
EP (1) EP3959314A4 (enExample)
JP (1) JP2022530018A (enExample)
CN (1) CN114026233A (enExample)
AU (1) AU2020262437A1 (enExample)
CA (1) CA3137450A1 (enExample)
MA (1) MA55766A (enExample)
WO (1) WO2020219941A1 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023534206A (ja) * 2020-07-10 2023-08-08 ジェネヴァント サイエンシズ ゲーエムベーハー 肺に治療薬を送達するための脂質ナノ粒子
JP2025523587A (ja) * 2022-07-06 2025-07-23 グリーン クロス コーポレーション 核酸送達のための局所送達用カチオン性コレステロールを使用した脂質ナノ粒子

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AU2019376006B2 (en) * 2018-11-09 2026-07-02 Arbutus Biopharma Corporation Cationic lipids containing silicon
CA3162019A1 (en) 2019-12-20 2021-06-24 Gemma NAVARRO Lipid nanoparticles for delivery of nucleic acids
US12023376B1 (en) 2020-04-17 2024-07-02 Triad National Security, Llc Conserved region T cell vaccines for coronavirus and methods of use
MX2023001109A (es) 2020-07-27 2023-04-24 Anjarium Biosciences Ag Composiciones de moleculas de adn, metodos para elaborar las mismas, y metodos de usos de las mismas.
CZ310613B6 (cs) 2020-09-23 2026-01-28 Ústav organické chemie a biochemie AV ČR, v. v. i. Lipidoidy pro transfekci nukleových kyselin a jejich použití
MX2023004371A (es) 2020-10-14 2023-07-26 George Mason Res Foundation Inc Lípidos ionizables, y métodos de fabricación y uso de los mismos.
WO2022099003A1 (en) 2020-11-06 2022-05-12 Sanofi Lipid nanoparticles for delivering mrna vaccines
CN117098541A (zh) 2020-11-25 2023-11-21 阿卡格拉医药公司 用于递送核酸的脂质纳米粒及相关使用方法
AU2021403156A1 (en) * 2020-12-18 2023-07-13 Genevant Sciences Gmbh Peg lipids and lipid nanoparticles
WO2022198229A1 (en) * 2021-03-17 2022-09-22 Board Of Regents Of The University Of Nebraska Lipid nanoparticle formulations and methods of use thereof
CN117203340A (zh) 2021-04-16 2023-12-08 基因泰克公司 优化的tlr7配体及其用途
CZ310443B6 (cs) 2021-07-19 2025-06-25 Ústav organické chemie a biochemie AV ČR, v. v. i. Cyklohexanové lipidoidy pro transfekci nukleových kyselin a jejich použití
IL309502A (en) 2021-09-03 2024-02-01 CureVac SE Lipid nanoparticles for nucleic acid delivery involving phosphatidylserine
WO2023069948A1 (en) 2021-10-18 2023-04-27 Flagship Pioneering Innovations Vii, Llc Dna compositions and related methods
KR20230061895A (ko) * 2021-10-29 2023-05-09 주식회사 아이큐어비앤피 지질 나노입자 및 세포 투과성을 갖는 신규 펩타이드의 복합체
WO2023216232A1 (zh) * 2022-05-13 2023-11-16 南方科技大学 一种含有二硫键的脂质化合物及其组合物
AU2023268051A1 (en) 2022-05-13 2025-01-02 BioNTech SE Rna compositions targeting hiv
WO2023230098A1 (en) 2022-05-23 2023-11-30 Logicbio Therapeutics, Inc. Gene therapy compositions and methods of use thereof
WO2023230295A1 (en) 2022-05-25 2023-11-30 BioNTech SE Rna compositions for delivery of monkeypox antigens and related methods
WO2023230587A2 (en) 2022-05-25 2023-11-30 Akagera Medicines, Inc. Lipid nanoparticles for delivery of nucleic acids and methods of use thereof
US20250375534A1 (en) 2022-05-30 2025-12-11 BioNTech SE Complexes for delivery of nucleic acids
CN119677852A (zh) 2022-07-29 2025-03-21 麻省理工学院 抑制信号调节蛋白α(SIRPα)基因表达的组合物和方法
WO2024037577A1 (en) * 2022-08-18 2024-02-22 Suzhou Abogen Biosciences Co., Ltd. Composition of lipid nanoparticles
WO2024057237A1 (en) 2022-09-16 2024-03-21 Pfizer Inc. Lipid nanoparticles
EP4342460A1 (en) 2022-09-21 2024-03-27 NovoArc GmbH Lipid nanoparticle with nucleic acid cargo
US20240108545A1 (en) 2022-10-03 2024-04-04 West Pharmaceutical Services, Inc. Methods and adapters for mixing pharmaceutical complexes
CN119095585A (zh) * 2022-12-21 2024-12-06 苏州艾博生物科技有限公司 包含固醇修饰的磷脂的脂质纳米颗粒
CN121127490A (zh) 2022-12-28 2025-12-12 生物技术欧洲股份公司 靶向hiv的rna组合物
EP4410316A1 (en) * 2023-02-01 2024-08-07 4basebio UK Ltd Nanoparticles for delivery of nucleic acid cargos
EP4661843A2 (en) * 2023-02-06 2025-12-17 University of Tennessee Research Foundation Multi-functional lipid nanoparticles and uses thereof
WO2024205499A1 (en) * 2023-03-27 2024-10-03 Agency For Science, Technology And Research A compound for preparing lipid nanoparticles encapsulating an agent, nanoparticle composition comprising said compound and related methods thereof
WO2024259158A2 (en) * 2023-06-13 2024-12-19 Cornell University Lipid nanoparticles for peptide delivery and methods of making and using the same
EP4754130A2 (en) 2023-08-03 2026-06-10 BioNTech SE Rna compositions targeting hiv
CN121866336A (zh) 2023-08-03 2026-04-14 百欧恩泰欧洲股份公司 靶向hiv的rna组合物
KR20260065891A (ko) 2023-09-01 2026-05-11 노보아크 게엠베하 핵산 카고 및 이온화가능한 지질을 갖는 지질 나노입자
WO2025124711A1 (en) 2023-12-13 2025-06-19 BioNTech SE Glycolipid compositions
WO2025219570A1 (en) 2024-04-17 2025-10-23 Johannes Kepler Universität Linz Composition for inhibiting protein translocation and methods using the same
WO2025242657A1 (en) 2024-05-21 2025-11-27 Shape Biopharmaceuticals Ag Lipopeptide building blocks and aggregates
GB202408360D0 (en) 2024-06-11 2024-07-24 Cancer Research Tech Ltd Tumour sensitisation
WO2026119908A1 (en) 2024-12-05 2026-06-11 Merck Patent Gmbh Helper lipids in nucleic acid delivery

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK3386484T3 (da) * 2015-12-10 2022-07-04 Modernatx Inc Sammensætninger og fremgangsmåder til afgivelse af terapeutiske midler
US11191849B2 (en) * 2016-06-30 2021-12-07 Arbutus Biopharma Corporation Compositions and methods for delivering messenger RNA

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2023534206A (ja) * 2020-07-10 2023-08-08 ジェネヴァント サイエンシズ ゲーエムベーハー 肺に治療薬を送達するための脂質ナノ粒子
JP2025523587A (ja) * 2022-07-06 2025-07-23 グリーン クロス コーポレーション 核酸送達のための局所送達用カチオン性コレステロールを使用した脂質ナノ粒子

Also Published As

Publication number Publication date
AU2020262437A1 (en) 2021-12-23
US20220168222A1 (en) 2022-06-02
EP3959314A1 (en) 2022-03-02
WO2020219941A1 (en) 2020-10-29
CA3137450A1 (en) 2020-10-29
MA55766A (fr) 2022-03-02
CN114026233A (zh) 2022-02-08
EP3959314A4 (en) 2023-02-08

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