|
AU2001271553A1
(en)
*
|
2000-06-23 |
2002-01-08 |
Genetastix Corporation |
High throughput generation and screening of fully human antibody repertoire in yeast
|
|
CN101333555B
(zh)
*
|
2007-12-25 |
2012-03-21 |
浙江大学 |
新型的g蛋白偶联受体细胞水平筛选系统构建与应用
|
|
JP2011517838A
(ja)
|
2008-04-11 |
2011-06-16 |
ユーティーシー パワー コーポレイション |
マニホルド・サンプを備えたバイポーラプレートおよび燃料電池
|
|
US8586526B2
(en)
|
2010-05-17 |
2013-11-19 |
Sangamo Biosciences, Inc. |
DNA-binding proteins and uses thereof
|
|
WO2013141680A1
(en)
|
2012-03-20 |
2013-09-26 |
Vilnius University |
RNA-DIRECTED DNA CLEAVAGE BY THE Cas9-crRNA COMPLEX
|
|
US9637739B2
(en)
|
2012-03-20 |
2017-05-02 |
Vilnius University |
RNA-directed DNA cleavage by the Cas9-crRNA complex
|
|
AU2013266968B2
(en)
|
2012-05-25 |
2017-06-29 |
Emmanuelle CHARPENTIER |
Methods and compositions for RNA-directed target DNA modification and for RNA-directed modulation of transcription
|
|
SG10201708959WA
(en)
|
2012-07-03 |
2017-11-29 |
Univ Washington |
Antibodies to tau
|
|
WO2014033644A2
(en)
|
2012-08-28 |
2014-03-06 |
Novartis Ag |
Methods of nuclease-based genetic engineering
|
|
AU2013335451C1
(en)
|
2012-10-23 |
2024-07-04 |
Toolgen Incorporated |
Composition for cleaving a target DNA comprising a guide RNA specific for the target DNA and Cas protein-encoding nucleic acid or Cas protein, and use thereof
|
|
US9910048B2
(en)
|
2012-12-03 |
2018-03-06 |
Washington University |
Method for detection of aggregates in biological samples
|
|
PL3360964T3
(pl)
|
2012-12-06 |
2020-03-31 |
Sigma-Aldrich Co. Llc |
Modyfikacja i regulacja genomu oparta na crispr
|
|
EP2840140B2
(en)
|
2012-12-12 |
2023-02-22 |
The Broad Institute, Inc. |
Crispr-Cas based method for mutation of prokaryotic cells
|
|
EP3031921B1
(en)
|
2012-12-12 |
2025-03-12 |
The Broad Institute, Inc. |
Delivery, engineering and optimization of systems, methods and compositions for sequence manipulation and therapeutic applications
|
|
EP2931899A1
(en)
|
2012-12-12 |
2015-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions, methods, knock out libraries and applications thereof
|
|
US20140186843A1
(en)
|
2012-12-12 |
2014-07-03 |
Massachusetts Institute Of Technology |
Methods, systems, and apparatus for identifying target sequences for cas enzymes or crispr-cas systems for target sequences and conveying results thereof
|
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
|
DK2931891T3
(da)
|
2012-12-17 |
2019-08-19 |
Harvard College |
Rna-styret modificering af menneskelige genomer
|
|
EP2922393B2
(en)
|
2013-02-27 |
2022-12-28 |
Helmholtz Zentrum München - Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) |
Gene editing in the oocyte by cas9 nucleases
|
|
CN112301024A
(zh)
|
2013-03-15 |
2021-02-02 |
通用医疗公司 |
使用RNA引导的FokI核酸酶(RFN)提高RNA引导的基因组编辑的特异性
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
US9267135B2
(en)
|
2013-06-04 |
2016-02-23 |
President And Fellows Of Harvard College |
RNA-guided transcriptional regulation
|
|
EP3725885A1
(en)
|
2013-06-17 |
2020-10-21 |
The Broad Institute, Inc. |
Functional genomics using crispr-cas systems, compositions methods, screens and applications thereof
|
|
WO2015048577A2
(en)
|
2013-09-27 |
2015-04-02 |
Editas Medicine, Inc. |
Crispr-related methods and compositions
|
|
WO2015065964A1
(en)
|
2013-10-28 |
2015-05-07 |
The Broad Institute Inc. |
Functional genomics using crispr-cas systems, compositions, methods, screens and applications thereof
|
|
JP2017512751A
(ja)
|
2014-02-14 |
2017-05-25 |
アイピエリアン,インコーポレイティド |
タウペプチド、抗タウ抗体、およびそれらの使用方法
|
|
US20150376586A1
(en)
|
2014-06-25 |
2015-12-31 |
Caribou Biosciences, Inc. |
RNA Modification to Engineer Cas9 Activity
|
|
CA2954791C
(en)
|
2014-07-14 |
2025-11-18 |
The Regents Of The University Of California |
CRISPR/CAS TRANSCRIPTIONAL MODULATION
|
|
WO2016049258A2
(en)
|
2014-09-25 |
2016-03-31 |
The Broad Institute Inc. |
Functional screening with optimized functional crispr-cas systems
|
|
WO2016106236A1
(en)
|
2014-12-23 |
2016-06-30 |
The Broad Institute Inc. |
Rna-targeting system
|
|
US9790490B2
(en)
|
2015-06-18 |
2017-10-17 |
The Broad Institute Inc. |
CRISPR enzymes and systems
|
|
US10676735B2
(en)
|
2015-07-22 |
2020-06-09 |
Duke University |
High-throughput screening of regulatory element function with epigenome editing technologies
|
|
AU2016365720B2
(en)
|
2015-12-07 |
2020-11-26 |
Arc Bio, Llc |
Methods and compositions for the making and using of guide nucleic acids
|
|
LT3436077T
(lt)
|
2016-03-30 |
2025-06-25 |
Intellia Therapeutics, Inc. |
Lipidų nanodalelių vaisto formos, skirtos crispr/cas komponentams
|
|
WO2017172764A1
(en)
|
2016-04-01 |
2017-10-05 |
The Regents Of The University Of California |
Modified cell line and method of determining tauopathies
|
|
JP2019513415A
(ja)
*
|
2016-04-04 |
2019-05-30 |
イーティーエッチ チューリッヒ |
タンパク質産生及びライブラリー生成のための哺乳類細胞株
|
|
CN110267985B
(zh)
|
2017-01-04 |
2023-05-23 |
H.隆德贝克有限公司 |
用于治疗眼科疾病的特异性针对过度磷酸化τ蛋白的抗体
|
|
GB201708998D0
(en)
|
2017-06-06 |
2017-07-19 |
Univ Leuven Kath |
Methods for identifying activators and suppressors
|
|
WO2019010384A1
(en)
|
2017-07-07 |
2019-01-10 |
The Broad Institute, Inc. |
METHODS FOR DESIGNING GUIDE SEQUENCES FOR GUIDED NUCLEASES
|
|
CN110891420B
(zh)
|
2017-07-31 |
2022-06-03 |
瑞泽恩制药公司 |
Cas转基因小鼠胚胎干细胞和小鼠及其应用
|
|
KR20200033259A
(ko)
*
|
2017-07-31 |
2020-03-27 |
리제너론 파마슈티칼스 인코포레이티드 |
생체내에서 CRISPR/Cas-매개된 파괴 또는 삭제 및 외인성 도너 핵산과의 CRISPR/Cas-유도된 재조합을 평가하기 위한 방법 및 조성물
|
|
EP3592140A1
(en)
|
2018-03-19 |
2020-01-15 |
Regeneron Pharmaceuticals, Inc. |
Transcription modulation in animals using crispr/cas systems
|
|
CA3133983A1
(en)
|
2019-03-18 |
2020-09-24 |
Regeneron Pharmaceuticals, Inc. |
Methods and systems for crispr selection
|
|
CN120648640A
(zh)
|
2019-03-18 |
2025-09-16 |
瑞泽恩制药公司 |
用于鉴定tau接种或聚集的基因修饰因子的CRISPR/Cas筛选平台
|
|
EP3769090B1
(en)
|
2019-03-18 |
2023-11-15 |
Regeneron Pharmaceuticals, Inc. |
Crispr/cas dropout screening platform to reveal genetic vulnerabilities associated with tau aggregation
|
|
CN113906134B
(zh)
|
2019-06-14 |
2025-06-24 |
瑞泽恩制药公司 |
Tau蛋白病模型
|