JP2022523806A - 閉端ｄｎａ（ｃｅｄｎａ）および免疫調節化合物 - Google Patents

閉端ｄｎａ（ｃｅｄｎａ）および免疫調節化合物 Download PDF

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JP2022523806A
JP2022523806A JP2021552582A JP2021552582A JP2022523806A JP 2022523806 A JP2022523806 A JP 2022523806A JP 2021552582 A JP2021552582 A JP 2021552582A JP 2021552582 A JP2021552582 A JP 2021552582A JP 2022523806 A JP2022523806 A JP 2022523806A
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cedna
vector
dna
itr
cedna vector
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デブラ クラット，
マシュー スタントン，
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ジェネレーション バイオ カンパニー
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    • A61K48/0058—Nucleic acids adapted for tissue specific expression, e.g. having tissue specific promoters as part of a contruct
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    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
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    • C12N2710/00011—Details
    • C12N2710/14011—Baculoviridae
    • C12N2710/14111—Nucleopolyhedrovirus, e.g. autographa californica nucleopolyhedrovirus
    • C12N2710/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2710/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2750/00011—Details
    • C12N2750/14011—Parvoviridae
    • C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
    • C12N2750/14141—Use of virus, viral particle or viral elements as a vector
    • C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/48—Vector systems having a special element relevant for transcription regulating transport or export of RNA, e.g. RRE, PRE, WPRE, CTE
    • C—CHEMISTRY; METALLURGY
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    • C12N2830/00—Vector systems having a special element relevant for transcription
    • C12N2830/50—Vector systems having a special element relevant for transcription regulating RNA stability, not being an intron, e.g. poly A signal

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  • Manufacturing & Machinery (AREA)
  • Virology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2021552582A 2019-03-06 2020-03-06 閉端ｄｎａ（ｃｅｄｎａ）および免疫調節化合物 Pending JP2022523806A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962814477P 2019-03-06 2019-03-06
US62/814,477 2019-03-06
PCT/US2020/021367 WO2020181182A1 (en) 2019-03-06 2020-03-06 Closed-ended dna (cedna) and immune modulating compounds

Publications (2)

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JP2022523806A true JP2022523806A (ja) 2022-04-26
JP2022523806A5 JP2022523806A5 (https=) 2023-03-14

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JP2021552582A Pending JP2022523806A (ja) 2019-03-06 2020-03-06 閉端ｄｎａ（ｃｅｄｎａ）および免疫調節化合物

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US (1) US20220184231A1 (https=)
EP (1) EP3934701A4 (https=)
JP (1) JP2022523806A (https=)
AU (1) AU2020231228A1 (https=)
CA (1) CA3132164A1 (https=)
IL (1) IL286031A (https=)
MA (1) MA55223A (https=)
SG (1) SG11202108864UA (https=)
WO (1) WO2020181182A1 (https=)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ762100A (en) 2017-08-09 2025-12-19 Bioverativ Therapeutics Inc Nucleic acid molecules and uses thereof
EP3833766A1 (en) 2018-08-09 2021-06-16 Bioverativ Therapeutics Inc. Nucleic acid molecules and uses thereof for non-viral gene therapy
JP2023535632A (ja) 2020-07-27 2023-08-18 アンジャリウム バイオサイエンシズ エージー Ｄｎａ分子の組成物、その作製方法、及びその使用方法
WO2025114932A1 (en) * 2023-11-30 2025-06-05 Sanofi Purification of closed-ended dna molecules

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016121942A1 (ja) * 2015-01-30 2016-08-04 日油株式会社 カチオン性脂質
WO2017152149A1 (en) * 2016-03-03 2017-09-08 University Of Massachusetts Closed-ended linear duplex dna for non-viral gene transfer

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2500434A1 (en) * 2011-03-12 2012-09-19 Association Institut de Myologie Capsid-free AAV vectors, compositions, and methods for vector production and gene delivery
US10086089B2 (en) * 2015-09-18 2018-10-02 DNARx Systems and methods for nucleic acid expression in vivo
GB2547179A (en) * 2015-10-26 2017-08-16 Quethera Ltd Genetic construct
CN117653654A (zh) * 2016-11-23 2024-03-08 柏林制药股份有限公司 用于抑制和/或压制tlr9激活的适体
WO2018237369A2 (en) * 2017-06-23 2018-12-27 Vical Incorporated Lipid nanoparticle (lnp)-mediated delivery of a crispr-expressing plasmid dna for treating chronic hepatitis b virus infection

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016121942A1 (ja) * 2015-01-30 2016-08-04 日油株式会社 カチオン性脂質
WO2017152149A1 (en) * 2016-03-03 2017-09-08 University Of Massachusetts Closed-ended linear duplex dna for non-viral gene transfer

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JOURNAL OF CONTROLLED RELEASE, vol. 279, JPN6024005137, 2018, pages 262 - 270, ISSN: 0005514989 *

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Publication number Publication date
SG11202108864UA (en) 2021-09-29
IL286031A (en) 2021-10-31
WO2020181182A1 (en) 2020-09-10
EP3934701A1 (en) 2022-01-12
US20220184231A1 (en) 2022-06-16
MA55223A (fr) 2022-01-12
EP3934701A4 (en) 2022-12-14
CA3132164A1 (en) 2020-09-10
AU2020231228A1 (en) 2021-09-02

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