JP2022523360A - Ｍｅｔに結合する抗ｍｅｔ抗体および二特異性抗原結合分子を使用した眼癌の治療方法 - Google Patents

Ｍｅｔに結合する抗ｍｅｔ抗体および二特異性抗原結合分子を使用した眼癌の治療方法 Download PDF

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JP2022523360A
JP2022523360A JP2021549279A JP2021549279A JP2022523360A JP 2022523360 A JP2022523360 A JP 2022523360A JP 2021549279 A JP2021549279 A JP 2021549279A JP 2021549279 A JP2021549279 A JP 2021549279A JP 2022523360 A JP2022523360 A JP 2022523360A
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met
amino acid
binding
antibody
acid sequence
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JP2022523360A5 (enExample
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ゲイリー シュワルツ，
オリバー スリガ，
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Regeneron Pharmaceuticals Inc
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Regeneron Pharmaceuticals Inc
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines ortho- or peri-condensed with heterocyclic ring systems
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    • A61K47/6889—Conjugates wherein the antibody being the modifying agent and wherein the linker, binder or spacer confers particular properties to the conjugates, e.g. peptidic enzyme-labile linkers or acid-labile linkers, providing for an acid-labile immuno conjugate wherein the drug may be released from its antibody conjugated part in an acidic, e.g. tumoural or environment
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  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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JP2021549279A 2019-02-21 2020-02-20 Ｍｅｔに結合する抗ｍｅｔ抗体および二特異性抗原結合分子を使用した眼癌の治療方法 Pending JP2022523360A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201962808839P 2019-02-21 2019-02-21
US62/808,839 2019-02-21
US201962823788P 2019-03-26 2019-03-26
US62/823,788 2019-03-26
PCT/US2020/019126 WO2020172475A1 (en) 2019-02-21 2020-02-20 Methods of treating ocular cancer using anti-met antibodies and bispecific antigen binding molecules that bind met

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JP2022523360A true JP2022523360A (ja) 2022-04-22
JP2022523360A5 JP2022523360A5 (enExample) 2022-12-14

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US (1) US20220040319A1 (enExample)
EP (1) EP3927435A1 (enExample)
JP (1) JP2022523360A (enExample)
KR (1) KR20210130755A (enExample)
CN (1) CN113727757A (enExample)
AU (1) AU2020224136C1 (enExample)
CA (1) CA3128519A1 (enExample)
IL (1) IL285308A (enExample)
MX (1) MX2021010114A (enExample)
SG (1) SG11202108525VA (enExample)
WO (1) WO2020172475A1 (enExample)

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US12545735B2 (en) 2016-11-16 2026-02-10 Regeneron Pharmaceuticals, Inc. Anti-met antibodies, bispecific antigen binding molecules that bind met, and methods of use thereof

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AU2020349462A1 (en) 2019-09-16 2022-03-03 Regeneron Pharmaceuticals, Inc. Radiolabeled MET binding proteins for immuno-PET imaging
WO2022204332A1 (en) * 2021-03-24 2022-09-29 Combangio, Inc. Compositions comprising c-met agonist antibodies and methods for use in ocular treatment
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CA3260255A1 (en) * 2022-06-29 2024-01-04 Doma Biopharmaceutical (Suzhou) Co., Ltd. EGFR/MET ANTIBODIES AND THEIR USES

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