JP2022527190A - 肝疾患の治療で使用するためのｇｈｒｈまたはその類似物 - Google Patents

肝疾患の治療で使用するためのｇｈｒｈまたはその類似物 Download PDF

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Publication number
JP2022527190A
JP2022527190A JP2021557925A JP2021557925A JP2022527190A JP 2022527190 A JP2022527190 A JP 2022527190A JP 2021557925 A JP2021557925 A JP 2021557925A JP 2021557925 A JP2021557925 A JP 2021557925A JP 2022527190 A JP2022527190 A JP 2022527190A
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Japan
Prior art keywords
ghrh
hexenoyl
pharmaceutically acceptable
trans
acceptable salt
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JP2021557925A
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Japanese (ja)
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JP2022527190A5 (cg-RX-API-DMAC10.html
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スティーヴン・ケー・グリンスプーン
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ザ ジェネラル ホスピタル コーポレイション
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Publication of JP2022527190A publication Critical patent/JP2022527190A/ja
Publication of JP2022527190A5 publication Critical patent/JP2022527190A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/22—Hormones
    • A61K38/25—Growth hormone-releasing factor [GH-RF], i.e. somatoliberin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
JP2021557925A 2019-03-29 2020-03-27 肝疾患の治療で使用するためのｇｈｒｈまたはその類似物 Pending JP2022527190A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962826284P 2019-03-29 2019-03-29
US62/826,284 2019-03-29
US201962861187P 2019-06-13 2019-06-13
US62/861,187 2019-06-13
PCT/US2020/025180 WO2020205498A1 (en) 2019-03-29 2020-03-27 Ghrh or analogues thereof for use in treatment of hepatic disease

Publications (2)

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JP2022527190A true JP2022527190A (ja) 2022-05-31
JP2022527190A5 JP2022527190A5 (cg-RX-API-DMAC10.html) 2023-04-05

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JP2021557925A Pending JP2022527190A (ja) 2019-03-29 2020-03-27 肝疾患の治療で使用するためのｇｈｒｈまたはその類似物

Country Status (10)

Country Link
US (4) US10799562B1 (cg-RX-API-DMAC10.html)
EP (1) EP3947426A4 (cg-RX-API-DMAC10.html)
JP (1) JP2022527190A (cg-RX-API-DMAC10.html)
KR (1) KR20210145226A (cg-RX-API-DMAC10.html)
CN (1) CN113646327A (cg-RX-API-DMAC10.html)
AU (1) AU2020253828A1 (cg-RX-API-DMAC10.html)
CA (1) CA3133319A1 (cg-RX-API-DMAC10.html)
IL (1) IL286703A (cg-RX-API-DMAC10.html)
SG (1) SG11202110469PA (cg-RX-API-DMAC10.html)
WO (1) WO2020205498A1 (cg-RX-API-DMAC10.html)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2020205498A1 (en) * 2019-03-29 2020-10-08 The General Hospital Corporation Ghrh or analogues thereof for use in treatment of hepatic disease
CA3183299A1 (en) * 2020-07-05 2022-01-13 Christian Marsolais Low-dose pharmaceutical compositions of ghrh analogs and uses thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2009010675A (es) * 2007-04-04 2009-10-23 Theratechnologies Inc Formulaciones farmaceuticas de moleculas de la hormona liberadora de la hormona delcrecimiento humana.
US9163091B2 (en) * 2007-05-30 2015-10-20 Lpath, Inc. Compositions and methods for binding lysophosphatidic acid
US20150174207A1 (en) * 2013-12-24 2015-06-25 University Of Miami Methods for treating cancer with ghrh agonists
EP3362053A4 (en) * 2015-10-16 2019-04-17 Hadasit Medical Research Services and Development Ltd. TREATMENT OF NON-ALCOHOLIC FATTYLENE OR NON-ALCOHOLIC STEATOHEPATITIS WITH 6-MERCAPTOPURIN WITH DELAYED RELEASE
MX2018012716A (es) * 2016-04-19 2019-02-11 Griffon Pharmaceuticals Inc Peptidos bioactivos pegilados y usos de los mismos.
EP4467158A3 (en) * 2018-02-14 2025-02-19 Lumos Pharma, Inc. Compositions for the treatment of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis
WO2020205498A1 (en) * 2019-03-29 2020-10-08 The General Hospital Corporation Ghrh or analogues thereof for use in treatment of hepatic disease
JP2023548156A (ja) * 2020-10-30 2023-11-15 ザ ジェネラル ホスピタル コーポレイション 肝疾患の評価のためのキット、試薬、及び方法
WO2022104289A1 (en) * 2020-11-16 2022-05-19 The Regents Of The University Of California Use of pharmaceutical doses of niacin, or an analog thereof, for the regression or reversal of fibrosis and/or liver cirrhosis

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
GROWTH HORMONE & IGF RESEARCH, vol. 37, JPN6024011713, 2017, pages 1 - 6, ISSN: 0005452178 *
GUT, vol. 66, no. 1, JPN6024011714, 2017, pages 180 - 190, ISSN: 0005452179 *
JAMA, AUTHOR MANUSCRIPT, JPN6024011715, 1 July 2015 (2015-07-01), pages 1 - 18, ISSN: 0005452180 *

Also Published As

Publication number Publication date
US10946073B2 (en) 2021-03-16
EP3947426A4 (en) 2023-01-04
US10799562B1 (en) 2020-10-13
WO2020205498A1 (en) 2020-10-08
KR20210145226A (ko) 2021-12-01
SG11202110469PA (en) 2021-10-28
CN113646327A (zh) 2021-11-12
US20200405816A1 (en) 2020-12-31
US20210177943A1 (en) 2021-06-17
US12233107B2 (en) 2025-02-25
CA3133319A1 (en) 2020-10-08
IL286703A (en) 2021-10-31
US20240091316A1 (en) 2024-03-21
US20200306345A1 (en) 2020-10-01
US11738066B2 (en) 2023-08-29
EP3947426A1 (en) 2022-02-09
AU2020253828A1 (en) 2021-10-28

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