JP2022517110A5 - - Google Patents

Info

Publication number
JP2022517110A5
JP2022517110A5 JP2021540534A JP2021540534A JP2022517110A5 JP 2022517110 A5 JP2022517110 A5 JP 2022517110A5 JP 2021540534 A JP2021540534 A JP 2021540534A JP 2021540534 A JP2021540534 A JP 2021540534A JP 2022517110 A5 JP2022517110 A5 JP 2022517110A5
Authority
JP
Japan
Prior art keywords
substituted
independently
independently selected
alkyl
ring atoms
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2021540534A
Other languages
English (en)
Japanese (ja)
Other versions
JP2022517110A (ja
JP7373571B2 (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2020/013262 external-priority patent/WO2020150113A1/en
Publication of JP2022517110A publication Critical patent/JP2022517110A/ja
Publication of JP2022517110A5 publication Critical patent/JP2022517110A5/ja
Application granted granted Critical
Publication of JP7373571B2 publication Critical patent/JP7373571B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2021540534A 2019-01-14 2020-01-13 がん治療に用いるためのnlrp3モジュレーターとしての置換キナゾリン Active JP7373571B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962791913P 2019-01-14 2019-01-14
US62/791,913 2019-01-14
PCT/US2020/013262 WO2020150113A1 (en) 2019-01-14 2020-01-13 Substituted quinazolines as nlrp3 modulators, for use in the treatment of cancer

Publications (3)

Publication Number Publication Date
JP2022517110A JP2022517110A (ja) 2022-03-04
JP2022517110A5 true JP2022517110A5 (enExample) 2022-09-05
JP7373571B2 JP7373571B2 (ja) 2023-11-02

Family

ID=69529008

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2021540534A Active JP7373571B2 (ja) 2019-01-14 2020-01-13 がん治療に用いるためのnlrp3モジュレーターとしての置換キナゾリン

Country Status (7)

Country Link
US (1) US12187706B2 (enExample)
EP (1) EP3911416B1 (enExample)
JP (1) JP7373571B2 (enExample)
KR (1) KR102903509B1 (enExample)
CN (1) CN113301963A (enExample)
ES (1) ES2981835T3 (enExample)
WO (1) WO2020150113A1 (enExample)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN114555565B (zh) * 2019-12-13 2024-03-05 四川科伦博泰生物医药股份有限公司 含氮并环化合物、其制备方法及用途
TWI911262B (zh) * 2020-08-14 2026-01-11 美商戴納立製藥公司 化合物、組合物及方法
UY39906A (es) * 2021-08-18 2023-03-31 Jacobio Pharmaceuticals Co Ltd Derivados de 1,4-oxazepano y usos de los mismos
UY40657A (es) 2023-03-01 2024-09-13 Novartis Ag Derivados de hidroquinazolina para el tratamiento de una enfermedad o un trastorno

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CZ302706B6 (cs) 1998-12-23 2011-09-14 Pfizer Inc. Lidská monoklonální protilátka, farmaceutická kompozice tuto protilátku obsahující, bunecná linie produkující tuto protilátku, izolovaná molekula kódující težký nebo lehký retezec uvedené protilátky, hostitelská bunka obsahující tuto izolovanou molek
EP1212422B1 (en) 1999-08-24 2007-02-21 Medarex, Inc. Human ctla-4 antibodies and their uses
US7927613B2 (en) 2002-02-15 2011-04-19 University Of South Florida Pharmaceutical co-crystal compositions
WO2006050843A1 (en) * 2004-11-09 2006-05-18 F. Hoffmann-La Roche Ag Aminoquinazolines compounds
PT1907424E (pt) 2005-07-01 2015-10-09 Squibb & Sons Llc Anticorpos monoclonais humanos para o ligando 1 de morte programada (pd-l1)
WO2008009077A2 (en) * 2006-07-20 2008-01-24 Gilead Sciences, Inc. 4,6-dl- and 2,4,6-trisubstituted quinazoline derivatives and pharmaceutical compositions useful for treating viral infections
BR122017025062B8 (pt) 2007-06-18 2021-07-27 Merck Sharp & Dohme anticorpo monoclonal ou fragmento de anticorpo para o receptor de morte programada humano pd-1, polinucleotídeo e composição compreendendo o referido anticorpo ou fragmento
EP3255060A1 (en) 2008-12-09 2017-12-13 F. Hoffmann-La Roche AG Anti-pd-l1 antibodies and their use to enhance t-cell function
PL2504364T3 (pl) 2009-11-24 2017-12-29 Medimmune Limited Ukierunkowane środki wiążące przeciwko B7-H1
JP6072771B2 (ja) 2011-04-20 2017-02-01 メディミューン,エルエルシー B7−h1およびpd−1に結合する抗体およびその他の分子
KR101764096B1 (ko) 2011-11-28 2017-08-02 메르크 파텐트 게엠베하 항-pd-l1 항체 및 그의 용도
HK1203971A1 (en) 2012-05-15 2015-11-06 Bristol-Myers Squibb Company Cancer immunotherapy by disrupting pd-1/pd-l1 signaling
KR20220084444A (ko) 2012-05-31 2022-06-21 소렌토 쎄라퓨틱스, 인코포레이티드 Pd-l1에 결합하는 항원 결합 단백질
SMT202100065T1 (it) 2013-05-02 2021-03-15 Anaptysbio Inc Anticorpi diretti contro la proteina della morte programmata (pd-1)
PE20160080A1 (es) 2013-05-18 2016-02-21 Aduro Biotech Inc Composiciones y metodos para activar la senalizacion que depende del estimulador del gen de interferon
WO2014194302A2 (en) 2013-05-31 2014-12-04 Sorrento Therapeutics, Inc. Antigen binding proteins that bind pd-1
CN112552401B (zh) 2013-09-13 2023-08-25 广州百济神州生物制药有限公司 抗pd1抗体及其作为治疗剂与诊断剂的用途
SG10201804945WA (en) 2013-12-12 2018-07-30 Shanghai hengrui pharmaceutical co ltd Pd-1 antibody, antigen-binding fragment thereof, and medical application thereof
TWI681969B (zh) 2014-01-23 2020-01-11 美商再生元醫藥公司 針對pd-1的人類抗體
PE20170255A1 (es) 2014-01-24 2017-03-22 Dana Farber Cancer Inst Inc Moleculas de anticuerpo que se unen a pd-1 y usos de las mismas
CN108112254B (zh) 2015-03-13 2022-01-28 西托姆克斯治疗公司 抗-pdl1抗体、可活化的抗-pdl1抗体、及其使用方法
MA53355A (fr) 2015-05-29 2022-03-16 Agenus Inc Anticorps anti-ctla-4 et leurs procédés d'utilisation
WO2017024465A1 (en) 2015-08-10 2017-02-16 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
AR105654A1 (es) 2015-08-24 2017-10-25 Lilly Co Eli Anticuerpos pd-l1 (ligando 1 de muerte celular programada)
AU2016317915B2 (en) 2015-09-01 2021-02-18 Agenus Inc. Anti-PD-1 antibodies and methods of use thereof
WO2017132827A1 (en) 2016-02-02 2017-08-10 Innovent Biologics (Suzhou) Co., Ltd. Pd-1 antibodies
CN108029076B (zh) 2016-02-02 2020-03-10 华为技术有限公司 确定发射功率的方法、用户设备和基站
KR20180134395A (ko) * 2016-04-19 2018-12-18 인네이트 튜머 이뮤니티, 인코포레이티드 Nlrp3 조정제
US10533007B2 (en) * 2016-04-19 2020-01-14 Innate Tumor Immunity, Inc. NLRP3 modulators
WO2018021977A1 (en) * 2016-07-29 2018-02-01 Agency For Science, Technology And Research Glycine metabolism modulators and uses thereof
TW201945003A (zh) * 2018-03-01 2019-12-01 愛爾蘭商健生科學愛爾蘭無限公司 2,4-二胺基喹唑啉衍生物及其醫學用途
EP3560922A1 (de) * 2018-04-24 2019-10-30 Bayer Aktiengesellschaft Verfahren zur herstellung von (4s)- 4-(4-cyano-2-methoxyphenyl)-5-ethoxy-2,8-dimethyl-1,4-dihydro-1,6-naphthyridin-3-carbox-amid durch racemat-spaltung mittels diastereomerer weinsäureester

Similar Documents

Publication Publication Date Title
JP2022517110A5 (enExample)
JP2021522249A5 (enExample)
JP2021534168A5 (enExample)
JP2021534158A5 (enExample)
JP2022517109A5 (enExample)
ES2728739T3 (es) Derivado de rapamicina para el tratamiento de un tumor sólido asociado con angiogénesis desregulada
JP7182304B2 (ja) インドリノン化合物の使用
JP2021508686A5 (enExample)
JP2020503299A5 (enExample)
CA3019450A1 (en) Indoleamine 2,3-dioxygenase inhibitor, preparation method therefor, and application
JP2020097596A5 (enExample)
RU2015121424A (ru) Комбинированная терапия
JP2023531709A5 (enExample)
JP2010500376A5 (enExample)
JP2023548657A5 (enExample)
JP2015536986A5 (enExample)
JP2023531495A5 (enExample)
JP2023506787A5 (enExample)
JP2018062523A5 (enExample)
JP2017530129A (ja) ツブリシン複合体を用いた癌の治療方法
RU2020113749A (ru) Аналоги таиланстатина
JP2022515670A5 (enExample)
JP2024501280A5 (enExample)
JP2025516358A5 (enExample)
WO2013181462A1 (en) Use of amg 900 for the treatment of cancer